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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21328 results · page 490 of 711

Negative / Null Result ReportMedicine

Action potential propagation in the rodent myelinated optic nerve does not trigger neurovascular coupling.

Suarez-Baquero DE, Boido D, Assali A et al. · 2026 · Nature communications

In brain gray matter, neurovascular coupling (NVC) maintains brain metabolism homeostasis by modulating blood flow according to neuronal activity. In white matter, the energy cost of information transmission along myelinated axons is…

View details →DOI: 10.1038/s41467-026-71656-w
Negative / Null Result ReportMedicine

Associations between paracetamol administration and delayed intravenous antibiotic administration among patients with in-hospital sepsis.

Senangkhanikorn S, Morapun N, Samansee A et al. · 2026 · Journal of hospital medicine

Background Timely antibiotic administration is crucial for improving sepsis outcomes, but delays are common and multifactorial. Fever, a key feature of sepsis, is often treated with paracetamol, which may mask the condition and contribute…

View details →DOI: 10.1002/jhm.70347
Negative / Null Result ReportMedicine

Effects of replacing porcine blood meal with rumen-protected lysine, while maintaining metabolizable methionine supply, on performance, nitrogen use efficiency, and nutrient partitioning in dairy cows.

Arshad U, Johnson SJ, Fukumori R et al. · 2026 · Journal of dairy science

The objectives of this experiment were to determine the effects of replacing metabolizable Lys from porcine blood meal (PBM) with rumen-protected (RP) Lys (RPL) on lactation performance, ECM/DMI, N use efficiency (NUE; milk N/N intake),…

View details →DOI: 10.3168/jds.2025-27475
Negative / Null Result ReportMedicine

COVID-19 infection prior to the onset of type 1 diabetes does not impair beta-cell function: a two-year nationwide follow-up study.

Bjerregaard-Andersen M, Hostrup PE, Kolnes KJ et al. · 2026 · BMC endocrine disorders

Background A possible association between infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and type 1 diabetes (T1D) development has been reported. Whether SARS-CoV-2 infection affects beta-cell loss in T1D…

View details →DOI: 10.1186/s12902-026-02358-z
Negative / Null Result ReportMedicine

Do Preoperative Intra-Articular Steroid Injections Affect the Choice of Surgical Procedures for Thumb Carpometacarpal Osteoarthritis?

Komura S, Hirakawa A, Hirose H et al. · 2026 · The Journal of hand surgery

Purpose This study investigated the influence of preoperative intra-articular steroid injections on surgical outcomes of trapeziectomy with ligament reconstruction and tendon interposition (LRTI) arthroplasty and arthrodesis and aimed to…

View details →DOI: 10.1016/j.jhsa.2026.01.024
Negative / Null Result ReportMedicine

Optimizing Risk Communication for Lynch Syndrome: Results of a Randomized Controlled Trial of Visual Arrays for Genetic Testing.

Keels JN, Babicheva V, McDonald IR et al. · 2026 · Cancers

Background/Objectives : We aimed to test two different visual arrays for helping individuals accurately interpret colorectal cancer risk in Lynch syndrome. We also sought to examine factors associated with intention to share genetic test…

View details →DOI: 10.3390/cancers18091369
Negative / Null Result ReportMedicine

Morphological, Physiological, and Metabolite Responses of Potato to Infestation by the Fall Armyworm (Spodoptera frugiperda) and the Potato Scab Bacterium (Streptomyces resiliuntiscabiei)

Ogugua UV, Maluleke S, Goszczynska T et al. · 2026 · Potato Res..

The effect of the fall armyworm (FAW) (Spodoptera frugiperda) and the pathogenic bacterium Streptomyces resiliuntiscabiei, in combination or singly, on the morphological and physiological (growth, yield, and gas exchange), and metabolite…

Negative / Null Result ReportMedicine

Unraveling effect pathways and biomagnification: The impact of a polyfluoroalkyl fungicide on an aquatic decomposer-detritivore system.

Arias M, Meyer M, Bundschuh M et al. · 2026 · Ecotoxicology and environmental safety

Leaf litter breakdown is a key ecosystem process in streams driven by detritivorous macroinvertebrates and microbial decomposers, but it can be disrupted by anthropogenic stressors. In this context, we examined the effects of the…

View details →DOI: 10.1016/j.ecoenv.2026.120205
Negative / Null Result ReportMedicine

Linguistic cues do not influence subliminal visual processing - An electrophysiological study.

Ching ASM, Kim J, Davis C · 2026 · Cortex; a journal devoted to the study of the nervous system and behavior

This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…

View details →DOI: 10.1016/j.cortex.2026.03.010
Negative / Null Result ReportMedicine

Nonapeptide modulation of looming-induced responses in male Betta splendens.

Fusani B, Cardoso SD, Ramos A et al. · 2026 · General and comparative endocrinology

The looming stimulus is a widely used paradigm for investigating defensive behaviours in prey-predator contexts, as it simulates an approaching threat through the rapid expansion of a dark disk. Such stimuli typically evoke fight, flight,…

View details →DOI: 10.1016/j.ygcen.2026.114965
Negative / Null Result ReportOpen accessMedicine

Milk Production, Composition, and Fatty Acid Profile in Milk from Dairy Cows Fed Increasing Levels of Dietary Soybean Oil: A Dose-Response Study.

Acho-Martínez YC, Hernández-García PA, Espinosa-Ayala E et al. · 2026 · Veterinary sciences

The objective of this study was to evaluate the effects of dietary inclusion of increasing levels of soybean oil on milk yield, milk composition, and milk fatty acid profile in dairy cows. The experiment was designed as a 4 × 4 double…

View details →DOI: 10.3390/vetsci13050456
Negative / Null Result ReportOpen accessMedicine

Effects of the combination of brefeldin A and tunicamycin on endoplasmic reticulum stress and apoptosis in human normal hepatocytes.

Yang Y, Hou M, Li M et al. · 2026 · Current research in toxicology

Background Due to its ability to inhibit the growth of hepatoma cells, brefeldin A (BFA) has been considered a promising drug candidate for liver cancer. However, there is limited research on its safety profile and potential impacts when…

View details →DOI: 10.1016/j.crtox.2026.100297
Negative / Null Result Report

The Effect of Variability in Appearance and Context on Face Learning

Nguy K, lapadula t, Devue C · 2026 · Preprint

Exposure to multiple unique images of the same face enhances recognition. Using ambient pictures and videos, face-learning studies have shown improved generalization, suggesting more refined memory representations for faces exhibiting…

View details →DOI: 10.31234/osf.io/bytde_v1
Negative / Null Result ReportMedicine

The effect of concentrate crude protein concentration and replacing imported feed ingredients with locally grown cereals and faba bean on milk production and nitrogen utilization in grazing dairy cows.

McCarthy KM, Pierce KM, McKay ZC et al. · 2026 · Journal of dairy science

Concentrate feeds with a lower CP concentration are an effective means of reducing nitrogen (N) excretion from grazing dairy cows. Typically, imported feedstuffs such as soybean meal and maize are included in concentrate feeds to increase…

View details →DOI: 10.3168/jds.2025-27732
Negative / Null Result ReportMedicine

The impact of very low nicotine cigarettes on cannabis and alcohol use during a 12-week clinical trial.

Hackworth EE, Lastovich J, Carroll DM et al. · 2026 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco

Introduction In January 2025, the US FDA announced a proposed rule for a reduced nicotine standard (RNS) in cigarettes. Evidence suggests that the use of very low nicotine content (VLNC) cigarettes decreases cigarette use and tobacco…

View details →DOI: 10.1093/ntr/ntag070
Negative / Null Result ReportMedicine

Intravenous tenecteplase is associated with a higher incidence of thrombus movement before endovascular treatment for acute ischemic stroke: a secondary analysis of the AcT randomized controlled trial.

Alhabli I, Ishaque N, Kate M et al. · 2026 · Journal of neurointerventional surgery

Background Thrombus migration can occur in patients receiving IV thrombolysis for acute stroke. This study compared the effects of IV tenecteplase (0.25 mg/kg) versus alteplase (0.9 mg/kg) on thrombus movement in patients undergoing…

View details →DOI: 10.1136/jnis-2025-023336