Negative / Null Result ReportMedicine
Ling L, Ali T, Li X et al. · 2026 · Neurochemistry international
Diabetic neuropathy (DN) is driven by neuroinflammation and oxidative stress, with c-Jun N-terminal kinase (JNK) as a key mediator; however, the effects of JNK inhibition on neuropathic pain remain unclear. Therefore, we investigated the…
View details →DOI: 10.1016/j.neuint.2026.106167 Negative / Null Result ReportMedicine
Wu Z, Menezes ES, Silva NMLE et al. · 2026 · Genes
Background/Objectives : MicroRNAs (miRNAs) are key regulators of skeletal muscle adaptation; however, the extent to which exercise modulates the miRNA biogenesis pathway remains poorly understood. To investigate the impact of acute and…
View details →DOI: 10.3390/genes17060626 Negative / Null Result ReportMedicine
Butcko AJ, Adeshina KA, Kamali P et al. · 2026 · Scientific reports
PNPLA3-I148M, the greatest genetic determinant for metabolic dysfunction-associated steatotic liver disease (MASLD), paradoxically associates with reduced cardiovascular disease (CVD); however, the mechanisms are poorly understood. To…
View details →DOI: 10.1038/s41598-026-47839-2 Negative / Null Result ReportMedicine
Chatzivasileiou K, Kamalakidis SN, Pissiotis AL et al. · 2026 · The International journal of prosthodontics
Purpose To evaluate the combined effect of different polishing protocols and different denture cleansers on the surface roughness of three heat-polymerized polymethyl methacrylate (PMMA) denture base materials. Materials and methods The…
View details →DOI: 10.11607/ijp.9294 Negative / Null Result ReportMedicine
Gu R, Qin FY, Sun Z et al. · 2026 · Toxicological sciences : an official journal of the Society of Toxicology
Deficiency of ferrochelatase (FECH) in erythropoietic protoporphyria (EPP) leads to accumulation of its substrate, protoporphyrin IX (PPIX), the final intermediate in the heme biosynthesis pathway. PPIX is produced primarily in the bone…
View details →DOI: 10.1093/toxsci/kfag041 Negative / Null Result ReportMedicine
Gasper K, Haynes E · 2026 · Cognition & emotion
Positive feelings may diminish. It is unclear whether this decrease stems from people feeling less positive, more negative, more neutral, or some combination. Using an evaluative conditioning (EC) paradigm, we investigated how pre-existing…
View details →DOI: 10.1080/02699931.2026.2616632 Negative / Null Result ReportMedicine
Duque-Estrada P, Markussen B, Schutyser M et al. · 2026 · Food chemistry
Thermal treatment can improve plant protein digestibility by inactivating antinutrients and partially denaturing proteins, but depending on the conditions applied, heating may also promote aggregation and amino acid modifications that…
View details →DOI: 10.1016/j.foodchem.2026.149181 Negative / Null Result Report
Both A, Chevalier C, Connor MG et al. · 2026 · Preprint
Crosstalk between respiratory bacteria and human airway epithelial cells initiates cellular immunity, yet the molecular determinants of asymptomatic carriage versus inflammation remain incompletely understood. A key regulator of airway…
View details →DOI: 10.64898/2026.02.13.705726 Negative / Null Result ReportMedicine
Souza VKB, Ferreira DA, Arantes APR et al. · 2026 · Cell biochemistry and biophysics
Chronic neuroinflammation contributes to neuronal damage through oxidative stress and inflammatory mediators, highlighting the need for novel therapeutic strategies. This study evaluated the cytotoxicity and neuroprotective effects of…
View details →DOI: 10.1007/s12013-026-02108-x Negative / Null Result Report
Litif C, Libster AM, Desfor S et al. · 2026 · Preprint
The Reln gene encodes the extracellular glycoprotein Reelin that regulates synaptic plasticity and activity-dependent gene expression with implications in several neuropsychiatric disorders, including substance use disorder. While reduced…
View details →DOI: 10.64898/2026.02.21.707172 Negative / Null Result Report
Anwar S, Ebrahimi-Iranpour S, Huq S et al. · 2025 · Preprint
Lysosomes are organelles responsible for degrading unwanted extracellular material that cells internalize, or intracellular material targeted for disposal. Typically, lysosomes are globular in morphology. However, in activated macrophages…
View details →DOI: 10.1101/2025.09.25.677195 Negative / Null Result ReportMedicine
Shim HG, Fanning AS, Raymond JL · 2026 · The Journal of neuroscience : the official journal of the Society for Neuroscience
It is increasingly recognized that learning and memory depend not only on changes in synaptic strength but also on experience-dependent modifications of intrinsic neuronal excitability. However, how these two forms of plasticity interact…
View details →DOI: 10.1523/jneurosci.1257-25.2026 Negative / Null Result ReportMedicine
Acton JP, Alsharif NS, Bond JW et al. · 2026 · European journal of applied physiology
Coenzyme Q10 (CoQ 10 ) is an integral component of the mitochondrial electron transfer system. Most studies have administered the oxidised form of CoQ 10 (ubiquinone) and observed no effects on mitochondrial respiratory function or…
View details →DOI: 10.1007/s00421-026-06275-w Negative / Null Result ReportMedicine
Su Y, Hu Q, Dou Z et al. · 2026 · Food research international (Ottawa, Ont.)
κ-Carrageenase with alkaline resistance can promote the resource utilization of κ-carrageenan industrial residues. In this study, a rational design strategy integrating surface charge optimization and consensus sequence analysis was…
View details →DOI: 10.1016/j.foodres.2026.119085 Negative / Null Result ReportMedicine
Hosny R, Saad M, Shebl R et al. · 2026 · Emergency radiology
PURPOSE: To evaluate the necessity of computed tomography (CT) in open globe injuries after ophthalmological assessment in the emergency department (ED) prior to primary repair. METHODS: A review of the medical records of patients…
View details →DOI: 10.1007/s10140-026-02439-5 Negative / Null Result ReportMedicine
Hofbauer LM, Rodriguez FS · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
PurposeThis study examined whether different types of help received influence subsequent levels of functional ability in older adults.MethodsLongitudinal data were drawn from the US Health and Retirement Study (HRS), the Survey of Health,…
View details →DOI: 10.1177/07334648261416580 Negative / Null Result ReportMedicine
Rees M, Vieira F, Yarragudi SB et al. · 2026 · Journal of applied physiology (Bethesda, Md. : 1985)
Nasal high flow (NHF) with the asymmetrical cannula interface (AI) is increasingly used as respiratory support across a broad range of patients. By incorporating one unilaterally oversized prong, the AI enhances dead-space clearance and…
View details →DOI: 10.1152/japplphysiol.00068.2026 Negative / Null Result ReportMedicine
Kagota S, Maruyama-Fumoto K, Niki A et al. · 2026 · Metabolic syndrome and related disorders
Background Perivascular adipose tissue (PVAT), found outside blood vessels, enhances vasorelaxation when endothelium-mediated vasorelaxation fails, as observed in the mesenteric arteries of rats with metabolic syndrome (MetS) and…
View details →DOI: 10.1177/15578518261431679 Negative / Null Result ReportMedicine
Yadav P, Hamrahian AH, Salvatori R · 2026 · Pituitary
PURPOSE: Macimorelin, a ghrelin receptor agonist, is used for diagnosing adult GH deficiency (AGHD). The FDA-approved GH cut-off is 2.8 ng/mL, whereas post-hoc analyses proposed a cut-off of 5.1 ng/mL. The real-world performance of these…
View details →DOI: 10.1007/s11102-026-01654-0 Negative / Null Result ReportMedicine
Peng Z, Xu C, Zhang Y et al. · 2026 · Innovative Food Science and Emerging Technologies.
Radio frequency (RF) heating, as a promising alternative roasting method, could effectively improve peanut oil quality and degrade aflatoxins. However, during the peanut oil processing, the modification effect and mechanism on protein by…
Negative / Null Result ReportOpen accessMedicine
Prasadan K, Saleh M, Thomas M et al. · 2026 · The Journal of biological chemistry
Several studies have analyzed the effect of glucagon on β-cells and glucose homeostasis, either by ablating α-cells or by globally deleting the glucagon/glucagon receptor gene. To investigate possible interactions between α-cells and…
View details →DOI: 10.1016/j.jbc.2026.113145 Negative / Null Result ReportMedicine
Sedghi A, Kaiser DPO, Arndt M et al. · 2026 · Annals of clinical and translational neurology
Objective Intravenous thrombolysis (IVT) before thrombectomy for ischemic stroke may alter clot structure and procedural performance. We investigated how IVT relates to thrombectomy metrics across stroke etiologies. Methods We performed a…
View details →DOI: 10.1002/acn3.70370 Negative / Null Result ReportMedicine
Elham Mahdavi, Ghorbani Yekta B, Fereshteh Atabi · 2026 · Cellular and molecular biology (Noisy-le-Grand, France)
Rapid-eye movement (REM) sleep is a critical stage of sleep that plays a pivotal role in memory formation, consolidation, and mood regulation. While REM sleep deprivation (REM SD) has been shown to impair cognitive and affective functions,…
View details →DOI: 10.14715/cmb/2025.72.2.7 Negative / Null Result ReportMedicine
Hsu G, Petticord DF, Slimon KF et al. · 2025 · Oikos
Prey capture by carnivorous plants is influenced by plant traits, environmental factors and interactions with animals. However, little is known about how interactions with heterospecific plant neighbors affect prey capture. Here, we…
Negative / Null Result ReportMedicine
Azzopardi S, Garcin B, Mesrati F et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology
Background and objective In patients with functional neurological disorder (FND), transcranial magnetic stimulation (TMS) can be used for either diagnostic or therapeutic purpose. This study aimed to determine patients' expectations and…
View details →DOI: 10.1016/j.neucli.2026.103158 Negative / Null Result ReportMedicine
Rodriguez AK, Taylor TL, Fawver B et al. · 2026 · Psychology of sport and exercise
Individuals experiencing anxiety exhibit attentional biases towards unpleasant stimuli. Exercise is an anxiolytic intervention, evidenced by changes in attentional bias following physical activity. Many individuals experience 'anxiety…
View details →DOI: 10.1016/j.psychsport.2026.103125 Negative / Null Result ReportMedicine
Amaravadi RK · 2022 · Autophagy
Macroautophagy/autophagy is a resistance mechanism to targeted therapy in BRAF mutant cancers. Preclinical evidence and clinical trial data demonstrate that hydroxychloroquine (HCQ) is an effective autophagy inhibitor at clinically…
View details →DOI: 10.1080/15548627.2022.2038899 Negative / Null Result ReportOpen accessMedicine
Okuizumi R, Maruyama S, Okamoto M et al. · 2026 · Journal of clinical biochemistry and nutrition
Coenzyme Q10 is a lipid-soluble antioxidant essential for the mitochondrial electron transport chain. Its concentration in the body decreases with age. The biosynthesis of coenzyme Q10 involves enzymes coq1 (PDSS1, PDSS2) through coq9,…
View details →DOI: 10.3164/jcbn.24-239 Negative / Null Result ReportMedicine
Martin BI, Mirza SK, Ko H et al. · 2026 · The spine journal : official journal of the North American Spine Society
Background context Medicare's Transforming Episode Accountability Model (TEAM) holds hospitals accountable for 30-day postoperative complications across 18 categories of spinal fusion bundles, yet baseline differences in complication rates…
View details →DOI: 10.1016/j.spinee.2026.03.009 Negative / Null Result ReportMedicine
Anijs RJS, Nguyen YN, Yanovska M et al. · 2025 · Thrombosis research
Background Colorectal cancer (CRC) patients are at increased risk of developing venous thromboembolism (VTE), leading to high morbidity and mortality. The exact mechanism remains unknown, which complicates risk prediction and treatment.…
View details →DOI: 10.1016/j.thromres.2025.109535 