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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 490 of 725

Negative / Null Result ReportMedicine

Effects of Dietary Nitrate and Caffeine on End Power and Work Above End Power During a 3 min All-Out Test in Trained Male Cyclists.

Hagele, Sunderland, Mumford et al. · 2026 · Nutrients

The purpose of this study was to examine the effects of acute dietary nitrate (NO 3 - ) and caffeine (CAF) supplementation on end power (EP) and work performed above EP (WEP) in trained male cyclists during a 3 min all-out test (3MT) on a…

View details →DOI: 10.3390/nu18091463
Negative / Null Result ReportMedicine

Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.

Petrache, Boldeanu, Diaconu et al. · 2026 · Journal of clinical medicine

Background: Dental caries in children has been explored not only as a local oral condition but also in relation to potential systemic inflammatory changes. This study evaluated systemic inflammatory biomarkers and hematologic indices in…

View details →DOI: 10.3390/jcm15093558
Negative / Null Result ReportMedicine

Clinical features of biliary atresia complicated by cytomegalovirus infection and prognostic analysis after Kasai portoenterostomy.

Teng, Wenqing, Shuhao et al. · 2026 · Journal of pediatric surgery

To explore the unique clinical characteristics of biliary atresia (BA) combined with cytomegalovirus (CMV) infection and its impact on early and late prognosis after Kasai portoenterostomy (KPE). This was a retrospective study involving…

View details →DOI: 10.1016/j.jpedsurg.2026.163190
Failed Experiment ReportMedicine

Efficacy and safety of belapectin for the prevention of esophageal varices in patients with MASH cirrhosis: The randomized, placebo-controlled NAVIGATE trial.

Chalasani, Vuppalanchi, Noureddin et al. · 2026 · Hepatology (Baltimore, Md.)

Belapectin reduced variceal development in a subgroup of patients with MASH cirrhosis. We report the efficacy and safety of belapectin in patients with MASH cirrhosis and portal hypertension without varices at baseline. NAVIGATE was a…

View details →DOI: 10.1097/hep.0000000000001774
Negative / Null Result ReportMedicine

Efficacy of a 10-MDP-Containing Cleaner on the Bond Strength to Saliva Contaminated Dentin.

Hayashi-Wells, Phark, Duarte · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

To evaluate the effect of saliva contamination and a 10-MDP-containing cleaner (Katana Cleaner; Kuraray Noritake, Japan) on the shear bond strength (SBS) of an ultra-mild universal adhesive applied in self-etch mode to human dentin.…

View details →DOI: 10.1111/jerd.70175
Negative / Null Result ReportMedicine

Short- versus long-course antibiotic therapy in mechanically ventilated sepsis patients with pneumonia: a real-world cohort analysis.

Wang, Gui, Mei et al. · 2026 · Clinics (Sao Paulo, Brazil)

To compare outcomes of short-course versus longer-course antibiotic regimens in mechanically ventilated adult patients with sepsis due to pneumonia. The authors performed a retrospective cohort study using the MIMIC-IV database…

View details →DOI: 10.1016/j.clinsp.2026.100932
Negative / Null Result ReportMedicine

Effect of gonadectomy and hormone replacement on habenula-induced dopamine inhibition in female and male rats.

Waldron, Suttawireesan, Fatimah et al. · 2026 · Journal of neuroendocrinology

Sex differences have been noted in the prevalence and severity of several neurological and mental health disorders. Midbrain dopaminergic activity is implicated in the etiology of many of these disorders and therefore may also contribute…

View details →DOI: 10.1111/jne.70183
Negative / Null Result ReportMedicine

Surgical strategy and prognostic factors in very elderly (≥ 75 Years) patients with stage I NSCLC: insights from a propensity score-matched analysis.

Lee, Chao, Shen et al. · 2026 · BMC pulmonary medicine

BACKGROUND: The optimal surgical strategy for very elderly patients (≥ 75 years) with stage I non–small cell lung cancer (NSCLC) remains uncertain. METHODS: We retrospectively analyzed 390 patients with pathologic…

View details →DOI: 10.1186/s12890-026-04265-4
Negative / Null Result ReportMedicine

Impact of the risk-treatment paradox on in-hospital and long-term outcomes in patients with very high-risk non-ST-elevation acute coronary syndrome.

Nesova, Vorobeva, Ryabov · 2026 · The Indian journal of medical research

Background and objectives The risk-treatment paradox (RTP) has not been studied in very high-risk patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). We aimed to describe the cohort of very high-risk NSTE-ACS patients,…

View details →DOI: 10.25259/ijmr_1781_2025
Short NoteMedicine

Effect of sugar and sweetener on the bleachability of coffee and tea-induced stains on composites: an in vitro experimental study.

Bayraktar, Karaca, Ekşılı et al. · 2026 · Restorative dentistry & endodontics

This in vitro study evaluated the effects of various sugary and non-sugary beverages on the color change of a dental composite and the subsequent bleaching efficacy. Forty-nine disc-shaped composite samples (Neo Spectra ST, Dentsply…

View details →DOI: 10.5395/rde.2026.51.e16
Negative / Null Result ReportMedicine

Adjuvant capecitabine in women with triple-negative breast cancer with residual disease after carboplatin-containing neoadjuvant chemotherapy.

Tavares, Ramalho, da Silva et al. · 2026 · Breast cancer research and treatment

Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by early relapse and limited therapeutic options. Carboplatin added to anthracycline/taxane neoadjuvant chemotherapy (NACT) raises pathologic complete response…

View details →DOI: 10.1007/s10549-026-07949-x
Negative / Null Result ReportMedicine

Investigating the necessity of preoperative coronary angiography for infection-related cardiac implantable electronic device explantation.

Caldonazo, Scheler, Fischer et al. · 2026 · American heart journal plus : cardiology research and practice

Device-associated endocarditis is a potentially life-threatening condition that typically requires the removal of the cardiac implantable electronic device (CIED). The role of routine coronary angiography (CAG) as part of preoperative…

View details →DOI: 10.1016/j.ahjo.2026.100762
Negative / Null Result ReportMedicine

The efficacy of acetic acid and citric acid on calcium silicate based cement removal from root canals and their effect on dentine structure - an in vitro study.

Alzraikat, Al-Hiyasat, Jamous et al. · 2026 · Biomaterial investigations in dentistry

This study evaluated the effectiveness of acids on calcium silicate cement surface hardness, perforation, and their impact on root dentine microstructure. Root dentine discs were exposed to hydrochloric, acetic, and citric acids. Fourier…

View details →DOI: 10.2340/biid.v13.45669
Negative / Null Result ReportMedicine

Effects of omega-3 fatty acid supplementation on heart rate variability.

Atef Abdelsattar Ibrahim, Gouda Kamal, Zid et al. · 2026 · World journal of clinical pediatrics

Obesity and overweight are major public health challenges and are associated with autonomic imbalance and decreased heart rate variability (HRV), a non-invasive indicator of cardiovascular risk. Omega-3 polyunsaturated fatty acids have…

View details →DOI: 10.5409/wjcp.v15.i1.116331
Negative / Null Result ReportMedicine

Comparative evaluation of irrigation techniques on dentin nanohardness, flexural strength, and chemical composition: an in vitro study.

Ahmed, AbuMostafa · 2026 · Scientific reports

This investigation sought to evaluate the comparative influence of different irrigation activation protocols-ultrasonic, sonic, XP-Endo Finisher, and manual dynamic activation (MDA)-on the nanohardness, elastic modulus, flexural strength,…

View details →DOI: 10.1038/s41598-026-45610-1
Negative / Null Result ReportMedicine

The impact of preoperative anticoagulant administration on postoperative coagulation function and blood loss following posterior lumbar interbody fusion: a case-control study.

Zhan, Hao, Li et al. · 2026 · Frontiers in medicine

Currently, there are few reports on the impact of preoperative anticoagulant administration on perioperative coagulation function and blood loss. Therefore, this study observed the effects of preoperative anticoagulant administration on…

View details →DOI: 10.3389/fmed.2026.1753809
Negative / Null Result ReportMedicine

Motor coordination in school-aged children with different nutritional statuses following a non-immersive virtual reality intervention.

Da Silva Souza, De Souza, Dos Santos et al. · 2026 · Frontiers in public health

Children with low motor coordination tend to engage in less physical activity. They are more likely to gain weight, establishing a bidirectional relationship, as weight gain may further restrict their participation in physical activity.…

View details →DOI: 10.3389/fpubh.2026.1779788
Negative / Null Result ReportMedicine

[The Effect of BMI on the Mobilization of Peripheral Blood Hematopoietic Stem Cells in Healthy Donors].

Liang, Zhu, Han et al. · 2026 · Zhongguo shi yan xue ye xue za zhi

To explore the effect of body mass index (BMI) on the efficiency of hematopoietic stem cell (HSC) mobilization. A retrospective analysis was conducted on the clinical data of 158 healthy donors who underwent peripheral blood HSC…

View details →DOI: 10.19746/j.cnki.issn.1009-2137.2026.01.025
Negative / Null Result ReportMedicine

Cumulative input sensitivity predicts both attenuation and stability of lexically guided perceptual learning.

Cummings, Hodges, Theodore · 2026 · Psychonomic bulletin & review

Listeners can use lexical information to accommodate ambiguity in speech input. Some evidence suggests that lexically guided perceptual learning persists over time. However, other evidence suggests that lexically guided perceptual learning…

View details →DOI: 10.3758/s13423-026-02862-2