A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21346 results · page 546 of 712
Wolff M, Winnberg I, Tronvik E et al. · 2024 · Cureus
Background A significant proportion of people with migraine do not achieve sufficient relief of their acute migraine symptoms with the currently available medications. A previous study showed that intranasal evaporative cooling reduced…
Li B, Edick AM, Fox MK et al. · 2024 · Preprint
It has been established that essential amino acids (EAA) regulate protein synthesis in mammary epithelial cells by rapidly altering the phosphorylation state of translation factors. However, the long-term transcriptional response to EAA…
Laso-García F, Díaz-Gamero N, Gallego-Ruiz R et al. · 2025 · International journal of molecular sciences
Extracellular vesicles (EVs) have emerged as potential therapeutic agents for neurological disorders. Their molecular cargo may reflect the clinical status of the donor and has been identified as a biomarker for the cellular damage and…
Lavigna G, Grasso A, Pasini C et al. · 2024 · Preprint
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. We previously found that the PERK kinase inhibitor GSK2606414 delayed…
Kant N, Garssen SH, Vernooij CA et al. · 2024 · Internal and emergency medicine
In Acute Admission Wards, vital signs are commonly measured only intermittently. This may result in failure to detect early signs of patient deterioration and impede timely identification of patient stability, ultimately leading to…
Bronshtein O, Konson A, Kuniavsky M et al. · 2025 · Quality management in health care
Background and objectives Early in the global COVID-19 pandemic, a concern was raised that potentially high volumes of COVID-19 inpatients in general hospitals might compromise the hospitals' capabilities to maintain high-quality care for…
Renko K, Thomas R, Hawks M et al. · 2026 · Frontiers in toxicology
Thyroid hormone (TH) availability is particularly critical for early brain development. TH transport across the blood-brain barrier is facilitated through two main transmembrane transporters: monocarboxylate transporter 8 (MCT8) and…
Lavigna G, Grasso A, Pasini C et al. · 2025 · PloS one
There is no cure for Marinesco-Sjögren syndrome (MSS), a genetic multisystem disease linked to loss-of-function mutations in the SIL1 gene, encoding a BiP co-chaperone. Previously, we showed that the PERK kinase inhibitor GSK2606414 delays…
Myhre MG, Azeem A, Barrett M · 2024 · New Zealand veterinary journal
Case history Medical records from 2009 to 2021 from a private equine referral hospital in Rochester, NH, USA were analysed for cases that underwent general anaesthesia for low-field MRI of the distal limb. These were used to determine…
Carney C, Jenkins L, Jewell C et al. · 2025 · microPublication biology
Several lines of evidence suggest a potential link between stemness and vitamin B12, which contributes to S-adenosylmethionine (SAM) generation and hence methylation-dependent epigenetic control. Here we found that the vitamin B12…
Kattler KR, Watkins HV, Perretta KN et al. · 2024 · Biol Invasions.
Organisms that settle and grow on other organisms (i.e., epibionts) are often costly to their hosts in terms of locomotion, growth, and/or reproduction. Such costs can potentially result in biotic resistance against invasion when native…
Cerpelloni F, Collignon O, Op de Beeck H · 2026 · Psychonomic bulletin & review
Most written systems share basic shape features with natural objects such as line junctions, a commonality thought to be at the basis of fluent reading. Studies that compared reading acquisition for different scripts used line-based…
Rivest D, Martin-Guay MO · 2024 · Nutrient cycling in agroecosystems.
Well-designed temperate tree-based intercropping (TBI) systems can enhance soil nutrient cycling compared to conventional agricultural systems. To improve the TBI designs and their subsequent wide-scale adoption, greater understanding is…
Leuschner S, Schenk P, Gräbsch C et al. · 2025 · Innovative surgical sciences
Objectives Non-technical skills (NTS) training of surgical staff is a quality improvement measure to improve patient safety. One factor that can compromise patient safety is impaired staff performance due to stressors such as tiredness.…
Muñiz-Anquela R, Redondo-Angulo I, Lewis EA et al. · 2026 · Arteriosclerosis, thrombosis, and vascular biology
Background Eradicating endothelial caveolae by deleting the Cav1 (caveolin-1) gene reduces LDL (low-density lipoprotein) uptake in arteries and efficiently prevents early atherogenesis, but the role in established atherosclerosis is…
Stephan K, Stephens AN, Scully M et al. · 2024 · Accident; analysis and prevention
Background Globally, road traffic crashes are the leading cause of death for young adults. The P Drivers Project was a trial of a behavioural change program developed for, and targeted at, young Australian drivers in their initial months…
Burgoyne K, Hargreaves S, Akhter N et al. · 2025 · JCPP advances
Background Parents play a key role in their child's early development but evidence that parental engagement strategies are effective is unclear. The current study evaluated a parent-delivered early language teaching programme that aimed to…
Hertler C, Lohmann J, Koulidiati J et al. · 2022 · European journal of public health
Abstract Background In 2020, about one in four women in Burkina Faso faced an unmet need for family planning (FP). Between 2013 and 2017, Burkina Faso implemented a performance-based financing (PBF) program to improve primary health care…
Howey C, McFetridge A, Luczak A · 2025 · International journal of molecular sciences
Epilepsy affects 50 to 70 million people worldwide and is characterized by recurring seizures that accelerate neurodegeneration; however, its mechanisms are still not well understood. It was proposed that epileptogenesis may be "hijacking"…
Tadenev ALD, Hatton CL, Burgess RW · 2024 · Journal of the peripheral nervous system : JPNS
Background Inhibition of HDAC6 has been proposed as a broadly applicable therapeutic strategy for Charcot-Marie-Tooth disease (CMT). Inhibition of HDAC6 increases the acetylation of proteins important in axonal trafficking, such as…
· 2022 · Journal of the Endocrine Society
Abstract Metformin, a lipophilic biguanide inhibiting hepatic gluconeogenesis and improving peripheral utilization of glucose, is a well-established medication for the management of type 2 diabetes. Furthermore, metformin has been shown to…
Lindig A, Mannagottera L, Hahlweg P et al. · 2024 · Health expectations : an international journal of public participation in health care and health policy
Background There is a need for better implementation of patient-centred (PC) communication and shared decision-making (SDM) in routine cancer care. Objective The aim of this study was to assess whether a programme to implement SDM in…
Peverill RE, Narayan O, Cameron JD · 2023 · Scandinavian cardiovascular journal : SCJ
Background Dobutamine effects on the relationships of the peak velocity of left ventricular (LV) long-axis systolic motion (s') with systolic excursion (SExc), systolic duration (SDur) and heart rate, of LV long-axis early diastolic…
Totsch SK, Sorge RE · 2024 · Behavioural brain research
Background and aims In rodents, placebo analgesia is often investigated through direct conditioning of stimuli, but humans can experience placebo analgesia through expectation without experience. In this study, we sought to determine…
Lopez-Alonso V, López-Bermúdez G, Pagaduan JC et al. · 2025 · Sensors (Basel, Switzerland)
Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions-anodal stimulation…
Lewandowski K, Kaniewska M, Tulewicz-Marti E et al. · 2024 · Journal of clinical medicine
Background : Oncological anxiety associated with biological therapy is a particular challenge in inflammatory bowel disease (IBD), and it has raised questions about the need for the dermatological assessment of the skin before starting…
Okada M, Tran TTT · 2024 · IBRO neuroscience reports
We have previously shown that a single dose of a TREK-1 channel activator, ostruthin, exhibited antidepressant and anxiolytic effects in acute behavioral test models in mice. To assess the potential clinical application, it is essential to…
Strickland JA, Austen JM, Sprengel R et al. · 2024 · Hippocampus
The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for…
Stoddart K, Davies M, Oughton J et al. · 2025 · Addiction biology
Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro-drug, N-acetyl-cysteine (NAC), is a promising glutamatergic agent that…
Bonne TC, Arthemalle V, Doherty CS et al. · 2025 · Physiological reports
Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on…