Negative / Null Result Report
li j, Chen Y, Chen Y et al. · 2026 · Preprint
Abstract Objective To investigate the association between perioperative hypothermia and postoperative muscular calf vein thrombosis (MCVT) in patients undergoing total knee arthroplasty (TKA), and to evaluate the predictive performance of…
View details →DOI: 10.21203/rs.3.rs-9873445/v1 Negative / Null Result ReportMedicine
Doğan D, Öksüz C, Çakır Ö et al. · 2026 · Biomedicines
Background/Objectives: Differentiating mediastinal lymphadenopathy associated with lung cancer from sarcoidosis remains a clinical challenge because of overlapping imaging findings. This study evaluated whether CT-derived radiomic…
View details →DOI: 10.3390/biomedicines14061327 Negative / Null Result ReportMedicine
Partoazar A, Shahabi S, Afrasiabi S · 2026 · BMC oral health
Background Biofilms contribute to the dental calculus formation, which in turn deteriorates oral and systemic health. The use of antimicrobial photodynamic therapy (PDT) may be limited by problems with photosensitizer penetration. In…
View details →DOI: 10.1186/s12903-026-09022-x Negative / Null Result ReportMedicine
Lipa AJ, Janata-Schwatczek K, Sterz M et al. · 2026 · Seminars in thrombosis and hemostasis
Pulmonary embolism (PE) in octogenarians (i.e., patients > 80 years) is associated with substantial morbidity and mortality, yet this population remains underrepresented in major studies. We compared the predictive performance of the…
View details →DOI: 10.1055/a-2896-8297 Negative / Null Result ReportMedicine
Chen W, Ge X, Hu C et al. · 2026 · Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Prospective studies are necessary to determine the association between circulating proteins and colorectal cancer (CRC) risk, offering non-invasive biomarkers for early CRC risk prediction and interventions. The Olink Explore-3072 platform…
View details →DOI: 10.1158/1055-9965.epi-26-0341 Negative / Null Result ReportMedicine
Umer H, Mumtaz T, Weiskirchen R et al. · 2026 · Chronobiology international
Disruption of circadian rhythm is common in rotating shift workers, individuals with jet lag, and people with irregular sleep schedules and contributes to metabolic diseases including obesity, type 2 diabetes, metabolic…
View details →DOI: 10.1080/07420528.2026.2681614 Negative / Null Result ReportMedicine
Liu Y, Tao G, Zhao Y et al. · 2026 · Frontiers in medicine
Objective To characterize choroidal structural and perfusion changes in children with emmetropia, low myopia, and moderate myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) and optical coherence tomography…
View details →DOI: 10.3389/fmed.2026.1861658 Negative / Null Result ReportMedicine
Kurogochi K, Stern JA, DeFrancesco TC et al. · 2026 · Journal of the American Veterinary Medical Association
Objective The T-wave peak-end (TpTe) interval and its ratio to the QT interval (TpTe:QT) are ECG markers of myocardial repolarization dispersion. We hypothesized that these markers are associated with echocardiographic indices reflecting…
View details →DOI: 10.2460/javma.25.12.0802 Negative / Null Result ReportOpen accessMedicine
Eydou Z, Garber S, Sikkema M · 2026 · Cureus
Fusobacterium necrophorum is a recognized cause of brain abscesses and has been classically associated with Lemierre syndrome. We report a case of a 17-year-old male patient who presented with seizures, fever, and altered mental status…
View details →DOI: 10.7759/cureus.108808 Negative / Null Result Report
Szeto CYY, Kwan HS · 2026 · Preprint
Dietary and lifestyle microbiome interventions often produce mild but heterogeneous remodeling rather than uniform community shifts. In this setting, scalar diversity or group-level summaries can appear weak or inconclusive even when…
View details →DOI: 10.64898/2026.05.22.726133 Negative / Null Result ReportOpen accessMedicine
Boualia B, Sandeli A, Boulebd H et al. · 2026 · ACS omega
In this research, we present the successful synthesis of benzimidazolium salts ( 2a - e ) and their corresponding selenium-NHC adducts ( 3a - e ), achieved with satisfactory yields ranging from 75% to 88%, and characterized using…
View details →DOI: 10.1021/acsomega.5c10880 Negative / Null Result ReportOpen accessMedicine
Qaid MM, Al-Garadi MA, Al-Abdullatif AA et al. · 2026 · Poultry science
Coccidiosis remains a major constraint in poultry production; therefore, this study evaluated the anticoccidial efficacy of a phytogenic blend of cinnamon bark and Rumex nervosus leaf in Eimeria tenella-challenged broilers. Birds were…
View details →DOI: 10.1016/j.psj.2026.107288 Negative / Null Result ReportOpen accessMedicine
Hayashi E, Kano H, Nakamura K et al. · 2026 · Respirology case reports
Small-cell lung cancer (SCLC) has a poor prognosis, and the efficacy of tarlatamab for untreated brain metastases remains unclear. We report a case demonstrating a discrepant response between extracranial and intracranial lesions after…
View details →DOI: 10.1002/rcr2.70615 Negative / Null Result ReportMedicine
Wei X, Xue M, Fan B et al. · 2026 · BMC pulmonary medicine
Background Long-term changes in lung function in children with symptom control asthma are rare. To assess the trajectory of pulmonary function in children and analyze the influence factors. Methods The effects of gender, age, Body Mass…
View details →DOI: 10.1186/s12890-026-04442-5 Negative / Null Result ReportMedicine
Eltahir M, Young K, Younes S et al. · 2026 · American journal of clinical pathology
Objectives Determination of B-cell clonality in formalin-fixed, paraffin-embedded tissues is challenging, especially in cases where tumor B cells are sparse. Flow cytometry is of limited utility in Hodgkin lymphomas, at least in part due…
View details →DOI: 10.1093/ajcp/aqag043 Negative / Null Result ReportMedicine
Hauck F, Herber V, Moecke S et al. · 2026 · International journal of oral implantology (Berlin, Germany)
Purpose The aim of this pilot preclinical study was to investigate the performance of a novel double-lead thread, conical bone-level ceramic implant manufactured by injection moulding (test group) in comparison to a well-established…
Negative / Null Result ReportMedicine
Uğurlu İ · 2026 · Journal of clinical laboratory analysis
Background Apelin-13 and Galectin-3 (Gal-3) are bioactive mediators linked to inflammation and cardiometabolic pathways. Their clinical utility in COVID-19 alongside routine laboratory tests remains unclear. Methods In this case-control…
View details →DOI: 10.1002/jcla.70284 Negative / Null Result Report
Yang B, Guo Y, Li J et al. · 2026 · Preprint
Abstract Purpose This study presents the first national-scale assessment of heavy metal contamination, ecological risks, and human health implications in paired park surface dust and soil across 40 Chinese cities over a 15 years period…
View details →DOI: 10.21203/rs.3.rs-10000272/v1 Negative / Null Result Report
Rouzic FL, Lacroix J, Ehrmann A et al. · 2026 · Preprint
Abstract Background Several walking tests assess mobility and fall-related function in older adults, but their clinimetric properties remain insufficiently documented across task conditions and assessment environments. Augmented reality…
View details →DOI: 10.21203/rs.3.rs-9912780/v1 Negative / Null Result ReportMedicine
Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…
View details →DOI: 10.1016/j.ijid.2026.108923 Negative / Null Result ReportOpen accessMedicine
Feng K, Bao Y, Ren J et al. · 2026 · Life (Basel, Switzerland)
MicroRNA (miRNA) regulation plays a pivotal role in intracellular gene expression. Analysis of miRNA profiles can provide critical insights into disease states. As cancer-associated molecules reported in previous studies, miRNAs may serve…
View details →DOI: 10.3390/life16050850 Negative / Null Result ReportMedicine
Khan H, Collela Be M, Khan Z et al. · 2026 · BMC plant biology
Background Sowing period has a considerable effect on cotton productivity by regulating the use of thermal resources, but its effect on various soils depth layers has not been properly measured. The current study investigated the impacts…
View details →DOI: 10.1186/s12870-026-08648-x Negative / Null Result ReportMedicine
Riehm A, Senicourt L, O'Shaughnessy E et al. · 2026 · Diagnostic and interventional imaging
Purpose The purpose of this study was to develop a machine learning-based algorithm based on a combination of magnetic resonance imaging (MRI) and color-Doppler ultrasound (CDUS) to characterize lacrimal gland lesions. Materials and…
View details →DOI: 10.1016/j.diii.2026.06.001 Negative / Null Result Report
Tran K · 2026 · Preprint
Abstract Objective: The aperiodic (1/f) component of the EEG power spectrum indexes the cortical excitation-to-inhibition (E:I) ratio and is predicted to be progressively altered by amyotrophic lateral sclerosis (ALS), a disease defined by…
View details →DOI: 10.21203/rs.3.rs-9903869/v2 Negative / Null Result Report
Kawakami H, Yuasa H, Kuroda H et al. · 2026 · Preprint
Terrestrial environmental DNA (eDNA) approaches are rapidly expanding, yet robust, field-ready substrates for detecting insect DNA remain limited in forest ecosystems. Tree sap is a localized microhabitat that attracts diverse insects and…
View details →DOI: 10.64898/2026.05.16.724188 Negative / Null Result Report
Cao C, Ma S · 2026 · Preprint
Short-term environmental exposures have been linked to cognitive and behavioral outcomes, although many reported associations may reflect broader geographic and contextual differences. Using longitudinal data from the All of Us Research…
View details →DOI: 10.64898/2026.06.18.26355982 Negative / Null Result Report
Itoh K, Otsuki N, Tsutani H et al. · 2026 · Preprint
Background: Recurrent pneumonia during antimicrobial therapy in patients receiving chemotherapy can be difficult to interpret. It may reflect persistence of the initial pathogen, inadequate antimicrobial exposure, noninfectious mimics,…
View details →DOI: 10.1099/acmi.0.001263.v1 Negative / Null Result ReportMedicine
Yılmaz NA · 2026 · Clinical oral investigations
Objectives This study evaluated the effects of two universal adhesives, applied under three protocols, self-etch (SE), conventional total-etch (CTE), and modified total-etch (MTE) with 1% (w/v) gallic acid, on shear bond strength (SBS),…
View details →DOI: 10.1007/s00784-026-06987-5 Negative / Null Result Report
Tatsuki O · 2026 · Preprint
Abstract Background Discrepancies between observational and randomized controlled trial (RCT) meta-analyses are typically attributed to confounding. An alternative explanation — that RCTs systematically exclude high-risk patients, causing…
View details →DOI: 10.21203/rs.3.rs-9420092/v1 Negative / Null Result ReportMedicine
Fyrand K, Xu C, Evensen Ø · 2026 · Fish & shellfish immunology
Streptococcus agalactiae serotype Ia is a major bacterial pathogen in Nile tilapia (Oreochromis niloticus), and vaccines for juvenile fish, especially immersion vaccines, remain unavailable. We evaluated live attenuated vaccine candidates…
View details →DOI: 10.1016/j.fsi.2026.111401 