A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19885 results in Negative / Null Result Report · page 520 of 663
Dikici B, Malinowski R, Kordaß J et al. · 2025 · Preprint
During non-rapid eye movement (NREM) sleep, cortical slow oscillation (SO; <1 Hz) and thalamic sleep spindle activity (12-15 Hz) interact through precise phase coupling to support memory consolidation. Slow oscillatory transcranial direct…
Junior PCGD, Vicente ACS, Santos IJd et al. · 2025 · Preprint
Abstract The study evaluated the effects of orange essential oil (OEO) as a feed additive on nutrient intake, digestibility, nitrogen balance, and rumen fermentation in meat sheep. Using ten rumen-cannulated Dorper × Santa Inês wethers in…
Badran PM, Stecca CM, de Souza de Castro JT et al. · 2025 · Clinical radiology
Aim Ovarian cancer is the most lethal gynecologic malignancy, with prognosis linked to stage at diagnosis. Ultrasonography is the first-line tool for adnexal mass evaluation, while computed tomography (CT) supports staging and surgical…
di Fonzo AR, Bertuzzi ML, Amusquibar MV et al. · 2025 · Animal reproduction science
Zinc oxide nanoparticles (ZnO-NPs) have been reported to enhance sperm cryopreservation in several species, but their effect on frozen llama semen remains unexplored. This study aims to evaluate the effect of ZnO-NPs on sperm parameters in…
Coste A, Wong AYS, Haguinet F et al. · 2025 · Pharmacoepidemiology and drug safety
Background Despite testing of epidemiological methods in US Claims databases for signal detection, such data sources have not become a routine capability. The Self Controlled Case Series (SCCS) is one of the most promising methods for drug…
Landínez-Martínez D, Grisales-Aguirre A · 2025 · Preprint
Background: /Objectives: Post-stroke cognitive impairment significantly impacts long-term functional outcomes, particularly in instrumental activities of daily living (IADLs). Working memory training (WMT) has emerged as a potential…
Pereyra EV, Kravetz S, Lucero J et al. · 2025 · Limnologica
Freshwater ecosystems face significant threats worldwide, particularly from land use changes that impact biodiversity and ecosystem functions in rivers and streams. Essential elements such as carbon, nitrogen, and phosphorus play crucial…
Wakui N, Kawakubo S, Harayama M et al. · 2025 · Journal of the American Pharmacists Association : JAPhA
Background In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible health care facilities, often serve as sources of health information. However,…
Zhang X, Wan C, Wang X et al. · 2025 · Preprint
Abstract Background: Despite considerable advances in therapeutic approaches for bronchopulmonary dysplasia (BPD), its incidence remains persistently high, with a troubling rise in moderate-to-severe cases. Given the progressive nature and…
Freislederer F, Dimitriu M, Endell D et al. · 2026 · Journal of experimental orthopaedics
Purpose To determine whether augmentation with the subacromial bursa influences postoperative tendon healing, particularly regarding morphology and vascularity, after arthroscopic rotator cuff repair. Methods In this prospective…
Verdecia-Mogena AM, Himmighofen PA, Mateo P et al. · 2025 · Plant, cell & environment
Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…
Chen F, Cooper J, Acharya A et al. · 2026 · JMIR public health and surveillance
Background Antimicrobial resistance (AMR) is a significant global health threat. Several public health campaigns aimed to raise AMR awareness and inspire related behavioral changes have been delivered in a time-specific, coordinated…
Verdecia-Mogena AM, Himmighofen P, Mateo P et al. · 2025 · Preprint
Entomopathogenic nematodes (EPNs) are key biological control agents in agriculture, but their direct effects on plant metabolism and resistance to herbivory remain underexplored. By combining transcriptomic, metabolomic, and herbivore…
Narang BJ, Štritof A, Debevec T · 2025 · International journal of sport nutrition and exercise metabolism
The ergogenic effects of caffeine for endurance performance at sea level are well established. However, whether caffeine enhances exercise capacity or modulates cardiorespiratory responses in hypoxia remains unclear. Twenty-nine healthy,…
Katseff AS, Toumanios C, Barahim E et al. · 2025 · Vaccine
Multi-drug-resistant Pseudomonas aeruginosa (PA) infections are a growing problem for at-risk populations, causing thousands of deaths per year, and novel therapies to treat or prevent severe PA infection are desperately needed. We…
Gill P, Tao X, Zhan Y et al. · 2026 · American journal of obstetrics and gynecology
Background Preimplantation genetic testing for aneuploidy is used to improve in vitro fertilization outcomes by identifying embryos with lethal chromosomal abnormalities that impair development or lead to pregnancy loss. The adoption of…
Barwood M, Barwood H, Davis D et al. · 2025 · International journal of sports physiology and performance
Purpose Topical menthol application improves thermal perception and enhances performance but reduces sweat production in hot environments. In the aquatic environment, where sweat evaporation is of limited thermoregulatory benefit (ie,…
Schwaner WR, Kumar S, Thippareddi H · 2025 · Journal of food protection
Ozone is an effective and safe disinfectant used globally in the bottled water industry. Ozone infusion at a high level helps maintain a residual level (0.1-0.4 mg/L) at the time of bottling, thus can ensure 4 log microbial reductions.…
Persson A, Łyczyńska Z, Shahata M et al. · 2026 · Chemical research in toxicology
Metal additive manufacturing (AM) relies on alloy feedstock powders that may come into contact with the workers' skin during handling, yet skin-relevant data on metal release and biological reactivity remain limited. Here, we assessed the…
Normand-Gravier T, Solsona R, Arnould F et al. · 2025 · Journal of thermal biology
The use of kaumatherapy (i.e. heat exposure like sauna-bathing) as passive intervention has become of growing interest to promote skeletal muscle adaptations such as strength gains and preservation of muscle mass. Importantly, the effects…
Román S, Vázquez E, Román M et al. · 2025 · Marine environmental research
Shellfish beds are key estuarine habitats coinhabited by commercial species and ecosystem engineers such as the seagrass Zostera noltei. Organisms inhabiting the intertidal areas of these beds are threatened by marine and atmospheric…
Folcher A, Piters J, Wallach D et al. · 2025 · Journal of neuroradiology = Journal de neuroradiologie
Background The Thrombolysis in Cerebral Infarction (TICI) scale is widely used to assess angiographic outcomes of mechanical thrombectomy despite significant variability. Our objective was to create and optimize an artificial intelligence…
Sales NAA, Carvalho JRG, Littiere TO et al. · 2025 · Journal of equine veterinary science
Whole-body vibration (WBV) has the potential to enhance post-exercise recovery in humans. Heart rate variability (HRV), a well-established biomarker of cardiac autonomic regulation (CAR), provides insight into autonomic reactivity during…
Fernandez M, Vernel-Pauillac F, Pezier T et al. · 2026 · Innate immunity
Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming…
Shamim MJ, Chiluwal A, Haramoto E et al. · 2025 · Field Crops Research.
Developing sustainable cultural practices that enhance soybean (Glycine max L. (Merr.)) productivity and seed protein concentration is critical. Previous research conducted during 2019 and 2020 (Fayetteville, Arkansas; Lexington, Kentucky;…
Birene B, Ferreira A, Raimond E et al. · 2025 · Journal of perinatal medicine
Objectives Large-for-gestational-age (LGA) fetuses present significant maternal and neonatal risks. However, prenatal screening is prone to inaccuracies, leading to potentially unnecessary interventions. This study aims to evaluate the…
Ageberg E, Donaldson A, Lucander K et al. · 2025 · Journal of science and medicine in sport
Objectives To compare the implementation of a co-created evidence-based injury prevention intervention with an existing program in youth team handball. Design Pragmatic two-armed cluster-randomized controlled trial, conducted…
Meier M, Merz CJ, Rüttgens T et al. · 2025 · Preprint
Stress and the associated cortisol release have profound effects on long-term memory (LTM). While glucose can increase the cortisol stress response and exhibits memory enhancing effects in non-stressful situations, the interaction of…
Tsai PS, Wu KC, Wu CH · 2025 · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Osteoarthritis (OA) is a degenerative and deteriorating disease. The accompanying pain, stiffness, inflammation of the synovial joint, and the loss of articular function compromise the mobility, stability, and routine of patients' lives.…
Rocchetto S, Rondonotti E, Alicante S et al. · 2025 · Endoscopy
Both computer-aided detection (CADe) systems and mucosal exposure devices can enhance adenoma detection during colonoscopy. This research investigates whether combining a CADe system with a balloon-based mucosal exposure device increases…