e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19895 results in Negative / Null Result Report · page 563 of 664

Negative / Null Result ReportMedicine

Evaluation of 4 Different Suture Threads in A Sample of Dentistry Suture-Naïve Students: A Randomised Controlled Trial.

Davide S, Domenico M, Fabio C et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Introduction Suturing is a crucial step in oral surgery, directly affecting wound healing quality. Simple interrupted suture is widely used in dentistry, often performed by novices using silk sutures due to their ease of use and low cost.…

View details →DOI: 10.1111/eje.70134
Negative / Null Result ReportMedicine

Effect of Arthroscopic Rotator Cuff Repair Combined With Different Long Head of the Biceps Tendon Fixation Techniques on Postoperative Clinical Outcomes and Shoulder Function.

Guan J, Chen Y, Ye J et al. · 2026 · Annali italiani di chirurgia

Aim Rotator cuff tears and long head of the biceps tendon (LHBT) injuries are primary causes of shoulder pain. During rotator cuff repair, concurrent LHBT injuries are frequently identified. Surgical management of LHBT injuries can…

View details →DOI: 10.62713/aic.4500
Negative / Null Result ReportMedicine

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co-Infected With HIV.

Phyo AP, Hoglund RM, Saito M et al. · 2026 · Tropical medicine & international health : TM & IH

Background HIV co-infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first-line anti-TB drugs and clinical outcomes in patients with and without HIV co-infection.…

View details →DOI: 10.1111/tmi.70165
Negative / Null Result ReportMedicine

Enhanced biomechanical outcomes of split-thickness skin grafts with a three-dimensional collagen-elastin matrix in deep second-degree burns: A 12-month comparative study.

Nicklas A, Bienger K, Rudari M et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Background Split-thickness skin grafting (STSG) remains the standard for deep second-degree burns, but grafted skin often shows suboptimal biomechanical properties. The dermal substitute MatriDerm® may improve elasticity, structural…

View details →DOI: 10.1016/j.burns.2026.107977
Negative / Null Result ReportMedicine

Mid- and long-term results of primary vs. secondary total elbow arthroplasty after index intra-articular fracture of the distal humerus in the elderly.

Deml O, Schenk P, Fritsche C et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Geriatric distal humerus fractures are difficult to manage. Open reduction and internal fixation remain the standard, but total elbow arthroplasty (TEA) appears to be a viable alternative. This study evaluated the long-term…

View details →DOI: 10.1016/j.jsea.2026.100027
Negative / Null Result ReportMedicine

Validation of aortic valve calcification quantification on contrast-enhanced computed tomography against ex vivo gravimetric analysis: comparison of fixed Hounsfield unit thresholds and deep learning segmentation.

Jiang D, Zhang W, Liu L et al. · 2026 · BMC cardiovascular disorders

Background Accurate quantification of aortic valve calcification (AVC) on contrast-enhanced computed tomography angiography (CTA) is pivotal for planning surgical and transcatheter aortic valve replacement. The optimal Hounsfield unit (HU)…

View details →DOI: 10.1186/s12872-026-06108-w
Negative / Null Result Report

Impact of First Medical Contact Time and Door-to-Balloon Time on In-Hospital Mortality in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Cohort Study Based on Monthly Chest Pain Center Data

liu p, Hu S, Zeng H et al. · 2026 · Preprint

Abstract Background : Timely reperfusion is critical for patients with acute ST-segment elevation myocardial infarction (STEMI). While door-to-balloon (D2W) time has been substantially optimized in chest pain centers, the impact of first…

View details →DOI: 10.21203/rs.3.rs-8972635/v1
Negative / Null Result ReportMedicine

Examination of elevated myocardial extracellular volume and exercise capacity in pediatric Fontan patients at moderate altitude.

Arnouts EC, Drysdale ND, Gerstner Saucedo J et al. · 2026 · Pediatric radiology

Background Diffuse myocardial fibrosis, as measured by T1 (longitudinal relaxation time) mapping and extracellular volume, may be associated with ventricular dysfunction in the Fontan circulation. However, the relationship between diffuse…

View details →DOI: 10.1007/s00247-026-06675-2
Negative / Null Result ReportMedicine

Development and evaluation of the IPEConnect model: A quasi-experimental study to enhance interprofessional collaboration among health students.

Hadi M, Natashia D, Purwati NH et al. · 2026 · Nurse education today

Background Effective interprofessional collaboration is essential for optimal patient care, but inadequate training often hinders teamwork and communication among healthcare professionals. Interprofessional Education (IPE) can address this…

View details →DOI: 10.1016/j.nedt.2026.107138
Negative / Null Result ReportOpen accessMedicine

Geriatric Nutritional Risk Index independently predicts mortality beyond frailty and sarcopenia screening in older adults: a retrospective cohort study.

Levent M, Akın S · 2026 · BMC geriatrics

Background Malnutrition drives adverse outcomes in older adults, but routine screening is often hindered by time constraints and reliance on subjective data. The Geriatric Nutritional Risk Index (GNRI), derived from serum albumin and body…

View details →DOI: 10.1186/s12877-026-07597-2
Negative / Null Result ReportOpen accessMedicine

T4bN0 colon cancer shows worse survival than T1-2N1 disease: a multicenter real-world study in China.

Li X, Liang L, Yang ZY et al. · 2026 · Translational cancer research

Background Growing evidence suggests that deeply invasive node-negative colon cancer, particularly T4bN0 disease, may have a worse prognosis than early node-positive tumors, challenging the current American Joint Committee on Cancer (AJCC)…

View details →DOI: 10.21037/tcr-2026-0545
Negative / Null Result ReportMedicine

Night shift work and epigenetic modifications: cardiovascular-related miRNA expression within a European cohort of night shift workers.

Harding BN, Jiang Z, Pineda D et al. · 2026 · Environmental health : a global access science source

Background The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to…

View details →DOI: 10.1186/s12940-026-01308-5
Negative / Null Result ReportMedicine

Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.

Perrignon C, Baudouin R, Perrignon M et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease that affects 1-4% of the population and markedly impairs quality of life, daily functioning, and socio-professional activities. As no…

View details →DOI: 10.1007/s00405-026-10190-3
Negative / Null Result ReportMedicine

Clinical and imaging differences between pancreatic carcinoma in situ and T1a/T1b pancreatic ductal adenocarcinoma.

Satoh T, Kawaguchi S, Nakatani E et al. · 2026 · Abdominal radiology (New York)

Background/objectives Accurate differentiation between pancreatic carcinoma in situ (CIS) and small invasive pancreatic ductal adenocarcinoma (PDAC) is critical for optimizing patient management. This study aimed to assess the diagnostic…

View details →DOI: 10.1007/s00261-026-05453-w
Negative / Null Result ReportMedicine

Intraoperative optic nerve sheath diameter changes in vNOTES versus total laparoscopic hysterectomy: a prospective randomized study.

Acil F, Dedeoğlu A, Tosun Söner H et al. · 2026 · Surgical endoscopy

Background Pneumoperitoneum and steep Trendelenburg positioning during laparoscopic hysterectomy may increase intracranial pressure. Optic nerve sheath diameter (ONSD), measured by transorbital ultrasonography, is a validated noninvasive…

View details →DOI: 10.1007/s00464-026-12731-7
Negative / Null Result ReportMedicine

Robot-Assisted TKA for Varus Knees: Post Hoc Exploratory Analysis of Alignment Strategy and Deformity Severity.

Lychagin AV, Gritsyuk AA, Elizarov MP et al. · 2026 · Journal of clinical medicine

Background: Robot-assisted total knee arthroplasty (raTKA) improves the precision of component positioning and coronal alignment restoration, but it remains uncertain whether that technical accuracy modifies the clinical effect of…

View details →DOI: 10.3390/jcm15124515
Negative / Null Result ReportMedicine

Construct Validity of the WAIS- 5: Complementary Exploratory and Confirmatory Factor Analyses of the 20 Primary and Secondary Subtests.

Canivez GL, Watkins MW, McGill RJ et al. · 2026 · Assessment

The Wechsler Adult Intelligence Scale-Fifth Edition (WAIS-5) latent factor structure was assessed using complementary hierarchical exploratory factor analyses (EFA) with the Schmid and Leiman procedure and confirmatory factor analyses…

View details →DOI: 10.1177/10731911251412219
Negative / Null Result ReportMedicine

Mortality Impact of Stroke and Major Bleeding Across the Ejection Fraction Spectrum in Patients Hospitalized for Acute Heart Failure With Prevalent Atrial Fibrillation.

Yamamoto J, Nakamura K, Hayama H et al. · 2026 · Cardiology

Whether the mortality impact of ischemic stroke and major bleeding differs across left ventricular ejection fraction (LVEF) categories in patients hospitalized for acute heart failure (AHF) with atrial fibrillation (AF) remains uncertain.…

View details →DOI: 10.1159/000553289
Negative / Null Result ReportMedicine

How Speaker Configuration of Recorded Media Affects Subjective Ratings for Listeners With and Without Hearing Loss.

Ricketts TA, Krivoshey R, Santos-Garrido J et al. · 2026 · Journal of speech, language, and hearing research : JSLHR

Purpose The purpose of this study was to evaluate the effects of loudspeaker configuration and relative dialogue-to-background sound levels on subjective ratings of speech understanding and sound quality of recorded media for listeners…

View details →DOI: 10.1044/2026_jslhr-25-00127
Negative / Null Result ReportMedicine

Temporal Masking Assessed With Cortical Auditory Evoked Potentials.

Maynart V, Menezes P, Batista C et al. · 2026 · Ear and hearing

Abstractobjectives The purpose of this experiment was to determine the effects of sequential sounds on cortical auditory evoked potentials and to investigate temporal masking. The study tested the hypotheses that forward masking reduces…

View details →DOI: 10.1097/aud.0000000000001842
Negative / Null Result ReportMedicine

Belief, bond, and relief: Longitudinal associations between client belief about counseling success, working alliance, and symptom relief.

Li X, Zhang Y, Chen S · 2026 · Journal of counseling psychology

This study examined how clients' outcome expectations (OE; belief about positive outcome of counseling session) was associated with working alliance and symptom relief longitudinally in a sample of Chinese beginning therapist trainees and…

View details →DOI: 10.1037/cou0000879
Negative / Null Result ReportMedicine

Examining the Factor Structure and Subgroup Invariance of the Deliberate Denial of Disordered Eating Behaviors Scale.

Howard L, Hawn S, Pitchford KD et al. · 2026 · Behavioral sciences (Basel, Switzerland)

The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the…

View details →DOI: 10.3390/bs16060898
Negative / Null Result ReportMedicine

Genetically predicted lower FLT3L levels increase the risk of hypertrophic cardiomyopathy partly mediated by phosphate: Evidence from a 2-step Mendelian randomization analysis.

Li Y, Chen R, Hou C et al. · 2026 · Medicine

We performed a 2-step Mendelian randomization (MR) study to investigate the associations of Fms-related tyrosine kinase 3 ligand (FLT3L) and phosphate levels with the risk of hypertrophic cardiomyopathy (HCM). Genetic instruments for 75…

View details →DOI: 10.1097/md.0000000000049477