Negative / Null Result ReportOpen accessMedicine
Haley Appel, Rogger P Carmen-Orozco, Clayton P Santiago et al. · 2025 · eLife
The RNA-binding protein Ptbp1 has been proposed as a master regulator of neuronal fate, repressing neurogenesis through its effects on alternative splicing and miRNA maturation. While prior studies using RNA interference suggested that Ptbp1 loss promotes neurogenesis, recent genetic studies have failed to replicate glia-to-neuron conversion following Ptbp1 loss of function. To evaluate the role of Ptbp1 in developmental neurogenesis in vivo, we conditionally disrupted Ptbp1 in mouse retinal progenitors. Ptbp1 was robustly expressed in both retinal progenitors and Müller glia but absent from p
View details →DOI: 10.7554/elife.108331 Negative / Null Result ReportOpen accessSocial Sciences
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect referred to as the unconscious thought advantage (UTA). The status of the DWA hypothesis is controversial, as many studies have tried but failed to replicate the UTA. Here, we report a series of experiments that sought to identify the conditions under which the UTA can be replicated. Our starting point was a recent meta-analysis that identified the conditions under whic
Negative / Null Result ReportOpen accessMedicine
Abraham D. Flaxman, Riley Hazard, Ian Riley et al. · 2020 · BMC Medicine
Abstract We recently published in BMC Medicine an evaluation of the comparative diagnostic performance of InSilicoVA, a software to map the underlying causes of death from verbal autopsy interviews. The developers of this software claim to have failed to replicate our results and appear to have also failed to locate our replication archive for this work. In this Correspondence, we provide feedback on how this might have been done more usefully and offer some suggestions to improve future attempts at reproducible research. We also offer an alternative interpretation of the results presented by
View details →DOI: 10.1186/s12916-020-01517-w Negative / Null Result ReportOpen accessSocial Sciences
Briony D. Pulford, Poonam Gill · 2014 · Judgment and Decision Making
We report a series of experiments investigating the influence of feeling lucky or unlucky on people’s choice of known-risk or ambiguous options using the traditional Ellsberg Urns decision-making task. We induced a state of feeling lucky or unlucky in subjects by using a rigged wheel-of-fortune game, which just missed either the bankrupt or the jackpot outcome. In the first experiment a large reversal of the usual ambiguity aversion effect was shown, indicating that feeling lucky made subjects significantly more ambiguity seeking than usual. However, this effect failed to replicate in five ref
View details →DOI: 10.1017/s1930297500005520 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Michael Weigl, Qi Shao, Qi Shao et al. · 2023 · Frontiers in Human Neuroscience
In recent years, several cross-cultural studies reported that Westerners focus more on central aspects of a scene (e.g., an object) relative to peripheral aspects (e.g., the background), whereas Easterners more evenly allocate attention to central and peripheral aspects. In memory tasks, Easterners exhibit worse recognition for the central object when peripheral aspects are changed, whereas Westerners are less affected by peripheral changes. However, most of these studies rely on hit rates without correcting for response bias, whereas studies accounting for response bias failed to replicate cu
View details →DOI: 10.3389/fnhum.2023.1233594 Negative / Null Result ReportOpen accessLanguage and Literature
Elisa Scerrati, Zachary Estes · 2025 · Language and Cognition
The spatial interference effect, whereby words with implicit spatial associations (e.g., ‘bird’) hinder identification of unrelated visual targets (e.g., a square) at the associated locations (i.e., at the top of a display), has been demonstrated many times in English, although it has failed to replicate several times in Italian. The current study tested whether the replication failures in Italian may be due to insufficient semantic processing of the words. Indeed, while languages with highly inconsistent pronunciations, such as English, are more likely to involve semantic processing during wo
View details →DOI: 10.1017/langcog.2025.10031 Negative / Null Result ReportOpen accessPharmacy and materia medica
Bazigha K. Al –Temimy, Alaa A. Abdul –Rasool · 2017 · Iraqi Journal of Pharmaceutical Sciences
ABSTRACT: Salbutamol sulphate nebules is considered as the most rapid effective route of administration for treatment of acute attacks of asthma . This study was carried out to formulate a stable formula of salbutamol nebules containing 0.1% (2.5mg / 2.5ml) of the active ingredient in a buffered solution . Stability study in different buffers at pH 3 showed that the longest shelf life was equal to 3.5 years for formula F .In addition the bioequivalency of this formula incomparison to ventolin nebules was measured and it was equal to (± 5.2) %. Also it was found that there was no significant d
Negative / Null Result ReportOpen accessTechnology
Alessandro Guarnieri, Fabiana Laurenti, Salvatore Mazzei et al. · 2025 · Applied Sciences
Table tennis (TT) is a high-speed sport requiring integrated cognitive and motor skills. However, the existing assessment tools have failed to replicate its sport-specific demands. Therefore, this study aimed to evaluate the validity and reliability of the Reactive Table Tennis test designed to assess cognitive–motor performance in TT. Sixty athletes were recruited from TT, combat sports (CS), team sports (TS), and track and field (TF). Participants were required to react to 10 visual stimuli randomly emitted from three devices placed 3 m frontally by performing 1.5 m lateral or frontal displa
View details →DOI: 10.3390/app151810163 Negative / Null Result ReportOpen accessPsychology
Sophie Gillet, Cristina Anca Barbu, Martine Poncelet · 2020 · Frontiers in Psychology
Advantages in diverse aspects of cognitive functioning have been reported in early bilinguals (Bialystok, 2011) as well as in children frequenting an early bilingual immersion school program (Nicolay and Poncelet, 2015). However, during the last decade, some studies failed to replicate these advantages. Currently, the presence of cognitive benefits in children frequenting an immersion program remains debated. The lack of consistency between the studies could come from the fact that time spent by children within the immersion program is variable from one study to the other and that studies used
View details →DOI: 10.3389/fpsyg.2020.587574 Failed Experiment ReportOpen accessMedicine
Christian Marcus Pedersen, Anders Rehfeld · 2022 · F1000Research
Opposing findings have been published on the regulation of the sperm-specific Ca2+ channel CatSper (cation channel of sperm) in human sperm cells by the plant triterpenoids lupeol and pristimerin. While the original study on this topic found these triterpenoids to act as potent inhibitors of human CatSper, subsequent studies have failed to replicate such an inhibitory effect. It has been suggested that these issues could in part be due to purity issues and/or batch variation between the plant-derived extracts of lupeol and pristimerin obtained for the studies. The aim of this study was to eluc
View details →DOI: 10.12688/f1000research.109279.2 Negative / Null Result ReportOpen accessPhysics
Javier De Miguel, Evanthia Hatziminaoglou, Frédéric Poidevin et al. · 2026 · Physics Letters B
We report a mm-wave search for axion dark matter from SGR 1745–2900, based on 4.8 h of ALMA observations. No candidate features are found between 133.99–135.78, 135.91–137.70, 145.99–147.78, and 147.99–149.78 GHz, corresponding to 0.55–0.62 meV. Interpreting this null result within a state-of-the-art stellar framework, we derive sensitivity to the axion–photon coupling at the level of gγ≳2×10−11 GeV−1 under a standard Navarro–Frenk–White profile; down to gγ≳2×10−13 GeV−1 upon accounting for a dense dark-matter spike around Sagittarius A*, probing the quantum chromodynamics axion parameter spac
View details →DOI: 10.1016/j.physletb.2026.140567 Negative / Null Result Report
Shishimi G, Akaishi R, Matsukami M · 2025 · Preprint
Mirror self-recognition (MSR) is a key indicator of self-awareness, primarily studied in vertebrates. Investigating MSR in invertebrates such as the western honeybee ( Apis mellifera ), an insect with advanced cognition, is essential to…
View details →DOI: 10.1101/2025.10.14.682345 Negative / Null Result ReportMedicine
Kato K, Honda Y, Kamatani T et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)
Objective Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in NLRP3. Although somatic NLRP3 mosaicism is increasingly recognized, it remains unclear how variant allele…
View details →DOI: 10.1002/art.43329 Negative / Null Result ReportMedicine
Demeckova V, Demcakova V, Sedlakova-Kadukova J · 2025 · IEEE transactions on nanobioscience
Silver nanoparticles (AgNPs) are widely used for their antimicrobial properties but pose risks like environmental contamination and potential harm to human health. Nanoparticles' small size facilitates translocation within the body, often…
View details →DOI: 10.1109/tnb.2025.3564822 Negative / Null Result ReportMedicine
Shaik NF, Denison L, Venezia GMA et al. · 2026 · Journal of hospital medicine
Background Hospitalized patients often experience poor sleep, which is associated with worse health outcomes, increased rates of delirium, and readmissions. Objective To improve overnight sleep for clinically stable general neurology…
View details →DOI: 10.1002/jhm.70223 Negative / Null Result ReportMedicine
Zhang J, Wu Q, Chi D et al. · 2025 · Soil & tillage research
Phosphorus-loaded iron-modified biochar (Fe-BP) can be used as farmlands' slow-release phosphorus (P) fertilizer. This study aimed to explore the effects of Fe-BP on soil P composition, phosphatase activity, peanut P accumulation, and P…
Negative / Null Result ReportMedicine
Lukyanov AN, Vargin PN, Yushkov VA · 2025 · Atmospheric research
The eruption of the underwater volcano Hunga Tonga – Hunga Ha'apai (20.54° S, 178.3° W) on January 15, 2022, resulted in the first significant increase in the stratospheric water vapor content in the entire satellite observation era. This…
Negative / Null Result ReportMedicine
Ackermann DM, Medcalf E, Bracken K et al. · 2026 · Journal of clinical epidemiology
Objectives Digital reminders are widely used in clinical trials, but their design is rarely evidence-based. We evaluated the effectiveness of two types of digital reminders for trial task completion. Study design and setting This…
View details →DOI: 10.1016/j.jclinepi.2026.112263 Negative / Null Result Report
Hadi CE, Dailaty AA, Sobh AH et al. · 2025 · Preprint
Abstract Background Postoperative pulmonary complications (PPCs) remain a major determinant of morbidity after noncardiac surgery. Whether prior SARS-CoV-2 infection independently heightens PPC risk in the contemporary, highly vaccinated,…
View details →DOI: 10.21203/rs.3.rs-8100907/v1 Negative / Null Result ReportMedicine
Jones PAT, Brockwell E, Hassan A et al. · 2025 · British journal of sports medicine
Objective Recreational and elite athletes report avoiding breastfeeding when returning to physical activity following childbirth due to a perceived increased risk of injury; yet, there are no empirical data to support this relationship. We…
View details →DOI: 10.1136/bjsports-2024-109310 Negative / Null Result ReportMedicine
Sadowska-Klasa A, Bełdzińska-Gądek K, Klein-Awerjanow K et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Objectives Cytomegalovirus (CMV) pneumonia is a serious complication in immunocompromised patients, but its role in non-transplant populations remains unclear. Methods We analyzed CMV DNA in bronchoalveolar lavage (BAL) samples from 100…
View details →DOI: 10.1016/j.ijid.2025.108231 Negative / Null Result Report
Wöhner S, Jescheniak JD · 2025 · Preprint
The production of a word is delayed by the recent production of one or more semantically related words. This phenomenon, known as semantic interference, has been observed in picture naming tasks involving either large sets of pictures…
View details →DOI: 10.31234/osf.io/ra82e_v4 Negative / Null Result ReportMedicine
Murray RL, Baldwin D, Brain K et al. · 2026 · Thorax
Introduction Lung cancer screening (LCS) with low-dose CT offers a teachable moment for smoking cessation (SC), but the optimal way to implement SC within LCS is unclear. The Yorkshire Enhanced Stop Smoking (YESS) study assessed the…
View details →DOI: 10.1136/thorax-2025-224217 Negative / Null Result ReportMedicine
Garrido-Bautista J, Ortega Z, Pérez-Jiménez A et al. · 2025 · Ecological and evolutionary physiology
AbstractClutch size variation may be adaptive in bird populations if parents lay a clutch size that maximizes offspring recruitment. Brood size manipulation experiments allow for testing the optimization of clutch size by studying the…
View details →DOI: 10.1086/738587 Negative / Null Result ReportMedicine
Brown N, King SW, Bagshaw O et al. · 2026 · Injury
Introduction The Ilizarov method is an established technique for complex cases. Decisions about circular frame removal are imprecise, with no fully reliable method to confirm union. Errors can lead to complications such as refracture,…
View details →DOI: 10.1016/j.injury.2025.112933 Negative / Null Result ReportMedicine
Nie C, Zhong H, Shi H et al. · 2026 · Food chemistry
This study evaluated the effects of sodium substitutes (KCl, MgCl 2 , and CaCl 2 ) and soybean dietary fiber (SDF) on the textural, sensory, digestive, and storage properties of emulsion sausages. Replacing 25 % of NaCl with KCl or MgCl 2…
View details →DOI: 10.1016/j.foodchem.2025.147414 Negative / Null Result ReportMedicine
Feng Y, Liu Y, Ding X et al. · 2026 · The Journal of nutritional biochemistry
Alcohol-related liver disease is accompanied by hepatic zinc deficiency. We synthesized a zinc-glutathione (ZnGSH) complex as a zinc delivery system to test the hypothesis that effective zinc supplementation can recover the liver from…
View details →DOI: 10.1016/j.jnutbio.2025.110166 Negative / Null Result ReportMedicine
Whitehead PS, Davis CP, Park JS et al. · 2025 · Journal of applied research in memory and cognition
Much research has focused on the language used for debunking false beliefs: communications should lead with facts, label misinformation as false, and reinforce true information. Pictures are used in debunking messages, but it remains…
View details →DOI: 10.1037/mac0000214 Negative / Null Result ReportMedicine
Cartujano-Barrera F, Catley D, Chávez-Iñiguez A et al. · 2026 · Chest
Background Little is known about the use of text messages to promote enrollment in smoking cessation treatment. Research question What is the impact of the number of outreach messages and monetary incentives on enrollment in smoking…
View details →DOI: 10.1016/j.chest.2025.11.054 Negative / Null Result ReportMedicine
Dumlu B, Bölükbaşi ŞC, Bayir A · 2026 · Lipids
We investigated molecular characteristics and tissue distribution of elongation of very long chain fatty acids (ELOVL) genes in the chicken (Gallus gallus) genome. The research specifically examines the expression levels of these genes in…
View details →DOI: 10.1002/lipd.70013 