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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21322 results · page 448 of 711

Negative / Null Result Report

Predictive Value of Polypharmacy and Inappropriate Medication Use in Older Emergency Department Patients: A Retrospective Observational Study

Holstein R, Hongisto M, Jämsen E et al. · 2026 · Preprint

Abstract Background. Polypharmacy and potentially inappropriate medication (PIM) use are well-known risk factors for drug-related problems among older adults, but their association with clinical outcomes of older emergency department (ED)…

View details →DOI: 10.21203/rs.3.rs-9326583/v1
Negative / Null Result ReportMedicine

The temporal interplay between physical activity, emotional well-being, and health-related quality of life in individuals with recently diagnosed type 2 diabetes mellitus: a cross-lagged panel analysis.

Kristoffersen SF, Domazet SL, Pouwer F et al. · 2026 · Diabetes research and clinical practice

Aims We investigated longitudinal, bidirectional associations between objectively measured moderate to vigorous physical activity (MVPA), health-related quality of life (HRQoL), and emotional well-being (EWB) in individuals recently…

View details →DOI: 10.1016/j.diabres.2026.113185
Negative / Null Result Report

Single-Cell-Validated Transcriptomic Proxies for the Maas Meningioma Microenvironment Risk Continuum: An NF2-Dependent Signal Attenuated Below Detectability in Bulk RNA-seq

Piccolo D, Vindigni M · 2026 · Preprint

Purpose Maas et al. recently showed that a microenvironment-determined risk continuum, driven by the shift from microglia-like to myeloid-derived macrophage-like tumor-associated macrophages (TAMs), independently predicts meningioma…

View details →DOI: 10.64898/2026.04.27.26351840
Negative / Null Result Report

Similar exercise adherence and physical fitness outcomes are observed across distinct motivation profiles in older adults participating in a home-based structured exercise programme

Munns A, Feron J, Duda J et al. · 2026 · Preprint

Purpose:Motivation and self-efficacy are established predictors of engagement and persistence within structured exercise programmes; however, it remains unclear whether these psychological factors predict objective adherence metrics and…

View details →DOI: 10.31234/osf.io/gk74p_v3
Negative / Null Result ReportMedicine

Effects of Impella 5.5 on right ventricular load and adaptation.

Silkowski MK, Olson A, Asempah M et al. · 2026 · The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Background The Impella 5.5 is increasingly used as a bridge to durable left ventricular assist device (dLVAD) implantation or heart transplantation, yet its effects on right ventricular (RV) hemodynamics remain incompletely characterized.…

View details →DOI: 10.1016/j.healun.2026.05.001
Negative / Null Result ReportMedicine

Blinking mimicry predicts preference.

Amihai L, Shahab S, Kligman T et al. · 2026 · Acta psychologica

Face-to-face conversations involve a rich array of social signals - facial expressions, gestures, vocal prosody, and gaze. While interpersonal mimicry of these signals has been extensively studied and shown to carry evaluative…

View details →DOI: 10.1016/j.actpsy.2026.107001
Negative / Null Result ReportMedicine

Relationships between vestibular dysfunction and cognitive performance in military veterans with mild to moderate TBI.

Boutzoukas EM, Skop KM, Silva MA · 2025 · The Clinical neuropsychologist

Objective: Vestibular dysfunction is common following mild-to-moderate traumatic brain injury (TBI) and impacts quality of life. However, little is known regarding the persistence and stability of vestibular symptoms over time and their…

View details →DOI: 10.1080/13854046.2025.2598370
Negative / Null Result ReportMedicine

The relationship between patterns of depression changes and suicide among older women in Korea.

Ryu JH, Kim S, Jeong KH et al. · 2026 · Health care for women international

Using data on causes of death(suicide) among older Korean women using data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2020, we examined changes in depression levels among 405 women over a period of three years or more…

View details →DOI: 10.1080/07399332.2025.2593265
Negative / Null Result ReportMedicine

Active exploration vs. passive observation in virtual navigation: The role of exploration quality and individual differences.

Lambey LD, Moffat SD · 2026 · Neuropsychologia

Active navigation involves direct control over movement and decision-making, whereas passive observation entails viewing another individual's exploration. Although active engagement is often assumed to benefit spatial learning, findings in…

View details →DOI: 10.1016/j.neuropsychologia.2026.109459
Negative / Null Result Report

Long-Term Outcomes of Immediate Implants in Endodontic, Periodontal, Endo–Perio Compromised Extraction Sockets and Failed Implant Sites: A Retrospective Single-Center Cohort Study

KARAASLAN F, BİNBAŞIOĞLU DD, ÇEKİÇ EC et al. · 2026 · Preprint

Abstract Objective To assess long-term outcomes of immediate implant placement in endodontic, periodontal and endo–perio compromised sockets and in sites immediately replaced after failed implant explantation, and to examine the roles of…

View details →DOI: 10.21203/rs.3.rs-9259324/v1
Negative / Null Result ReportMedicine

Physical activity and patient-reported outcomes after decompressive endoscopic lumbar spine surgery.

Noroozi Gilandehi S, Shoubash L, Leyendecker J et al. · 2026 · Journal of neurosurgery. Spine

Objective Although patients often report improvements in pain and functional capacity after endoscopic lumbar spine surgery, objectively measured real-life physical activity may differ from that reported. This multicenter prospective study…

View details →DOI: 10.3171/2026.1.spine25926
Negative / Null Result ReportMedicine

Parsing apart the effects of anxiety and intolerance of uncertainty on the acquisition of fear during category fear conditioning.

Sullivan AJ, Whalen M, Cooper SE et al. · 2026 · Biological psychology

Fear conditioning research can provide insight into how individuals with clinically relevant traits learn to distinguish between threatening and safe stimuli. Prior studies have found higher anxiety symptoms to be associated with increased…

View details →DOI: 10.1016/j.biopsycho.2026.109282
Negative / Null Result ReportOpen accessMedicine

Alpha-linolenic acid associations with disability and brain volume in multiple sclerosis: a brief replication report.

Korbmacher M, Myhr KM, Wergeland S et al. · 2026 · Frontiers in neurology

Objective To replicate and extend recent findings, suggesting that higher serum alpha-linolenic acid (ALA) levels are associated with reduced disease activity and progression in multiple sclerosis (MS). Methods We reanalysed clinical trial…

View details →DOI: 10.3389/fneur.2026.1796427
Negative / Null Result ReportMedicine

Percutaneous Screw Fixation of Scaphoid Nonunion Without Bone Grafting.

Munsch MA, Nguyen DM, Crowley S et al. · 2026 · Hand (New York, N.Y.)

Background This study evaluated the results of minimally invasive headless compression screw (HCS) fixation for treatment of scaphoid delayed union or nonunion. A minimally invasive approach has several potential benefits, including…

View details →DOI: 10.1177/15589447261437823
Negative / Null Result ReportMedicine

Achieving therapeutic antibiotic levels during intermittent dosing of meropenem and piperacillin-tazobactam in critically ill children: the ATACC study.

Joffe AR, Humber A, Bates A et al. · 2026 · Antimicrobial agents and chemotherapy

Achieving antibiotic pharmacodynamic targets is critical to surviving sepsis. The purpose of this study was to determine the achievement of pharmacodynamic target-free minimum plasma concentration (fCmin)-during the first 2 days of…

View details →DOI: 10.1128/aac.01968-25
Negative / Null Result Report

Microbe-mediated plant acclimation to drought may be rare in agriculture

Howard MM, Bolin LG, Bogar GD et al. · 2026 · Preprint

ABSTRACT Microbial communities can shift under drought in ways that enhance plant performance during drought (“microbe-mediated acclimation”). However, it is also possible for microbial communities to shift in ways that worsen the effects…

View details →DOI: 10.64898/2026.04.02.715620
Negative / Null Result ReportMedicine

Predictive value of thromboelastography with platelet mapping on hematoma expansion in spontaneous intracerebral hemorrhage.

Sammani N, Radosevich JJ, Martinez S et al. · 2026 · Journal of thrombosis and thrombolysis

Spontaneous intracerebral hemorrhage (ICH) accounts for about 10% of strokes in the United States and is linked to high mortality and morbidity. Hematoma expansion independently predicts poor outcomes. Thromboelastography with platelet…

View details →DOI: 10.1007/s11239-026-03292-6
Negative / Null Result ReportMedicine

Overconfidence, gender, and authority attribution in algorithmic versus human advice: A cognitive perspective on compliance.

Güner Gültekin D, Siniksaran E · 2025 · Acta psychologica

Authority bias and overconfidence are two common cognitive tendencies that influence how individuals react to expert advice when faced with uncertainty. This study explores the interaction between these biases in decision-making,…

View details →DOI: 10.1016/j.actpsy.2025.105668
Negative / Null Result ReportMedicine

Anger predicts suicidal ideation in a sample of veterans with nonsuicidal self-injury: An ecological momentary assessment study.

Crowe ML, Halverson TF, Kimbrel NA et al. · 2026 · Journal of affective disorders

Suicide remains a critical concern within the United States, particularly among U.S. veterans. Anger is a known correlate of suicidal ideation (SI) but little is understood about their moment-to-moment relationship. This short…

View details →DOI: 10.1016/j.jad.2025.121136