Negative / Null Result ReportMedicine
Watanabe S, Furuya N, Nakamura A et al. · 2024 · European journal of cancer (Oxford, England : 1990)
Introduction Treatment options for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) after EGFR-tyrosine kinase inhibitor (TKI) treatment failure are limited. An exploratory analysis of 26…
View details →DOI: 10.1016/j.ejca.2023.113469 Negative / Null Result ReportMedicine
Boess FG, Scelsi MA, Grimmer T et al. · 2024 · The journal of prevention of Alzheimer's disease
Background Monoclonal antibodies that target amyloid-beta and remove amyloid plaques can slow cognitive and functional decline in early Alzheimer's disease. Gantenerumab is a subcutaneously administered fully-human anti-amyloid-beta…
View details →DOI: 10.14283/jpad.2024.60 Negative / Null Result ReportMedicine
Del Rivero J, Donahue RN, Marte JL et al. · 2026 · The oncologist
Background Medullary thyroid cancer (MTC) accounts for approximately 4% of thyroid carcinomas. Patients with unresectable, metastatic disease are candidates for approved agent-targeted therapies such as vandetanib, cabozantinib, or…
View details →DOI: 10.1093/oncolo/oyaf429 Negative / Null Result ReportOpen accessMedicine
Hanna GJ, Scarfo N, Shin KY et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose Glycogen synthase kinase 3β (GSK-3β) is a known therapeutic target in cancer. Aberrant nuclear GSK-3β (nGSK-3β) expression has been shown in some salivary gland cancers. Elraglusib is a small-molecule GSK-3β inhibitor with…
View details →DOI: 10.1158/1078-0432.ccr-25-2731 Negative / Null Result ReportMedicine
Finch L, Andres S, Iasonos A et al. · 2025 · International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
Objective We sought to determine the safety and efficacy of the oral progesterone antagonist onapristone in combination with anastrozole in patients with recurrent progesterone receptor-positive adult-type granulosa cell tumor of the…
View details →DOI: 10.1016/j.ijgc.2024.100005 Negative / Null Result ReportOpen accessMedicine
Kim EH, Carr WW, Assa'ad AH et al. · 2025 · The journal of allergy and clinical immunology. Global
Background Oral immunotherapy is an established approach to desensitize the immune system in the context of allergic disease; however, the only currently approved product is for peanut allergy. ADP101 is a novel, pharmaceutical-grade,…
View details →DOI: 10.1016/j.jacig.2024.100382 Negative / Null Result ReportMedicine
Ozer BH, Cohen AL, Colman H et al. · 2026 · Neuro-oncology advances
Background Glioblastoma (GBM) has limited effective salvage therapy options. The combination of the Type 1B topoisomerase/HIF1α inhibitor topotecan and the tyrosine kinase inhibitor pazopanib has shown promise in solid tumors and may be…
View details →DOI: 10.1093/noajnl/vdaf261 Negative / Null Result ReportOpen accessMedicine
Roberts G, Just J, Nolte H et al. · 2025 · Allergy
Background In children, house dust mite (HDM) sensitisation is a contributing factor for developing allergic asthma. HDM allergen immunotherapy has demonstrated efficacy and safety in adults with allergic asthma; however, evidence for its…
View details →DOI: 10.1111/all.70073 Negative / Null Result ReportMedicine
Pignanelli C, Robertson AA, Handy RM et al. · 2025 · Scandinavian journal of medicine & science in sports
Physical inactivity depresses glycemic control, an impairment that can be prevented with exercise. We investigated whether electrical muscle stimulation (EMS) with blood flow restriction (BFR) could similarly prevent the impairments in…
View details →DOI: 10.1111/sms.70056 Negative / Null Result ReportOpen accessMedicine
Cairang Z, Kanasaki H, Tumurbaatar T et al. · 2025 · International journal of endocrinology
Prolactin (PRL) plays a variety of roles to maintain female reproductive functions. In female rats, Prl mRNA expression in the anterior pituitary was significantly suppressed by OVX. The OVX-induced inhibition of PRL expression was…
View details →DOI: 10.1155/ije/8883536 Negative / Null Result ReportOpen accessMedicine
De Jesus O · 2024 · Surgical neurology international
Background The effectiveness of autologous stem cell transplantation (ASCT) in preventing the development of central nervous system (CNS) plasmacytomas in multiple myeloma (MM) patients is not well understood. An ASCT patient who developed…
View details →DOI: 10.25259/sni_964_2023 Negative / Null Result ReportMedicine
Prahalad V, Aalders J, Kirkpatrick JB · 2024 · Wetlands.
The effects of grazing and browsing by terrestrial vertebrates are poorly understood for southern hemisphere saltmarshes, many of which are recovering from stock grazing. We investigated whether the native late-successional shrub,…
View details →DOI: 10.1007/s13157-024-01859-8 Negative / Null Result ReportMedicine
Mendes TGM, Nunes ACP, Dantas de Carvalho AV et al. · 2025 · Clinical nutrition ESPEN
Background The nutritional needs of preterm newborns (PTNB) are increased and enhancing nutritional management is essential to meet them. The addition of multicomponent additive (MA) to human milk (HM) is used as a treatment strategy. The…
View details →DOI: 10.1016/j.clnesp.2025.03.032 Negative / Null Result ReportMedicine
Cho MJ, Song MK, Jun SY et al. · 2025 · The American journal of cardiology
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare but life-threatening inherited arrhythmia in children, often associated with sudden cardiac death (SCD). Risk stratification remains challenging. This study aimed to…
View details →DOI: 10.1016/j.amjcard.2025.08.008 Negative / Null Result ReportOpen accessMedicine
Ishiguro Y, Kuriyama A, Ishiguro S · 2025 · Annals of medicine and surgery (2012)
Introduction and importance Cytomegalovirus (CMV) can cause severe colitis in immunocompromised patients. While its morphological manifestations vary, diverticular perforation is rare, with most lesions remaining intact. We report a rare…
View details →DOI: 10.1097/ms9.0000000000003573 Negative / Null Result ReportMedicine
Yılmaz Dağlı H, Artan R, Civan DD et al. · 2024 · Pediatric transplantation
Aim To examine the long-term results and treatment effectiveness of liver transplantation (LT) in the treatment of homozygous familial hypercholesterolemia (HoFH) in children and adolescents. Method Patients who underwent LT due to HoFH…
View details →DOI: 10.1111/petr.14853 Negative / Null Result ReportMedicine
Zierke L, John D, Gischke M et al. · 2024 · Cell. Mol. Life Sci
The co-localization of the lysosomal protease cathepsin B (CTSB) and the digestive zymogen trypsinogen is a prerequisite for the initiation of acute pancreatitis. However, the exact molecular mechanisms of co-localization are not fully…
Negative / Null Result ReportMedicine
Wang F, Gao T, Yang X et al. · 2025 · Aquaculture.
The significance of DNA methylation in fish sex determination and differentiation is increasingly being recognized. Exploring the role of DNA methylation in sex determination and differentiation is advantageous for the advancement of sex…
Negative / Null Result ReportMedicine
Feldman S, Basra J, Lawani A et al. · 2025 · Ophthalmic surgery, lasers & imaging retina
Background and objective To determine if subthreshold micropulse laser (SML) therapy can prevent or delay vision loss in diabetic macular edema (DME) with good visual acuity (VA). Patients and methods Prospective, single-masked,…
View details →DOI: 10.3928/23258160-20240924-03 Negative / Null Result ReportOpen accessMedicine
Chen H, Huang X, Wang C et al. · 2025 · The Journal of infectious diseases
Assessing the time-varying effectiveness of coronavirus disease 2019 (COVID-19) vaccines is critical to guiding vaccine strategies and public health policies. We developed a Bayesian framework to estimate the waning vaccine effectiveness…
View details →DOI: 10.1093/infdis/jiaf207 Negative / Null Result ReportMedicine
Horizono J, Mizumoto K, Suico MA et al. · 2025 · Biological & pharmaceutical bulletin
Cyclodextrins (CDs) are cyclic oligosaccharides that encapsulate hydrophobic molecules such as cholesterol. Hydroxypropyl-β-cyclodextrin (HP-β-CD), a cyclic heptasaccharide, has gained attention as a protective agent for chronic kidney…
View details →DOI: 10.1248/bpb.b25-00417 Negative / Null Result ReportMedicine
Hojo FR, Martins TC, Vieira-Junior WF et al. · 2025 · Operative dentistry
This study evaluated the influence of six resin composite coating agents on color stability and surface roughness after toothbrushing abrasion. Discs (Ø6 mm x 2 mm) of nanofilled resin composite (Filtek Z350XT) were prepared for…
View details →DOI: 10.2341/24-069-l Negative / Null Result Report
Chen A, Chou TY, Chen Y et al. · 2024 · Preprint
Fusarium wilt caused by Fusarium oxysporum f. sp. cubense (Foc) is a major disease affecting banana production around the globe. To study the movement of Foc in planta and investigate potential physical mechanisms of deterrence, the roots…
View details →DOI: 10.20944/preprints202410.2171.v1 Negative / Null Result Report
Giles C, Lee J · 2024 · Preprint
Abstract Nearly 90% of cancer deaths are due to metastasis. Conventional cancer therapeutics including chemotherapy, surgery, and radiotherapy, are effective in treating primary tumors, but may aggravate disseminated tumor cells (DTCs)…
View details →DOI: 10.21203/rs.3.rs-4719290/v1 Negative / Null Result ReportMedicine
Beningaza AM, Di Benedetto IMD, Babino L et al. · 2025 · Acta tropica
Chagas disease, vectored by kissing bugs, poses a public health problem across the Americas. The best way for reducing disease transmission is through vector control, which is currently based on the use of insecticides. However,…
View details →DOI: 10.1016/j.actatropica.2024.107520 Negative / Null Result ReportMedicine
Asadikorayem M, Weber P, Zhang S et al. · 2025 · Biomaterials advances
Osteoarthritis (OA) is one of the most common degenerative joint diseases, with no effective therapeutic options available. In this study, we aimed to develop an interpenetrating, in-situ-forming hydrogel based on biocompatible and…
View details →DOI: 10.1016/j.bioadv.2024.214151 Negative / Null Result ReportMedicine
Baudat M, Joosten EAJ, Simons SHP · 2025 · Pediatric research
Background While the incidence of neonatal intensive care unit (NICU) admission steadily increases, neonatology lacks evidence of a safe, effective, and preventive analgesic for treating procedural pain. Given its role in nociception and…
View details →DOI: 10.1038/s41390-024-03680-9 Negative / Null Result ReportOpen accessMedicine
Moksi L, Sissala N, Ojala R et al. · 2026 · Journal of orthopaedic surgery and research
Background Avascular necrosis (AVN) of the femoral head is a progressive condition that leads to collapse of the femoral head in 85% of symptomatic patients when left untreated. As it is typically a disease that occurs among the younger…
View details →DOI: 10.1186/s13018-025-06647-6 Negative / Null Result Report
Wongkraisri C, Chusuwanrak K, Laocharoenkeat A et al. · 2024 · Preprint
Abstract Background Hand-foot syndrome (HFS) is a common adverse event of capecitabine causing treatment modifications. Topical urea cream can reduce sorafenib-induced hand-foot skin reaction. However, its benefit in preventing…
View details →DOI: 10.21203/rs.3.rs-4712325/v1 Negative / Null Result ReportMedicine
Rajsiglova L, Babic M, Krausova K et al. · 2024 · Journal of immunotoxicology
Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles…
View details →DOI: 10.1080/1547691x.2024.2416988 