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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 506 of 725

Negative / Null Result ReportOpen accessMedicine

Osteoporosis independent of traditional risk factors in hyperthyroid patients in a resource-limited setting: An observational study.

Tadesse M, Tesfaye BA, Taye B et al. · 2026 · Medicine

Hyperthyroidism accelerates bone turnover and increases the risk of secondary osteoporosis. However, evidence from sub-Saharan Africa remains scarce. This study assessed the prevalence and predictors of osteoporosis among hyperthyroid…

View details →DOI: 10.1097/md.0000000000048715
Negative / Null Result ReportOpen accessMedicine

Safety and clinical outcomes of micro-axial intravascular flow pump compared to intra-aortic balloon pump in cardiogenic shock.

Makino M, Shishikura D, Kusumoto H et al. · 2026 · Cardiovascular diagnosis and therapy

Background The micro-axial intravascular flow pump (mAFP) may potentially improve the prognosis of cardiogenic shock (CS). Despite its advanced hemodynamic profile, efficacy remains undetermined. Safety and mid-term outcomes were compared…

View details →DOI: 10.21037/cdt-2025-302
Negative / Null Result ReportMedicine

Identification of specific codon 201 mutation of the DCC Gene in the colonoscopic specimen of colorectal cancer.

Serwer T, Wahid M, Imtiaz F et al. · 2024 · JPMA. The Journal of the Pakistan Medical Association

Objective To identify the mutation in codon 201 of the deleted in colorectal cancer gene in colorectal cancer, and to correlate that mutation to the histopathological grading of colorectal cancer. Methods The cross-sectional study was…

View details →DOI: 10.47391/jpma.9158
Negative / Null Result ReportOpen accessMedicine

Comparative Evaluation of Antimicrobial Activity and Minimum Inhibitory Concentration of Commercially Available Pediatric Dentifrices: An In Vitro Study.

Dureha R, Navit S, Khan SA et al. · 2024 · International journal of clinical pediatric dentistry

Aim The aim of this study was to evaluate the antimicrobial efficacy and minimum inhibitory concentration (MIC) of commercially available pediatric dentifrices containing different compositions against Streptococcus mutans and…

View details →DOI: 10.5005/jp-journals-10005-2939
Negative / Null Result ReportMedicine

CaMKII protein expression and phosphorylation in human skeletal muscle by immunoblotting: Isoform specificity.

Martinez-Canton M, Gallego-Selles A, Galvan-Alvarez V et al. · 2024 · Free radical biology & medicine

Calcium (Ca 2+ )/calmodulin-dependent protein kinase II (CaMKII) is activated during exercise by reactive oxygen species (ROS) and Ca 2+ transients initiating muscle contraction. CaMKII modulates antioxidant, inflammatory, metabolic and…

View details →DOI: 10.1016/j.freeradbiomed.2024.08.030
Negative / Null Result ReportOpen accessMedicine

The "inverted-U" of cognitive effort across speech rates holds for simple but not complex sentence structures.

O'Leary RM, Zavlun N, Kinney A et al. · 2025 · Frontiers in psychology

Pupil dilation has become a well-established physiological index of cognitive effort. Here we examined the often-cited finding of an inverted U-shaped function of pupil size across the continuum from highly degraded to clear speech. Unlike…

View details →DOI: 10.3389/fpsyg.2025.1685938
Negative / Null Result ReportMedicine

Bactericidal Efficacy of So-Called Sanitizers in Japan.

Funaki R, Nomura S, Ushima A et al. · 2024 · Biological & pharmaceutical bulletin

Commercially available so-called sanitizers in Japan are often touted as having remarkable "sanitizing (jokin)" effect, "virus-removal" capabilities, and "99.99%" removal rate of microbes and pathogens. In this study, we investigated the…

View details →DOI: 10.1248/bpb.b24-00439
Negative / Null Result Report

Predicting clinical outcomes of post-operative focal neurological deficits after glioma resection based on MRI characteristics: A retrospective chart review

Bukhari SS, Saeed F, Tahir I et al. · 2023 · Preprint

Abstract Background: The standard of care for gliomas includes maximum safe resection of the tumor. This may lead to inadvertent damage to tissue directly or vasculature supplying normal brain tissue. This may result in perilesional brain…

View details →DOI: 10.21203/rs.3.rs-2616875/v1
Negative / Null Result ReportMedicine

Weight Suppression, Brain Reward Response to Food Cues, and Bulimic Behaviours: A Pilot fMRI Study.

Singh S, Jagannathan K, Childress AR et al. · 2026 · European eating disorders review : the journal of the Eating Disorders Association

Objective Weight suppression (WS), or the difference between one's highest past and current weights, may help maintain bulimia nervosa (BN) by altering reward response to food cues. This pilot study tested associations among WS, brain…

View details →DOI: 10.1002/erv.70127
Negative / Null Result ReportOpen accessMedicine

Alcohol

· 2006

The effects of maternal alcohol (ethanol) ingestion during lactation are complex and depend on the pattern of maternal drinking. With casual alcohol use (such as 1 glass of wine or beer) it is best to wait 2 to 2.5 hours per drink before…

Negative / Null Result ReportMedicine

An Exploratory Analysis of Eye-Tracking During a Virtual Reality Social Cognition Intervention for Children with Autism Spectrum Disorders.

Gámez Martínez S, Lovatón Romero G, Alcañiz Raya M et al. · 2026 · Cyberpsychology, behavior and social networking

The diagnosis of autism spectrum disorder is based on clinical judgment, as there are no clearly identified markers to determine the presence of this condition. Gaze patterns have been proposed as a potential biomarker for autism. This…

View details →DOI: 10.1177/21522715261439451
Negative / Null Result ReportMedicine

Aphantasia and visual working memory: No direct evidence of impaired visual working memory in aphantasics, either in behavioral performance or the accuracy of a multivoxel pattern classifier.

Knight KF, Milton F, Zeman A · 2026 · Neuropsychologia

Visual mental imagery and visual working memory are often thought to be closely related. After all, both have been argued to involve the temporary maintenance of visual representations in conscious awareness. We might expect, therefore,…

View details →DOI: 10.1016/j.neuropsychologia.2026.109430
Negative / Null Result ReportMedicine

Nightly sleep as a predictor of next-day arrhythmias in ambulatory adults.

Randa L, Lee C, Cheng J et al. · 2026 · Journal of electrocardiology

Background The frequency of cardiac ectopy, including premature atrial contractions (PACs), premature ventricular contractions (PVCs), non-sustained supraventricular tachycardia (SVT), and non-sustained ventricular tachycardia (NSVT), is…

View details →DOI: 10.1016/j.jelectrocard.2026.154364
Negative / Null Result ReportMedicine

A 25-year longitudinal study on dipping/nondipping tracking in the general population: the PAMELA study.

Cuspidi C, Facchetti R, Tadic M et al. · 2026 · Journal of hypertension

Background The long-term reproducibility of the nighttime blood pressure (BP) phenotypes, namely, dipping (D) and nondipping (ND) has never been described in population-based studies. We investigated this issue in the participants to the…

View details →DOI: 10.1097/hjh.0000000000004276
Negative / Null Result ReportMedicine

Associations of fear, anger, happiness, and hope with risk judgments: Revisiting appraisal-tendency framework with a replication and extensions registered report of Lerner and Keltner (2001).

Lu S, Efendić E, Feldman G · 2025 · Journal of personality and social psychology

The appraisal-tendency framework proposed that specific emotions predispose individuals to appraise future events corresponding to the core appraisal themes of the emotions. In a registered report with a U.S. American online Amazon…

View details →DOI: 10.1037/pspp0000586
Negative / Null Result ReportMedicine

Caregiver emotional support and youth mental health after sexual abuse.

Sitton MJ, McDonald R, Rosenfield D et al. · 2026 · Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

Emotional support from a caregiver is theorized to benefit adolescents after sexual abuse, yet the empirical evidence for this is inconsistent. The present study examines the cross-sectional relation between caregiver emotional support and…

View details →DOI: 10.1037/fam0001371
Negative / Null Result ReportMedicine

Mobile App Use in Clinical Care for Cleft Patients in the UK and Republic of Ireland.

de Berker HT, Rivers CM · 2026 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

ObjectiveTo establish whether mobile applications (apps) are used as part of routine care for patients with cleft lip and palate in the UK and Republic of Ireland and to determine what role apps could play in the delivery of care.DesignA…

View details →DOI: 10.1177/10556656251338951
Negative / Null Result ReportMedicine

Tumor-induced rickets/osteomalacia (TIO): diagnostic pitfalls and therapeutic options.

Ito N, Fukumoto S · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

A 10-year-old girl developed bilateral gonalgia and waddling gait. Biochemical and imaging studies showed hypophosphatemia with impaired proximal tubular phosphate reabsorption and high intact fibroblast growth factor 23 (FGF23) level,…

View details →DOI: 10.1093/jbmr/zjaf047
Negative / Null Result ReportOpen accessMedicine

Randomized controlled trial of intravenous dexamethasone to prevent relapse in the treatment of migraine in a pediatric emergency department.

Tourigny-Ruel G, Bailey B, Jean-Charles S et al. · 2026 · Headache

Objective This study aimed to evaluate whether a single dose of intravenous dexamethasone, when added to standard abortive therapy, reduces relapse of migraine after emergency department (ED) discharge in children and adolescents.…

View details →DOI: 10.1111/head.70087
Negative / Null Result ReportMedicine

Phonological biases in lexical access in French and German: Data from a familiar word-recognition conflict task.

Piot L, Nazzi T, Boll-Avetisyan N et al. · 2025 · Infant behavior & development

Consonants have been proposed to be more important than vowels in lexical processes (i.e., C-bias). This study investigated the existence and strength of the C-bias using a familiar word recognition conflict task, in which recognition…

View details →DOI: 10.1016/j.infbeh.2025.102070
Negative / Null Result ReportMedicine

The European earwig Forficula auricularia (Dermaptera: Forficulidae) in California citrus: a sampling method, population surveys, and description of earwig movement into the tree canopy.

Rosenheim JA, Cluff E, Morrow K · 2025 · Journal of economic entomology

The European earwig F. auricularia L. is an omnivore that has only recently been identified as a direct, fruit-feeding pest of citrus. Here, we start to build the basic tools needed for integrated pest management for this species. We…

View details →DOI: 10.1093/jee/toaf023
Negative / Null Result ReportOpen accessMedicine

Looking for Biomarkers Which May Explain Idiopathic Environmental Intolerance Attributed to Electromagnetic Fields (IEI-EMF): Does RF-EMF Exposure Influence Salivary Cortisol Response?

Verrender A, Manley J, Wallace NK et al. · 2025 · Bioelectromagnetics

In order to understand Idiopathic Environmental Intolerance attributed to Electromagnetic Fields (IEI-EMF), it has been argued that it is crucial to test for effects of radiofrequency electromagnetic fields (RF-EMF) on biomarkers, given…

View details →DOI: 10.1002/bem.70021
Negative / Null Result ReportMedicine

Emotion regulation strategy use and forecasting in response to dynamic, multimodal stimuli.

Mitchell WJ, Stasiak J, Martinez S et al. · 2025 · Journal of experimental psychology. General

Successful emotion regulation (ER) requires effective strategy selection. Research suggests that disengagement strategies (e.g., distraction) are more often selected than engagement strategies (e.g., reappraisal) as emotional experiences…

View details →DOI: 10.1037/xge0001715