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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 437 of 724

Negative / Null Result ReportOpen accessMedicine

Efficacy of mesotherapy in patients with acute and subacute neck pain: A randomized controlled trial.

Gonultas D, Kulcu DG, Kaymaz EP et al. · 2026 · Turkish journal of physical medicine and rehabilitation

Objectives This study aims to investigate the effectiveness of mesotherapy in patients with acute or subacute neck pain compared to oral medications with the same active ingredients. Patients and methods In this randomized, single-blind…

View details →DOI: 10.5606/tftrd.2025.16956
Negative / Null Result ReportOpen accessMedicine

Modulation of the gut microbiota as a novel strategy to prevent anastomotic leak after colorectal surgery: Systematic scoping review.

Helliwell JA, Sciberras P, Dosis A et al. · 2026 · Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Background Anastomotic leak (AL) remains a major source of morbidity following colorectal surgery. Increasing evidence implicates the gut microbiome in the pathogenesis of AL, with certain microbial species disrupting tissue repair through…

View details →DOI: 10.1111/codi.70472
Negative / Null Result ReportOpen accessMedicine

Effects of different intensities of repetitive peripheral magnetic stimulation on corticospinal excitability and motor performance in healthy humans.

Omiya A, Shitara K, Miyazaki D et al. · 2026 · PloS one

Repetitive peripheral magnetic stimulation (rPMS) has been applied in clinical settings to enhance the recovery of motor function following central nervous system lesions. However, the optimal intensity of rPMS for inducing neural…

View details →DOI: 10.1371/journal.pone.0349300
Negative / Null Result ReportMedicine

Low Vision Assessment in Virtual Reality (LVAVR): Spatial Computing in Virtual Reality and Real-World.

Bailey E, Roy P, Shifflett K et al. · 2026 · 2026 IEEE Conference on Virtual Reality and 3D User Interfaces Abstracts and Workshops

The Low Vision Assessment in Virtual Reality project aims to create performance assessments of activities of daily living for a broad low vision population in virtual reality. In this study, our goal is to validate representative virtual…

View details →DOI: 10.1109/vrw70859.2026.00284
Negative / Null Result Report

Efficacy and safety of rituximab combined with glucocorticoids in patients with primary membranous nephropathy: a single-center retrospective cohort study

Zhao C, Feng S, Hu Z et al. · 2026 · Preprint

Abstract Background To compare the clinical efficacy and safety of rituximab (RTX) monotherapy versus the combination of RTX and glucocorticoids (GC) in the treatment of primary membranous nephropathy (PMN). Methods This retrospective,…

View details →DOI: 10.21203/rs.3.rs-9750129/v1
Negative / Null Result ReportMedicine

Quantitative assessment of tumor burden in multiple myeloma using MY-RADS from whole-body MRI: comparison with established prognostic biomarkers.

Xiong X, Yan Z, Wang J et al. · 2026 · Cancer imaging : the official publication of the International Cancer Imaging Society

Background To explore the value of MY-RADS from whole-body MRI in assessing tumor burden in MM with reference to established prognostic biomarkers. Methods 108 consecutive newly diagnosed MM patients were retrospectively enrolled. Bone…

View details →DOI: 10.1186/s40644-026-01076-y
Negative / Null Result ReportMedicine

Feasibility and signal quality of the Minder® implantable continuous EEG monitoring® system compared to 10-20 scalp electrodes over extended monitoring periods.

Ganguly TM, Lai A, Niemiec A et al. · 2026 · Epilepsia

Objective To evaluate the signal quality of the Minder implantable continuous EEG monitoring (iCEM) system compared to traditional scalp EEG in the context of long-term, continuous monitoring in individuals with epilepsy. Methods…

View details →DOI: 10.1002/epi.70290
Negative / Null Result ReportOpen accessMedicine

Enhancing wheat bran deconstruction with enzyme cocktails from Penicillium spp. and Trichoderma harzianum: the impact of β-glucosidase supplementation.

Hamann PRV, Martins HS, da Costa PHC et al. · 2026 · Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Forests and natural environments are valuable sources of organisms capable of degrading plant cell wall carbohydrates. In the present study, two isolates, Penicillium polonicum and Penicillium chrysogenum, obtained from Brazilian Cerrado…

View details →DOI: 10.1007/s42770-026-01974-0
Negative / Null Result ReportMedicine

Comparison of 2% lidocaine with epinephrine and 4% articaine with epinephrine in local anesthesia of maxillary molars affected by molar incisor hypomineralization: a randomized controlled trial.

Haidar M, Raslan N · 2026 · Scientific reports

The use of local anesthesia is essential for pain control during the treatment of MIH-affected molars. This study aimed to compare injection-related pain and anesthetic efficacy between 2% lidocaine with epinephrine (LE) and 4% articaine…

View details →DOI: 10.1038/s41598-026-54698-4
Negative / Null Result ReportOpen accessMedicine

Protective role of lycopene against salinity-induced oxidative stress in Medicago sativa L. seedlings.

de Araujo Monteiro AA, da Silva Teles BR, Kamdem JP et al. · 2026 · Scientific reports

Soil salinization is one of the major challenges to agriculture, reducing productivity and directly affecting plant growth, germination, and physiology, especially in economically important crops such as Medicago sativa. Conventional soil…

View details →DOI: 10.1038/s41598-026-42699-2
Replication FailureMedicine

The Effect of a Mobile-Based Lymphedema Self-care Support Program in Women With Breast Cancer-Related Lymphedema: A Single-blind Randomized Controlled Study.

Deveci Koçbilek Z, Karayurt Ö, Bilik Ö et al. · 2026 · Computers, informatics, nursing : CIN

This single-blind, randomized controlled design study aims to examine the effect of a mobile-based Lymphedema Self-care Support Program on self-care, the quality of life, and lymphedema symptoms in women with breast cancer-related…

View details →DOI: 10.1097/cin.0000000000001336
Negative / Null Result ReportOpen accessMedicine

Effect of yeast selenium on autophagy and PINK1/Parkin expression in Diquat-induced chicken liver and kidney cells.

Jin Y, Cheng X, Tan Y et al. · 2026 · Poultry science

(Objective) This study aims to explore the effect of yeast selenium on alleviating autophagy and PINK1/Parkin expression in chicken liver and kidney cells induced by diquat. (Method) A total of 120 180-day-old Kangle Yellow chickens were…

View details →DOI: 10.1016/j.psj.2026.106786
Negative / Null Result ReportMedicine

The impact of couple-focused counseling based on the Ex-PLISSIT model on the sexual self-concept of infertile couples: a randomized trial.

Dalvand R, Otogara M, Shayan A et al. · 2026 · Scientific reports

The negative impact of infertility and its treatments on sexual health is well-documented. Self-concept plays a crucial role in sexual behavior and overall sexual health. This study aims to investigate how couple-oriented counseling, using…

View details →DOI: 10.1038/s41598-026-43203-6
Negative / Null Result ReportMedicine

Observational study on the therapeutic effects of two different negative pressure drainage devices on skin graft donor sites.

Chen P, Wang L, Gao S et al. · 2026 · Journal of tissue viability

Objective To conduct a retrospective analysis of patients who received treatment with two types of negative pressure materials for intermediate-thickness skin graft donor sites, comparing the clinical efficacy and exploring potential…

View details →DOI: 10.1016/j.jtv.2026.101005
Negative / Null Result ReportMedicine

Interplay of anemia in inborn errors of energy metabolism.

Shetye S, Bhat YR, Lewis LES et al. · 2026 · Scientific reports

Inborn errors of energy metabolism (IEEM) are inherited conditions that typically present with impaired mitochondrial energy production and multisystem involvement, leading to adverse developmental outcomes. Iron is essential for…

View details →DOI: 10.1038/s41598-026-58126-5
Negative / Null Result ReportMedicine

Repurposing traditional cerclage and suture techniques for the reduction of comminuted patellar fractures.

Pan Y, Wang T, An M et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

Purpose This study aimed to compare the cerclage and suture reduction technique with the point-type reduction technique in the management of comminuted patellar fractures using the modified Kirschner wire tension band. Methods We conducted…

View details →DOI: 10.1007/s00590-026-04829-4
Negative / Null Result ReportOpen accessMedicine

Impact of Sensory Re-education Paradigm on Quality of Life, Tactile Sensation, and Proprioceptive Acuity in Patients with Post-COVID-19 Polyneuropathy: A Randomized Controlled Trial.

Alsaid HM, Khadour YA, Zakaria HM et al. · 2026 · Journal of musculoskeletal & neuronal interactions

Objectives This study evaluated the effect of sensory re-education on quality of life and sensation in patients with post-COVID-19 polyneuropathy. Methods Forty patients with post-COVID-19 polyneuropathy were randomly assigned to a study…

Negative / Null Result ReportOpen accessMedicine

Foam Versus Silver-Impregnated Foam Dressings for Pediatric Tracheostomy: A Randomized Trial.

Bostancı ŞA, Önder SŞ, Sürmeli M et al. · 2026 · Laryngoscope investigative otolaryngology

Objectives Peristomal skin complications occur in up to 29% of pediatric tracheostomy patients. While foam dressings have demonstrated superiority over traditional gauze, comparative evidence regarding silver-impregnated versus standard…

View details →DOI: 10.1002/lio2.70436
Negative / Null Result ReportMedicine

The effect of stress ball use on stress, sleep quality, and comfort in individuals receiving hemodialysis: a randomized controlled trial.

Kacaroglu Vicdan A, Gibyeli Genek D · 2026 · BMC complementary medicine and therapies

Background Hemodialysis often leads to various physiological, psychological, and social challenges for individuals receiving this treatment. This study was conducted to determine the effects of stress ball use on stress, sleep quality, and…

View details →DOI: 10.1186/s12906-026-05429-9
Negative / Null Result ReportOpen accessMedicine

Carboxymethyl cellulose-based edible coatings emulsified with Lemongrass oil for enhancing the storage stability of refrigerated broiler meat.

Ahmad U, Ishaq A, Khalid N · 2026 · Food science of animal resources

The present study aimed to analyze the effects of lemongrass essential oil emulsified with carboxymethyl cellulose (CMC) based edible coating on the physicochemical characteristics, microbial status, and oxidation level of raw chicken meat…

View details →DOI: 10.1007/s44463-025-00045-6
Negative / Null Result ReportOpen accessMedicine

P2X7 receptor and neuroinflammation in neurodegenerative disorders: an autoradiography study with [ 18 F]JNJ-64413739.

Ashok AH, Field S, Ramakrishnan NK et al. · 2026 · Nuclear medicine communications

Background Neuroinflammation plays a crucial role in neurodegenerative disorders such as Alzheimer's disease. The P2X7 receptor (P2X7R), expressed on microglia, is involved in neuroinflammatory responses. Despite evidence of P2X7R…

View details →DOI: 10.1097/mnm.0000000000002153
Negative / Null Result ReportMedicine

Comparison of Outcomes after Minimally Invasive Transverse Distal Metatarsal Osteotomy (MITO) and Proximal Phalangeal Osteotomy for Hallux Valgus With and Without Rheumatoid Arthritis: A Matched Cohort Study.

Yoon YK, Shim DW, Kim JH et al. · 2026 · Foot & ankle international

Background There is an increasing role for joint-preserving surgery in hallux valgus (HV) management among patients with rheumatoid arthritis (RA). We compared radiologic and clinical outcomes after minimally invasive transverse distal…

View details →DOI: 10.1177/10711007261435610
Negative / Null Result ReportOpen accessMedicine

Comparative evaluation of <i>Calotropis gigantea</i> latex and sodium hypochlorite as tissue-dissolving agents - an <i>in vitro</i> study on concentration and time-dependent proficiency.

Ravi M, Annadurai P, Gupta R · 2026 · Biomaterial investigations in dentistry

Background Complete removal of organic tissue and microorganisms from the root canal system is essential for successful endodontic therapy. Sodium hypochlorite (NaOCl) remains the gold standard irrigant for its tissue-dissolving and…

View details →DOI: 10.2340/biid.v13.45992
Negative / Null Result ReportOpen accessMedicine

Radiological differentiation of succinate dehydrogenase-deficient renal cell carcinoma from renal oncocytoma and chromophobe renal cell carcinoma.

Wang G, Yu Y, Han Y et al. · 2026 · BMC cancer

Purpose To characterize the imaging features of succinate dehydrogenase-deficient renal cell carcinoma (SDH-RCC) and compare them with those of renal oncocytoma (RO) and chromophobe RCC (chRCC). Methods This retrospective two-center study…

View details →DOI: 10.1186/s12885-026-16112-0
Negative / Null Result ReportOpen accessMedicine

The effects of 8 weeks of repeated sprint training on aerobic endurance, anaerobic power, agility and explosive strength in college badminton players.

Wei C, An J, Lin Y et al. · 2026 · PeerJ

Background Badminton is a physically demanding sport requiring a combination of aerobic endurance, anaerobic power, agility, and explosive strength. Repeated sprint training (RST) has emerged as a time-efficient strategy for improving…

View details →DOI: 10.7717/peerj.21111
Negative / Null Result ReportMedicine

Laparoscopic vs. robotic cholecystectomy for patients with cirrhosis: A propensity score-matched, single center analysis.

McCabe M, Cheung Z, Mungara T et al. · 2026 · Journal of robotic surgery

Patients with cirrhosis have increased rates of gallstone formation. While laparoscopic cholecystectomy (LC) is known to be safe in cirrhosis, perioperative morbidity remains higher than the general population. Prior work has suggested…

View details →DOI: 10.1007/s11701-026-03583-3
Negative / Null Result ReportOpen accessMedicine

Some carcass and meat quality characteristics of Anatolian local and Mast geese in semi-intensive conditions.

Ürer H, Yıldırım İ, Asker G et al. · 2026 · Tropical animal health and production

In this study, meat quality characteristics of Anatolian local geese (Anser anser domesticus) and Mast geese (Anser anser) reared under semi-intensive conditions were compared. A total of 100 geese were used: 50 from each breed, 25 males…

View details →DOI: 10.1007/s11250-026-05076-9