A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 51 of 660
Nichole D. Mahnert, Daniel M. Morgan, Darrell A. Campbell et al. · 2015 · Obstetrics and Gynecology
OBJECTIVE: To define the incidence of unexpected gynecologic malignancies among women who underwent hysterectomy for benign indications. METHODS: We conducted a data analysis of hysterectomy cases from a quality and safety database…
Zhonglei He, Kangze Liu, Eline Manaloto et al. · 2018 · Scientific Reports
Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains challenging. Cold atmospheric plasma (CAP) can be combined with AuNP to achieve synergistic anti-cancer cytotoxicity. To explore synergistic mechanisms, we demonstrate both rate of AuNP uptake and total amount accumulated in U373MG Glioblastoma multiforme (GBM) cells are significantly increased when exposed to 75 kV CAP generated by dielectric barrier discharge. No significant changes in the physical parameters of AuNP were caused by CAP but acti
Aaron K. Remenschneider, Sarah Lookabaugh, Avner Aliphas et al. · 2014 · Otology & Neurotology
OBJECTIVE: Otologic trauma was the most common physical injury sustained after the April 15, 2013, Boston Marathon bombings. The goal of this study is to describe the resultant otologic morbidity and to report on early outcomes. STUDY…
Patrick L. Kelly, Ori D. Fox, Alexei V. Filippenko et al. · 2014 · The Astrophysical Journal
We constrain the properties of the progenitor system of the highly reddened Type Ia supernova (SN Ia) 2014J in Messier 82 (M82; d ≈ 3.5 Mpc). We determine the supernova (SN) location using Keck-II K-band adaptive optics images, and we find…
Jiang He, Marion R. Wofford, Kristi Reynolds et al. · 2011 · Circulation
BACKGROUND: Observational studies have reported an inverse association between dietary protein intake and blood pressure (BP). We compared the effect of soy protein, milk protein, and carbohydrate supplementation on BP among healthy…
James Chih‐Hsin Yang, Dae Ho Lee, Jong Seok Lee et al. · 2023 · Journal of Clinical Oncology
LBA9000 Background: EGFR TKIs are standard 1L therapy for metastatic NSCLC with sensitizing EGFR mutations; however, most patients (pts) ultimately experience PD. We report the protocol-specified final analysis (FA) from the randomized,…
Teng Moua, Ana Carro Martínez, Misbah Baqir et al. · 2014 · Respiratory Research
BACKGROUND: Although usual interstitial pneumonia (UIP) appears to portend better survival when associated with connective tissue disease (CTD-UIP), little is known about the presenting clinical, radiologic, and pathologic features that differentiate pathologically confirmed UIP with CTD from idiopathic pulmonary fibrosis (IPF). In patients with atypical radiologic and clinical features, what specific findings predict underlying IPF vs. CTD-UIP diagnosis and their respective long term survival? METHODS: A large retrospective cohort analysis was done of consecutive patients seen from 1995 throu
Mark R. Petersen, Daniel Livescu · 2010 · Physics of Fluids
Linear forcing has been proposed as a useful method for forced isotropic turbulence simulations because it is a physically realistic forcing method with a straightforward implementation in physical-space numerical codes [T. S. Lundgren,…
Chipote Precious · 2014 · Mediterranean Journal of Social Sciences
This paper explores the role played by monetary policy in promoting economic growth in the South African economy over the period 2000-2010. The study employs the Augmented Dickey-Fuller and Phillips Perron unit root tests to test for…
Brady T. West, Kristen Olson · 2010 · Public Opinion Quarterly
classical intra-interviewer correlation (q int ) provides survey researchers with an estimate of the effect of interviewers on variation in measurements of a survey variable of interest. This correlation is an undesirable product of the…
Christian O. Dimkpa, Trevor Hansen, Jacob Stewart et al. · 2014 · Nanotoxicology
Nanoparticles (NPs) incorporated into commercial products are reactive on plants. Here, the influence of a root-associated bacterium, Pseudomonas chlororaphis O6 (PcO6) on the responses of bean (Phaseolus vulgaris) to commercial ZnO…
Gabriel Fitzpatrick, Florian Vogt, Osman Gbabai et al. · 2015 · The Journal of Infectious Diseases
This paper describes patient characteristics, including Ebola viral load, associated with mortality in a Médecins Sans Frontières Ebola case management centre (CMC).Out of 780 admissions between June and October 2014, 525 (67%) were…
Nate Kornell, Patricia Jacobs Klein, Katherine A. Rawson · 2014 · Journal of Experimental Psychology Learning Memory and Cognition
Retrieving information from memory enhances learning. We propose a 2-stage framework to explain the benefits of retrieval. Stage 1 takes place as one attempts to retrieve an answer, which activates knowledge related to the retrieval cue.…
Ahmed M. Elkhatat · 2023 · International Journal for Educational Integrity
Abstract Academic plagiarism is a pressing concern in educational institutions. With the emergence of artificial intelligence (AI) chatbots, like ChatGPT, potential risks related to cheating and plagiarism have increased. This study aims to investigate the authenticity capabilities of ChatGPT models 3.5 and 4 in generating novel, coherent, and accurate responses that evade detection by text-matching software. The repeatability and reproducibility of both models were analyzed, showing that the generation of responses remains consistent. However, a two-sample t-test revealed insufficient evidenc
Bertha Briceño, Aidan Coville, Paul Gertler et al. · 2017 · PLoS ONE
SUMMARY: The current evidence on handwashing and sanitation programs suggests limited impacts on health when at-scale interventions have been tested in isolation. However, no published experimental evidence currently exists that tests the interaction effects between sanitation and handwashing. We present the results of two large-scale, government-led handwashing and sanitation promotion campaigns in rural Tanzania, with the objective of tracing the causal chain from hygiene and sanitation promotion to changes in child health outcomes and specifically testing for potential interaction effects o
Mingshu Wang, Neil Debbage · 2021 · Computers Environment and Urban Systems
Traffic congestion is an ever-increasing issue across urban environments in the US. One potential mitigation strategy is to improve our understanding of how the geographical patterns of urban land use influence congestion. Unfortunately, there is no consensus regarding if more sprawling or dense urban morphologies help mitigate congestion issues. To potentially clarify the conflicting findings of previous studies, we used a detailed spatial metric-based approach and panel regression to quantify the relationships between urban development patterns and congestion in 98 US urban areas from 2001 t
Duc Hong Vo, Anh The Vo · 2021 · Energy Sustainability and Society
Abstract The energy–environment–growth nexus has been examined for the Association of Southeast Asian Nations (ASEAN) region, mainly using time series data. However, the important role of renewable energy and population has largely been ignored in previous studies. As such, this study is conducted to investigate a causal link between renewable energy usage, population, carbon dioxide emissions, and economic growth. In addition, a relatively new and advanced panel vector autoregressive model and the Granger non-causality test for heterogeneous panels are utilized with a sample of seven ASEAN co
Boris Worm, Sara Orofino, Echelle S. Burns et al. · 2024 · Science
Over the past two decades, sharks have been increasingly recognized among the world's most threatened wildlife and hence have received heightened scientific and regulatory scrutiny. Yet, the effect of protective regulations on shark…
Seung Joo Kang, Charleston W. K. Chiang, C. D. Palmer et al. · 2010 · Human Molecular Genetics
Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide…
Nancy Kass, Holly A. Taylor, Joseph Ali et al. · 2014 · Clinical Trials
BACKGROUND: Research suggests that participants do not always adequately understand studies. While some consent interventions increase understanding, methodologic challenges have been raised in studying consent outside of actual trial…
Julian Gold, Raph Goldacre, H Maruszak et al. · 2014 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: Even though multiple sclerosis (MS) and HIV infection are well-documented conditions in clinical medicine, there is only a single case report of a patient with MS and HIV treated with HIV antiretroviral therapies. In this…
Dong Dong, Nicky Thomas, Benjamin Thierry et al. · 2015 · PLoS ONE
BACKGROUND: Staphylococcus aureus and Pseudomonas aeruginosa are major pathogens in chronic rhinosinusitis (CRS) and their biofilms have been associated with poorer postsurgical outcomes. This study investigated the distribution and anti-biofilm effect of cationic (+) and anionic (-) phospholipid liposomes with different sizes (unilamellar and multilamellar vesicle, ULV and MLV respectively) on S. aureus and P. aeruginosa biofilms. METHOD: Specific biofilm models for S. aureus ATCC 25923 and P. aeruginosa ATCC 15692 were established. Liposomal distribution was determined by observing SYTO9 sta
Philip T. Leftwich, Naomi V. E. Clarke, Matthew I. Hutchings et al. · 2017 · Proceedings of the National Academy of Sciences
Significance The evolutionary significance of assortative mating by diet, mediated by gut bacteria is a puzzle, but it has had a huge impact and has provided a keystone to support increasing interest in the “holobiome.” However, in species…
Sheng‐Kai Wu, Marc A. Santos, Stuart L. Marcus et al. · 2019 · Scientific Reports
Abstract Glioblastoma multiforme (GBM) continues to have a dismal prognosis and significant efforts are being made to develop more effective treatment methods. Sonodynamic therapy (SDT) is an emerging modality for cancer treatment which combines ultrasound with sonosensitizers to produce a localized cytotoxic effect. It has long been known that ultrasound exposure can cause both thermal and non-thermal bioeffects and it remains an open question to what degree does temperature impact the efficacy of SDT. In order to optimize the ultrasound parameters of SDT, transcranial MRI-guided focused ultr
Robert D. Boutin, Sara Bamrungchart, Cyrus Bateni et al. · 2017 · American Journal of Roentgenology
OBJECTIVE: Our objective was to determine the association between muscle cross-sectional area and attenuation, as measured on routine CT scans, and mortality in older patients with hip fracture. MATERIALS AND METHODS: A retrospective…
E. J. Kerschen, Irene Hernández, Mark Zogg et al. · 2010 · Journal of Clinical Investigation
Activated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through protease-activated…
Ian Y. Wong, Raymond Wong, Paul Zhao et al. · 2012 · Retina
PURPOSE: To investigate the relationship of hypercholesterolemia and choroidal thickness in normal healthy volunteers. METHOD: This was a cross-sectional observational study. Volunteers with no ocular abnormalities were examined using…
Nancy L. Bartlett, Sarit Assouline, Pratyush Giri et al. · 2023 · Blood Advances
As part of a phase 1 or 2 study, this single-arm expansion cohort established the efficacy and safety of mosunetuzumab monotherapy in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) (received ≥2 previous lines…
Hande Sezgin, Omer B Berkalp · 2016 · Journal of Industrial Textiles
In this study, four plied jute, carbon, E-glass fabric-reinforced and their hybridized composites are manufactured. Nine composite laminates with different stacking sequences are manufactured by vacuum infusion technique. In order to…
Leigh L. van den Heuvel, Nathaniel Chishinga, Eugene Kinyanda et al. · 2013 · AIDS Care
We determined the frequency and correlates of current common mental disorders (CMDs) in a consecutive series of 649 adult patients with human immunodeficiency virus (HIV), tuberculosis (TB) or both receiving treatment at 16 primary health…