A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 525 of 663
Berge M, Hultgren O, Hugosson S et al. · 2026 · Scientific reports
There are large variations in how individual patients respond to allergen immunotherapy (AIT) against grass and/or birch allergy. There are currently no reliable biomarkers to predict which patients are likely to benefit from the…
Mariani C, Al Dababsekh A, Carta F et al. · 2025 · Medicina (Kaunas, Lithuania)
Background and Objectives : Hemostasis during thyroid surgery is crucial to avoid postoperative complications, particularly hematoma, which can cause life-threatening airway compromise. Arista™ AH, a plant-based absorbable hemostatic…
Jobson I, Vo NTN, Kujawinski E et al. · 2025 · Bioelectronic medicine
Background In glioblastoma (GBM) therapy research, tumour treating fields by the company Novocure™, have shown promise for increasing patient overall survival. When used with the chemotherapeutic agent temozolomide, they extend median…
Johnson KV, Steenbergen L · 2025 · Npj mental health research
The burgeoning field of the microbiome-gut-brain axis has inspired research into how the gut microbiome can affect human emotion. Probiotics offer ways to investigate microbial-based interventions but results have been mixed, with more…
Nimkulrat SD, Wagner MR, Waters BJ et al. · 2025 · Scientific reports
RNA binding proteins (RBPs) are increasingly being recognized as important regulators of pancreatic β cells' identity and function. We identified the poly-A binding RBP, CPEB1, as a potential new regulator linked to β cell failure in…
Ó Dúinín E, Steopan JK, Kessler K et al. · 2025 · Scientific reports
We investigated the effects of cognitive training with transcranial random noise stimulation (tRNS) applied to the intraparietal sulcus (IPS) or dorsolateral prefrontal cortex (DLPFC) on improving a multidirectional number line estimation…
Cesanelli L, Venckunas T, Minderis P et al. · 2026 · Antioxidants (Basel, Switzerland)
Background/Objectives : This study aimed to evaluate the effects of short-term broccoli powder supplementation on metabolically demanding exercise performance, muscle power, and blood lactate recovery. It also investigated broccoli…
Turton S, Hawkins PCT, Muller-Pollard C et al. · 2025 · Psychopharmacology
Rationale It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used…
Caballero P, Prieto-Amador M, Martínez-Guitarte J · 2022 · Preprint
Abstract Pesticides are an environmental problem. The search for new pest control methods has focused on compounds with low or no toxic effects in non-target organisms. Analogs of the juvenile hormone (JH) interfere endocrine system of…
Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)
α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…
Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health
This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…
Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
Winter AL, Peter M, Thunell E et al. · 2026 · Neural plasticity
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent…
Chen P, Lv J · 2024 · Nephrology (Carlton, Vic.)
This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid…
Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology
Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…
Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research
We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…
Tseng M, Middleton SJ, Farah A et al. · 2025 · Pain reports
Introduction Hyperexcitability, particularly of DRG neurons, is a key driver of persistent pain states including neuropathic pain. Contactin-associated protein-like 2 (CASPR2) is transmembrane protein known to interact and regulate the…
Poljo A, Reichl JJ, Bürgi S et al. · 2025 · Obesity surgery
Background Obesity, a chronic disease with serious associated medical problems, remains a global health challenge. While metabolic bariatric surgery (MBS) is the most effective treatment for weight loss, GLP-1 receptor agonists (RAs) are…
Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity
Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…
Ragamin A, Schappin R, Pasmans SGMA et al. · 2023 · Skin health and disease
National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of therapeutic clothing in atopic dermatitis. Therapeutic clothing is most frequently prescribed by dermatologists in a hospital…
Merlo JK, da Silva AV, Casonatto J et al. · 2024 · Healthcare (Basel, Switzerland)
Objective To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods Thirty-eight adults with CNLBP were randomly assigned to two…
Stroemel-Scheder C, Lautenbacher S · 2023 · The journal of pain
Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the…
Moretti L, Richelmi L, Cosentini D et al. · 2024 · Breast (Edinburgh, Scotland)
The efficacy of adjuvant denosumab in combination with hormonotherapy in breast cancer patients was investigated in two randomized trials, ABCSG-18 and D-Care, but the results were mixed with respect to the impact of this drug on…
Góis KS, Braga M, Souza VH et al. · 2026 · Einstein (Sao Paulo, Brazil)
Objective This study aimed to analyze the possible association between rs2814778, rs12075 ( ACKR1 gene), and rs4073 ( CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods This cross-sectional study included 319 COVID-19…
Gažarová M, Lenártová P, Kopčeková J et al. · 2026 · Nutrients
Background/Objectives: The aim of the study was to assess the metabolic response of women to a six-week consumption of full-fat sheep milk yogurt, with a focus on cardiovascular risk markers, lipid profile, and subfractions of low-density…
Majewska A, J NW, Chambers J et al. · 2026 · Preprint
Abstract Objective: To evaluate the association between metformin treatment in gestational diabetes mellitus and severity of intrahepatic cholestasis of pregnancy (ICP). Design: Retrospective multicentre cohort study. Setting: Six…
Starowicz M, Domínguez-Soberanes J, Garcia-Gutierrez E et al. · 2026 · Preprint
Bread is an important source of energy and is ubiquitous in human diets. As a carbohydrate-rich food, it is often considered to impair glycaemic homeostasis; however, clinical and molecular evidence suggests that its effects may vary…
Vogel MJ, Hacker K, Herting J et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Electrical cardioversion (ECV) is an effective treatment for restoring sinus rhythm in supraventricular tachycardias such as atrial fibrillation (AFib) and atrial flutter (AFlu). In clinical practice, serum potassium is often…
Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology
Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…