A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21322 results · page 443 of 711
Shetty PMV, Matzen A, Hille S et al. · 2026 · Scientific reports
Marfan syndrome (MFS) is a connective tissue disorder caused by FBN1 mutations, characterised by aortic aneurysms leading to life-threatening dissections. Asprosin is the C-terminal propeptide of fibrillin-1 that was shown to function as a…
Lou Z, Yang H · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
OBJECTIVE: The objective of this study was to evaluate the graft success rate, hearing outcomes, and complications associated with three-layer graft myringoplasty for repairing subtotal and total perforations. MATERIALS AND METHODS:…
Phillipson J, Menson E, Barclay S et al. · 2026 · Archives of disease in childhood
Objective Evaluation of the Medical Mediation Foundation's Conflict Management Programme (CMP)-a structured process for managing conflict. Design Mixed-methods evaluation using Kirkpatrick's framework, a four-level model for evaluating…
Xiang Y, Li S, Wang T et al. · 2026 · Seizure
Background This study aimed to evaluate the effectiveness of the China Acute Seizure Action Plan (CASAP), a context-adapted acute seizure action plan developed for China, on caregivers' knowledge, attitudes, and practices (KAP) regarding…
Greene T, Dicker-Oren SD, Sznitman SR et al. · 2026 · Journal of traumatic stress
The processing of positive memories technique (PPMT) is a promising new treatment for posttraumatic stress disorder (PTSD) involving the detailed narration and processing of specific positive autobiographical memories. This study used an…
Scott R, Sale C, James R et al. · 2026 · Bone
Exercise interventions frequently prescribe impact activities assuming that identical tasks produce similar mechanical loads, yet few studies quantify the external loads experienced during such interventions. This study examined drop-jump…
Sadic AK, Susgun S, Alkhalidi D et al. · 2026 · Nutrition and health
BackgroundAspartame, a widely used artificial sweetener, is metabolized into phenylalanine, aspartic acid, and methanol. Previous studies have suggested that these metabolites may exert detrimental effects on the human body, particularly…
Huang CT, Wen YT, Liu PK et al. · 2026 · QJM : monthly journal of the Association of Physicians
Background Indirect traumatic optic neuropathy (TON) is associated with severe vision loss and no proven treatment. Aim To evaluate the safety and exploratory functional outcomes of intravitreal pegfilgrastim in patients with indirect TON.…
Hodgson NA, Latif S, Talwar S et al. · 2026 · Journal of the American Geriatrics Society
Background The Alzheimer's Association partnered with health systems in Illinois, Greater Missouri, and Washington to implement and evaluate the Knight Family dementia care coordination (DCC) program, a novel telephone-based care…
Deniz B, Arpaci MF, Pekmez H et al. · 2026 · Journal of neuro-oncology
Purpose Brain tumors, characterized by the uncontrolled proliferation of abnormal cells within cerebral tissue, remain clinically challenging entities. Radiotherapy and chemotherapy constitute fundamental therapeutic modalities; however,…
Virupakshaiah A, Gill AJ, Schoeps VA et al. · 2026 · Brain and behavior
Purpose/introduction The anti-JC virus (JCV) antibody index is used to stratify the risk of progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS), particularly with natalizumab therapy. B-cell-depleting therapies may…
Sen E, Aytekin A · 2026 · Revista da Associacao Medica Brasileira (1992)
Objective Thiol-disulfide homeostasis is a marker of oxidative stress. The aim of the study was to compare the effects of low-flow desflurane and sevoflurane anesthesia on perioperative changes in thiol-disulfide balance in patients…
Sinha R, Singh R, Tripathi M et al. · 2025 · Indian journal of ophthalmology
Purpose To study the change in the vault of phakic Intraocular Lens (IOL) (pIOL) with RT view anterior segment optical coherence tomography (ASOCT) in different light conditions and define its relationship with the change in pupillary…
Hu G, Xie M, Wang G et al. · 2026 · Preprint
Abstract Background and aim Soil microbiomes are critical for sustaining ecosystem functioning and soil health. Monocropping often disrupts soil microbial communities, leading to yield penalties and soil degradation. Although bio-organic…
Anthuparambil ND, Timmermann S, Dargasz M et al. · 2026 · The Journal of chemical physics
The effect of lowered pH on the thermal gelation behavior of hen egg yolk was investigated over the temperature range of 58-72 °C using low-dose X-ray photon correlation spectroscopy in ultra-small-angle X-ray scattering geometry.…
Tikhonova P, Mekonnen Z, Belanger KD et al. · 2026 · Communications medicine
Background Mass deworming programs using anthelmintic drugs are a common public health strategy for controlling soil-transmitted helminth (STH) infections in high-risk, low-income countries. However, whether routine deworming induces…
Ma CY, Chen J, Fu Y et al. · 2026 · BMC medical education
Background Competence in radiation oncology is still commonly expected to emerge through apprenticeship, although essential tasks such as target delineation, treatment-plan review, and multidisciplinary reasoning are not reliably sampled…
Burnet G, Vasic I, Sauaia A et al. · 2026 · Journal of surgical education
Objective To determine the efficacy of cognitive behavioral therapy (CBT) on stress, anxiety, burnout, and depression in surgical interns and to determine the optimal timing of CBT. Our hypothesis was that CBT could improve each of these…
Mehraj F, Bhat MA, Mangulkar A et al. · 2025 · Journal of pharmacy & bioallied sciences
Introduction In recent years, there has been a great deal of interest in research because of the changes that the extraction of premolars has caused to the structures surrounding of the upper airway. This is because it's thought that these…
CEVİZ E, GENÇ H, TÜRKMEN M et al. · 2026 · Preprint
Abstract Background Although the effects of different training practices on motor and swimming performance in male swimmers have been previously examined, studies investigating the effects of calisthenics exercises (CE) and life kinetics…
Benson JC, Carr CM, Mark IT et al. · 2026 · AJNR. American journal of neuroradiology
Background and purpose Wrong-site vertebroplasty is a known complication of image-guided procedures. Although rare, these errors have considerable clinical and medicolegal implications and are considered "never" events. This iterative…
Rodriguez-Belenguer P, Beser-Robles M, Marfil-Trujillo M et al. · 2026 · Computer methods and programs in biomedicine
Background and objectives Radiomics-based machine learning models are increasingly used for clinical decision-making, yet their reliability is often constrained by limited sample sizes and class imbalance in imaging datasets. While prior…
Denstad SE, Volløyhaug I, Lieng M et al. · 2026 · Journal of minimally invasive gynecology
Study objective To evaluate changes in health-related quality of life (HRQoL) 3 years after laparoscopic hysterectomy (LH) for benign, prophylactic, and malignant indications, and to identify baseline factors associated with these changes.…
Yuan L, Li T, Jiang D et al. · 2026 · Insect science
A broad host range facilitates the rapid spread of Hyphantria cunea. This study explored the mechanism underlying the multi-host adaptability of H. cunea larvae, focusing on glutathione S-transferase (GST), and developed nucleic acid…
Hirsch T, Moser U, Wolf A et al. · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Purpose This prospective pilot study aimed to evaluate whether dupilumab therapy induces measurable changes in the sinonasal microbiome of patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Methods Eight CRSwNP patients…
Parakkal T, Kuriakose MJ, Natarajan PV et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie
Surgically facilitated anterior maxillary distraction (AMD) is used for the treatment of maxillary hypoplasia secondary to cleft lip and palate (CLP). In this study, the soft and hard tissue changes following AMD in growing patients with…
Stanford K, Cain RM, Millis D et al. · 2026 · American journal of veterinary research
Objective To identify the effects of incline and decline treadmill trotting on forelimb muscle activity in dogs using electromyography (EMG). Methods Data were collected for a prospective within-subject, repeated-measures study in January…
Kapoor A, Ni Y, Isaac G et al. · 2026 · Preprint
ABSTRACT Background Low-intensity focused ultrasound (LIFU) is an emerging noninvasive neuromodulation technique capable of targeting deep cortical and subcortical structures with high spatial precision. In healthy human volunteers, LIFU…
da Silva PCH, Faria TV, Galvani LD et al. · 2026 · The Angle orthodontist
Objectives To evaluate the effect of different antimicrobial solutions on the mechanical properties of aligners (Invisalign, Align Technology Inc., San Jose, CA, USA). Material and methods Invisalign aligners were used, originating from an…
Ayazi H, Kalani N, Rabiee M et al. · 2026 · Musculoskeletal care
Background and purpose Lumbopelvic rhythm describes the relationship between the lumbar spine and hip motion during trunk bending tasks, while the lumbar lordosis angle represents the normal sagittal curvature of the lumbar spine. This…