Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Maxime W. Lafarge, Enric Domingo, Korsuk Sirinukunwattana et al. · 2024 · npj Precision Oncology
Abstract The development of deep learning (DL) models to predict the consensus molecular subtypes (CMS) from histopathology images (imCMS) is a promising and cost-effective strategy to support patient stratification. Here, we investigate whether imCMS calls generated from whole slide histopathology images (WSIs) of rectal cancer (RC) pre-treatment biopsies are associated with pathological complete response (pCR) to neoadjuvant long course chemoradiotherapy (LCRT) with single agent fluoropyrimidine. DL models were trained to classify WSIs of colorectal cancers stained with hematoxylin and eosin
View details →DOI: 10.1038/s41698-024-00580-3 Negative / Null Result ReportOpen accessMedicine
Seyed Seifollah Beladi Mousavi, Abbasali Zeraati, Sajad Moradi et al. · 2015 · Saudi Journal of Kidney Diseases and Transplantation
Hemodialysis‐associated muscle cramps (HAMC) are a common complication during hemodialysis (HD) sessions. A number of pharmacologic agents have been evaluated to prevent and or diminish HAMC; however, none of them has an established role. To the best of our knowledge, this is the first study to evaluate the possible effect of gabapentin on HAMC. In a double-blinded clinical trial, we compared the possible effect of gabapentin with a placebo in prevention and or diminishing episodes of HAMC in HD patients who had experienced frequent intradialytic muscle cramps. At first, placebo was given befo
View details →DOI: 10.4103/1319-2442.168588 Negative / Null Result ReportOpen accessMedicine
Annikka Polster, Lena Öhman, Julien Tap et al. · 2021 · Scientific Reports
Abstract Although incompletely understood, microbiota-host interactions are assumed to be altered in irritable bowel syndrome (IBS). We, therefore, aimed to develop a novel analysis pipeline tailored for the integrative analysis of microbiota-host interactions and association to symptoms and prove its utility in a pilot cohort. A multilayer stepwise integrative analysis pipeline was developed to visualize complex variable associations. Application of the pipeline was demonstrated on a dataset of IBS patients and healthy controls (HC), using the R software package to analyze colonic host mRNA a
View details →DOI: 10.1038/s41598-021-84686-9 Negative / Null Result ReportOpen accessEnvironmental technology. Sanitary engineering
Han Wu, Baofa Jiang, Ping Zhu et al. · 2018 · Environmental Research Letters
When discussing the association between birth weight and air pollution, previous studies mainly focus on the maternal trimester-specific exposures during pregnancy, whereas the possible associations between birth weight and weekly-specific exposures have been largely neglected. We conducted a nested 1:4 matched case-control study in Jinan, China to examine the weekly-specific associations during pregnancy between maternal fine particulate matter (aerodynamic diameter < 2.5 μm, PM _2.5 ), nitrogen dioxide (NO _2 ), and sulfur dioxide (SO _2 ) exposure and birth weight, which is under a represen
View details →DOI: 10.1088/1748-9326/aaa346 Negative / Null Result ReportOpen access
L. L. D. Paiva, Tatiane Kelly Barbosa de Azevedo, A. Pimenta et al. · 2023 · Revista Árvore
ABSTRACT This research aimed to evaluate the effect of thinning on the wood volumes per hectare on the tannin content in the bark of Mimosa caesalpiniifolia. The planting was subdivided into two plots, one thinned at 12 and 55 months of…
View details →DOI: 10.1590/1806-908820230000028 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Mostafa Shahraki Jazinaki, Mostafa Shahraki Jazinaki, Mohammad Safarian et al. · 2024 · Frontiers in Nutrition
Background and aimThe Global Leadership Initiative on Malnutrition (GLIM) recently proposed a new malnutrition diagnostic tool known as the GLIM criteria. The GLIM criteria need confirmed validation before being widely used in each population or healthcare system. This study aimed to investigate the validation of the GLIM criteria for malnutrition diagnosis in hospitalized patients.MethodsThe content validity was assessed by calculating the content validity ratio (CVR) and content validity index (CVI). Subjective global assessment (SGA) is considered the reference tool to diagnose malnutrition
View details →DOI: 10.3389/fnut.2024.1438158 Negative / Null Result ReportOpen accessSports medicine
Stian Kjennvold MD, Jan Harald Røtterud MD, PhD, Magnus Forssblad MD, PhD et al. · 2025 · Orthopaedic Journal of Sports Medicine
Background: It is well-established that patients undergoing anterior cruciate ligament reconstruction (ACLR) have a less favorable prognosis if a concomitant full-thickness cartilage lesion is present at the time of surgery. However, the long-term benefits of surgically addressing these cartilage lesions remain uncertain. Purpose: To evaluate whether the most used surgical treatments for cartilage lesions influenced patient-reported outcomes 10 years after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: This study was based on a cohort of all patients with primary unilateral A
View details →DOI: 10.1177/23259671251381340 Negative / Null Result ReportOpen accessPublic aspects of medicine
Louis Okeibunor Odeigah, Yahkub Babatunde Mutalub, Olalekan Ayodele Agede et al. · 2022 · PLOS Global Public Health
Safe and effective vaccination remains the mainstay of control of COVID-19 because there is still no universally recommended treatment. This strategy is however being threatened by vaccine hesitancy and resistance due to fear of adverse events and safety concerns. It is, therefore, necessary to study post-vaccination adverse events (AE) in various populations and geographical areas. The objective of this study was to analyze the adverse events following COVID-19 vaccination in five major immunization centers of Kwara State Nigeria. A retrospective descriptive study of the adverse events follow
Negative / Null Result ReportOpen accessPsychiatry
Junjun Liu, Junjun Liu, Junjun Liu et al. · 2023 · Frontiers in Psychiatry
ObjectiveTriglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naïve (FEDN) MDD.MethodsThis cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 ± 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Mul
View details →DOI: 10.3389/fpsyt.2023.1231524 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Dulharie T. Wijeratne, Samitha Fernando, Laksiri Gomes et al. · 2019 · Immunity, Inflammation and Disease
Abstract Introduction Although the role of dengue virus (DENV)‐specific T cells in the pathogenesis of acute dengue infection is emerging, the functionality of virus‐specific T cells associated with milder clinical disease has not been well studied. We sought to investigate how the functionality of DENV–NS3 and DENV–NS5 protein‐specific T cells differ in patients with dengue fever (DF) and dengue hemorrhagic fever (DHF). Methods Using intracellular cytokine assays, we assessed the production of interferon γ (IFNγ), tumor necrosis factor‐α (TNF‐α), macrophage inflammatory protein‐1β (MIP‐1β), a
View details →DOI: 10.1002/iid3.271 Negative / Null Result ReportOpen accessDentistry
Patrícia Petromilli Nordi Sasso Garcia, Camila Pinelli, Juliana dos Reis Derceli et al. · 2015 · Brazilian Journal of Oral Sciences
Aim: This study assessed the risk factors of undergraduate students to develop musculoskeletal disorders (MSD) in the upper limbs, regarding gender, type of dental clinical procedure, mouth region treated, and the four-handed dentistry practice. Methods: Dental students enrolled in the 8th semester in the Araraquara School of Dentistry, UNESP, Brazil, were photographed while practicing 283 dental procedures. The Rapid Upper Limb Assessment (RULA) method was used to evaluate the working postures of each student. The photographs were evaluated and a final risk score was attributed to each analyz
View details →DOI: 10.20396/bjos.v11i2.8641448 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yabe Ichiro, Miyagishi Ryuji, Fukazawa Toshiyuki et al. · 2002 · BMC Neurology
Abstract Background The Apo-1/Fas (CD95) molecule is an apoptosis-signaling cell surface receptor belonging to the tumor necrosis factor (TNF) receptor family. Both Fas and Fas ligand (FasL) are expressed in activated mature T cells, and prolonged cell activation induces susceptibility to Fas-mediated apoptosis. The Apo-1/Fas gene is located in a chromosomal region that shows linkage in multiple sclerosis (MS) genome screens, and studies indicate that there is aberrant expression of the Apo-1/Fas molecule in MS. Methods Mva I polymorphism on the Apo-1/Fas promoter gene was detected by PCR-RFLP
View details →DOI: 10.1186/1471-2377-2-8 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mansour S Almetwazi, Ahmad O Noor, Diena M Almasri et al. · 2017 · Saudi Pharmaceutical Journal
Objective: To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes. Research design and method: We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin
View details →DOI: 10.1016/j.jsps.2017.09.001 Negative / Null Result ReportOpen accessMedicine
Xin Zhao, Chaoxuan Wang, Jian Wang et al. · 2026 · Scientific Reports
Abstract Sarcopenia, the progressive loss of muscle mass and function, is a significant health concern in middle-aged and older adults, potentially linked to adverse outcomes like falls and fractures. A cohort study was conducted utilizing participants aged ≥ 45 years from CHARLS. Sarcopenia was defined using established criteria. Primary outcomes were isolated falls, isolated hip fractures, and composite outcomes. Associations were assessed using multivariable Cox regression (adjusted for confounders), propensity score matching (PSM), and inverse probability weighting (IPW), reporting hazard
View details →DOI: 10.1038/s41598-026-43398-8 Negative / Null Result ReportOpen accessPsychiatry
Ahmed Kamil Toman, Ahmed Kamil Toman, Ahmed Kamil Toman et al. · 2025 · Frontiers in Psychiatry
IntroductionCo-occurring conditions are common in children with autism spectrum disorder (ASD) and have important negative impacts on the children and their families. For Iraqi children, local healthcare systems tend to place more emphasis on the management of ASD itself while neglecting co-occurring conditions.ObjectivesThis study aims to investigate the prevalence, characteristics, and potential risk factors of co-occurring epilepsy, sleep, and weight issues among Iraqi children with ASD.MethodsA multicenter cross-sectional study was conducted from January 24 to August 7, 2024, including chi
View details →DOI: 10.3389/fpsyt.2025.1592374 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Sharmin Chowdhury, Sheikh Joly Ferdous Ara, Shirazum Monira Mili et al. · 2022 · Advances in Cancer Biology - Metastasis
Background: Colorectal carcinoma (CRC) is the third most common cancer in the world and incidences are on the rise in Bangladesh. KRAS, NRAS, BRAF, PIK3CA, and AKTI gene mutations are predictive markers of biological therapies, monoclonal antibodies targeting EGFR. The purpose of this study was to detect KRAS, NRAS, BRAF, PIK3CA, and AKT1 genes mutation in CRC patients by multiplex real-time Polymerase Chain Reaction (PCR) and evaluate the association of the mutations with clinicopathological features. Methodology: This cross-sectional study was carried out in the Department of Microbiology &
View details →DOI: 10.1016/j.adcanc.2022.100054 Negative / Null Result ReportMedicine
H. Henjum, Karoline Mo Feten, Erlend Hartvigsen et al. · 2025 · Acta oncologica
Background and purpose Proton Arc Therapy (PAT) is an emerging proton therapy treatment modality with the potential to reduce radiation exposure to healthy tissues compared to conventional Intensity-Modulated Proton Therapy (IMPT) with…
View details →DOI: 10.2340/1651-226x.2025.42001 Negative / Null Result ReportOpen accessPublic aspects of medicine
Sanjay B Tripathi, Vishakha K Kapadia · 2015 · National Journal of Community Medicine
Objectives: To evaluate the clinical profile and the factors influencing treatment outcome of TB patients co-infected with HIV attending DOT centers of Southeast area of Ahmedabad, Gujarat Methodology: A Prospective observation study was conducted to assess the treatment outcome of TB in TB-HIV co-infected patients on DOTs conducted at L.G. Hospital and tuberculosis units (TUs) of south and east region of Ahmedabad. TB patients started DOTS were registered and were followed till treatment outcome was declared. Results: The treatment success rate was found to be 84.17% (101 of 120 patients). Tr
Negative / Null Result ReportOpen accessMedicine
Artha Falentin Putri Susilo, Hanom Husni Syam, Hartanto Bayuaji et al. · 2024 · Scientific Reports
Abstract Vitamin D and calcium in follicular fluid play an important role in modulating steroidogenesis, folliculogenesis, and oocyte quality determination. Both collaborate to produce top-quality embryos (TQE) during in vitro fertilization (IVF). In this study, we compared free 25(OH)D3 and calcium levels in follicular fluid between TQE and non-TQE groups. This cross-sectional study included women who underwent IVF procedures at tertiary hospitals in Bandung, Indonesia. Ovarian follicular fluid was collected during the ovum pick-up procedure. The examination of 25(OH)D3 levels, vitamin d-bind
View details →DOI: 10.1038/s41598-024-71769-6 Negative / Null Result ReportOpen accessMedicine
Sarah Moreira de Sousa Gomes, Paulo César Apolinário de Souza, Cassiane Freitas Rodrigues et al. · 2026 · DST
Introduction: Women living with HIV/AIDS (WLHA) are more vulnerable to human papillomavirus (HPV) infection, particularly by high-risk oncogenic subtypes, due to HIV-associated immunosuppression. Objective: To assess the prevalence and distribution profile of HPV subtypes in WLHA, correlating findings with CD4 levels and age group. Methods: A cross-sectional study was conducted with 184 WLHA receiving care at a public referral center in Juiz de Fora, Minas Gerais, from May 2021 to May 2022. Self-collected vaginal samples were analyzed by RT-PCR to detect HPV subtypes. Associations between HPV
View details →DOI: 10.5327/dst-2177-8264-1457 Negative / Null Result ReportOpen accessGeriatrics
Socheat Cheng, Tahreem Ghazal Siddiqui, Michael Gossop et al. · 2020 · BMC Geriatrics
Abstract Background Central nervous system depressant medications (CNSDs) such as opioid analgesics and sedative-hypnotics are commonly prescribed to older patients for the treatment of chronic pain, anxiety and insomnia. Yet, while many studies reported potential harms, it remains unknown whether persistent use of these medications is beneficial for older patients’ self-reported health-related quality of life (HRQoL). The present study clarified this knowledge gap through comparing HRQoL of hospitalized older patients with versus without using CNSD drugs for ≥4 weeks. Moreover, we explored th
View details →DOI: 10.1186/s12877-020-01838-8 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Karthikeyan R, Marimuthu G, Ramasubramanian C et al. · 2014 · Neuropsychiatric Disease and Treatment
Ramanujam Karthikeyan,1 Ganapathy Marimuthu,1 Chellamuthu Ramasubramanian,2 Gautham Arunachal,2 Ahmed S BaHammam,3 David Warren Spence,4 Daniel P Cardinali,5 Gregory M Brown,6 Seithikurippu R Pandi-Perumal7 1Department of Animal Behaviour and Physiology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India; 2MS Chellamuthu Trust and Research Foundation, KK Nagar, Madurai, India; 3University Sleep Disorders Center, College of Medicine, National Plan for Science and Technology, King Saud University, Riyadh, Saudi Arabia; 4Independent researcher, Toronto, Ontario, C
Negative / Null Result ReportOpen access
Padma B Prabha, Jyothi P T · 2022 · Journal of Education Technology in Health Sciences
Structured interactive lectures (SIL) and Flipped classroom methods (FCM) are newer teaching learning methods which utilise pedagogical way of teaching. This study intends to compare efficacy of both methods in the understanding of…
View details →DOI: 10.18231/j.jeths.2021.019 Negative / Null Result ReportOpen accessVeterinary medicine
K. Wojdak-Maksymiec, M. Kmiec, J. Ziemak · 2006 · Veterinární Medicína
The study included 124 Polish Black-and-White dairy cows of various share of the Holstein-Friesian (HF) breed. Lactoferrin (LTF) gene polymorphism was obtained with PCR-RFLP method using EcoRI enzyme. Two alleles of LTF, A and B, were found in the studied population. Their frequencies were 67.74% and 32.56%, respectively. The alleles controlled the occurrence of three genotypes: AA, BB and AB, of frequencies equal to 37.90%, 2.42% and 59.68%, respectively. It was established that statistically significant associations exist between the somatic cell count (SCC) and LTF genotype, lactation month
View details →DOI: 10.17221/5512-vetmed Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sofya Ilmer, Rubab Sohail, Sharon Hyman · 2026 · Frontiers in Endocrinology
IntroductionThis retrospective chart review investigated the relationship between 25-hydroxyvitamin D levels and the initial clinical and biochemical presentation of type 1 diabetes mellitus (T1DM) in children under 18 years of age, specifically: (1) presence or absence of diabetic ketoacidosis and the severity of diabetic ketoacidosis (DKA) - among those with DKA, and (2) beta-cell function.MethodsThis study included 99 children with new-onset Type 1 Diabetes Mellitus (T1DM). Patients were diagnosed at our pediatric endocrinology practice at Northwell Health between June 2023 and February 202
View details →DOI: 10.3389/fendo.2026.1814563 Negative / Null Result ReportOpen accessMedicine (General)
S Bakhti, S Latifi-Navid, S Zahri et al. · 2015 · Journal of Ardabil University of Medical Sciences
Background & objectives: Several studies have described VacA and CagA as the two important virulence determinants of Helicobacter pylori, which are associated with gastric ulcer (GU) and duodenal ulcer (DU). The aim of present study was to determine the associations of the i and d regions genotypes of H. pylori vacA gene and cagA status with GU and DU risk. Methods: A total of 177 isolates were cultured from the biopsies of Iranian patients with different geographic origins and genotyped. Data were collected and analyzed. Results: Frequency of the vacA i1, i2, i1i2, d1, and d2 alleles and cagA
Negative / Null Result ReportOpen accessGenetics
Erik Artur Cortinhas-Alves, Victor Henrique Botelho Lourenço, Andreza Juliana Moreira da Costa et al. · 2025 · Genetics and Molecular Biology
ABSTRACT The literature shows a correlation between ethnicity and pathogenic variants of the thyroid stimulating hormone receptor (TSHR) gene. Some of these polymorphisms may be risk factors for the development of primary congenital hypothyroidism (PCH). In this study, we investigated the relationship between the frequency of TSHR gene polymorphisms and the genetic influence of African, Amerindian, and European ancestry-informative markers in patients from an Amazonian population in Brazil who were diagnosed with PCH. The study was conducted on samples from 106 patients who were diagnosed with
View details →DOI: 10.1590/1678-4685-gmb-2024-0147 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Mahdieh Hosseinzadeh, Niloufar Saber, Sakineh Shab Bidar et al. · 2024 · BMC Endocrine Disorders
Abstract Background Type 2 diabetes mellitus (T2DM) is often linked to chronic inflammation, which can be influenced by both lifestyle and dietary choices. However, the relationship between the inflammatory potential of diet and lifestyle factors and the risk of developing T2DM remains unclear. The present study aimed to investigate the associations of the empirical dietary inflammatory index (EDII), dietary inflammatory score (DIS), and lifestyle inflammatory score (LIS) with the risk of T2DM among Iranian adults. Methods The current study was conducted on 5714 individuals from Yazd Health St
View details →DOI: 10.1186/s12902-024-01673-7 Negative / Null Result ReportOpen accessMedicine
Hajibagheri K, Abaszade A, Afrasiabian Sh et al. · 2018 · مجله علمی دانشگاه علوم پزشکی کردستان
Background and Aim: Genital wart is the most common sexually transmitted infection and its role in cervical cancer has been confirmed. The aim of this study was to determine the presence of human papillomavirus (HPV) and the frequency of its genotypes in the patients with genital lesions referring to the clinics in Sanandaj, Iran. Material and Method: This descriptive analytical study included 50 women with genital lesions referring to the clinics in Sanandaj City from February 2016 to February 2017. Biopsy samples were examined for four genotypes (HPV 16, 18 (high risk) and HPV 11, 6 (Low ris
Negative / Null Result ReportOpen accessDentistry
Leena Verma, Ravi Sharma, Sidhi Passi et al. · 2023 · Journal of South Asian Association of Pediatric Dentistry
Aim: To evaluate the correlation between dental caries and obesity in 8–10 years school children of Chandigarh, India. Materials and methods: Around 100 children of the age range of 8–10 years who attended the Pediatrics OPD of Dr Harvansh Singh Judge Institute of Dental Sciences & Hospital, Chandigarh, India were selected. Four groups were made group I—25 healthy teeth and nonobese (HNO) children, group II—25 carious teeth and nonobese (CNO) children, group III—25 healthy teeth and obese (HO) children, and group IV—carious teeth and obese (CO) children. Caries score was recorded after careful
View details →DOI: 10.5005/jp-journals-10077-3265 