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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 557 of 664

Negative / Null Result ReportOpen accessMedicine

Acute Effects of Commercial Yerba Mate Products on Cardiometabolic Responses during Submaximal Cycling: Brewed to Perform?

Zaki S, Berkachy R, Zein Eddine R et al. · 2026 · Current developments in nutrition

Background Yerba mate ( Ilex paraguariensis ) is an herb native to South America known for its caffeine and polyphenol content, with suggested benefits for fat oxidation and energy metabolism. However, few studies have evaluated its brewed…

View details →DOI: 10.1016/j.cdnut.2026.107637
Negative / Null Result ReportOpen accessMedicine

Comparative Assessment of Cartilage Quality in Human Induced Chondrocytes (hiCHOs) and Primary Articular Chondrocytes (hACs) Following Fibronectin-Based Selection.

Mazzini G, Tuerlings M, van der Stap V et al. · 2026 · Cartilage

BackgroundCell-based cartilage repair is limited by loss of chondrogenic potential during in vitro expansion. Fibronectin (FN)-based selection may enrich progenitor-like cells with better matrix-forming ability, but its long-term effect on…

View details →DOI: 10.1177/19476035261458719
Negative / Null Result ReportMedicine

Prior exposure to doxorubicin exacerbates atherosclerotic plaque formation in apolipoprotein-E-deficient mice on a high-fat diet.

Bosman M, Krüger D, Roth L et al. · 2025 · Atherosclerosis

Background and aims Epidemiological data suggest that anthracyclines, such as doxorubicin (DOX), promote atherosclerosis in cancer survivors. However, this has not been established experimentally so far. Here, we investigated whether DOX…

View details →DOI: 10.1016/j.atherosclerosis.2025.119168
Negative / Null Result ReportMedicine

Acute metformin intake on exercise performance in healthy participants during functional fitness training.

Pinheiro AH, Silva LG, Bastos-Silva VJ · 2025 · The Journal of sports medicine and physical fitness

Background The study aimed to assess whether prior intake of metformin enhances performance in the FRAN workout, a popular Functional Fitness Training protocol. Methods Fourteen men (mean±SD: 24.2±3.5 years; height: 173.3±7.8 cm; weight:…

View details →DOI: 10.23736/s0022-4707.24.16591-7
Negative / Null Result ReportMedicine

Vitamin C and D do not increase the chemopreventive effect of aspirin on colon carcinogenesis in a mouse model.

Pereira M, Brandão Ostermann RA, de Fáveri W et al. · 2025 · Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Aspirin has significant antineoplastic effects on the colon, whereas the outcomes of Vitamin C and D supplementation have been inconsistent. This study addressed the isolated and combined effects of vitamins C and D with aspirin on…

View details →DOI: 10.1016/j.fct.2025.115400
Negative / Null Result Report

The temporal copulatory patterns of female rat sexual behavior

Oyem JC, Heijkoop R, Snoeren EM · 2024 · Preprint

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

View details →DOI: 10.1101/2024.10.07.616964
Negative / Null Result ReportMedicine

Roles of spermary-specific carboxylesterases in Nilaparvata lugens reproduction: Opposite between insecticide-induced upregulation and resistance-associated overexpression.

Zhang H, Yang B, Xu X et al. · 2025 · International journal of biological macromolecules

Seminal fluid proteins (SFPs) in insect males are critical for reproduction, being transported into female ovary. In Nilaparvata lugens, a significant rice pest, seven spermary-specific carboxylesterases (CarEs) were found abundantly in…

View details →DOI: 10.1016/j.ijbiomac.2024.138991
Negative / Null Result ReportMedicine

A detailed inquiry of the differences between headphones and loudspeakers influences on dynamic postural task performance.

Lubetzky AV, Wu Y, Lin D et al. · 2024 · Experimental brain research

We examined the impact of auditory stimuli and their methods on a dynamic balance task performance. Twenty-four young adults wore an HTC Vive headset and dodged a virtual ball to the right or left based on its color (blue to the left, red…

View details →DOI: 10.1007/s00221-024-06983-9
Negative / Null Result ReportMedicine

The role of loading-induced convection versus diffusion on the transport of small molecules into the intervertebral disc.

Salzer E, Gorgin Karaji Z, van Doeselaar M et al. · 2025 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

Purpose Limited nutrient transport is hypothesized to be involved in intervertebral disc (IVD) degeneration. It is widely recognized that the dominant mode of transport of small molecules such as glucose is via diffusion, rather than…

View details →DOI: 10.1007/s00586-024-08589-9
Negative / Null Result ReportOpen accessMedicine

Transcranial Direct Current Stimulation Does Not Enhance Perceptual Learning of Chinese Character Reading in Adults With Macular Degeneration.

Lyu A, Mungalsingh MA, Silva AE et al. · 2026 · Investigative ophthalmology & visual science

Purpose Macular degeneration impairs central vision, compelling patients to use their peripheral vision for reading, which is difficult due to reduced spatial resolution and crowding. Although perceptual learning improves reading,…

View details →DOI: 10.1167/iovs.67.1.16
Negative / Null Result ReportMedicine

Biological soil amendments can support survival of pathogenic and non-pathogenic Escherichia coli in soils and sporadic transfer to Romaine lettuce.

Xiong ZR, Gabriel E, Gutierrez A et al. · 2025 · International journal of food microbiology

Biological soil amendments (BSAs) are essential agricultural inputs that provide critical nutrients in organic leafy green production. Heat-treated poultry pellets (HTPP) and seabird guano (SBG), which have been treated to reduce microbial…

View details →DOI: 10.1016/j.ijfoodmicro.2025.111147
Negative / Null Result ReportMedicine

A single session of whole-body vibration did not affect cardiovascular autonomic recovery after a high intensity exercise in horses.

Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science

Background Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic…

View details →DOI: 10.1016/j.jevs.2025.105631
Negative / Null Result ReportOpen accessMedicine

Topical betulinic acid for treatment of equine melanoma and sarcoid.

Moreno C, Mudge M, Horne R et al. · 2026 · Frontiers in veterinary science

Introduction Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence…

View details →DOI: 10.3389/fvets.2026.1821503
Negative / Null Result ReportMedicine

Cryoprotective effects of cholesterol-loaded cyclodextrin and iodixanol on ram sperm: assessment of post-thaw quality and in vitro fertilization outcomes.

Arıcı R, Eser A, Yağcıoğlu S et al. · 2026 · BMC veterinary research

Background This study aimed to investigate the effects of cholesterol-loaded cyclodextrin (CLC) and iodixanol, added individually or in combination to a ram semen extender, on post-thaw sperm quality, in vitro fertilization outcomes, and…

View details →DOI: 10.1186/s12917-026-05533-5
Negative / Null Result ReportOpen accessMedicine

Exercise and Weekly Sirolimus (Rapamycin) in Older Adults: RAPA-EX-01 Randomised, Double-Blind, Placebo-Controlled Trial.

Stanfield B, Leroux B, Kaeberlein M et al. · 2026 · Journal of cachexia, sarcopenia and muscle

Background Preclinical models suggest alternating activation and inhibition of mechanistic target of rapamycin complex 1 (mTORC1) could enhance adaptation to exercise ('cycling hypothesis'). Whether this concept translates to older adults…

View details →DOI: 10.1002/jcsm.70274
Negative / Null Result ReportOpen accessMedicine

The Effect of L-Carnitine Supplementation in Culture Medium on the Development and Cryopreservation of in Vitro Produced Bovine Embryos.

Yildiz M, Cetin Y · 2025 · Veterinary medicine and science

Background In vitro culture media play a crucial role in supporting the growth and development of bovine embryos. Despite advancements in media formulations, there is ongoing interest in optimising these media by supplementing them with…

View details →DOI: 10.1002/vms3.70376
Negative / Null Result ReportMedicine

Comparisons of the amylolytic enzymes and malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar developed in Japan) and Kitanohoshi (currently used cultivar for beer production).

Saburi W, Mori H · 2024 · Bioscience, biotechnology, and biochemistry

Starch degradation in malted barley produces yeast-fermentable sugars. In this study, we compared the amylolytic enzymes and composition of the malt starch hydrolysates of two barley cultivars, Hokudai 1 (the first cultivar established in…

View details →DOI: 10.1093/bbb/zbae096
Negative / Null Result ReportOpen accessMedicine

In Vitro Evaluation of Olorofim and Amphotericin B Combination Therapy Against <i>Talaromyces marneffei</i>.

Lan LHN, Natesan Sambath H, Brown L et al. · 2026 · Journal of fungi (Basel, Switzerland)

The dimorphic fungus Talaromyces marneffei causes talaromycosis, a life-threatening fungal disease with limited treatment options. Olorofim, a first-in-class orotomide antifungal that targets pyrimidine synthesis essential for fungal…

View details →DOI: 10.3390/jof12060441
Negative / Null Result ReportMedicine

Acute Effects of Taurine Supplementation on Maximal Fat Oxidation and FATmax in Recreational Endurance Runners: A Randomized, Placebo-Controlled, Crossover, and Triple-Blinded Study.

Ghazzagh A, Naderi A, Agha-Alinejad H et al. · 2025 · International journal of sport nutrition and exercise metabolism

Taurine (TAU) has been shown to improve time to exhaustion (TTE) and fat oxidation during exercise; however, no studies have examined the effect of acute TAU supplementation on maximal fat oxidation (MFO) and related intensity to MFO…

View details →DOI: 10.1123/ijsnem.2024-0076
Negative / Null Result ReportOpen accessMedicine

Effects of curved carbon fiber plate bending stiffness on plantar pressure characteristics and performance during speed step in jump rope athletes.

Wu K, Li J, Suo B et al. · 2026 · Scientific reports

This study aimed to (1) investigate the plantar pressure characteristics of the speed step technique and (2) evaluate the effects of curved carbon fiber plates with varying stiffness on plantar pressure distribution and performance.…

View details →DOI: 10.1038/s41598-026-43636-z
Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Assisted Oocyte Activation in ICSI: Pairwise Meta-Analyses and Systematic Evidence Evaluation.

Fawzy M, Elsuity MA, Magdi Y et al. · 2025 · BJOG : an international journal of obstetrics and gynaecology

Background Artificial oocyte activation (AOA) is used to improve fertilisation rates in intracytoplasmic sperm injection (ICSI) cycles. Objectives To assess the effectiveness of AOA on fertilisation, embryo development, and clinical…

View details →DOI: 10.1111/1471-0528.18085
Negative / Null Result ReportMedicine

Superior Vena Cava Isolation With Cryoballoon in AF Ablation: Randomized CAVAC AF Trial.

Castro-Urda V, Segura-Dominguez M, Jiménez-Sánchez D et al. · 2025 · Circulation. Arrhythmia and electrophysiology

Background Superior vena cava (SVC) has been considered a specific trigger in atrial fibrillation development. Methods We investigated the efficacy and safety of combining cryoballoon pulmonary vein isolation (PVI) with SVC ablation…

View details →DOI: 10.1161/circep.124.012917
Negative / Null Result ReportOpen accessMedicine

When 'Calls for Help' Backfire: Induced Plant Volatiles Reduce the Attraction of a Nocturnal Predator in Sugarcane.

Pec M, Salazar-Mendoza P, Azevedo KEX et al. · 2026 · Journal of chemical ecology

While herbivore-induced plant volatiles are well-established cues that guide natural enemies to herbivores in ecosystems, microbe-induced plant volatiles have recently gained attention as promising tools for achieving similar outcomes.…

View details →DOI: 10.1007/s10886-025-01682-3
Negative / Null Result ReportOpen accessMedicine

Effect of final irrigation protocols on the bond strength and dentinal tubule penetration of root canal sealers: an ex vivo laboratory study.

Örs SA, Yılmaz GA, Şengül N et al. · 2026 · BMC oral health

BACKGROUND: Effective disinfection and sealing of the root canal system are essential for the long-term success of endodontic treatment. Final irrigation solutions can influence the interactivity between dentin and sealers. This study…

View details →DOI: 10.1186/s12903-025-07610-x
Negative / Null Result ReportMedicine

Matrigel-encapsulated articular cartilage derived fibronectin adhesion assay derived chondroprogenitors for enhanced chondrogenic differentiation: An in vitro evaluation.

Parasuraman G, Rani J MS, Zachariah MM et al. · 2025 · Tissue & cell

Purpose In cartilage research, three-dimensional (3D) culture models are pivotal for assessing chondrogenic differentiation potential. Standard pellet cultures, despite their utility, pose challenges like uneven differentiation and…

View details →DOI: 10.1016/j.tice.2024.102638