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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 509 of 725

Negative / Null Result ReportOpen accessMedicine

Outcome analysis of conservative treatment of a distal radius fracture with OPTIVOhand orthosis versus plaster cast: a randomized controlled trial.

Friederich M, Brunner J, Kirsch E et al. · 2026 · BMC musculoskeletal disorders

Background Distal radius fractures (DRF) are often immobilized using a conventional plaster cast although orthoses offer a time- and resource-saving alternative. This prospective randomized study compared the conservative DRF treatment…

View details →DOI: 10.1186/s12891-026-09585-4
Negative / Null Result ReportOpen accessMedicine

Association of 25(OH)D status with calcium metabolism, inflammation, and thyroid autoimmunity in patients with type 2 diabetes mellitus.

Lv N, Xiang J, Kuang J et al. · 2026 · Frontiers in endocrinology

Introduction 25-hydroxyvitamin D [25(OH)D] deficiency is highly prevalent in type 2 diabetes mellitus (T2DM) and may contribute to immune and metabolic dysfunction. This study aimed to investigate the clinical associations of serum 25(OH)D…

View details →DOI: 10.3389/fendo.2026.1867755
Failed Experiment ReportOpen accessMedicine

Is biceps augmentation effective for scope-assisted lower trapezius tendon transfer in posterosuperior irreparable rotator cuff tears? A retrospective short-term clinical comparison.

Baek CH, Elhassan BT, Lim C et al. · 2026 · Archives of orthopaedic and trauma surgery

Introduction Although favorable clinical outcomes of scope-assisted lower trapezius tendon transfer (SALTT) have been reported in posterosuperior irreparable rotator cuff tears (PSIRCTs) patients, the limited restoring of static stability…

View details →DOI: 10.1007/s00402-026-06290-8
Negative / Null Result ReportMedicine

Similar Strength and Hypertrophic Adaptations in Less Time? Myo-Reps vs. Traditional Straight-Sets in Resistance-Trained Men.

Bradshaw JT, Sanzo K, Barakat C et al. · 2026 · Journal of strength and conditioning research

Abstract Bradshaw, JT, Sanzo, K, Barakat, C, Barshun, A, Inglima, S, Gotla, T, Thompson, BK, De Souza, EO, and Walters, JA. Similar strength and hypertrophic adaptations in less time? Myo-reps vs. traditional straight-sets in…

View details →DOI: 10.1519/jsc.0000000000005388
Negative / Null Result ReportOpen accessMedicine

Effect of output intensity of light curing unit on coronal tooth discoloration induced by silicate calcium-based materials: an ex vivo study.

Farshad F, Shokouhinejad N, Pedram P et al. · 2026 · Biomaterial investigations in dentistry

Objective Clinicians have various curing options due to new light-cure devices with different intensities. The present study aimed to evaluate the effect of two light-curing intensities (1,200 mW/cm² vs. 3,000 mW/cm²) on coronal…

View details →DOI: 10.2340/biid.v13.45896
Negative / Null Result ReportOpen accessMedicine

Association Between DOAC Exposure and Lower-Extremity Arterial Calcification: A Propensity-Matched Exploratory CT Study.

Pomozi E, Zatyko DZ, Suhai FI et al. · 2026 · Journal of clinical medicine

Background : Lower limb arterial calcification (LLAC) is a robust imaging biomarker of peripheral artery disease (PAD) severity. Vitamin K antagonists are presumed to accelerate cardiovascular calcification. Direct oral anticoagulants…

View details →DOI: 10.3390/jcm15093399
Negative / Null Result ReportOpen accessMedicine

Impact of Neoadjuvant Chemotherapy on Prognosis of Patients with Mucinous Gastric Adenocarcinoma: A Propensity Score Matching Study.

Lu Y, Zhu D, Shen K et al. · 2026 · Annals of surgical oncology

Background Mucinous gastric adenocarcinoma (MGC) is a rare, aggressive malignancy. This study aimed to explore whether MGC is associated with poorer survival compared with nonmucinous gastric adenocarcinoma (NMGC) and to further…

View details →DOI: 10.1245/s10434-025-19069-9
Negative / Null Result ReportMedicine

Effect of Pharmacological Neuroprotection During Surgical Clipping of Anterior Circulation Intracranial Aneurysm on Neurological Outcome-A Randomized Controlled Study.

Gopalakrishna KN, Chakrabarti D, Bharadwaj S et al. · 2026 · Neurology India

Objective Patients with intracranial aneurysms while undergoing neurosurgical clipping frequently require the use of temporary clip, and this involves the risk of cerebral ischemia. The usual approaches for prevention of such an adverse…

View details →DOI: 10.4103/neurol-india.neurol-india-d-25-00595
Negative / Null Result ReportMedicine

Long-term clinical outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) compared with open TLIF(O-TLIF): A retrospective cohort study for at least 5 years.

Zhu F, Ning Y, Leng X et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

OBJECTIVE: The short-term outcomes of minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF) and Open TLIF (O-TLIF) have been reported in previous studies. However, the long-term clinical outcomes of both procedures have been…

View details →DOI: 10.1007/s00586-026-09824-1
Negative / Null Result ReportOpen accessMedicine

Preoperative Lugol's solution and surgical outcomes in Graves' disease: a single-center retrospective study.

Ünlü MT, Caliskan O, Çetinoğlu I et al. · 2026 · Frontiers in surgery

Introduction Basedow Graves disease (BG) is the most common cause of hyperthyroidism. Lugol's solution (LS) is used preoperatively to inhibit thyroid hormone production, decrease thyroid gland vascularity and ensure a safer surgical field.…

View details →DOI: 10.3389/fsurg.2026.1755477
Negative / Null Result ReportOpen accessMedicine

Does Inguinal TAPP Repair Increase the Rate of Midline Supraumbilical Trocar Site Hernia?-A Single-Center Retrospective Study.

Augustin G, Jeričević K, Bogdanić B · 2026 · Journal of clinical medicine

Background/Objectives : This study aimed to determine the inguinal hernia recurrence rate after transabdominal preperitoneal (TAPP) repair, particularly considering the effect of simultaneous umbilical hernia repair. The secondary aim was…

View details →DOI: 10.3390/jcm15083083
Negative / Null Result ReportMedicine

Clinical characteristics and kidney outcomes in children with posterior urethral valve: a single-center experience.

Inceoğlu S, Uçkardeş D, Göknar N et al. · 2026 · International urology and nephrology

Introduction and aim Posterior urethral valve (PUV) represent a congenital obstructive uropathy, and despite advances in prenatal diagnosis and postnatal management, chronic kidney disease (CKD) develops in nearly 20% of affected patients.…

View details →DOI: 10.1007/s11255-026-05149-6
Negative / Null Result ReportOpen accessMedicine

Evaluating poultry by-product meal, tomato pomace, and azolla with or without Natuzyme supplementation as sustainable alternatives to fish meal for Nile tilapia (Oreochromis niloticus).

Kamel AM, Mahmoud MM, Ibrahim MT et al. · 2026 · Tropical animal health and production

Several studies have predicted that developing countries will be unable to afford fish meal as a primary aquafeed protein source in the future. This experiment evaluated the effect of replacing fish meal (FM) with poultry by-product meal…

View details →DOI: 10.1007/s11250-026-05001-0
Negative / Null Result Report

Body Mass Index and Outcomes in HR+/HER2−Metastatic Breast Cancer Treated with Palbociclib: Insights from a National Real-World Study

Badau LM, Epure P, Margan M et al. · 2026 · Preprint

Background: /Objectives: The prognostic and predictive role of BMI in patients with HR+/HER2– MBC remains controversial, particularly in the era of CDK4/6 inhibitors. This study aimed to evaluate the association between baseline BMI and…

View details →DOI: 10.20944/preprints202604.1156.v1
Negative / Null Result ReportOpen accessMedicine

Monitoring the Adverse Implications of Coronavirus 2019-induced Pulmonary Complications on Patients' Respiratory Capacity and Physical Abilities with Moderate and Severe Signs during Interval Follow-up.

Aali F, Habibi Z, Aali F et al. · 2026 · Journal of medical signals and sensors

Background The respiratory system of individuals with coronavirus 2019 (COVID-19) experiences significant strain due to the body's immunological response and inflammation, leading to organ failure. Over time, patients have improvement in…

View details →DOI: 10.4103/jmss.jmss_15_25
Negative / Null Result ReportOpen accessMedicine

Endometrial HOXA-10, HOXA-11, ß-1 integrin, ECM-1, FAK, and CD44 immunohistochemical expressions in endometriosis-related recurrent IVF failure: a retrospective case-control study.

Toruk EŞ, Kaplan EA, Sarıbaş GS et al. · 2026 · Journal of ovarian research

BACKGROUND: Endometriosis is a common cause of infertility and is frequently associated with recurrent implantation failure in assisted reproductive technologies. Impaired endometrial receptivity, mediated by altered transcription factors,…

View details →DOI: 10.1186/s13048-026-02072-3
Negative / Null Result ReportOpen accessMedicine

Efficacy of Normobaric High-Flow Oxygen Therapy Combined with Low Molecular Weight Heparin in the Management of Fetal Growth Restriction: A Prospective Cohort Study.

He M, Zhao K, Wei Q et al. · 2026 · International journal of women's health

Objective This study investigated the clinical efficacy of adding normobaric high-flow oxygen therapy (NHFOT) to low molecular weight heparin (LMWH) and standard supportive care for the management of the present FGR cohort, idiopathic…

View details →DOI: 10.2147/ijwh.s574440
Negative / Null Result ReportMedicine

Outcomes of Patients With Reduced Left Ventricular Function Undergoing Left Atrial Appendage Occlusion.

Higgins AY, Huang CY, Zimmerman S et al. · 2026 · JACC. Clinical electrophysiology

Background Transcatheter left atrial appendage occlusion (LAAO) is an alternative treatment to prevent stroke in patients with atrial fibrillation. Patients with reduced left ventricular ejection fraction (LVEF) represent a particularly…

View details →DOI: 10.1016/j.jacep.2026.04.004
Negative / Null Result ReportMedicine

Single antiplatelet therapy vs oral anticoagulation monotherapy in patients with atrial fibrillation and coronary artery disease after successful catheter ablation: A target trial emulation.

Li F, Zhao Y, Peng X et al. · 2026 · Heart rhythm

Background The optimal long-term antithrombotic strategy in patients with atrial fibrillation (AF) and coronary artery disease (CAD) after successful catheter ablation (CA) remains uncertain. Objective This study aimed to compare the…

View details →DOI: 10.1016/j.hrthm.2026.05.027
Negative / Null Result ReportOpen accessMedicine

Are Skip Laminectomy and Oblique Corpectomy Effective Options to Treat Degenerative Cervical Myelopathy While Preserving Motion? Results of a Scoping Review.

Lomax JL, Mehta A, Vedantam A et al. · 2026 · Global spine journal

Study DesignScoping Literature Review.ObjectiveThe aim of this literature review is to examine the results of both skip laminectomy and oblique corpectomy in the setting of degenerative cervical myelopathy (DCM).MethodsA scoping review of…

View details →DOI: 10.1177/21925682251366642
Null DatasetOpen accessMedicine

A quantitative method to assess DNA extraction efficiency.

Mullen LE, Romsos EL, Vallone PM · 2026 · Journal of forensic sciences

Obtaining an accepted minimum amount of extracted and purified DNA is critical for generating complete forensic short tandem repeat (STR) profiles. Certain sample types encountered in forensic laboratories may pose challenges in obtaining…

View details →DOI: 10.1111/1556-4029.70302
Negative / Null Result ReportOpen accessMedicine

Health-related quality of life scores of ultralow rectal cancer patients after conformal sphincter preservation operation compared to newly derived preoperative EORTC QLQ-C30, CR38 reference values and EORTC QLQ-C30 norm.

Ding HB, Sun G, Yu GY et al. · 2026 · Frontiers in oncology

Background Postoperative quality of life (Post-QoL) is the key to measuring the effectiveness of sphincter-preserving operation such as Conformal sphincter preservation operation (CSPO) for ultralow rectal cancer. This study aimed to…

View details →DOI: 10.3389/fonc.2026.1724255
Negative / Null Result ReportOpen accessMedicine

Mesenchymal stem cell derived exosomes and injectable platelet-rich fibrin enhance SDFT healing in a donkey tendonitis model.

Najeb M, Samy A, Rizk A et al. · 2026 · Scientific reports

Tendon injuries pose a significant challenge in equine medicine due to the inherently limited regenerative capacity of tendon tissue and the high likelihood of reinjury. Recently, injectable platelet-rich fibrin (I-PRF) and exosomes…

View details →DOI: 10.1038/s41598-026-44967-7
Negative / Null Result ReportMedicine

Traditional Chinese medicine constitution and physical fitness-based strategies for adolescent myopia prevention and control.

Gong H, Yu H, Cheng FF et al. · 2026 · Photodiagnosis and photodynamic therapy

Objective Traditional Chinese Medicine (TCM) constitution represents a relatively stable individual characteristic, whereas physical fitness reflects overall physical condition. Both factors have been associated with adolescent health and…

View details →DOI: 10.1016/j.pdpdt.2026.105504
Negative / Null Result ReportOpen accessMedicine

Two novel paralogous <i>C. elegans</i> proteins bind to LON-1 but do not have a major role in body size regulation.

Gardner DM, Williams B, Liu Z et al. · 2026 · microPublication biology

The BMP signaling pathway regulates body size and mesoderm fate specification in C. elegans . The secreted protein LON-1 both regulates and is regulated by BMP signaling. The mechanism through which LON-1 functions is unclear. In this…

View details →DOI: 10.17912/micropub.biology.002205