A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 481 of 676
Dutta P, Verma S, Patni P et al. · 2026 · The British journal of ophthalmology
Automated pupillometry (AP) has been studied in established optic neuropathies. This prospective, sequential AP evaluation of 62 newly diagnosed adult patients with pulmonary/extra-pulmonary tuberculosis, showed a statistically significant…
Zhang H, Zhao Y · 2026 · Pakistan journal of pharmaceutical sciences
Background Narlumosbart is a key agent for modulating bone cell function. Given the potential of curcumin nanoparticles to inhibit cell growth when applied alone. Objectives This study aims to investigate the role of their combination with…
Arfaee F, Shariati S, Armin A · 2026 · Veterinary ophthalmology
Objective Mydriatic and cycloplegic agents are widely used in veterinary ophthalmology to enable posterior segment examination. This study evaluated the effects of topical 1% cyclopentolate on intraocular pressure (IOP), horizontal pupil…
Zhang D, Qi X, Zhang M et al. · 2026 · Preprint
Abstract Background Postoperative pulmonary complications (PPCs) are a significant source of morbidity and mortality in neurosurgical patients. Intraoperative phrenic nerve stimulation (PNS) may preserve diaphragm function and mitigate…
Xu HJ, Liu QL, Zhang YF et al. · 2026 · International journal of molecular sciences
Dendrobium huoshanense water extract (DHWE) exhibits hypoglycemic effects in streptozotocin-induced type 1 diabetic (STZ-T1D) rats. However, its regulatory impact on the gut microbiota of T1D rats remains largely unclear. In this study,…
Sayyed-Hosseinian SH, Samadi S, Yazdi P et al. · 2026 · BMC musculoskeletal disorders
Background Calcaneal fractures, the most common tarsal fractures, often result in significant long-term disability and impose substantial healthcare burdens. Surgical intervention aims to restore hindfoot anatomy, but the role of…
Parikh P, Zeilani M, Pieret A et al. · 2026 · Nutrition reviews
Malaria and malnutrition adversely affect maternal and neonatal health in Sub-Saharan Africa. While intermittent preventive treatment of malaria in pregnancy (IPTp) is widely used to reduce malaria incidence, the potential additional…
Eze CE, Alveo R, Barria L et al. · 2026 · Functional plant biology : FPB
Mitigating the negative impact of climate change on tropical forests requires a comprehensive understanding of the direct and indirect effects of climate variables such as temperature and vapor pressure deficit (VPD). We investigated the…
Cheung J, Huang T, Tarar A et al. · 2026 · Clinical nutrition ESPEN
Background Neurocritically ill patients often face challenges in achieving adequate nutrition due to hypermetabolism and feeding difficulties, which may influence neurological recovery and overall clinical outcomes. Methods This…
Emori H, Shiono Y, Yamanobe H et al. · 2026 · International journal of cardiology
Background Intravascular lithotripsy (IVL) and rotational atherectomy (RA) are established plaque-modifying strategies for heavily calcified coronary lesions. Despite their different mechanisms, the incidence of significant periprocedural…
Yushanaji B, Zhang X, Tian T et al. · 2026 · Animals : an open access journal from MDPI
This study tested the hypothesis that dietary L. acidophilus would improve nutrient utilization in yellow-feathered broilers mainly through intestinal changes rather than a consistent increase in growth performance. A total of 195…
Shaju A, Mishra BR, Mohapatra D et al. · 2026 · Journal of psychopharmacology (Oxford, England)
BackgroundRecent evidence increasingly links schizophrenia to mitochondrial dysfunction, implicating altered mitochondrial respiratory and metabolic processes in its pathophysiology. Preclinical data suggest that atypical antipsychotics…
Le Basle Y, Sautou V, Sarraute S et al. · 2026 · Biomedical materials (Bristol, England)
The study of extractable chemicals is used to evaluate whether a medical device contains harmful substances susceptible to migrate and contaminate the patients they are used in. The analysis of the biomaterial itself after extraction is…
Yılmaz T, Özdemir S · 2026 · Heart & lung : the journal of critical care
Background Norepinephrine is widely used as a first-line vasopressor in acute hypotension and septic shock. Its acute effects on electrocardiographic (ECG) parameters, particularly the frontal QRS-T angle, remain unclear. Objectives To…
Wentink N, van Gent M, Borns C · 2026 · The British journal of radiology
Objectives To quantify the reduction in effective dose achieved through organ dose modulation (ODM) on a General Electric Revolution Apex CT scanner, while preserving image quality. Methods First, the noise index (NI) corresponding to…
Pomierska M, Milska-Musa KA · 2026 · Preprint
Introduction: Pregnancy comes with many physical and mental changes, which can affect one’s sexual satisfaction, body image and general well-being. The aim of the study was to analyse these variables.Material and methods: The study was…
Abid R, Murphy RF, Hogue GD et al. · 2026 · Journal of pediatric orthopedics
Background Treatment options for early-onset scoliosis (EOS) are confounded by the risks associated with intervention at a younger age. Spinal instrumentation must be considered carefully due to potentially adverse effects to the spine,…
Hooper L, Erridge S, Clarke E et al. · 2026 · Brain and behavior
Introduction Migraine is a primary headache disorder, which leads to diminished health-related quality of life (HRQoL). There is limited evidence assessing efficacy of cannabis-based medicinal products (CBMPs) for migraine. This study…
Kato T, Motokawa T, Seto S et al. · 2026 · Preprint
Abstract Background Smartphone-based mental health applications are increasingly used for stress self-management; however, evidence from real-world settings remains limited, particularly for interventions combining subjective and…
Chaudhary H, Saeed S, Carroll A · 2026 · Irish medical journal
Aim This retrospective study aimed to evaluate changes in body mass index (BMI) and haemoglobin A1c (HbA1c) levels among children and adolescents with type 1 diabetes mellitus (T1DM) transitioning from multiple daily injections (MDI) to…
Fuse Y, Tsukada N, Yamaguchi M et al. · 2026 · Biological trace element research
Adequate iodine intake is essential for maintaining thyroid function. School meal iodine content (SMIC) is one of the main sources of iodine for schoolchildren. The median urinary iodine concentration (mUIC) in spot urine samples is a…
Milinski L, Nodal FR, King AJ et al. · 2026 · Preprint
Subjective tinnitus is the most common auditory phantom perception in the absence of an acoustic stimulus yet there is no cure nor widely effective treatment to date. Previously, we suggested that sleep may contribute to tinnitus…
Costa E, Vercoutere A, Alexander S et al. · 2026 · Preprint
Introduction During the COVID-19 pandemic, gestational diabetes mellitus (GDM) prevalence showed variable changes across regions, with most reporting increases and others decreases; anxiety and lifestyle modifications linked to…
Shen R, Yu Y, Ma Y et al. · 2026 · Biomolecules
Gatifloxacin (GTFX), a fourth-generation fluoroquinolone, causes metabolic disturbances in mammals, but its hepatotoxic mechanisms in aquatic vertebrates remain unclear. This study investigated whether GTFX induces liver injury in…
Yıldırım Erdal BD, Bayraktar S · 2026 · Turkish journal of ophthalmology
Objectives To investigate the effects of selective laser trabeculoplasty (SLT) on the iridocorneal angle, anterior chamber, and iris in patients with pseudoexfoliation glaucoma (PEXG) and to evaluate the relationship between these…
Streese L, Ritter ET, Schoch R et al. · 2026 · Journal of vascular research
Purpose We aimed to investigate the effect of different exercise modes on retinal microvascular endothelial function in patients with HF with preserved ejection fraction (HFpEF). Methods Twenty-eight patients were randomly allocated to…
Kumar D S, Dandekar S, Prakash GH · 2026 · BMC medical education
Background Antimicrobial resistance is a major global public health threat, necessitating improved antibiotic stewardship. India's Competency-Based Medical Education (CBME) framework requires robust methods to assess and cultivate clinical…
Hornemann A, Bosserhoff M, Coltan L et al. · 2026 · International urogynecology journal
Introduction and hypothesis This study investigates the postoperative mobility following partial semitendinosus tendon harvesting performed during pelvic organ prolapse (POP) repair using the Hornemann Tendon Transplantation (HoTT®)…
Sethi D, Prajapati S, Garg G · 2026 · Anesthesia and pain medicine
Background A few studies investigating the perioperative use of lung ultrasound (LUS) have shown loss of lung aeration with decline in diaphragmatic function after general anesthesia. We aimed to measure changes in lung aeration and…
Kume D, Horiuchi M, Nishiwaki M · 2026 · Microvascular research
Acute mental stress (MS) can impair macrovascular function, causing increased arterial stiffness and endothelial dysfunction; however, its effect on microvascular function remains largely unclear. This study examined the impact of acute MS…