Negative / Null Result ReportOpen accessMedicine
Giuseppe Carruba, Maria Luisa Calagna, Ildegarda Campisi et al. · 2022 · Diseases
This paper presents a multi-professional integrated approach toward the recognition and management of the nutritional and psychological needs of cancer patients. In particular, the patients undertook a multi-professional, multistep process that included the collection of both personal and clinical data, the evaluation of anthropometric measures, nutritional status and psychometric indices, and an ensuing personalized nutritional prescription and psychological support, ultimately leading to combined nutritional and psychological interventions to control their adherence to a nutritional program
View details →DOI: 10.3390/diseases10030047 Negative / Null Result ReportOpen accessMedicine
Davis C Woodworth, Adelle Dagher, Adam Curatolo et al. · 2018 · PLoS ONE
The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network has yielded neuroimaging and urinary biomarker findings that highlight unique alterations in brain structure and in urinary proteins related to tissue remodeling and vascular structure in patients with Urological Chronic Pelvic Pain Syndrome (UCPPS). We hypothesized that localized changes in diffusion tensor imaging (DTI) measurements might be associated with corresponding changes in urinary protein levels in UCPPS. To test this hypothesis, we created statistical parameter maps depicting the linear corre
View details →DOI: 10.1371/journal.pone.0206807 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Ji-Young Lee, Hae In Cho, Heejin Kimm · 2024 · European Journal of Breast Health
Objective: There have been inconsistencies in the evidence for a role of dietary patterns in the development of breast cancer. In this study, we used a large-scale cohort [Korean Cancer Prevention Study-II (KCPS-II)] to examine the association between dietary patterns and breast cancer risk in Korean women. Materials and Methods: The dietary patterns of 14,807 women from the KCPS-II were derived by factor analysis and 135 cases of breast cancer were diagnosed during the follow-up period. Cox proportional models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) fo
View details →DOI: 10.4274/ejbh.galenos.2024.2024-3-4 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Lívia Beraldo de LIMA, André MALBERGIER, Priscila Dib GONÇALVES et al. · 2025 · Arquivos de Gastroenterologia
ABSTRACT Background: Hepatitis C virus (HCV) infection remains a significant public health concern. Behavioral factors such as alcohol use and psychiatric comorbidities, particularly depression, may influence disease progression and eligibility for antiviral treatment. Objective: To assess the prevalence and clinical impact of current alcohol consumption in patients with chronic HCV infection eligible for treatment with direct-acting antivirals (DAAs), and to explore its associations with depressive symptoms and clinical characteristics. Methods: This was a cross-sectional study including 109
View details →DOI: 10.1590/s0004-2803.24612025-054 Negative / Null Result ReportOpen accessMedicine
Hana Wakasa, Satoshi Sunohara, Takashi Kimura et al. · 2025 · PLoS ONE
Obesity is a growing global health concern and has been associated with increased mortality from various cancer types, including hematological malignancies. However, evidence for this association in Asian populations, particularly among Japanese adults, remains limited. Thus, this study aimed to examine the association between obesity and mortality due to hematological malignancies. Data from 97,073 participants in the Japan Collaborative Cohort (JACC) Study were analyzed. The participants were followed for a mean duration of 17 years. Body mass index (BMI) was calculated using self-reported h
View details →DOI: 10.1371/journal.pone.0335750 Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Maha M. AlRasheed · 2022 · Saudi Pharmaceutical Journal
Background: The role of thyroid-stimulating hormone in the pathogenesis of thyroid cancer is not yet fully explored. This study aimed to evaluate the role of the TSH-β polymorphism in thyroid cancer in a Saudi cohort. Methods: A prospective case-control study was conducted on 507 patients with differentiated thyroid carcinoma and compared them with 560 controls of Saudi origin. The association of two variants, the rs201857310, and rs7530810, in the TSH-β gene with thyroid cancer risk as well as thyroxine dose, were evaluated. Results: The rs201857310_A > G [OR: 0.50 (95 % CI: 0.35–0.71); P < 0
View details →DOI: 10.1016/j.jsps.2022.07.015 Negative / Null Result ReportOpen accessNursing
Z Gharehboghlou, M Adib-Hajbaghery, M Hajimohammad Hoseini · 2016 · نشریه پرستاری ایران
Abstract Background & Aim: Depression is the fourth leading cause of community disability in the world and it has high prevalence among students. Since spirituality is positively associated to physical and mental health, this study aimed to determine the relationship of spiritual well-being and depression among nursing students in Qom and Kashan Universities of Medical Sciences. Materials & Methods: This cross-sectional study was conducted on nursing students of Kashan and Qom Universities of Medical Sciences. Using a two-stage sampling method, 250 nursing students were randomly selected. Data
Negative / Null Result ReportOpen accessAnesthesiology
Mayureshkumar Pareek, Vandana Parmar, Jigisha Badheka et al. · 2018 · Indian Journal of Anaesthesia
Background and Aims: Nurses should have cardiopulmonary resuscitation (CPR) knowledge and skills to be able to implement effective interventions during in-hospital cardiac arrest. The aim of this descriptive study was to assess mortality impact after nurses' CPR training with pre-CPR training data at our institute. Methods: Training regarding CPR was given to nurses, and CPR mortality 1-year before basic life support (BLS) and advanced cardiac life support (ACLS) training were collected and compared with post-training 1-year CPR mortality. Results: A total of 632 adult patients suffering in-ho
View details →DOI: 10.4103/ija.ija_17_18 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Elahe Kamali, Simin Hemmati, Forouzan Safari et al. · 2015 · The International Journal of Biological Markers
Numerous epidemiological studies have evaluated the association between transforming growth factor beta receptor type 1 ( TGFBR1 ) polymorphisms and the risk of cancer; however, the results remain inconclusive and controversial. To determine the association between breast cancer risk and the *6A polymorphism of the TGFBR1 gene, a case-control study of 280 breast cancer patients and 280 controls was performed in Iranian women. Our study demonstrates that women who carry the TGFBR1*6A allele are at lower risk of developing breast cancer. The highest protection against breast cancer was observed
View details →DOI: 10.5301/jbm.5000102 Negative / Null Result ReportOpen accessPublic aspects of medicine
A Aleyasin, M Ghazanfari, M Houshmand · 2010 · Iranian Journal of Public Health
"nBackground: Leber hereditary optic neuropathy (LHON) is an inherited form of bilateral optic atrophy leading to the loss of central vision. The primary cause of vision loss is mutation in the mitochondrial DNA (mtDNA), however, unknown secon­dary genetic and/or epigenetic risk factors are suggested to influence its neuropathology. In this study folate gene polymor­phisms were examined as a possible LHON secondary genetic risk factor in Iranian patients."nMethods: Common polymorphisms in the MTHFR (C677T and A1298C) and MTRR (A66G) genes were tested in 21 LHON pa
Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Jessica McIntyre, Rahaba Marima, Babatunde Alabi et al. · 2026 · Onco
Background: Cervical cancer is the second most prevalent malignancy among South African women, with high-risk human papillomavirus (HPV) infection as a critical risk factor. HPV plays a central role in cervical carcinogenesis, particularly in high-grade squamous intraepithelial lesions (HSIL). Increased programmed death ligand 1 (PD-L1) expression has been implicated in cervical carcinoma tumorigenesis. Using immunohistochemistry, this study investigated the correlation between high-risk HPV-driven cervical intraepithelial neoplasia (CIN) and PD-L1 expression. Methods: An analytical cross-sect
View details →DOI: 10.3390/onco6010014 Negative / Null Result ReportOpen accessFinance
Sayyede Elnaz Afzaliyan Boroujeni, Abdolmajid Abdolbaghi Ataabadi, Naser Khani · 2025 · Mathematics and Modeling in Finance
The present study aims to assess the impact of implied volatility (IV) extracted from call option prices on abnormal stock returns. IV, as a critical market volatility index, plays an essential role in explaining investor behavior. The Black-Scholes model was used to extract IV, applying Brent’s method due to the absence of an explicit closed-form solution. In addition, daily call option trading data from the Tehran Stock Exchange (TSE) were utilized during 2016-24. Further, quantile multivariate regression, along with wild bootstrap resampling (1,000 repetitions), was employed for model estim
View details →DOI: 10.22054/jmmf.2025.87610.1205 Negative / Null Result ReportOpen accessMedicine
Vivek Nagappa, Akhila Bhandarkar · 2025 · Journal of Family Medicine and Primary Care
Background: New research points to a complicated relationship between gallstone disease (GSD), thyroid function, and lipid profiles. To better understand how to prevent and treat GSD, this study will look at how common thyroid abnormalities are among people with the diagnosis, as well as any dyslipidemias that may be present. Material and Methods: This is a cross-sectional observational study worked out at a tertiary care hospital in southern India’s Department of General Surgery. We enrolled 60 persons with a GSD diagnosis. We divided patients with only gallstones and gallstones with common b
View details →DOI: 10.4103/jfmpc.jfmpc_1772_24 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Peipei Liu, Guoqing Dong, Mingzhu Li et al. · 2026 · Frontiers in Endocrinology
ObjectiveTo investigate the association between estrogen receptor β (ERβ) gene RsaI (rs1256049) and AluI (rs4986938) polymorphisms and the risk of idiopathic central precocious puberty (ICPP) in girls, and to provide potential molecular genetic references for early risk prediction and individualized management of ICPP.MethodsA total of 100 girls with ICPP from the Pediatric Endocrinology Clinic and Inpatient Ward of Shenzhen Maternity & Child Healthcare Hospital were enrolled, and 100 agematched healthy girls undergoing routine physical examinations during the same period served as controls. T
View details →DOI: 10.3389/fendo.2026.1809152 Negative / Null Result ReportOpen accessPublic aspects of medicine
Tao Yi, Zi Lin, Feng Hu et al. · 2025 · BMC Public Health
Abstract Background Data for the study cohort were sourced from the National Health and Nutrition Examination Survey (1999–2018). Study participants were classified as obese (BMI ≥ 30 kg/m²) or nonobese (BMI < 30 kg/m²) then further categorized as metabolically healthy or unhealthy on the basis of metabolic syndrome criteria, resulting in four groups: metabolically healthy obese (MHO), metabolically unhealthy obese (MUO), metabolically healthy nonobese (MHNO), and metabolically unhealthy nonobese (MUNO). Complex sampling statistical methods were employed for descriptive analysis. The associati
View details →DOI: 10.1186/s12889-025-22901-2 Negative / Null Result ReportOpen accessInternal medicine
Richard Lowry, Danice K. Eaton, Kathryn Foti et al. · 2012 · Journal of Obesity
Increasing attention is being focused on sleep duration as a potential modifiable risk factor associated with obesity in children and adolescents. We analyzed data from the national Youth Risk Behavior Survey to describe the association of obesity (self-report BMI ≥95th percentile) with self-reported sleep duration on an average school night, among a representative sample of US high school students. Using logistic regression to control for demographic and behavioral confounders, among female students, compared to 7 hours of sleep, both shortened (≤4 hours of sleep; adjusted odds ratio (95% con
View details →DOI: 10.1155/2012/476914 Negative / Null Result ReportOpen accessMedical emergencies. Critical care. Intensive care. First aid
Gustav Torisson, MD, PhD, Martin Bruun Madsen, MD, PhD, Agnes Schmidt Davidsen, MD et al. · 2021 · Critical Care Explorations
Objectives:. To explore the association between antibiotic combination therapy and in-hospital mortality in patients with septic shock in two tertiary ICUs in different countries. Design:. Retrospective observational study. Setting:. ICUs of two tertiary hospitals, Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia, and Rigshospitalet, Copenhagen, Denmark. Patients:. Adult patients with antibiotic treatment greater than or equal to 72 hours and vasopressor therapy greater than or equal to 24 hours. Intervention:. Combination versus mono antibiotic therapy. Measurements and Main Resu
View details →DOI: 10.1097/cce.0000000000000383 Negative / Null Result ReportOpen accessSurgery
Sandro Hügli, Philip C. Müller, Matthias Pfister et al. · 2023 · Transplantology
Background: Despite great progress in graft survival and complication rates, pronounced inflammatory responses are common after pancreas transplantation (PT). Subsequent to the first postoperative increase in inflammatory markers, we have frequently observed a second peak of C-reactive protein (CRP) and white blood cells (WBCs) following PT. This analysis is to assess the incidence and clinical relevance of late-onset increases in inflammatory markers following PT. Materials and methods: We analyzed all consecutive PTs over a 20-year period. The second peak of CRP (SCP) and WBCs (SWP) was defi
View details →DOI: 10.3390/transplantology4020010 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Haohui Zhu, Jianjun Yuan, Yisa Wang et al. · 2014 · Brazilian Journal of Infectious Diseases
Objective: To evaluate whether or not highly active antiretroviral therapy is associated with carotid artery stiffness in human immunodeficiency virus-positive patients in Henan Province, China. Method: Fifty human immunodeficiency virus-positive patients with at least a 5-year history of highly active antiretroviral therapy use and 50 human immunodeficiency virus-positive patients without a history of highly active antiretroviral therapy use were enrolled in this study. Carotid artery intima-media thickness and stiffness were determined by quantitative inter-media thickness and quantitative a
View details →DOI: 10.1016/j.bjid.2014.02.007 Negative / Null Result ReportOpen accessDentistry
Reza Pourabbas, Samin Farajzadeh, Amirreza Babaloo et al. · 2023 · Journal of Dental Research, Dental Clinics, Dental Prospects
Background. Studies have suggested a correlation between periodontitis and reduced male fertility. Inflammation has been described as the link between these ailments. Oral inflammatory load (OIL) can be measured through oral polymorphonuclear neutrophil (oPMN) count, which is associated with periodontal diseases. This cross-sectional study assessed the possible correlation between OIL and the functional parameters of sperm cells. Methods. In 229 volunteers, oral rinse and semen samples were assessed for oPMN, semen polymorphonuclears (sPMNs), sperm concentration, total sperm count, motility, m
View details →DOI: 10.34172/joddd.2023.37106 Negative / Null Result Report
S. Saini, Sarita Pandey, Kanika · 2026 · Journal of Clinical and Diagnostic Research
Introduction: Rehabilitation plays a vital role in managing Parkinson’s Disease (PD), particularly in addressing both motor and cognitive impairments. Dual Task Training (DTT) improves motor symptoms and cognitive performance, while…
View details →DOI: 10.7860/jcdr/2026/89283.23743 Negative / Null Result ReportOpen accessMedicine (General)
Katarzyna Budzynska, Daniel Passerman, Denise White-Perkins et al. · 2018 · BMC Family Practice
Abstract Background Colorectal cancer (CRC) develops from colorectal adenomatous polyps. This study is to determine if diabetes mellitus (DM), its treatment, and hemoglobin A1c (HbA1c) level are associated with increased risk of colorectal adenomatous polyps. Methods This was a retrospective cohort study that included patients who had at least one colonoscopy and were continuously enrolled in a single managed care organization during a 10-year period (2002–2012). Of these patients (N = 11,933), 1800 were randomly selected for chart review to examine the details of colonoscopy and pathology fin
View details →DOI: 10.1186/s12875-018-0835-1 Negative / Null Result ReportOpen accessPsychiatry
U. Raja, A. Misra, N. Kar · 2024 · European Psychiatry
Introduction The Crisis and Home Treatment Teams (CRHT) in psychiatry manages patients with risk to self and others in the community. The number of patents under CRHT who attempt or die of suicide is high in the UK (Hunt et al BJPsych Bull. 2016;40:172-4). The CRHT is an option to help support patients in managing their risk using various interventions and also aim to prevent admission to acute psychiatric wards where possible. Objectives We intended to study the change in risk to self and others and the factors associated with it during the intervention from a CRHT taking care of adult patien
View details →DOI: 10.1192/j.eurpsy.2024.1188 Negative / Null Result ReportOpen accessMedicine
Hoda Shamsaddin, Fatemeh Jahanimoghadam, Hamidreza Poureslami et al. · 2017 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Early childhood caries (ECC) is a specific form of rampant dental caries affecting infants and young children. ECC is still a problem that threatens the health of the community and its management is important. It is believed that the majorities of children with ECC also suffer from malnutrition, anemia, low weight and altered physical growth patterns. This study was undertaken to compare blood indices [mean corpuscular volume (MCV), hemoglobin and serum ferritin] in a population of children in Kerman, Iran, and the association between growth factors, blood parameters, and E
Negative / Null Result ReportOpen accessMedicine
Yousef Roosta, Ahmad Nazarpour, Farhad Behzadi et al. · 2025 · Disease and Diagnosis
Background: The number of individuals undergoing dialysis is rising. Impaired renal function has been linked to a heightened risk of cancer. This study aimed to examine cancer incidence among hemodialysis (HD) patients. Materials and Methods: This retrospective cross-sectional study analyzed the medical records of individuals with newly diagnosed end-stage renal disease (ESRD) who initiated HD sessions between July 2018 and December 2023 at Urmia Imam Khomeini hospital. The data collected for this study included patient demographics, underlying diseases, malignancy status, and duration of mali
View details →DOI: 10.34172/ddj.1643 Negative / Null Result ReportOpen accessOrthopedic surgery
Koichiro Yanai, MD, Tsuyoshi Tajika, MD, PhD, Yuhei Hatori, MD et al. · 2025 · JSES International
Background: An increase in carrying angle (CA) on the throwing side has been reported in professional baseball pitchers. However, no reports have investigated high school baseball pitchers, and the associated factors remain unknown. This study aimed to examine the difference in the CA between the throwing and nonthrowing sides in high school baseball pitchers and to investigate the association between the CA and medial instability of the elbow and general joint laxity (GJL). Methods: We surveyed 216 high school baseball pitchers who underwent medical checkups during the 2023-24 off-season. All
View details →DOI: 10.1016/j.jseint.2025.02.023 Negative / Null Result ReportOpen accessMedicine (General)
Shichong Jia, Xuyang Wen, Min Zhou et al. · 2021 · Frontiers in Medicine
Purpose: To evaluate the efficacy of an external carotid artery (ECA) alternative route in intra-arterial chemotherapy (IAC) for treatment of retinoblastoma.Methods: In this retrospective, single-centre, case-control study, 98 retinoblastoma patients who received successful IAC were included. The drug delivery routes were the primary ophthalmic artery (OA) route and the ECA route when OA catheterization was not feasible.Results: A total of 337 successful IAC procedures were performed in our study, of which 32 (9.5%) procedures were performed through the ECA route. Eighteen eyes (18.4%) accepte
View details →DOI: 10.3389/fmed.2021.658305 Negative / Null Result ReportOpen accessMedicine
Arno C Hessels, Abraham Rutgers, Jan Stephan F Sanders et al. · 2018 · PLoS ONE
Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations. We investigated whether these associations also exist for ANCA associated vasculitis (AAV) patients, who receive azathioprine maintenance therapy after remission induction with cyclophosphamide.207 AAV patients treated with cyclophosphamide induction and azathioprine maintenance therapy were included and followed for 60 months. TPMT genotype and tertiles of TPMT activity we
View details →DOI: 10.1371/journal.pone.0195524 Negative / Null Result ReportOpen accessMedicine (General)
Almansour A, Alagil J, Alamoudi NB et al. · 2022 · Journal of Multidisciplinary Healthcare
Abdulelah Almansour,1 Jumana Alagil,2 Naela B Alamoudi,3 Rahmah M Alamrie,3 Sundus Alarifi,4 Sarah AlUrifan,4 Abdullatif Althunyan,1 Abdullah Alghumlas,1 Abdullah Alreedy,1 Adam Aldhawyan,1 Shaher Alshehri,1 Arwa Alumran5 1Family and Community Medicine Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 2College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 3College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia; 4General Dentist, Ministry of Health, Dammam, Saudi Arabia; 5Health Information Man
Negative / Null Result ReportOpen accessPublic aspects of medicine
Ulrike Stentzel, Jeanette Bahr, Daniel Fredrich et al. · 2018 · BMC Health Services Research
Abstract Background In rural regions with a low population density, distances to health care providers as well as insufficient public transport may be barriers for the accessibility of health care. In this analysis it was examined whether the accessibility of gynecologists and GPs, measured as travel time both by car and public transport has an influence on the utilization of health care in the rural region of Western Pomerania in Northern Germany. Methods Utilization data was obtained from the population based Study of Health in Pomerania (SHIP). Utilization was operationalized by the paramet
View details →DOI: 10.1186/s12913-018-3143-5 