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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19878 results in Negative / Null Result Report · page 472 of 663

Negative / Null Result ReportOpen access

A pilot, double blind randomised controlled trial of prednisolone for women with recurrent miscarriage and raised uterine natural killer cell density [Abstract]

Dawood, Feroza, Farquharson, Roy G., Turner, M. A. et al. · 2011

Introduction: Multiple trials of immunotherapy for reproductive failure have failed to demonstrate significant benefit. A reason for this may be the lack of a test that selects which women will benefit from treatment. High density of…

View details →DOI: 10.1093/humrep/26.s1.34
Negative / Null Result ReportOpen access

Good laboratory practice: preventing introduction of bias at the bench

Macleod, Malcolm R.; id_orcid, Donnan, Geoffrey A., Traystman, RJ et al. · 2009

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating…

View details →DOI: 10.1038/jcbfm.2008.101
Negative / Null Result ReportOpen access

Subscriptions: Information about subscribing to Stroke is online at at UNIV OF EDINBURGH on Comments, Opinions, and Reviews Good Laboratory Practice Preventing Introduction of Bias at the Bench

Marc Fisher, Ulrich Dirnagl, Geoffrey A Donnan et al. · 2020

Background and Purpose-As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review-Accumulating…

Negative / Null Result ReportOpen access

Feasibility of progesterone treatment for ischaemic stroke

Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…

Negative / Null Result ReportOpen access

Feasibility of progesterone treatment for ischaemic stroke

Claire L. Gibson (6162488), Philip M. Bath (3111867) · 2015

Two multi-centre phase III clinical trials examining the protective potential of progesterone following traumatic brain injury have recently failed to demonstrate any improvement in outcome. Thus, it is timely to consider how this impacts…

Negative / Null Result ReportOpen access

Intra Vascular Ultra Sound: One More Tool to Diagnose Aorto-duodenal Fistula

Maternini, M., Von Segesser, L.K., Tozzi, P. et al. · 2006

The incidence of aorto-enteric fistula in the first 5 years after abdominal aortic replacement ranges from 0.3 to 2%. We present a clinical case in which all conventional diagnostic tools failed to demonstrate the aorto-enteric fistula. A…

View details →DOI: 10.1016/j.ejvs.2006.05.011
Negative / Null Result ReportOpen access

Early effect of moderate altitude stress on plasma potassium in the dog

Armand J. Gold, Jeanne Q. Barry, Frederick P. Ferguson · 1960

Exposure of dogs to a simulated altitude of 30,000 feet for 30 minutes resulted in marked respiratory alkalosis and hypokalemia. The data failed to demonstrate, however, the appearance of the early transient hyperkalemic response which has…

View details →DOI: 10.1152/jappl.1960.15.1.37
Negative / Null Result ReportOpen access

Influence of Job Familiarity on Job Evaluation Ratings

Kaupins, Gundars · 1990

The effect of job familiarity on job evaluation ratings was investigated. Data came from a survey of 222 personnel specialists and middle to upper level managers. The results failed to show significant associations between various measures…

View details →DOI: 10.19030/jabr.v6i3.6293
Negative / Null Result ReportOpen access

Is there any role for the Hydroxychloroquine (HCQ) in refractory obstetrical antiphospholipid syndrome (APS) treatment?

Botta, Angela, De Carolis, S, Botta, A. et al. · 2015

The best therapy regimen for refractory obstetrical antiphospholipid syndrome remains to be determined. Additional treatments with steroids, plasma exchanges and immunoglobulins failed to show any beneficial effect. We present a case of a…

View details →DOI: 10.1016/j.autrev.2015.04.010
Negative / Null Result ReportOpen access

Carbon dioxide-induced amnesia in the cockroach Periplaneta americana

Wahlsten, Douglas, NC DOCKS at The University of North Carolina at Greensboro · 1968

Cockroaches (Periplaneta americana) learned to passively avoid electric shock in a two-compartment box after a single training trial. However, Ss exposed to CO2 gas immediately after the training trial failed to show retention of the…

Negative / Null Result ReportOpen access

Risk of dementia hospitalisation associated with cardiovascular risk factors in midlife and older age: the Atherosclerosis Risk in Communities (ARIC) study

Mosley, T H, Catellier, D, Sharrett, A R et al. · 2009

Cardiovascular risk factors are associated with a higher risk of developing dementia. Studies in older populations, however, have often failed to show this relationship. We assessed the association between cardiovascular risk factors…

View details →DOI: 10.17615/9nxm-j737
Negative / Null Result ReportOpen access

Patent foramen ovale : story closed?

Schellinger, Peter Dieter, Steiner, Thorsten, Köhrmann, Martin et al. · 2019

The optimal treatment strategy for secondary prevention in patients with cryptogenic stroke and patent foramen ovale (PFO) has been a matter of controversy for decades. After three randomized trials failed to show a benefit of closure with…

View details →DOI: 10.5853/jos.2018.03097