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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19893 results in Negative / Null Result Report · page 549 of 664

Negative / Null Result ReportMedicine

The Association Between Neonatal Jaundice and Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder: Findings From the Millennium Cohort Study.

Lee A, Higgins S, O'Driscoll D et al. · 2026 · Journal of autism and developmental disorders

OBJECTIVE: To examine the association between neonatal jaundice requiring hospital treatment and autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) in offspring by age 14 years. METHODS: We used data from…

View details →DOI: 10.1007/s10803-026-07317-0
Negative / Null Result ReportMedicine

A study comparing the efficacy of R-CHOP and R-DA-EPOCH regimens in young, high-risk treatment-naïve diffuse large B-cell lymphoma patients: a multicenter retrospective analysis.

Lan H, Ding Y, Liu M · 2026 · American journal of cancer research

Background Patients with high-risk diffuse large B-cell lymphoma (DLBCL) have poor prognoses, and the comparative efficacy between R-CHOP and R-DA-EPOCH regimens remains controversial. Objective To compare the efficacy and safety of R-CHOP…

View details →DOI: 10.62347/rivm5316
Negative / Null Result ReportMedicine

Novel use of intrauterine instillation of Hyaluronan enriched media on clinical outcomes of intrauterine insemination treatment: a pilot randomized controlled trial.

Yadav D, Ghuman NK, Kathuria P et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objective To study the effect of intrauterine instillation of Hyaluronan enriched media on reproductive outcomes of intrauterine insemination treatment. Design and participants 100 couples with unexplained infertility were approached and…

View details →DOI: 10.1016/j.ejogrb.2026.115100
Negative / Null Result ReportOpen accessMedicine

The Impact of MOUD Initiation in Patients With Injection Drug Use-Associated Infective Endocarditis.

Losiewicz S, Collis B, El-Dalati S et al. · 2026 · Open forum infectious diseases

This single-center retrospective study evaluated 218 patients with injection drug use-associated infective endocarditis, 169 of whom received medications for opioid use disorder (MOUD). Initiation of MOUD was associated with a…

View details →DOI: 10.1093/ofid/ofag288
Negative / Null Result ReportMedicine

Methylprednisolone Taper After Total Knee Arthroplasty: A Prospective Single-Blinded Randomized Trial.

Premkumar A, Arellano E, Heo KY et al. · 2026 · The Journal of arthroplasty

Background The use of short-term postoperative corticosteroid regimens has been reported to improve pain control and decrease opioid consumption following total knee arthroplasty (TKA). The purpose of this study was to evaluate the effect…

View details →DOI: 10.1016/j.arth.2026.04.076
Negative / Null Result ReportOpen accessMedicine

Screening and Cohorting of CRE Patients: The Strategic Role of Bed Management in a Monocentric Pre-Post Observational Study.

Altavilla S, Di Pietro N, Loconsole D et al. · 2026 · Antibiotics (Basel, Switzerland)

Background Carbapenem-resistant Enterobacterales (CRE) require early identification and appropriate patient placement to prevent in-hospital transmission. Bed Management plays a key organizational role in coordinating screening results and…

View details →DOI: 10.3390/antibiotics15030290
Negative / Null Result ReportMedicine

The clinicopathologic characteristics and outcomes of uncommon KRAS mutations in patients with non-small cell lung cancer.

Zhang Y, Zhao J, Gao Q et al. · 2026 · Virchows Archiv : an international journal of pathology

Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations occur in 25-30% of non-small cell lung cancer (NSCLC) patients. Pooled analyses in previous research have largely focused on the prognostic and predictive value of overall or…

View details →DOI: 10.1007/s00428-026-04475-5
Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of PHPV Fusion Factor Vaginal Gel (PHPV®) in Clearing Cervical Persistent High-Risk Human Papillomavirus Infection: A Randomized Controlled Clinical Trial.

Yan L, Yin H, Shi L et al. · 2026 · Drug design, development and therapy

Purpose To evaluate the efficacy and safety of PHPV in the treatment of persistent high-risk papillomavirus (hrHPV) infection of the cervix. Patients and methods A randomized controlled trial (RCT) was conducted on patients with persistent…

View details →DOI: 10.2147/dddt.s542859
Negative / Null Result ReportMedicine

Evaluating the Effectiveness of Bloom's Taxonomy-Based Occupational Exposure Prevention in Oral Emergency Departments: A Quasi-Experimental Study.

Shi Y, Shen Y, Zhou X et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Objective To evaluate a Bloom's Taxonomy-based occupational exposure (OE) prevention program's impact on dental trainees' competencies compared to conventional training, assessing knowledge, skills, satisfaction, and exposure rates to…

View details →DOI: 10.1111/eje.70138
Negative / Null Result ReportMedicine

CLINICAL CHARACTERISTICS, IMAGING EFFICACY, AND SAFETY OF MRI-GUIDED FOCUSED ULTRASOUND ABLATION (FUS-MRI) IN THE TREATMENT OF UTERINE FIBROIDS: A SINGLE-CENTER EXPERIENCE.

Meirmanova M, Abiltayeva A, Noso Y et al. · 2026 · Georgian medical news

Introduction Uterine fibroids remain one of the most common benign tumors of the female reproductive system and a significant cause of menorrhagia, pain, symptoms of pelvic organ compression, and a reduced quality of life. Due to the…

Negative / Null Result ReportMedicine

A Biodegradable Polymeric Sealant Applied to Transected Margin Following Stapled Distal Pancreatectomy Reduces Overall Complication: A Randomised Controlled Trial.

Furtado R, Weinberg L, Haghighi KS et al. · 2026 · ANZ journal of surgery

Background Postoperative pancreatic fistula (POPF) is the primary cause of morbidity after distal pancreatectomy (DP). This trial investigated the application of a combined polyethylene glycol (PEG) and recombinant human albumin sealant…

View details →DOI: 10.1111/ans.70419
Negative / Null Result ReportMedicine

Functional and quality of life outcomes following surgical treatment for cauda equina syndrome: A retrospective tertiary centre study.

Kumar A, Aduri TT, Dhatt SS et al. · 2026 · Journal of clinical orthopaedics and trauma

Background This study evaluated bladder, bowel, and sexual function outcomes following surgical decompression for cauda equina syndrome (CES) using urodynamic studies (UDS) and patient-reported outcome measures (PROMs), and explored the…

View details →DOI: 10.1016/j.jcot.2026.103423
Negative / Null Result ReportMedicine

Effect of 0.01% Atropine on Choroidal Thickness and Ocular Growth in Pre-myopic Children.

He M, Wang L, Zhang S et al. · 2026 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)

Purpose To investigate the effect of nightly 0.01% atropine eye drops on choroidal thickness (ChT) in pre-myopic children (at risk of myopia). Methods In a 12-month randomised, double-blind, placebo-controlled trial, 54 children aged 5-12…

View details →DOI: 10.1007/s44402-026-00058-8
Negative / Null Result ReportMedicine

Potentially impaired dynamic ankle control despite increased eversion and first-ray plantarflexion strength after peroneus longus tendon harvest for anterior cruciate ligament reconstruction: an observational study.

Masoud M, El-Assal MA, Ibrahim MA et al. · 2026 · International orthopaedics

Background The peroneus longus tendon (PLT) has emerged as a promising graft option for anterior cruciate ligament reconstruction (ACLR), with acceptable outcomes; however, concerns have been raised about potential donor-site morbidity,…

View details →DOI: 10.1007/s00264-026-06850-y
Negative / Null Result ReportMedicine

Association between echocardiographic parameters and white matter hyperintensities in patients with ischemic cerebrovascular disease.

Zhang Y, Wang Y, You S et al. · 2026 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background White matter hyperintensities (WMHs) are associated with an increased risk of stroke, cognitive decline, and all-cause mortality. However, the relationship between cardiac function, particularly left ventricular ejection…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2026.108656
Negative / Null Result ReportMedicine

Evaluation of 4 Different Suture Threads in A Sample of Dentistry Suture-Naïve Students: A Randomised Controlled Trial.

Davide S, Domenico M, Fabio C et al. · 2026 · European journal of dental education : official journal of the Association for Dental Education in Europe

Introduction Suturing is a crucial step in oral surgery, directly affecting wound healing quality. Simple interrupted suture is widely used in dentistry, often performed by novices using silk sutures due to their ease of use and low cost.…

View details →DOI: 10.1111/eje.70134
Negative / Null Result ReportMedicine

Effect of Arthroscopic Rotator Cuff Repair Combined With Different Long Head of the Biceps Tendon Fixation Techniques on Postoperative Clinical Outcomes and Shoulder Function.

Guan J, Chen Y, Ye J et al. · 2026 · Annali italiani di chirurgia

Aim Rotator cuff tears and long head of the biceps tendon (LHBT) injuries are primary causes of shoulder pain. During rotator cuff repair, concurrent LHBT injuries are frequently identified. Surgical management of LHBT injuries can…

View details →DOI: 10.62713/aic.4500
Negative / Null Result ReportMedicine

Altered Pharmacokinetics and Delayed Sputum Conversion in Tuberculosis Patients Co-Infected With HIV.

Phyo AP, Hoglund RM, Saito M et al. · 2026 · Tropical medicine & international health : TM & IH

Background HIV co-infection affects host responses and pharmacokinetics (PK) of tuberculosis (TB) treatment. This study assessed the PK of first-line anti-TB drugs and clinical outcomes in patients with and without HIV co-infection.…

View details →DOI: 10.1111/tmi.70165
Negative / Null Result ReportMedicine

Enhanced biomechanical outcomes of split-thickness skin grafts with a three-dimensional collagen-elastin matrix in deep second-degree burns: A 12-month comparative study.

Nicklas A, Bienger K, Rudari M et al. · 2026 · Burns : journal of the International Society for Burn Injuries

Background Split-thickness skin grafting (STSG) remains the standard for deep second-degree burns, but grafted skin often shows suboptimal biomechanical properties. The dermal substitute MatriDerm® may improve elasticity, structural…

View details →DOI: 10.1016/j.burns.2026.107977
Negative / Null Result ReportMedicine

Mid- and long-term results of primary vs. secondary total elbow arthroplasty after index intra-articular fracture of the distal humerus in the elderly.

Deml O, Schenk P, Fritsche C et al. · 2026 · Journal of shoulder and elbow arthroplasty

Background Geriatric distal humerus fractures are difficult to manage. Open reduction and internal fixation remain the standard, but total elbow arthroplasty (TEA) appears to be a viable alternative. This study evaluated the long-term…

View details →DOI: 10.1016/j.jsea.2026.100027
Negative / Null Result ReportMedicine

Validation of aortic valve calcification quantification on contrast-enhanced computed tomography against ex vivo gravimetric analysis: comparison of fixed Hounsfield unit thresholds and deep learning segmentation.

Jiang D, Zhang W, Liu L et al. · 2026 · BMC cardiovascular disorders

Background Accurate quantification of aortic valve calcification (AVC) on contrast-enhanced computed tomography angiography (CTA) is pivotal for planning surgical and transcatheter aortic valve replacement. The optimal Hounsfield unit (HU)…

View details →DOI: 10.1186/s12872-026-06108-w
Negative / Null Result Report

Impact of First Medical Contact Time and Door-to-Balloon Time on In-Hospital Mortality in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Retrospective Cohort Study Based on Monthly Chest Pain Center Data

liu p, Hu S, Zeng H et al. · 2026 · Preprint

Abstract Background : Timely reperfusion is critical for patients with acute ST-segment elevation myocardial infarction (STEMI). While door-to-balloon (D2W) time has been substantially optimized in chest pain centers, the impact of first…

View details →DOI: 10.21203/rs.3.rs-8972635/v1
Negative / Null Result ReportMedicine

Examination of elevated myocardial extracellular volume and exercise capacity in pediatric Fontan patients at moderate altitude.

Arnouts EC, Drysdale ND, Gerstner Saucedo J et al. · 2026 · Pediatric radiology

Background Diffuse myocardial fibrosis, as measured by T1 (longitudinal relaxation time) mapping and extracellular volume, may be associated with ventricular dysfunction in the Fontan circulation. However, the relationship between diffuse…

View details →DOI: 10.1007/s00247-026-06675-2
Negative / Null Result ReportMedicine

Development and evaluation of the IPEConnect model: A quasi-experimental study to enhance interprofessional collaboration among health students.

Hadi M, Natashia D, Purwati NH et al. · 2026 · Nurse education today

Background Effective interprofessional collaboration is essential for optimal patient care, but inadequate training often hinders teamwork and communication among healthcare professionals. Interprofessional Education (IPE) can address this…

View details →DOI: 10.1016/j.nedt.2026.107138
Negative / Null Result ReportOpen accessMedicine

Geriatric Nutritional Risk Index independently predicts mortality beyond frailty and sarcopenia screening in older adults: a retrospective cohort study.

Levent M, Akın S · 2026 · BMC geriatrics

Background Malnutrition drives adverse outcomes in older adults, but routine screening is often hindered by time constraints and reliance on subjective data. The Geriatric Nutritional Risk Index (GNRI), derived from serum albumin and body…

View details →DOI: 10.1186/s12877-026-07597-2
Negative / Null Result ReportOpen accessMedicine

T4bN0 colon cancer shows worse survival than T1-2N1 disease: a multicenter real-world study in China.

Li X, Liang L, Yang ZY et al. · 2026 · Translational cancer research

Background Growing evidence suggests that deeply invasive node-negative colon cancer, particularly T4bN0 disease, may have a worse prognosis than early node-positive tumors, challenging the current American Joint Committee on Cancer (AJCC)…

View details →DOI: 10.21037/tcr-2026-0545
Negative / Null Result ReportMedicine

Night shift work and epigenetic modifications: cardiovascular-related miRNA expression within a European cohort of night shift workers.

Harding BN, Jiang Z, Pineda D et al. · 2026 · Environmental health : a global access science source

Background The major pathways contributing to cardiovascular disease among night shift workers remain poorly understood. MicroRNAs (miRNAs) have been identified as novel regulators of cardiovascular risk factors. Our objective was to…

View details →DOI: 10.1186/s12940-026-01308-5
Negative / Null Result ReportMedicine

Development of a therapeutic education program for patients with chronic rhinosinusitis with nasal polyps.

Perrignon C, Baudouin R, Perrignon M et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Introduction Chronic rhinosinusitis with nasal polyps (CRSwNP) is a long-lasting inflammatory disease that affects 1-4% of the population and markedly impairs quality of life, daily functioning, and socio-professional activities. As no…

View details →DOI: 10.1007/s00405-026-10190-3
Negative / Null Result ReportMedicine

Clinical and imaging differences between pancreatic carcinoma in situ and T1a/T1b pancreatic ductal adenocarcinoma.

Satoh T, Kawaguchi S, Nakatani E et al. · 2026 · Abdominal radiology (New York)

Background/objectives Accurate differentiation between pancreatic carcinoma in situ (CIS) and small invasive pancreatic ductal adenocarcinoma (PDAC) is critical for optimizing patient management. This study aimed to assess the diagnostic…

View details →DOI: 10.1007/s00261-026-05453-w