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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19885 results in Negative / Null Result Report · page 521 of 663

Negative / Null Result Report

Patient-Reported Chief Complaints Do Not Independently Improve Machine Learning–Based Sagittal Skeletal Classification Beyond Standard Cephalometric Parameters: A Nested Cross-Validation Study

Dinç G, Öztürk B, Ciğerim SÇ · 2026 · Preprint

Abstract Objectives Sagittal skeletal classification is central to orthodontic diagnosis. This study aimed to (1) develop and validate an interpretable machine learning (ML) model for three-class sagittal skeletal classification (Class I,…

View details →DOI: 10.21203/rs.3.rs-9470812/v1
Negative / Null Result Report

Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors

Schwartz MA, Lue D, Mutaher M et al. · 2026 · Preprint

Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade. We systematically identified regulators of this cell state using genome-wide CRISPR screens in primary T cells in vitro . Using random…

View details →DOI: 10.64898/2026.06.14.732162
Negative / Null Result ReportMedicine

Predictive value of ultrasound-measured tongue base thickness for upper airway obstruction during monitored anesthesia care: a single-center prospective observational study.

Kikkawa K, Takeuchi M, Sakaguchi D et al. · 2026 · Journal of anesthesia

Purpose Monitored anesthesia care (MAC) is increasingly used for various procedures, but sedation-related upper airway obstruction may lead to hypoxemia or conversion to general anesthesia. This study evaluated whether preoperative tongue…

View details →DOI: 10.1007/s00540-026-03792-y
Negative / Null Result ReportMedicine

Effect of Pericapsular Nerve Group Block on Prehabilitation in Femoral Neck Fractures: A Randomized, Double-Blind, Placebo-Controlled Trial.

Jin Z, Ueda K, Higo F et al. · 2026 · Anesthesia and analgesia

Background Prehabilitation during unavoidable surgical delay after an acute femoral neck fracture may mitigate rapid functional decline but is often limited by movement-evoked pain. The pericapsular nerve group (PENG) block is a…

View details →DOI: 10.1213/ane.0000000000008147
Negative / Null Result ReportMedicine

Association between arterial to end-tidal carbon dioxide gradient and prehospital hemodynamic status in patients with moderate-to-severe traumatic brain injury.

Navarro LP, Combes X, Galinski M et al. · 2026 · BMC emergency medicine

Introduction We aimed to assess the relationship between arterial partial pressure of carbon dioxide (PaCO 2 ) and end-tidal carbon dioxide (EtCO 2 ) according to three prehospital hemodynamic status and to evaluate whether…

View details →DOI: 10.1186/s12873-026-01649-x
Negative / Null Result ReportMedicine

Effects of high oleic expeller-pressed soybean meal on milk fat production and fatty acid digestibility in lactating dairy cows undergoing a milk fat depression challenge.

Burtnett SL, Bomberger RA, Harvatine KJ · 2026 · Journal of dairy science

Oleic acid has a lower risk for biohydrogenation-induced milk fat depression (MFD) than linoleic acid and can act as an emulsifier to aid fatty acid (FA) digestion in the small intestine. Our objective was to evaluate the effect of high…

View details →DOI: 10.3168/jds.2026-28283
Negative / Null Result ReportOpen accessMedicine

Prognostic Performance of a Modified TRI-SCORE Incorporating RV-PA Uncoupling After Transcatheter Tricuspid Valve Interventions.

Alachkar MN, Schlegl J, Bannehr M et al. · 2026 · Journal of cardiovascular development and disease

Background The TRI-SCORE was developed to predict mortality after tricuspid valve surgery and has demonstrated prognostic value in patients undergoing transcatheter tricuspid valve interventions (TTVI). Right ventricular-pulmonary arterial…

View details →DOI: 10.3390/jcdd13060250
Negative / Null Result ReportMedicine

The Effect of a Series of Lower Limb Pressotherapy Treatments on the Range of Motion of the Lower Limb Joints, Lower Limb Circumferences, and Body Composition in Young, Healthy Women.

Ptaszek B, Kurek O, Podsiadło S · 2026 · Lymphatic research and biology

Purpose In times when health and physical activity are gaining in value, the search for effective methods to support fitness and improve quality of life is becoming a priority. One of the therapies that is gaining increasing popularity is…

View details →DOI: 10.1177/15578585261461974
Negative / Null Result ReportMedicine

Anthropometric differences between twins at birth and their association with later cognitive performance.

Eves R, Deppe M, Kandler C et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background Past studies indicate significant associations between birth anthropometrics, such as relative birthweight or head circumference, and later cognitive performance. Using twin data, we investigated whether these associations are…

View details →DOI: 10.1111/jcpp.70170
Negative / Null Result ReportMedicine

Insulin therapy improves bone microstructure and material properties without restoring whole-bone strength in male insulin-deficient Akita mice.

Toillon I, Badoud I, Ferrari S et al. · 2026 · Bone

Type 1 diabetes is associated with increased fracture risk, yet the respective contributions of insulin deficiency and replacement to skeletal fragility remain poorly understood. Using insulin-deficient male Akita mice, we characterized…

View details →DOI: 10.1016/j.bone.2026.117971
Negative / Null Result ReportMedicine

Prognostic dynamics of pathological complete response and ctDNA clearance after neoadjuvant/perioperative immunotherapy in cancer: a reconstructed individual patient analysis.

Garitaonaindia Y, Witteveen S, Dionisio E et al. · 2026 · Journal of the National Cancer Institute

Background Pathological complete response (pCR) and circulating tumor DNA (ctDNA) clearance are increasingly used as intermediate endpoints in neoadjuvant and perioperative immunotherapy (IO) trials. However, whether complete pathological…

View details →DOI: 10.1093/jnci/djag197
Negative / Null Result ReportMedicine

Hybrid Inpatient POCUS Course for Rising Senior Family Medicine Residents.

Alsharif P, Strauss A, Ng W et al. · 2026 · Family medicine

Background and objectives Point-of-care ultrasound (POCUS) is increasingly used in inpatient settings to evaluate patients. Common applications include cardiac, lung, hemodynamic assessment, and venous access. Teaching and achieving…

View details →DOI: 10.22454/fammed.2026.581315
Negative / Null Result ReportMedicine

[Anti-leucine-rich glioma-inactivated 1 antibody-positive encephalitis with a poor response to corticosteroids 2 months after onset of impaired memory: a case report].

Araga Y, Nakamura Y, Sugita C et al. · 2026 · Rinsho shinkeigaku = Clinical neurology

The patient was a 30-year-old man who was admitted to our department 2 months after the onset of anterograde amnesia. Cognitive function tests indicated memory impairment only. MRI FLAIR images of the head showed a high signal in the…

View details →DOI: 10.5692/clinicalneurol.cn-002223
Negative / Null Result ReportMedicine

Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy: implications for personalized toxicity risk stratification.

Pham TN, Chamseddine I, Lebhertz D et al. · 2026 · Physics in medicine and biology

Introduction. Radiation-induced optic neuropathy (RION) is a rare but functionally-disabling complication of radiotherapy for brain and head/neck tumors. Even with modern proton therapy and adherence to dose constraints, about 6% of…

View details →DOI: 10.1088/1361-6560/ae752c
Negative / Null Result ReportMedicine

Neoadjuvant chemoimmunotherapy versus neoadjuvant chemoradioimmunotherapy for locally advanced esophageal squamous cell carcinoma.

Shi L, Li Y, Li C et al. · 2026 · International journal of clinical oncology

Background Comparative evidence for neoadjuvant chemoimmunotherapy (NCIT) versus neoadjuvant immunotherapy combined with chemoradiotherapy (NICRT) in locally advanced esophageal squamous cell carcinoma (ESCC) is limited. We compared…

View details →DOI: 10.1007/s10147-026-03093-0
Negative / Null Result ReportMedicine

Comparative performance of one-stage and two-stage deep learning models for instance segmentation of overhanging dental restorations on bitewing radiographs.

Hatipoğlu Ö, Başar Ö, Mağat G et al. · 2026 · Scientific reports

Accurate detection of overhanging dental restorations on bitewing radiographs is clinically important but remains challenging due to subtle marginal discrepancies. This study aimed to develop and compare deep learning-based instance…

View details →DOI: 10.1038/s41598-026-57540-z
Negative / Null Result ReportMedicine

The sonographic subpubic area is a predictor of anal incontinence after a first vaginal delivery: A prospective cohort study.

Packet B, Van Severen R, Cattani L et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology

Objectives To study the association between the subpubic arch angle and area, the latter a novel estimator of maternal pelvic outlet dimensions, and postpartum anal incontinence. Methods Convenience sample from a prospective observational…

View details →DOI: 10.1016/j.ejogrb.2025.114867
Negative / Null Result ReportMedicine

Hand therapy or not following collagenase treatment for Dupuytren's disease? A randomized controlled trial.

Aglen T, Matre KH, Selles RW et al. · 2026 · Journal of hand therapy : official journal of the American Society of Hand Therapists

Background Collagenase treatment can improve finger extension and hand function in patients with Dupuytren's disease. The role of hand therapy in enhancing or prolonging these effects remains unclear. Purpose The primary aim was to examine…

View details →DOI: 10.1016/j.jht.2026.02.004
Negative / Null Result ReportMedicine

Psychometric Evaluation and Discriminative Validity of the Short-Form Brief Pain Inventory Across Nociceptive, Neuropathic, and Nociplastic Pain Mechanisms.

Steen JP, Jaiswal KS, Dilipkumar J et al. · 2026 · The journal of pain

The measurement performance of the Short-Form Brief Pain Inventory (BPI-SF) across IASP-recognized pain mechanisms remains unclear. We evaluated the reliability and structural validity of BPI-SF across clinician-assigned predominant…

View details →DOI: 10.1016/j.jpain.2026.106365
Negative / Null Result ReportMedicine

Mature oocyte yield in patients with diminished ovarian reserve treated with luteal estradiol priming with or without GnRH antagonist.

Ghofranian A, Baird M, Reckhow J et al. · 2026 · Minerva obstetrics and gynecology

Background Luteal phase E2 priming is commonly used in patients with DOR to 30 synchronize follicular development before controlled ovarian hyperstimulation (COH). Some protocols 31 incorporate a GnRH antagonist during the luteal phase to…

View details →DOI: 10.23736/s2724-606x.26.05836-7
Negative / Null Result ReportMedicine

The Effect of PTFE Coating and PTFE Tape Wrapping Abutment Screw After Cyclic Loading: An In Vitro Study.

Kongkhuntian P, Aunmeungtong W, Khongkhunthian P · 2026 · Clinical implant dentistry and related research

Objective This study aimed to compare the effect of PTFE tape wrapping and PTFE-coated titanium alloy screws on the removal torque after cyclic loading and on preload values under repetitive tightening. Methods A total of 60 titanium…

View details →DOI: 10.1111/cid.70162
Negative / Null Result ReportMedicine

Reduction in copper and pesticide levels in grape musts: A new asset for the implementation of bioprotection in oenology.

Tournu E, Tourdot-Maréchal R, Coelho C · 2026 · International journal of food microbiology

Phytosanitary and copper treatments in viticulture are essential to protect vines against biotic and abiotic stresses. However, residues from these treatments can persist in grape musts and wines, potentially raising risks to consumer…

View details →DOI: 10.1016/j.ijfoodmicro.2026.111877
Negative / Null Result ReportMedicine

Personalized Treatment Selection for Digital Eating Disorder Interventions: A Proof-of-Concept for the Personalized Advantage Index.

McClure Z, Fuller-Tyszkiewicz M, Messer M et al. · 2026 · The International journal of eating disorders

Objective Although a range of evidence-based treatments for eating disorders exist, treatment response varies substantially. The ability to match individuals to a treatment which they are most likely to benefit from may help improve…

View details →DOI: 10.1002/eat.70112
Negative / Null Result ReportMedicine

Can biochar and late-season nitrogen fertilization overcome the sulfur-containing amino acid deficiency and improve oil stability in soybean seeds?

Khatri D, Poudel S, Pun Magar L et al. · 2026 · Frontiers in plant science

Soybean meal quality for monogastric animals is limited by low sulfur-containing amino acids, especially methionine and cysteine, while oil oxidative stability is restricted by the high polyunsaturated fatty acid content. This two-year…

View details →DOI: 10.3389/fpls.2026.1849670
Negative / Null Result ReportMedicine

A novel face scale and National Early Warning Score 2 prediction model to assess deteriorating patients in hospital wards: A quick visual early warning score study.

Wall A, Fisher JA, Watkinson EK et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses

Background Early warning scores like the National Early Warning Score 2 (NEWS2) identify patient deterioration but do not incorporate clinician-intuitive assessment. Previous research suggests facial expressions can be critical indicators…

View details →DOI: 10.1016/j.aucc.2026.101628