Negative / Null Result ReportMedicine
Endo S, Tanaka R, Yamaguchi T et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Large type 3 (≥ 8 cm) and type 4 gastric cancers are associated with extremely poor prognoses. The phase III JCOG0501 trial, which evaluated neoadjuvant S-1 plus cisplatin, failed to demonstrate any survival benefits. Docetaxel,…
View details →DOI: 10.1007/s10120-025-01705-8 Negative / Null Result Report
Chaudhari A, Rosenstein ZM, Kamal R et al. · 2025 · Preprint
Background Intracranial atherosclerotic disease (ICAD) is associated with up to 10% of ischemic strokes and a high risk of recurrence. Endovascular treatments including percutaneous transluminal angioplasty and stenting have failed to…
View details →DOI: 10.1101/2025.09.17.25336036 Negative / Null Result ReportMedicine
Schreiner M, Thien H, Braasch T et al. · 2025 · Abdominal radiology (New York)
Background Many patients are instructed to fast before abdominal ultrasound examinations in order to obtain better image quality. However, the few available studies on this topic have so far failed to demonstrate an advantage of several…
View details →DOI: 10.1007/s00261-025-04947-3 Negative / Null Result ReportMedicine
Thery G, Noly PE, Cavayas YA et al. · 2025 · Seminars in thoracic and cardiovascular surgery
ECLS-SHOCK is the largest randomized control trial on Veno-Arterial Extracorporeal Membrane Oxygenation (VA-ECMO) in Acute Myocardial Infarction-related Cardiogenic Shock (AMI-CS). Unfortunately, ECLS-SHOCK failed to demonstrate a…
View details →DOI: 10.1053/j.semtcvs.2025.01.004 Negative / Null Result ReportOpen accessMedicine
Liu S, Chen B, Zhu Y et al. · 2025 · The oncologist
Background Previous results of our trial demonstrated that the addition of induction chemotherapy (IC) prior to definitive chemoradiotherapy (CRT) failed to significantly improve the response rate or 3-year survival in patients with…
View details →DOI: 10.1093/oncolo/oyae295 Negative / Null Result ReportMedicine
Emborg C, Kothari SF, Finnerup NB et al. · 2025 · Handbook of clinical neurology
Over the past decades, a growing number of clinical trials in neurologic conditions have failed to demonstrate superiority of active treatments over placebo. A key question in this context is whether an increase in placebo response can…
View details →DOI: 10.1016/b978-0-443-29884-4.00018-2 Negative / Null Result ReportOpen accessMedicine
Hattori Y, Abe S, Kakino Y et al. · 2026 · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
Interventional trials with high-density lipoprotein cholesterol (HDL-C)-raising drugs have generally failed to demonstrate a beneficial effect on cardiovascular outcomes, although low HDL-C levels confer the risk of cerebrocardiovascular…
View details →DOI: 10.1016/j.neurot.2026.e00849 Negative / Null Result ReportOpen accessChemistry
Tóth Štefan, Olexa Peter, Hertelyová Zdenka et al. · 2020 · Open Chemistry
The aim of this study was to detect the concentrations of PCSK9 in various subclinical stages of atherosclerosis and to highlight its relationship with inflammation. One hundred and fifty-nine healthy patients were divided into three groups, based on the extent of atherosclerotic changes in the carotid artery: a group without identifiable atherosclerosis, cIMT>75‰ and an asymptomatic plaque group. The PCSK9 was measured by ELISA and hsCRP by the immunoturbidimetric method. Vascular changes were identified by a carotid ultrasound. PCSK9 was elevated, when comparing the healthy group with the cI
View details →DOI: 10.1515/chem-2020-0147 Negative / Null Result ReportMedicine
Deng S, Hu L, Chen G et al. · 2025 · Advanced materials (Deerfield Beach, Fla.)
Although the combination of radiotherapy and immunotherapy is regarded as a promising clinical treatment strategy, numerous clinical trials have failed to demonstrate synergistic effects. One of the key reasons is that conventional…
View details →DOI: 10.1002/adma.202419418 Negative / Null Result ReportOpen accessMedicine
Brenner H, Sergeev D, Heisser T et al. · 2025 · Alimentary pharmacology & therapeutics
NordICC, the first randomised trial on long-term effects of screening colonoscopy, failed to demonstrate a significant reduction in colorectal cancer (CRC) mortality. We compared reported 10-year CRC mortality results from NordICC with…
View details →DOI: 10.1111/apt.70231 Negative / Null Result ReportMedicine
Steendam ST, Prutean N, Clybouw F et al. · 2024 · Biological psychology
Previous research suggests that the mere presence of a smartphone can detrimentally affect performance. However, other studies failed to observe such detrimental effects. A limitation of existing studies is that no indexes of (potentially…
View details →DOI: 10.1016/j.biopsycho.2024.108893 Negative / Null Result ReportMedicine
Imam R, Chastang KM, Olowojesiku R et al. · 2025 · The Pediatric infectious disease journal
Background Multiple clinical trials evaluating therapies for cerebral malaria (CM) have failed to demonstrate improved outcomes. This may derive from inclusion of children at all risk levels, including those at low risk of mortality or…
View details →DOI: 10.1097/inf.0000000000004581 Negative / Null Result ReportMedicine
Wolpe N, Perrottelli A, Giuliani L et al. · 2025 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
The negative symptoms of schizophrenia can determine functional outcome in patients. Despite its clinical significance, no treatment exists to date, as numerous pharmacological and non-pharmacological clinical trials have failed to…
View details →DOI: 10.1016/j.euroneuro.2024.12.016 Negative / Null Result ReportOpen accessMedicine
Bommersbach TJ, Saliba M, Gilman CK et al. · 2025 · JAACAP open
Objective Attention-deficit/hyperactivity disorder (ADHD) is a risk factor for future substance use. Stimulant medication has largely failed to demonstrate protection against future substance use, but no studies have assessed whether…
View details →DOI: 10.1016/j.jaacop.2025.05.004 Negative / Null Result ReportMedicine
Li X, Li Y, Wang T et al. · 2025 · Stroke
Background Previous trials have failed to demonstrate the benefits of extracranial-intracranial (EC-IC) bypass surgery for patients with carotid or middle cerebral artery occlusion. However, little evidence has focused on the effect of age…
View details →DOI: 10.1161/strokeaha.124.048766 Negative / Null Result Report
Tojo K, Yazawa T · 2024 · Preprint
Abstract Background Although alveolar hyperoxia exacerbates lung injury, clinical studies have failed to demonstrate the beneficial effects of lowering the fraction of inspired oxygen (F I O 2 ) in patients with acute respiratory distress…
View details →DOI: 10.21203/rs.3.rs-4449408/v1 Negative / Null Result ReportOpen accessMedicine
Woittiez AJ, Postma CT, de Leeuw PW · 2026 · Kidney medicine
Atherosclerotic renal artery stenosis (ARAS) remains a complex contributor to hypertension and kidney disease. Although randomized trials failed to show benefit of revascularization on top of medical therapy over medical therapy alone,…
View details →DOI: 10.1016/j.xkme.2026.101406 Negative / Null Result ReportMedicine
Peker Y, Saygin M, Celik Y et al. · 2026 · Annals of the American Thoracic Society
Rationale Recent randomized controlled trials failed to show cardiovascular benefits of treating obstructive sleep apnea (OSA) in intention-to-treat analyses which has been a matter of debate since publication of the results. Objectives To…
View details →DOI: 10.1093/annalsats/aaoag072 Negative / Null Result ReportMedicine
Gaub M, Shaffer KV, Patel P et al. · 2026 · Clinical neurology and neurosurgery
Objective EC-IC bypass for symptomatic atherosclerotic internal carotid and middle cerebral artery chronic occlusion (AIMCAO) failed to show benefit over medical management in previous randomized controlled trials. We explored how a…
View details →DOI: 10.1016/j.clineuro.2026.109417 Negative / Null Result ReportMedicine
Hajime T, Shiota M, Fukuchi G et al. · 2026 · Annals of surgical oncology
Background Although lymph node involvement (LNI) is a critical prognostic factor guiding adjuvant therapy, randomized trials have failed to show a survival advantage of extended versus standard pelvic lymph node dissection (PLND) but have…
View details →DOI: 10.1245/s10434-026-19088-0 Negative / Null Result ReportMedicine
Dintakurti A, Parikh MA, Silver RJ et al. · 2025 · Cardiology in review
Large-scale clinical trials of intensive glycemic control have failed to show cardiovascular benefit, with hypoglycemia implicated as a key factor. Increasing evidence suggests hypoglycemia is not merely a complication of diabetes therapy…
View details →DOI: 10.1097/crd.0000000000001114 Negative / Null Result ReportMedicine
Bhardwaj A, Saili A, Yadav DK et al. · 2025 · Journal of neonatal-perinatal medicine
BackgroundThe prolonged ductal patency in preterm newborns despite being associated with short- and long-term morbidities has failed to show significant improvement in the long-term outcome with routine ductal treatment. Echocardiography…
View details →DOI: 10.1177/19345798251343494 Negative / Null Result ReportMedicine
Van Gent JM, Clements TW, Gurney JM et al. · 2025 · The journal of trauma and acute care surgery
Background Empiric cryoprecipitate administration has recently failed to show survival benefit in hemorrhaging trauma patients. However, a recent Trauma Quality Improvement Program query suggested a survival benefit in massive transfusions…
View details →DOI: 10.1097/ta.0000000000004643 Negative / Null Result ReportMedicine
Sant VR, Zhou H, Zhou MM et al. · 2025 · The Journal of clinical endocrinology and metabolism
Context Primary hyperparathyroidism (PHPT) has initially been implicated in adverse maternal and neonatal outcomes, while subsequent population studies have failed to show an association. Objective This work aimed to compare maternal,…
View details →DOI: 10.1210/clinem/dgae409 Negative / Null Result Report
Perdue MV, Geeraert BL, Manning KY et al. · 2024 · Preprint
Numerous studies have linked reading ability to white matter microstructure using diffusion tensor imaging, but recent large studies have failed to show consistency. Fiber-specific diffusion-weighted magnetic resonance imaging (dMRI)…
View details →DOI: 10.1101/2024.09.24.614799 Negative / Null Result ReportMedicine
Wang X, Men C, Shan S et al. · 2025 · Gene
Chemoresistance is a considerable challenge for gastric cancer (GC), and the combination of cisplatin (DDP) and anti-EGFR therapy failed to show remarkable benefit. So other targets in EGFR-overexpressed and DDP-resistant GC need to be…
View details →DOI: 10.1016/j.gene.2024.149005 Negative / Null Result ReportMedicine
Drieghe B, De Buyzere M, Bové T et al. · 2024 · Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
Randomized clinical trials failed to show additional benefit of renal artery stenting on top of medical therapy. Instead of writing an obituary on renal artery stenting, we try to explain these disappointing results. A transstenotic…
View details →DOI: 10.1002/ccd.31117 Negative / Null Result Report
Davani SZ, Pazooki D, Kamalzadeh N · 2024 · Preprint
41-year-old male with no significant past medical history presented as an outpatient with atypical chest pain and had positive nuclear stress test. The patient subsequently underwent left heart catheterization, which revealed a fistula…
View details →DOI: 10.22541/au.170666620.00830324/v1 Negative / Null Result ReportMedicine
Morimoto J, Satogami K, Naraoka T et al. · 2024 · International heart journal
Deficiency of vitamin B 1 (VB1), an essential micronutrient, causes heart failure (HF). A recent randomized controlled trial failed to show any improvement in HF prognosis after short-term VB1 supplementation. In the current study, we…
View details →DOI: 10.1536/ihj.23-550 Negative / Null Result ReportMedicine
Canning C, McCormack T, Clifford E et al. · 2024 · The British journal of developmental psychology
Previous studies have failed to show an effect of episodic future thinking (EFT) on children's delay of gratification (DoG), contrasting strikingly with adult findings. Recent findings from a sample of 8-11-year-old children by Canning et…
View details →DOI: 10.1111/bjdp.12477 