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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21742 results · page 530 of 725

Negative / Null Result ReportMedicine

Effect of copper and iron on the oxidation of vegetable oil during aging

Randhawa S, Mukherjee T · 2025 · Journal of Food Composition and Analysis.

The research paper investigates how elemental copper and iron, affect the aging process of canola, coconut, groundnut, rice bran, soybean, and sunflower oils. Samples analysed biannually over two years indicate that the addition of copper,…

Negative / Null Result ReportMedicine

Effect of Arginine Supplementation on Vasodilation and Muscular Performance in Young Men: A Randomized, Double-Blind, Crossover Study.

Borges CC, Alves da Silva W, de Sá Filho AS et al. · 2026 · International journal of sport nutrition and exercise metabolism

This study aimed to evaluate the effects of short-term oral L-arginine (ARG) supplementation on vascular parameters, nitric oxide (NO) concentration, and muscular performance during upper limb resistance exercise in healthy young men. A…

View details →DOI: 10.1123/ijsnem.2025-0125
Negative / Null Result Report

Metabolic interoceptive rewards shape affect, but not action

Fleming HA, Whines A, Whelehan P et al. · 2025 · Preprint

Central to survival is our ability to learn that the sensory properties of food are associated with metabolic interoceptive signals (e.g., changing blood glucose). These signals influence cognition and brain activity, shaping the hedonic…

View details →DOI: 10.31234/osf.io/px3ub_v1
Negative / Null Result ReportMedicine

Electrocardiographic LVH criteria: Poor diagnostic accuracy even with optimized cutoffs. Insights from MESA study.

de Alencar JN, Felicioni SP · 2025 · Journal of electrocardiology

Background Electrocardiographic (ECG) "left ventricular hypertrophy (LVH) criteria" are widely used as surrogates for increased LV mass but show limited sensitivity. We evaluated their diagnostic performance against cardiac magnetic…

View details →DOI: 10.1016/j.jelectrocard.2025.154138
Negative / Null Result ReportOpen accessMedicine

Biomechanical evaluation of patch augmentation in a rotator cuff repair model using a porcine flexor digitorum profundus tendon: influence of knot tying and time-zero stability.

Rhee SM, Cho CH, Kim M et al. · 2025 · Clinics in shoulder and elbow

Background This study evaluates the biomechanical effects of acellular dermal matrix (ADM) patch augmentation in a rotator cuff repair model and determines the effect of medial knot tying on time-zero stability. Methods A biomechanical…

View details →DOI: 10.5397/cise.2025.00164
Negative / Null Result ReportMedicine

A Simplified and Data-Driven Lung Ultrasound Approach for Predicting Surfactant Need in Preterm Infants: A Pilot Study Using Machine Learning and Rule-Based Models.

Meau-Petit V, Mottez C, Bhojnagarwala B et al. · 2026 · Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Objectives Six-region lung ultrasound (LUS) scores show good predictive value for predicting surfactant need in preterm infants but rely on a fixed threshold, which may lead to misclassification near the cut-off and lack data-driven…

View details →DOI: 10.1002/jum.70092
Negative / Null Result ReportOpen accessMedicine

Correlation between systemic blood pressure and free flap perfusion: A photoplethysmography study.

Sahu SA, Mishra JK, De M et al. · 2026 · GMS Interdisciplinary plastic and reconstructive surgery DGPW

Background Microvascular tissue transfer is the method of choice for oncological and trauma reconstruction. Successful free tissue transfer requires technical expertise and management of patients and surgery related factors. However,…

View details →DOI: 10.3205/iprs000194
Negative / Null Result ReportMedicine

Does Hypnosis Aid Memory Retrieval?: A Review of Steven Jay Lynn's Research.

Krackow E, Rashed J, Thompson I · 2025 · The International journal of clinical and experimental hypnosis

Steven Jay Lynn was one of the most prolific clinical psychologists who made major contributions to the scientific literature in numerous areas, including in the area of hypnosis and memory. We review this work, limited to studies…

View details →DOI: 10.1080/00207144.2025.2508410
Negative / Null Result Report

Effects of enzymatically-synthesized sialylated oligosaccharides on the N- and O-glycosylation of etanercept in recombinant CHO cell culture

Kim T, Lee H, Ryu S et al. · 2025 · Preprint

Abstract In mammalian cell-based bioprocesses, glycosylation of recombinant therapeutic proteins requires stringent control and monitoring as it may affect therapeutic efficacy and safety. The sialylation of glycosylated moieties plays an…

View details →DOI: 10.21203/rs.3.rs-7324359/v1
Negative / Null Result Report

Effect of Interactive Ultrasound Intervention on Moderate Depressive Symptoms and Maternal Attachment: A Randomized Controlled Trial

Pulliainen H, Kataja E, Löyttyniemi E et al. · 2025 · Preprint

Abstract Background We examined whether an interactive four-dimensional (4D) ultrasound intervention decreases prenatal and early postnatal depressive symptoms and improves maternal-fetal attachment. Methods This randomized controlled…

View details →DOI: 10.21203/rs.3.rs-6672112/v1
Negative / Null Result ReportMedicine

Revisiting NaOH Addition during the Amination of Cellulose Nanocrystals.

Clouse DE, Collins EG, Khodakovskaya MV et al. · 2025 · Biomacromolecules

There is growing recognition that both cellulose nanocrystal (CNC) source and production scheme affect their physicochemical properties and dispersion behavior. However, how these differences affect CNC surface chemistry modification has…

View details →DOI: 10.1021/acs.biomac.4c01710
Negative / Null Result Report

Orange (Citrus sinensis) essential oil as feed additive for sheep: nutrient intake and apparent digestibility, nitrogen balance, and rumen fermentation characteristics

Junior PCGD, Vicente ACS, Santos IJd et al. · 2025 · Preprint

Abstract The study evaluated the effects of orange essential oil (OEO) as a feed additive on nutrient intake, digestibility, nitrogen balance, and rumen fermentation in meat sheep. Using ten rumen-cannulated Dorper × Santa Inês wethers in…

View details →DOI: 10.21203/rs.3.rs-6986736/v1
Negative / Null Result ReportMedicine

Open- source computed tomography (CT)-based sarcopenia assessment in women with suspicious adnexal masses: a feasibility and reproducibility study.

Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology

Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…

View details →DOI: 10.1016/j.crad.2025.107088
Negative / Null Result ReportMedicine

Effects of Zinc oxide nanoparticles on llama sperm cryopreservation.

di Fonzo AR, Bertuzzi ML, Amusquibar MV et al. · 2025 · Animal reproduction science

Zinc oxide nanoparticles (ZnO-NPs) have been reported to enhance sperm cryopreservation in several species, but their effect on frozen llama semen remains unexplored. This study aims to evaluate the effect of ZnO-NPs on sperm parameters in…

View details →DOI: 10.1016/j.anireprosci.2025.107994
Negative / Null Result ReportOpen accessMedicine

Performance of the Self-Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using Merative MarketScan Research Databases.

Coste A, Wong AYS, Haguinet F et al. · 2025 · Pharmacoepidemiology and drug safety

Background Despite testing of epidemiological methods in US Claims databases for signal detection, such data sources have not become a routine capability. The Self Controlled Case Series (SCCS) is one of the most promising methods for drug…

View details →DOI: 10.1002/pds.70250
Negative / Null Result ReportMedicine

Effects of passive information dissemination on human papillomavirus vaccination attitudes and knowledge among pharmacy visitors: A cluster randomized controlled trial.

Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA

Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…

View details →DOI: 10.1016/j.japh.2025.102901
Negative / Null Result ReportOpen accessMedicine

Subacromial bursa augmentation in arthroscopic rotator cuff repair: Clinical and doppler ultrasound assessment-A preliminary study.

Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics

Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…

View details →DOI: 10.1002/jeo2.70714
Negative / Null Result ReportMedicine

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots Without Altering the Performance of Two Root Herbivores, Diabrotica virgifera and Diabrotica balteata.

Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

View details →DOI: 10.1111/pce.70143
Negative / Null Result ReportOpen accessMedicine

The Impact on Audience Engagement of Coordinating a Public Health Campaign on Antimicrobial Resistance Through a Network of Health Content Creators: Longitudinal Observational Study.

Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance

Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…

View details →DOI: 10.2196/86587
Negative / Null Result Report

Entomopathogenic Nematodes Induce Metabolic Reallocation in Maize Roots without Altering Root Herbivore Performance

Verdecia-Mogena AM, Himmighofen P, Mateo P et al. · 2025 · Preprint

Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…

View details →DOI: 10.22541/au.174918965.53456893/v1
Negative / Null Result ReportMedicine

The Acute Effects of Caffeine and Normobaric Hypoxia on Cardiorespiratory Exercise Responses in Healthy Adults: A Randomized Controlled Trial.

Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism

The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…

View details →DOI: 10.1123/ijsnem.2025-0024
Negative / Null Result ReportMedicine

PcrV in an intranasal adjuvanted tobacco mosaic virus conjugate vaccine mediates protection from Pseudomonas aeruginosa via an early Th1/Th17 skewed localized and systemic immune response.

Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine

Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…

Negative / Null Result ReportMedicine

Preimplantation genetic testing for aneuploidy mosaicism reporting lacks clinical predictive value for live birth in a multisite, double-blinded study with independent validation.

Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology

Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…

View details →DOI: 10.1016/j.ajog.2025.12.033
Negative / Null Result ReportMedicine

Will a co-created program enhance implementation of injury prevention training in youth handball in Sweden? A cluster-randomized controlled trial.

Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport

Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…

View details →DOI: 10.1016/j.jsams.2025.06.011
Negative / Null Result ReportMedicine

The metal-organic framework MIL-100(Fe) and ferric citrate as potential counteracting biomaterials against osteoarthritis-induced articular inflammation and fibrosis.

Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…

View details →DOI: 10.1016/j.biopha.2025.118519