e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21733 results · page 474 of 725

Negative / Null Result Report

Switch to generic formulation of temozolomide results in statistically significant increase in grade 3 and 4 bone marrow toxicity in glioma patients in the province of Alberta

Egiroh Omene, Omar Abdel-Rahman, Eugene Batuyong et al. · 2023 · Neuro-Oncology Practice

Abstract Background Temozolomide (TMZ) is an oral, systemic chemotherapy used chiefly for treating high-grade glioma. Due to the rising costs of systemic chemotherapy, many jurisdictions have replaced brand name with generic formulations.…

View details →DOI: 10.1093/nop/npad065
Negative / Null Result Report

Abstract P142: A Statistically Significant Reduction in Heart Failure Length of Stay: Moving the Mean Through Process Improvement

Carolyn M Moffa, William Weintraub, Rocco A DeMaio et al. · 2011 · Circulation: Cardiovascular Quality and Outcomes

Background: The burden of acute heart failure (HF) remains formidable. Length of stay (LOS) must be minimized to control costs, while still maintaining positive outcomes. Inappropriate diagnoses and the lack of coordinated care remain…

View details →DOI: 10.1161/circoutcomes.4.suppl_1.ap142
Negative / Null Result Report

Clariant's third quarter 2019 results demonstrate ‘resilience’

· 2019 · Additives for Polymers

Switzerland's Clariant reported sales from continuing operations of CHF1.043 billion (c. €960 million) for the third quarter of 2019, a decline of 1% from sales of CHF1.054 billion in 3Q 2018 but an increase of 2% in local currency terms.…

View details →DOI: 10.1016/s0306-3747(19)30231-3
Negative / Null Result Report

Techniques to demonstrate immunoproteasome in retinal functions

D FERRINGTON · 2013 · Acta Ophthalmologica

Abstract The catalytic core of the proteasome contains three pair of catalytic subunits that perform distinct proteolytic activities referred to as caspase‐like, trypsin‐like, and chymotrypsin‐like. In the standard proteasome, the…

View details →DOI: 10.1111/j.1755-3768.2013.3253.x
Negative / Null Result Report

Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes

Douglas E. Barre, Kazimiera A. Mizier-Barre, Odette Griscti · 2025 · Endocrine Regulations

Abstract Objective. The objective of the present study was to determine if there would be statistically significant differences among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in persons…

View details →DOI: 10.2478/enr-2025-0016
Negative / Null Result Report

Dysregulation of LYN Gene Expression in Melanoma Patients: A Statistically Significant Association with Clinical Outcomes

Maryam Khalid, Sadia Tameez Ud Din, Mumtaz Hussain et al. · 2025 · South Eastern European Journal of Public Health

Skin cancer accounts for one-third of all diagnosed cancers, with 132,000 new cases of melanoma detected each year (1). By 2040, the melanoma burden is projected to reach 510,000 new cases (a 50% increase) and 96,000 deaths (a 68%…

View details →DOI: 10.70135/seejph.vi.5288
Negative / Null Result ReportOpen accessMedicine

Study preregistration: an early example and analysis.

Wiseman R, Watt C · 2026 · PeerJ

Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…

View details →DOI: 10.7717/peerj.21360
Abandoned Hypothesis

Editorial Commentary: Anterolateral Ligament: How Do We Find It?

Nikhil N. Verma · 2016 · Arthroscopy

Abstract There is considerable current interest in the role of the anterolateral ligament in persistent instability after anterior cruciate ligament reconstruction. The normal ligament may be identified using magnetic resonance imaging or…

View details →DOI: 10.1016/j.arthro.2015.11.012
Negative / Null Result Report

Apathy - where do we find it and how to treat

R. Gomes, C. Santos, N. Descalço et al. · 2022 · European Psychiatry

Introduction Although defined heterogeneously within the literature apathy is classified as a multidimensional deficit with emotional, behavioral, and cognitive domains in which there is a decrease in self-motivated/goal-directed activity.…

View details →DOI: 10.1192/j.eurpsy.2022.2275
Negative / Null Result Report

Distance Measurement Between a Camera and a Human Subject Using Statistically Determined Interpupillary Distance

Marinel Costel Temneanu, Codrin Donciu, Elena Serea · 2025 · AppliedMath

This paper presents a non-intrusive method for estimating the distance between a camera and a human subject using a monocular vision system and statistically derived interpupillary distance (IPD) values. The proposed approach eliminates…

View details →DOI: 10.3390/appliedmath5030118
Negative / Null Result Report

Can we find early phase biomarkers for ALS: What are the prospects and challenges?

Christopher A. Shaw, Ceilidh Beck, Leal Marakoff · 2025 · Exploration of Neuroprotective Therapy

Age-related neurological disorders such as ALS (Lou Gehrig’s disease), Parkinson’s disease, and Alzheimer’s disease have few truly effective treatment options. At best, these may slow the inexorable disease progression without providing a…

View details →DOI: 10.37349/ent.2025.1004133
Negative / Null Result Report

Motor Imaginary Task Classification using Statistically Significant Time Domain and Frequency Domain EEG features

Murside Degirmenci, Yilmaz Kemal Yuce, Yalcın Isler · 2022 · Akıllı sistemler ve uygulamaları dergisi

Motor Imaginary (MI) electroencephalography (EEG) signals are obtained when a subject imagines a task without essentially applying it. The accurate decoding of MI EEG signals plays an important role in the design of brain-computer…

View details →DOI: 10.64799/joiswa.v5.i1.10
Negative / Null Result Report

Can education quality be statistically measured?

Ekaterina Bagrova, Sergei Kruchinin · 2021 · SHS Web of Conferences

Currently there are many theories about quality education. The paper presents some of them. It also includes some points of Deming’s philosophy and statistical indicators implemented to determine lecturers’ achievements in Russian higher…

View details →DOI: 10.1051/shsconf/20219402003
Negative / Null Result Report

Startle response and its prepulse modification in health and under different psychopathologies: Could we find any specific patterns?

Zinaida I Storozheva · 2025 · World Journal of Psychiatry

The startle response (SR) is a generalized defensive response elicited by the presentation of a sudden intense stimulus. The presentation of a less intense signal (prepulse) before the central stimulus (pulse) affects the amplitude and…

View details →DOI: 10.5498/wjp.v15.i8.107791
Negative / Null Result Report

Knowledge of General Practitioner Doctors and Midwives Who Has and Has Not Attended Neonatal Resuscitation Course Has No Significant Difference

Vincent Geraldus Enoch Lusida, Bambang Puijo Semedi, Bambang Herwanto · 2020 · Indonesian Journal of Anesthesiology and Reanimation

Introduction: Infant death is most prominent in the neonatal period. The success of neonatal resuscitation practice has many contributing factors. One of which is the health workers’ knowledge of the Neonatal Resuscitation Program (NRP)…

View details →DOI: 10.20473/ijar.v1i22019.38-42
Negative / Null Result Report

Abstract P200: Oscillometric Ambulatory Blood Pressure Monitors Are Prone To Clinically & Statistically Significant Errors When Tested In A Controlled Laboratory Setting

V. P Lombardi, Patrick C Reichhold, Jennifer L Cramer et al. · 2020 · Hypertension

Purpose: To compare the accuracy & level of agreement of Oscar 2 & Spacelabs 90207 ABPMs with 2 observers (O1O2) using an Hg column & ThinkLabs digital stethoscope. Methods: O1O2 measured simultaneous same arm Hg column BPs & ABPMs…

View details →DOI: 10.1161/hyp.76.suppl_1.p200
Negative / Null Result Report

P-B02 Does the length of alimentary limb make a significant difference in the weight loss in Roux en y gastric bypass patients?

Mayank Bhandari, Sabyasachi Chowdhary, Milind Rao et al. · 2021 · British Journal of Surgery

Abstract Background Roux en Y gastric bypass (RYGB) surgery for morbid obesity is considered as gold standard, but there can be a difference in the length of alimentary and biliopancreatic limb to achieve optimum weight loss. Till now…

View details →DOI: 10.1093/bjs/znab430.001
Negative / Null Result Report

Statistically significant improvement in hemophilia A control: a retrospective analysis of the effectiveness and safety of emicizumab in children with severe and inhibitor forms of hemophilia A

V. Yu. Petrov, I. N. Lavrentyeva, V. V. Vdovin et al. · 2024 · Pediatric Hematology/Oncology and Immunopathology

Hemophilia A presents a serious problem, especially in its severe and inhibitor forms, leading to severe bleeding and complications. The importance of studying the effectiveness and safety of new treatment approaches, particularly…

View details →DOI: 10.24287/1726-1708-2024-23-1-99-107
Negative / Null Result Report

Can We Still Find an Ideal Memristor?

Frank Zhigang Wang · 2024 · Magnetism

In 1971, Chua defined an ideal memristor that links magnetic flux φ and electric charge q. In a magnetic lump with a current-carrying conductor, we found that the direct interaction between physical magnetic flux φ and physical electric…

View details →DOI: 10.3390/magnetism4030014
Abandoned Hypothesis

Before We Can Find a Model, We Must Forget about Perfection

Dimiter Dobrev · 2022 · Serdica Journal of Computing

With Reinforcement Learning we assume that a model of the world does exist. We assume furthermore that the model in question is perfect (i.e. it describes the world completely and unambiguously). This article will demonstrate that it does…

View details →DOI: 10.55630/sjc.2021.15.85-128
Negative / Null Result Report

Can we find accessible and relevant markers for sepsis outcome?

Andreea Paula Cioară, Mirela Flonta, Astrid Binder et al. · 2017 · Revista Romana de Medicina de Laborator

Abstract Background and Aim: Sepsis is a life-threatening disease with high mortality, therefore establishing early diagnostic and finding reliable prognostic biomarkers is vital. We aimed to investigate the prognostic role, as a single…

View details →DOI: 10.1515/rrlm-2017-0005
Negative / Null Result Report

This study examined belief, concern, and practice of the in-service postgraduate science teachers towards solid waste management and recycle (SWMR) in one of the colleges of education in Bhutan. A structured online survey questionnaire was administered to 39 first-year in-service science teachers out of which 22 (13 male and 9 female) responded. The data were subjected to descriptive statistics su

Sherab Jatsho1, Sonam Dhendup · 2021 · Contemporary Education and Teaching Research

This study examined belief, concern, and practice of the in-service postgraduate science teachers towards solid waste management and recycle (SWMR) in one of the colleges of education in Bhutan. A structured online survey questionnaire was…

View details →DOI: 10.47852/bonviewcetr2021020102
Negative / Null Result ReportMedicine

Parental oral health knowledge and sociodemographic influences in children aged 2-12 years: a cross-sectional study in Valencia, Spain.

Borrell-García, Mestanza-Tocto, Boo-Gordillo et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

The present study aimed to assess parental knowledge of paediatric oral health among parents and guardians of children aged 2-12 years in Valencia, Spain, and to analyse its association with key sociodemographic variables. A…

View details →DOI: 10.1007/s40368-026-01240-9
Negative / Null Result Report

Investigations for Statistically Controlled TIG Welding Solution of 304 SS

Rupinder Singh · 2014 · Asian Review of Mechanical Engineering

The purpose of the present investigations is to study statistically controlled solution (from sensitization point of view) for 304 stainless steel (ss) joints using tungsten inert gas welding (tig) process. starting from the parametric…

View details →DOI: 10.51983/arme-2014.3.2.2386
Negative / Null Result Report

The history of statistics in statistically valid regulation

Christopher J. Phillips · 2026 · BJHS Themes

Abstract This paper uses the introduction at the US Food and Drug Administration of dose–response extrapolation for ascertaining toxicity between 1950 and 1980 to analyse the negotiations between statistical knowledge and regulation. Those…

View details →DOI: 10.1017/bjt.2026.10034