Evaluation of genetic correlation with fluoroquinolones resistance in rifampicin-resistant Mycobacterium tuberculosis isolates
Chong Teng; Ling Li; Dan Su; Hui Li; Bing Zhao; Hui Xia; Hui Teng; Yuanyuan Song · 2024 · Heliyon
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Objective: To detect levofloxacin (LFX) and moxifloxacin (MFX) resistance among rifampicin-resistant tuberculosis (RR-TB) isolates, and predict the resistance level based on specific mutations in gyrA and gyrB genes. Methods: A total of 686 RR-TB isolates were collected from Chinese Drug Resistance Surveillance Program from 2013 to 2020. The minimum inhibitory concentrations (MICs) of 12 anti-TB drugs were acquired using the broth microdilution method, followed by whole genome sequencing (WGS) analysis. Results: Among the 686 RR isolates, the most prevalent resistance was to isoniazid (80.5 %)
Abstract by Chong Teng; Ling Li; Dan Su; Hui Li; Bing Zhao; Hui Xia; Hui Teng; Yuanyuan Song, Heliyon (2024) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1016/j.heliyon.2024.e31959