Negative / Null Result ReportMedicine
Ozer BH, Cohen AL, Colman H et al. · 2026 · Neuro-oncology advances
Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…
View details →DOI: 10.1093/noajnl/vdaf261 Negative / Null Result ReportOpen accessMedicine
Roberts G, Just J, Nolte H et al. · 2025 · Allergy
Background In children, house dust mite (HDM) sensitisation is a contributing factor for developing allergic asthma. HDM allergen immunotherapy has demonstrated efficacy and safety in adults with allergic asthma; however, evidence for its…
View details →DOI: 10.1111/all.70073 Negative / Null Result ReportMedicine
Delibasi IB, Gumusburun N, Bulut S et al. · 2025 · Reproductive toxicology (Elmsford, N.Y.)
Citalopram is a selective serotonin reuptake inhibitor (SSRI) and has been associated with reproductive dysfunction in women. In this study, the effects of citalopram on reproductive health in female rats were investigated. Albino Wistar…
View details →DOI: 10.1016/j.reprotox.2025.108859 Negative / Null Result ReportOpen accessMedicine
Lodefalk M, Nilsson O · 2025 · Hormone research in paediatrics
Introduction Vitamin D-dependent rickets type 2A (VDDR2A) is a rare, autosomal recessive disorder caused by pathogenic variants of the VDR gene encoding the vitamin D receptor. It has been proposed to be a form of parathyroid hormone…
View details →DOI: 10.1159/000546444 Negative / Null Result ReportOpen accessMedicine
Mann K, Potluri P, Paul EE et al. · 2026 · Journal of cosmetic dermatology
Introduction Chemotherapy-induced alopecia (CIA) is known to have a significant psychological and quality of life impact. Although cold caps have been shown to prevent CIA, expense and extension of treatment durations are barriers for…
View details →DOI: 10.1111/jocd.70797 Negative / Null Result Report
Shakhidzhanov S, Filippova A, Bovt E et al. · 2025 · Preprint
Introduction: Critically ill COVID-19 patients receiving prophylactic-dose antico-agulation exhibit high rates of thrombosis and mortality. Escalation of anticoagu-lation also does not reduce mortality and has an uncertain impact on the…
View details →DOI: 10.20944/preprints202502.1172.v1 Negative / Null Result ReportOpen accessMedicine
Pereira GF, Sanches MC, De-Paula OC et al. · 2025 · Scientific reports
Classifying seed dormancy is an essential task for plant propagation; however, several plant species lack information about the kind of dormancy the seeds have or inaccurate reports are passed on without an in-depth investigation. We…
View details →DOI: 10.1038/s41598-025-27823-y Negative / Null Result ReportMedicine
He Y, Ding Y, Gong C et al. · 2024 · Behavioural brain research
The tail plays important roles in locomotion control in many animals. But in animals with multiple body segments, the roles of the hind body segments and corresponding innervating neurons in locomotion control are not clear. Here, using…
View details →DOI: 10.1016/j.bbr.2024.115074 Negative / Null Result ReportMedicine
Bosnali E, Mutlu N, Cakmak K et al. · 2025 · Journal of pediatric surgery
Background Pediatric urolithiasis remains a significant health problem in certain regions worldwide. Extracorporeal shock wave lithotripsy (ESWL) is the preferred treatment for upper urinary tract stones smaller than 20 mm in children due…
View details →DOI: 10.1016/j.jpedsurg.2025.162274 Negative / Null Result ReportOpen accessMedicine
Roque-Torres JL, Woolcock AD, Santos A et al. · 2025 · Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
Objective To describe storage and oxidative lesions in canine packed red blood cells (pRBCs) during routine storage with additives, including saline, N-acetylcysteine (NAC), ascorbic acid (AA), and vitamin E analog (VE). Design…
View details →DOI: 10.1111/vec.70002 Negative / Null Result ReportOpen accessMedicine
Battaglia-Vieni A, Marchant V, Tejedor-Santamaria L et al. · 2025 · Pharmaceuticals (Basel, Switzerland)
Background/Objectives : Acute kidney injury (AKI) remains an unsolved medical problem due to the lack of effective treatments, high mortality, and increased susceptibility to progression to chronic kidney disease (CKD), especially in the…
View details →DOI: 10.3390/ph18060822 Negative / Null Result ReportOpen accessMedicine
Zierke L, Gischke M, Sendler M et al. · 2026 · Molecular biomedicine
Acute pancreatitis is caused by a premature activation of digestive proteases. One hypothesis is based on the proteolytic activation of the serine protease trypsinogen by the lysosomal enzyme cathepsin B (CTSB) after co-localization in the…
View details →DOI: 10.1186/s43556-026-00479-4 Negative / Null Result ReportOpen accessMedicine
Chen AP, Pandey H, Hancock WO · 2026 · The Journal of biological chemistry
The kinesin-3 family member, KIF1A is an essential motor protein that carries out intracellular transport in neurons. Previous work has established that: (1) intracellular transport can be impaired in neurodegenerative diseases such as…
View details →DOI: 10.1016/j.jbc.2026.111471 Negative / Null Result ReportMedicine
Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2025 · Neurobiology of disease
The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important…
View details →DOI: 10.1016/j.nbd.2025.106803 Negative / Null Result ReportMedicine
Kang JI, Choi YK, Han SC et al. · 2025 · Chemico-biological interactions
Chemotherapy-induced alopecia (CIA) is a side effect of the anticancer drug 5-fluorouracil (5-FU). However, the mechanism of action in hair follicle cells is unclear. This study investigated the mechanism of action of 5-FU on the hair…
View details →DOI: 10.1016/j.cbi.2025.111416 Negative / Null Result ReportOpen accessMedicine
De Carli G, Giombini E, Colosi A et al. · 2025 · Pathogens (Basel, Switzerland)
To determine whether patient-to-doctor transmission of measles occurred in an emergency department (ED) despite isolation precautions and full personal protective equipment (PPE) during the COVID-19 pandemic, an epidemiological and…
View details →DOI: 10.3390/pathogens14060519 Negative / Null Result ReportOpen accessMedicine
Levaro-Loquio D, Cruz-Baquero A, Higuera-Martínez G et al. · 2026 · BioMed research international
During amoebic infection, neutrophils are the first cells of the immune system to interact with trophozoites of Entamoeba histolytica, initiating amoebicidal activity. Different lectins and carbohydrates can participate in the mechanism of…
View details →DOI: 10.1155/bmri/8280585 Negative / Null Result ReportOpen accessMedicine
Ebensperger M, Kreuzer M, Kratzer S et al. · 2025 · British journal of anaesthesia
Background The GE Entropy™ module uses frontal EEG to compute the processed indices state entropy (SE), response entropy (RE), and burst suppression ratio (BSR) to guide maintenance of anaesthesia by supposedly minimising overly 'deep' or…
View details →DOI: 10.1016/j.bja.2024.11.050 Negative / Null Result Report
Christiansen JR, Ferreira SA, Szymkowski DE et al. · 2024 · Preprint
ABSTRACT The underlying cause of neuronal loss in Parkinson’s disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an…
View details →DOI: 10.1101/2024.10.11.617361 Negative / Null Result ReportMedicine
Gudziol H, Hummel T, Guntinas-Lichius O · 2025 · HNO
Background There are various views in the literature regarding the influence of chronic rhinosinusitis (CRS) as a comorbidity on the occurrence of COVID-19 disease. Objective Did CRS prevent or promote infection with severe acute…
View details →DOI: 10.1007/s00106-024-01534-8 Negative / Null Result ReportMedicine
Henriksen K, Jørgensen A, Kaur S et al. · 2025 · Molecular and cellular endocrinology
Immune-mediated beta-cell destruction and lack of alpha-cell responsiveness to hypoglycaemia are hallmarks of type 1 diabetes pathology. The incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may hold therapeutic potential…
View details →DOI: 10.1016/j.mce.2025.112522 Negative / Null Result ReportMedicine
Shimada T, Iwahashi T, Suzuki K et al. · 2025 · Journal of pharmacological sciences
Chronic nerve compression disorders, such as carpal tunnel syndrome, are common and can significantly impair daily activities due to motor and sensory dysfunctions. Currently, no systemic pharmacotherapy exists for preventing or treating…
View details →DOI: 10.1016/j.jphs.2024.12.006 Negative / Null Result ReportMedicine
Guo Z, Hu Y, Zhou J et al. · 2025 · Biochemical and biophysical research communications
Iron overload leads to apoptosis and increased expression of receptor activator of nuclear factor kappa-Β ligand (RANKL) in osteocytes, which in turn accelerates osteoclastogenesis. Since osteocytes are the main RANKL producers, we…
View details →DOI: 10.1016/j.bbrc.2024.151152 Negative / Null Result ReportMedicine
Rumanova VS, Foppen E, Okuliarova M et al. · 2025 · Physiology & behavior
Exposure to artificial light at night (ALAN) disrupts natural darkness and desynchronizes daily rhythms in physiological processes and behavior. Previously, in rats, we have shown that dim ALAN disturbed the central circadian control and…
View details →DOI: 10.1016/j.physbeh.2024.114780 Negative / Null Result ReportOpen accessMedicine
Lima da Silva AP, de Oliveira TP, Nogueira RD et al. · 2025 · Journal of clinical and experimental dentistry
Background The objective was to evaluate the surface hardness of white spot lesions (WSL) treated with different caries prevention methods. Material and methods The Knoop microhardness (µKH) of 50 bovine dental enamel fragments was…
View details →DOI: 10.4317/jced.62588 Negative / Null Result ReportMedicine
Correia de Lima Junior N, Fernandes-Batista T, Ferreira-Serra L et al. · 2025 · Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
The consumption of Western diet, characterized by high sugar and saturated fat content, often leads to weight gain and promotes oxidative stress. Intermittent fasting has emerged as a potential strategy to combat obesity, but its effects…
View details →DOI: 10.1055/a-2634-0201 Negative / Null Result ReportOpen accessMedicine
Dubourg V, Akhtar N, Kopf M et al. · 2026 · iScience
Vascular smooth muscle cells (VSMCs) are at the center of vascular diseases but studies on VSMCs from human females are rare and the medical need for female-specific vascular research is urgent. VSMCs are simultaneously subjected to…
View details →DOI: 10.1016/j.isci.2026.115886 Negative / Null Result ReportMedicine
Lyons J, Chatha HN, Boutros C et al. · 2025 · Surgical endoscopy
Background Fundoplication at the time of paraesophageal hernia (PEH) repair is thought to help prevent the development or persistence of postoperative gastroesophageal reflux (GERD) and might also prevent hernia recurrence. However, the…
View details →DOI: 10.1007/s00464-024-11317-5 Negative / Null Result ReportMedicine
Weerts EM, Jenkins BW, Kuang RY et al. · 2024 · Pharmacology, biochemistry, and behavior
Cannabigerol (CBG) is a phytocannabinoid found in cannabis that is promoted for medical use and other health benefits, but current empirical data on the behavioral effects of CBG are lacking. The purpose of this study was to evaluate the…
View details →DOI: 10.1016/j.pbb.2024.173883 Negative / Null Result ReportOpen accessMedicine
Maier KS, Schiener T, Frigg A · 2025 · Journal of orthopaedic surgery and research
Background Short femoral stems were introduced for total hip arthroplasty (THA) to preserve bone stock, increase proximal load transfer, and enable minimal invasive approaches. However, after implanting the short curved Fitmore hip stem,…
View details →DOI: 10.1186/s13018-025-06064-9 