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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21337 results · page 510 of 712

Negative / Null Result ReportOpen access

The SOS Pilot Study: a RCT of routine oxygen supplementation early after acute stroke—effect on recovery of neurological function at one week

Khalid Mustafa Ali (4461853), Christine Roffe (220471), Anushka Warusevitane (220475) et al. · 2011

Mild hypoxia is common after stroke and associated with poor long-term outcome. Oxygen supplementation could prevent hypoxia and improve recovery. A previous study of routine oxygen supplementation showed no significant benefit at 7 and 12…

Negative / Null Result ReportOpen access

Treatment outcomes of different prognostic groups of patients on cancer and leukemia group B trial 39801: induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for unresectable stage III non-small cell lung cancer

Akerley, Wallace, Herndon, James E. 2nd, Vokes, Everett E. et al. · 2017

BACKGROUND: In Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…

View details →DOI: 10.1097/jto.0b013e3181b27b33.
Negative / Null Result ReportOpen access

Treatment Outcomes of Different Prognostic Groups of Patients on Cancer and Leukemia Group B Trial 39801: Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Unresectable Stage III Non-small Cell Lung Cancer

Akerley, Wallace, Vokes, Everett E., Cicchetti, M Giulia et al. · 2009

BackgroundIn Cancer and Leukemia Group B 39801, we evaluated whether induction chemotherapy before concurrent chemoradiotherapy would result in improved survival and demonstrated no significant benefit from the addition of induction…

View details →DOI: 10.1097/jto.0b013e3181b27b33
Negative / Null Result ReportOpen access

IL-24 regulated CXCR4 at post-transcriptional level.

Jiankang Jin (703171), Stephen J. Archibald (703175), Janani Panneerselvam (703170) et al. · 2015

A , RT-PCR analysis showed IL-24 reduced CXCR4 mRNA levels at 6 h and 24 h ( P B , CXCR4 promoter activity was determined using a luciferase reporter vector. Induction of IL-24 showed no significant reduction in luciferase activity…

View details →DOI: 10.1371/journal.pone.0122439.g004
Negative / Null Result ReportOpen access

Effects of α-MSH treatment on Caspase 3 activity.

Andrew W. Taylor (451751) · 2013

The macrophages lysates were assayed for protein concentration and Caspase 3 activity. There was no significant change of Caspase 3 activity in cells treated with α-MSH compared to SFM cells. The graft is the mean ± SD of Caspase 3…

View details →DOI: 10.1371/journal.pone.0074488.g004
Negative / Null Result ReportOpen access

Supplementary Table S1 from Radiation-induced Adaptive Response: New Potential for Cancer Treatment

Sandra Demaria (15026216), Shannon Martello (11246282), Molykutty J. Aryankalayil (5544962) et al. · 2020

Metabolic data from PC3 cells 6h, 24h, and 48h after SD or MF radiation. Samples were sent to Metabolon for processing. Results indicate decrease in glycolysis intermediates in SD sample at 6h. No significant changes to TCA cycle…

View details →DOI: 10.1158/1078-0432.22477403.v1
Negative / Null Result ReportOpen access

Water radial arm maze performance.

Tristan G. Pesaresi (6751925), Grayson Breneman Ashby (6751931), Min-Ken Liao (6751934) et al. · 2019

Working memory correct (A), working memory incorrect (B) and reference memory (C) errors over the 12 days of testing are shown between low fat and high fat-fed rats. There were no significant differences between dietary group for any of…

View details →DOI: 10.1371/journal.pone.0217553.g002
Negative / Null Result ReportOpen access

Birth Order and past-Orientation

Christopher D. Green, Gladys M. Batten, Anton F. De Man et al. · 1983

Three studies examined Adler's suggestion that firstborns are past-oriented. The first study of the relationship between birthorder and temporal relatedness and dominance in 37 female undergraduates yielded no significant differences. The…

View details →DOI: 10.2466/pr0.1983.53.2.425
Negative / Null Result ReportOpen access

A. Box plot of the maximum decrease of temperatures from the baseline.

Ayako Asakura (711890), Takahisa Goto (711892), Takahiro Mihara (789554) · 2015

No significant differences were detected among the groups, but the maximum decreases tended to be smaller in the CHO and ORS groups than in the control group. B. Box plot of the final temperature changes at the end of surgery. No…

View details →DOI: 10.1371/journal.pone.0133309.g003
Negative / Null Result ReportOpen access

Conflict duration on the flanker task (i.e., reaction time for each incongruent trial–reaction time for each congruent trial) pre- (white bar) and post-treatment (black bar) with OT or placebo.

Yuko Yoshimura (283970), Hirotoshi Hiraishi (283977), Mitsuru Kikuchi (140272) et al. · 2015

Two-way ANOVA (treatment × drug) failed to demonstrate any drug or treatment effects, and no significant interaction between these two factors was detected. Therefore, we failed to demonstrate any OT-related effect on…

View details →DOI: 10.1371/journal.pone.0116918.g004
Negative / Null Result ReportOpen access

Cutaneous sterile pyogranuloma/granuloma syndrome in a dog

SPATERNA, Andrea, MECHELLI A., SANTORO D. et al. · 2008

A case of canine cutaneous sterile pyogranuloma/granuloma syndrome (SPGS) with generalized asymmetrical alopecia and plaques is described. Results from histopathologic examination were suggestive of SPGS and failed to demonstrate any…

Negative / Null Result ReportOpen access

Visual impairment, aging and driving ability

Wood, Joanne M. · 2002

It has been suggested that over 90% of the sensory information for driving is visual. Despite this belief, traditional studies have failed to demonstrate that increased crash rates arise from impaired vision. However, more recent studies…

Replication FailureOpen access

Heritability of the Carabelli Cusp in Twins

Robert H. Biggerstaff · 1973

The study of the Carabelli trait among 199 monozygotic and dizygotic twin pairs failed to demonstrate a high degree of heritability. Analyses of antimere differences in individuals indicated a lack of mirroring and no sexual dimorphism.…

View details →DOI: 10.1177/00220345730520013301
Negative / Null Result ReportOpen access

Sodium lactate versus mannitol in the treatment of intracranial hypertensive episodes in severe traumatic brain-injured patients.

Grimaud, Dominique, Berthier, Fréderic, Ichai, Carole et al. · 2009

International audienceOBJECTIVES: Traumatic brain injury (TBI) is still a major cause of mortality and morbidity. Recent trials have failed to demonstrate a beneficial outcome from therapeutic treatments such as corticosteroids,…

View details →DOI: 10.1007/s00134-008-1283-5
Negative / Null Result ReportOpen access

The MINERVA study design and rationale: A controlled randomized trial to assess the clinical benefit of minimizing ventricular pacing in pacemaker patients with atrial tachyarrhythmias

Manolis AS, Padeletti L., Mont L et al. · 2008

Dual-chamber (DDD) pacing has generally been regarded as "physiologic pacing" and therefore expected to be superior to ventricular pacing. Major randomized trials have so far failed to demonstrate significant reductions in the incidences…

View details →DOI: 10.1016/j.ahj.2008.05.004
Negative / Null Result ReportOpen access

Transient Crossed Aphasia: A Case Study with SPECT

José M. Ferro, Guilhermina Cantinho, Élia Baeta · 1991

A 45-year-old right-handed man developed “crossed” anomie aphasia, neglect and inaccurate reaching of his left arm in both hemispaces due to a right parietal haemorrhage. Aphasia cleared in a few days. SPECT failed to demonstrate crossed…

View details →DOI: 10.3233/ben-1991-4203
Failed Experiment ReportOpen access

Mental rehearsal and skill acquisition in sports

Jim Sheedy (20157615) · 2009

Mental rehearsal is thought to have positive effects upon the learning and retention of gross motor skills such as those demanded in many sports. A field study using 30 participants from the sport of lawn bowls failed to demonstrate a…

Negative / Null Result ReportOpen access

A pilot, double blind randomised controlled trial of prednisolone for women with recurrent miscarriage and raised uterine natural killer cell density [Abstract]

Dawood, Feroza, Farquharson, Roy G., Turner, M. A. et al. · 2011

Introduction: Multiple trials of immunotherapy for reproductive failure have failed to demonstrate significant benefit. A reason for this may be the lack of a test that selects which women will benefit from treatment. High density of…

View details →DOI: 10.1093/humrep/26.s1.34
Negative / Null Result ReportOpen access

Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.; id_orcid, Donnan, Geoffrey A., Traystman, RJ et al. · 2009

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating…

View details →DOI: 10.1038/jcbfm.2008.101