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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19761 results in Negative / Null Result Report · page 44 of 659

Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Training and organisational performance: A meta‐analysis of temporal, institutional and organisational context moderators

Thomas N. Garavan, Alma McCarthy, Yanqing Lai et al. · 2020 · Human Resource Management Journal

Abstract Drawing on systems theory, we conducted a moderated meta‐analysis of the training and organisational performance relationship using 119 primary studies. We examined the moderating effects of quality versus quantity of training,…

View details →DOI: 10.1111/1748-8583.12284Cited by 119
Negative / Null Result ReportOpen accessSocial Sciences

(When) are religious people nicer? Religious salience and the “Sunday Effect” on pro-social behavior

Deepak Malhotra · 2010 · Judgment and Decision Making

Abstract Prior research has found mixed evidence for the long-theorized link between religiosity and pro-social behavior. To help overcome this divergence, I hypothesize that pro-social behavior is linked not to religiosity per se, but…

View details →DOI: 10.1017/s1930297500001005Cited by 119
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

E2112: Randomized Phase III Trial of Endocrine Therapy Plus Entinostat or Placebo in Hormone Receptor–Positive Advanced Breast Cancer. A Trial of the ECOG-ACRIN Cancer Research Group

Roisín M. Connolly, Fengmin Zhao, Kathy D. Miller et al. · 2021 · Journal of Clinical Oncology

PURPOSE Endocrine therapy resistance in advanced breast cancer remains a significant clinical problem that may be overcome with the use of histone deacetylase inhibitors such as entinostat. The ENCORE301 phase II study reported improvement…

View details →DOI: 10.1200/jco.21.00944Cited by 119
Negative / Null Result Report

The Evidence for Generation Me and Against Generation We

Jean M. Twenge · 2013 · Emerging Adulthood

According to the empirical evidence, today’s emerging adults (Millennials/GenY, born after 1980) are more Generation Me than Generation We when compared to previous generations. Five data sets show a generational increase in narcissism,…

View details →DOI: 10.1177/2167696812466548Cited by 119
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Scientific Opinion on the re‐evaluation of curcumin (E 100) as a food additive

EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS) · 2010 · EFSA Journal

The Panel on Food Additives and Nutrient Sources added to Food provides a scientific opinion re-evaluating the safety of curcumin (E 100). Curcumin has been previously evaluated by the Joint FAO/WHO Expert Committee on Food Additives…

View details →DOI: 10.2903/j.efsa.2010.1679Cited by 119
Negative / Null Result ReportSocial Sciences

Experimental Evidence on Teachers’ Racial Bias in Student Evaluation: The Role of Grading Scales

David M. Quinn · 2020 · Educational Evaluation and Policy Analysis

A vast research literature documents racial bias in teachers’ evaluations of students. Theory suggests bias may be larger on grading scales with vague or overly general criteria versus scales with clearly specified criteria, raising the…

View details →DOI: 10.3102/0162373720932188Cited by 119
Negative / Null Result Report

Will There Be a Significant Change to El Niño in the Twenty-First Century?

Samantha Stevenson, Baylor Fox-Kemper, Markus Jochum et al. · 2012 · Journal of Climate

Abstract The El Niño–Southern Oscillation (ENSO) response to anthropogenic climate change is assessed in the following 1° nominal resolution Community Climate System Model, version 4 (CCSM4) Coupled Model Intercomparison Project phase 5…

View details →DOI: 10.1175/jcli-d-11-00252.1Cited by 119
Negative / Null Result Report

Ten-year panel data confirm generation gap but climate beliefs increase at similar rates across ages

Taciano L. Milfont, Elena Zubielevitch, Petar Milojev et al. · 2021 · Nature Communications

Abstract Accumulating evidence indicates that climate change awareness and concern has increased globally, but commentators suggest a climate change generation gap whereby younger people care more about climate change than older people.…

View details →DOI: 10.1038/s41467-021-24245-yCited by 119
Negative / Null Result ReportOpen accessNeuroscience

A phase synchrony measure for quantifying dynamic functional integration in the brain

Selin Aviyente, Edward M. Bernat, Westley S. Evans et al. · 2010 · Human Brain Mapping

The temporal coordination of neural activity within structural networks of the brain has been posited as a basis for cognition. Changes in the frequency and similarity of oscillating electrical potentials emitted by neuronal populations…

View details →DOI: 10.1002/hbm.21000Cited by 119
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

How to run far: multiple solutions and sex-specific responses to selective breeding for high voluntary activity levels

Theodore Garland, Scott A. Kelly, Jessica L. Malisch et al. · 2010 · Proceedings of the Royal Society B Biological Sciences

The response to uniform selection may occur in alternate ways that result in similar performance. We tested for multiple adaptive solutions during artificial selection for high voluntary wheel running in laboratory mice. At generation 43,…

View details →DOI: 10.1098/rspb.2010.1584Cited by 118
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Effects of oil spills on fish production in the Niger Delta

Eze Simpson Osuagwu, Eseoghene Olaifa · 2018 · PLoS ONE

The Niger Delta region is the oil producing area of Nigeria, which consists of highly diverse ecosystems that are supportive of numerous species of terrestrial and aquatic fauna and flora. Crude oil spills endanger fish hatcheries in coastal water and also contaminate valuable fish. This study examines the effects of oil spills on fish production in the Niger Delta of Nigeria from 1981-2015 using an estimable Cobb Douglas production function. The findings suggest that oil production and spills negatively affect fish production, while farm labour has a positive effect on fish production. On the

View details →DOI: 10.1371/journal.pone.0205114Cited by 118
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Organic and Conventional Agriculture: A Useful Framing?

Carol Shennan, Timothy J. Krupnik, Graeme Baird et al. · 2017 · Annual Review of Environment and Resources

In this review, we examine the debate surrounding the role for organic agriculture in future food production systems. Typically represented as a binary organic–conventional question, this debate perpetuates an either/or mentality. We…

View details →DOI: 10.1146/annurev-environ-110615-085750Cited by 118
Negative / Null Result ReportOpen accessMedicine

The cell size and distribution of adipocytes from subcutaneous and visceral fat is associated with type 2 diabetes mellitus in humans

Lingling Fang, Fangjian Guo, Lihua Zhou et al. · 2015 · Adipocyte

AIMS/HYPOTHESIS: Regional deposition of adipose tissue and adipocyte morphology may contribute to increased risk for insulin resistance. The aim of this study was to compare adipocyte cell size and size distribution from multiple fat…

View details →DOI: 10.1080/21623945.2015.1034920Cited by 118
Negative / Null Result ReportBusiness, Management and Accounting

Financial Knowledge and Financial Literacy at the Household Level

Alan L. Gustman, Thomas L. Steinmeier, Nahid Tabatabai · 2012 · American Economic Review

There is evidence of a relation between numeracy and wealth held outside of pensions and Social Security. With pensions and Social Security accounting for half of wealth at retirement, and evidence that those with pensions save more in…

View details →DOI: 10.1257/aer.102.3.309Cited by 118
Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology

Curcumin Treatment Suppresses IKKβ Kinase Activity of Salivary Cells of Patients with Head and Neck Cancer: A Pilot Study

Suejung G. Kim, Mysore S. Veena, Saroj K. Basak et al. · 2011 · Clinical Cancer Research

PURPOSE: To determine whether curcumin would inhibit IκB kinase β (IKKβ) kinase activity and suppress expression of proinflammatory cytokines in head and neck squamous cell carcinoma cancer (HNSCC) patients. EXPERIMENTAL DESIGN: Saliva was…

View details →DOI: 10.1158/1078-0432.ccr-11-1272Cited by 118
Negative / Null Result ReportOpen accessSocial Sciences

No Replication, No Trust? How Low Replicability Influences Trust in Psychology

Tobias Wingen, Jana Berkessel, Birte Englich · 2019 · Social Psychological and Personality Science

In the current psychological debate, low replicability of psychological findings is a central topic. While the discussion about the replication crisis has a huge impact on psychological research, we know less about how it impacts public trust in psychology. In this article, we examine whether low replicability damages public trust and how this damage can be repaired. Studies 1–3 provide correlational and experimental evidence that low replicability reduces public trust in psychology. Additionally, Studies 3–5 evaluate the effectiveness of commonly used trust-repair strategies such as informati

View details →DOI: 10.1177/1948550619877412Cited by 118
Negative / Null Result ReportOpen accessMedicine

Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study

Ji Min Choi, Jong In Yang, Seung Joo Kang et al. · 2018 · Journal of Neurogastroenterology and Motility

BACKGROUND/AIMS: The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the psychological status (anxiety and depression) according to each…

View details →DOI: 10.5056/jnm18069Cited by 118
Negative / Null Result ReportOpen accessMedicine

Comparison of Machine Learning Methods and Conventional Logistic Regressions for Predicting Gestational Diabetes Using Routine Clinical Data: A Retrospective Cohort Study

Yunzhen Ye, Yu Xiong, Qiongjie Zhou et al. · 2020 · Journal of Diabetes Research

BACKGROUND: Gestational diabetes mellitus (GDM) contributes to adverse pregnancy and birth outcomes. In recent decades, extensive research has been devoted to the early prediction of GDM by various methods. Machine learning methods are flexible prediction algorithms with potential advantages over conventional regression. OBJECTIVE: The purpose of this study was to use machine learning methods to predict GDM and compare their performance with that of logistic regressions. METHODS: We performed a retrospective, observational study including women who attended their routine first hospital visits

View details →DOI: 10.1155/2020/4168340Cited by 117
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Warming Oceans, Phytoplankton, and River Discharge: Implications for Cholera Outbreaks

Antarpreet Jutla, A. S. Akanda, Jeffrey K. Griffiths et al. · 2011 · American Journal of Tropical Medicine and Hygiene

Phytoplankton abundance is inversely related to sea surface temperature (SST). However, a positive relationship is observed between SST and phytoplankton abundance in coastal waters of Bay of Bengal. This has led to an assertion that in a…

View details →DOI: 10.4269/ajtmh.2011.11-0181Cited by 117
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Cecropin A Alleviates Inflammation Through Modulating the Gut Microbiota of C57BL/6 Mice With DSS-Induced IBD

Zhenya Zhai, Fan Zhang, Ruihua Cao et al. · 2019 · Frontiers in Microbiology

The present study is undertaken to assess the alleviating effects of antimicrobial peptide cecropin A on inflammatory bowel disease (IBD) in C57BL/6 mice and changes in the gut microbiota, compared to an antibiotic gentamicin. Different doses of cecropin A were intraperitoneally injected into C57BL/6 mice for 5 days to determine the safe doses. The injection doses at ≤ 15 mg/kg showed no negative impact on the liver, heart, spleen and kidney. The severe and moderate IBD mice model was successfully established via supplementation of 4% or 2.5% dextran sulfate sodium (DSS) in drinking water for

View details →DOI: 10.3389/fmicb.2019.01595Cited by 117
Negative / Null Result ReportOpen accessMedicine

Phase II Trial of Pemetrexed and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer

Athanassios Argiris, Michalis V. Karamouzis, William E. Gooding et al. · 2011 · Journal of Clinical Oncology

PURPOSE: We hypothesized that bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF), will potentiate the activity of pemetrexed, a multitargeted antifolate, in squamous cell carcinoma of the head and neck…

View details →DOI: 10.1200/jco.2010.33.3591Cited by 117
Negative / Null Result ReportOpen accessEngineering

<p>Low-Dose Exposure of Silica Nanoparticles Induces Neurotoxicity via Neuroactive Ligand–Receptor Interaction Signaling Pathway in Zebrafish Embryos</p>

Jialiu Wei, Jianhui Liu, Shuang Liang et al. · 2020 · International Journal of Nanomedicine

Objective: Silica nanoparticles (SiO 2 NPs) have been extensively employed in biomedical field. SiO 2 NPs are primarily designed to enter the circulatory system; however, little information is available on potential adverse effects of SiO…

View details →DOI: 10.2147/ijn.s254480Cited by 117
Negative / Null Result ReportMedicine

Xenon augmented hypothermia reduces early lactate/N‐acetylaspartate and cell death in perinatal asphyxia

Stuart Faulkner, Alan Bainbridge, Takenori Kato et al. · 2011 · Annals of Neurology

OBJECTIVE: Additional treatments for therapeutic hypothermia are required to maximize neuroprotection for perinatal asphyxial encephalopathy. We assessed neuroprotective effects of combining inhaled xenon with therapeutic hypothermia after…

View details →DOI: 10.1002/ana.22387Cited by 117
Negative / Null Result ReportOpen accessHealth Professions

The effects of health expenditure on infant mortality in sub-Saharan Africa: evidence from panel data analysis

Girmay Tsegay Kiross, Catherine Chojenta, Daniel Barker et al. · 2020 · Health Economics Review

INTRODUCTION: Although health expenditure in sub-Saharan African countries is the lowest compared with other regions in the world, most African countries have improved their budget allocations to health care over the past 15 years. The majority of health care sources in sub-Saharan Africa are private and largely involve out-of-pocket expenditure, which may prevent healthcare access. Access to healthcare is a known predictor of infant mortality. Therefore the objective of this study is to determine the impact of health care expenditure on infant mortality in sub-Saharan Africa. METHODS: The stu

View details →DOI: 10.1186/s13561-020-00262-3Cited by 117
Negative / Null Result ReportOpen accessMedicine

Hemoglobin A1c and Mortality in Older Adults With and Without Diabetes: Results From the National Health and Nutrition Examination Surveys (1988–2011)

Priya Palta, Elbert S. Huang, Rita R. Kalyani et al. · 2017 · Diabetes Care

OBJECTIVE Hemoglobin A1c (HbA1c) level has been associated with increased mortality in middle-aged populations. The optimal intensity of glucose control in older adults with diabetes remains uncertain. We sought to estimate the risk of…

View details →DOI: 10.2337/dci16-0042Cited by 116
Negative / Null Result ReportOpen accessMedicine

Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease

Harry Sokol, Laurent Beaugerie, Marc Maynadié et al. · 2012 · Inflammatory Bowel Diseases

BACKGROUND: It remains to be shown whether inflammatory bowel disease (IBD) is associated with an increased risk of primary intestinal lymphoproliferative disorders (PILD). We assessed this risk in the CESAME French nationwide prospective…

View details →DOI: 10.1002/ibd.22889Cited by 116
Negative / Null Result ReportOpen accessChemistry

Significant Association between Sulfate-Reducing Bacteria and Uranium-Reducing Microbial Communities as Revealed by a Combined Massively Parallel Sequencing-Indicator Species Approach

Erick Cardenas, Wei‐Min Wu, Mary Beth Leigh et al. · 2010 · Applied and Environmental Microbiology

Massively parallel sequencing has provided a more affordable and high-throughput method to study microbial communities, although it has mostly been used in an exploratory fashion. We combined pyrosequencing with a strict indicator species…

View details →DOI: 10.1128/aem.01097-10Cited by 116
Negative / Null Result Report

Deep-learning-based gene perturbation effect prediction does not yet outperform simple linear baselines

Constantin Ahlmann-Eltze, Wolfgang Huber, Simon Anders · 2025 · Nature Methods

Abstract Recent research in deep-learning-based foundation models promises to learn representations of single-cell data that enable prediction of the effects of genetic perturbations. Here we compared five foundation models and two other…

View details →DOI: 10.1038/s41592-025-02772-6Cited by 116