Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors
Schwartz MA; Lue D; Mutaher M; McNerney M; Olajide O; Mehta A; Rowe JH; Park RJ · 2026 · Preprint
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade. We systematically identified regulators of this cell state using genome-wide CRISPR screens in primary T cells in vitro . Using random…
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Metadata source: Europe PMC · DOI 10.64898/2026.06.14.732162