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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21321 results · page 437 of 711

Negative / Null Result Report

Solar fields design and management, drivers of bird species richness

Tavernier C, van Mourik R, van Diepen R et al. · 2026 · Preprint

Solar fields are increasingly common in European landscapes, and research on their impact on bird communities has been growing. However, solar fields vary substantially in their design and management, making it difficult to generalise…

View details →DOI: 10.22541/authorea.15003794/v1
Negative / Null Result ReportMedicine

The effect of the liquid motion bubbler timer soothing sensory toy on children's fear and anxiety levels during blood sampling: a randomized clinical trial.

Sariali̇oğlu A, Oluç T · 2026 · BMC psychology

Background Blood sampling is one of the invasive procedures in a hospital setting that can cause fear, anxiety, and stress in children. Aim The study aimed to determine the effect of the Liquid Motion Bubbler Timer Soothing Sensory Toy on…

View details →DOI: 10.1186/s40359-026-04943-2
Negative / Null Result Report

Micro-credentials, Skill-based Certifications and the Future Demand for University Education in a Digital Economy: Evidence From Northern Ghana

Yidana P, Bangase EA, Billa G · 2026 · Preprint

Abstract Despite the growing global discourse on alternative credentials such as micro-credentials and skill-based certifications, empirical evidence on their influence on demand for traditional higher education in African contexts remains…

View details →DOI: 10.21203/rs.3.rs-9772176/v1
Negative / Null Result ReportOpen accessMedicine

An improved translational approach to studying persistence-strengthening effects of differential reinforcement of alternative behavior.

Layton KL, Edwards TL, Foster TM · 2026 · Journal of the experimental analysis of behavior

Translational research investigating traditional differential reinforcement of alternative behavior (DRA) suggests that such procedures increase the persistence of target behavior relative to when the alternative behavior is first…

View details →DOI: 10.1002/jeab.70117
Negative / Null Result ReportOpen accessMedicine

Elevated temperature and enhanced UV-B radiation alter soil nitrogen supply and allocation within rice plants in high-altitude paddy fields.

Li H, Meng W, Xiao H et al. · 2025 · BMC plant biology

BACKGROUND: Elevated temperature and enhanced ultraviolet B (UV-B) radiation are two major global climate change issues of concern today, but their effects on high-elevation rice paddy ecosystems are of limited understanding. A Two-year…

View details →DOI: 10.1186/s12870-025-07816-9
Negative / Null Result ReportOpen accessMedicine

Sex-Specific Reversal of Stress-Induced Depressogenic Behaviors by Inhibition of HMGB1, TLR4, and NF-κB Signaling.

Bahadır-Varol A, Solgun B, Küreli G et al. · 2026 · Molecular neurobiology

Acute stress and inflammatory mediators are linked to stress-related mental disorders, yet sex-specific differences in the molecular pathways connecting them remain poorly understood. Male and female C57BL/6 mice underwent predator stress…

View details →DOI: 10.1007/s12035-026-05908-7
Failed Experiment ReportOpen accessMedicine

Do Forms of Silicon Other than Orthosilicic Acid, Application Date and Dose Have a Beneficial Effect on Sugar Beet Yield?

Artyszak A, Gozdowski D, Litwińczuk-Bis M · 2026 · Plants (Basel, Switzerland)

In 2017-2019, in a field experiment in Sahryń, Poland (50°40'42″ N, 23°47'35″ E), the effect of foliar application of various forms of silicon (calcium silicate-CS, sodium metasilicate-SM, and micronized silica-MS) and the timing of their…

View details →DOI: 10.3390/plants15101449
Negative / Null Result ReportOpen accessMedicine

Relationship Between Pulmonary Thromboembolism, its Mortality and Seasonal, Meteorological Factors

Seda Beyhan Sağmen, Sevda Cömert, Nesrin Kıral et al. · 2019 · Southern Clinics of Istanbul Eurasia

INTRODUCTION[|]Seasonal and weather changes may affect the development of pulmonary embolism. The effects of seasonal and meteorological factors on mortality are controversial. We aimed to investigate the effects of seasons and meteorological data on patients with a low and high pulmonary embolism severity index and those with 30-day mortality. [¤]METHODS[|]Pulmonary embolism cases were included in our study. Daily pressure, humidity, temperature, and wind values were taken from the general online information by the Directorate of Meteorology. All cases were divided into the low-risk and high-

View details →DOI: 10.14744/scie.2019.98700
Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system

Renal sympathetic denervation in resistant hypertension: The association between vitamin D and positive early response in systolic blood pressure

Gonçalo Costa, Joana Delgado-Silva, Eric Monteiro et al. · 2022 · Revista Portuguesa de Cardiologia

Aims and objectives: Vitamin D deficiency is a common finding and there is a suggested association with hypertension. Resistant hypertension is a clinical problem observed in 5–30% of hypertensive patients. Renal denervation (RDN) has been used for patients with resistant hypertension and has proven to lower blood pressure. Our primary goal was to assess the vitamin D serum concentration as a predictor of blood pressure response to RDN in highly selected patients. Methods: This prospective, nonrandomized, single-center study included 24 patients treated with RDN. Based on their one-year respon

View details →DOI: 10.1016/j.repc.2021.02.025
Negative / Null Result ReportOpen accessBusiness

Air quality protection behaviour and stock returns of public companies: Sectoral aspects

Maksim S. Maramygin, Natalya B. Boldyreva, Lyudmila G. Reshetnikova · 2025 · Управленец

In the new economic reality, air quality protection behaviour of companies remains a burning issue shifting the em phasis towards saving human life and health. The article explores the relationship between the air quality protection behav iour of public companies and stock returns in different economic sectors. The research methodology is based on environmental management theory, financial management theory, and stakeholder theory. The analytical procedures performed on the data involved cross-sectoral economic analysis and econometric analysis. Empirical data are retrieved from the Federal St

View details →DOI: 10.29141/2218-5003-2024-15-6-6
Negative / Null Result ReportOpen accessMedicine

Low-dose oral pregabalin is not effective enough to control the acute post-thoracotomy pain

Swati Dogra , Altaf Hussain Mir , Suhail Sidiq et al. · 2025 · Asian Journal of Medical Sciences

Background: Acute post-thoracotomy pain (APTP) is severe and can lead to various respiratory complications if left untreated. Epidural (Ep) analgesia is the gold standard for APTP relief. Aims and Objectives: The aims and objectives of this study were to study the impact of low-dose oral pregabalin 75 mg on APTP. Materials and Methods: 100 patients were randomized into two groups (Group P and C). The Group P, study group received pregabalin 75 mg per oral preoperatively and for 2 days postoperatively. Group C received no medication. All the patients received thoracic Ep as a standard practice.

View details →DOI: https://doi.org/10.71152/ajms.v16i5.4484
Negative / Null Result ReportOpen accessDermatology

Comparison of efficacy and safety between intralesional injection of heparin sodium and CO2 laser ablation in the treatment of xanthelasma

JI Liyue, QIU Xiaonan, WANG Xijuan et al. · 2025 · Pifu-xingbing zhenliaoxue zazhi

[Objective] To evaluate the clinical efficacy and safety of intralesional injection of heparin sodium versus carbon dioxide (CO2) laser ablation in the treatment of xanthelasma palpebrarum. [Methods] A total of 38 patients with Grade Ⅰ-Ⅲ xanthelasma and normal blood lipid levels were retrospectively enrolled, and divided into two groups based on the treatment modality: the heparin sodium group (n=20) treated with intralesional injection of heparin sodium and the CO2 laser group (n=18) treated with CO2 laser ablation. The primary and secondary outcomes were compared between the two groups, incl

View details →DOI: 10.3969/j.issn.1674-8468.2025.12.003
Negative / Null Result ReportOpen accessOtorhinolaryngology

Um estudo piloto na avaliação das estratégias posturais em jovens e idosos usando um sistema eletromagnético tridimensional A pilot study on the evaluation of postural strategies in young and elderly subjects using a tridimensional electromagnetic system

José Ailton Oliveira Carneiro, Taiza Elaine Grespan Santos-Pontelli, José Fernando Colafêmina et al. · 2013 · Brazilian Journal of Otorhinolaryngology

Para manter o equilíbrio postural, algumas estratégias posturais são normalmente usadas. OBJETIVO: Avaliar as estratégias posturais de jovens e idosos em diferentes condições sensoriais usando um sistema de sensores eletromagnéticos tridimensionais posicionados na primeira vértebra torácica e região sacral. Também reportamos valores de oscilação postural dos jovens e idosos. MÉTODO: Estudo transversal observacional. Participaram do estudo 25 jovens e 16 idosas. O equipamento PolhemusTM com dois sensores foi usado para avaliar os parâmetros de oscilação postural (deslocamento máximo, velocidade

Negative / Null Result ReportOpen accessInfectious and parasitic diseases

ASSOCIATION BETWEEN FAS/FASL EXPRESSION AND RHEUMATOLOGICAL MANIFESTATIONS IN PATIENTS INFECTED WITH HTLV-1

Aline Cecy Rocha de Lima, Wandrey Roberto dos Santos Brito, Luciana Cristina Coelho Pantoja Santos et al. · 2026 · Brazilian Journal of Infectious Diseases

Introduction: Fas and FasL are known modulators of cellular apoptosis in immunoregulation of the innate immune response, as well as in the elimination of defective cells, and may be associated with antiviral activity of HTLV-1 – infected cells. Understanding the immunological mechanisms involved in the progression of HTLV-1 – associated diseases may contribute to predicting the clinical prognosis of infected individuals. Objective: To evaluate mRNA expression of the apoptotic modulators FAS and FASL in patients infected with HTLV-1. Methods: A total of 54 HTLV-1 – infected individuals were eva

View details →DOI: 10.1016/j.bjid.2026.105460
Negative / Null Result ReportOpen accessTechnology

Influence of the Process Parameters on the Mechanical Properties of the FDM 3D Printed Samples

Sara Havrlišan, Martina Tokić, Štefanija Klarić et al. · 2026 · Tehnički Glasnik

This research analyses the impact of infill density and layer thickness on the tensile strength of test samples fabricated using FDM 3D printing, with a particular focus on comparing samples produced with and without an adhesion layer. A two-factor factorial experimental design was employed, consisting of two levels and three replications. The infill density (20% and 50%) and layer thickness (0.1 mm and 0.2 mm) were defined as input variables, while tensile strength served as the output variable. Statistical methods, such as ANOVA, were used to analyse the experimental data and evaluate the si

View details →DOI: 10.31803/tg-20251030095053
Negative / Null Result ReportOpen accessDentistry

Minimal alterations on the enamel surface by micro-abrasion: in vitro roughness and wear assessments

Marcela Charantola Rodrigues, Rafael Francisco Lia Mondelli, Gabriela Ulian Oliveira et al. · 2013 · Journal of Applied Oral Science

Objective: To evaluate the in vitro changes on the enamel surface after a micro-abrasion treatment promoted by different products. Material and Methods: Fifty (50) fragments of bovine enamel (15 mm × 5 mm) were randomly assigned to five groups (n=10) according to the product utilized: G1 (control)= silicone polisher (TDV), G2= 37% phosphoric acid (3M/ESPE) + pumice stone (SS White), G3= Micropol (DMC Equipment), G4= Opalustre (Ultradent) and G5= Whiteness RM (FGM Dental Products). Roughness and wear were the responsible variables used to analyze these surfaces in four stages: baseline, 60 s an

View details →DOI: 10.1590/1678-7757201302117
Negative / Null Result ReportOpen accessMedicine

Clinical outcomes in low risk coronary artery disease patients treated with different limus-based drug-eluting stents--a nationwide retrospective cohort study using insurance claims database.

Chao-Lun Lai, Ching-Fen Wu, Raymond Nien-Chen Kuo et al. · 2015 · PLoS ONE

The clinical outcomes of different limus-based drug-eluting stents (DES) in a real-world setting have not been well defined. The aim of this study was to investigate the clinical outcomes of three different limus-based DES, namely sirolimus-eluting stent (SES), Endeavor zotarolimus-eluting stent (E-ZES) and everolimus-eluting stent (EES), using a national insurance claims database. We identified all patients who received implantation of single SES, E-ZES or EES between January 1, 2007 and December 31, 2009 from the National Health Insurance claims database, Taiwan. Follow-up was through Decemb

View details →DOI: 10.1371/journal.pone.0122860
Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology

Randomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients Ensaio clínico randomizado comparando picosulfato de sódio com manitol no preparo para colonoscopia em pacientes hospitalizados

Suzana Müller, Carlos Fernando de Magalhães Francesconi, Ismael Maguilnik et al. · 2007 · Arquivos de Gastroenterologia

BACKGROUND: The cleansing of the colon for a colonoscopy exam must be complete so as to allow the visualization and inspection of the intestinal lumen. The ideal cleansing agent should be easily administered, have a low cost, and minimum collateral effects. Sodium picosulfate together with the magnesium citrate is a cathartic stimulant and mannitol is an osmotic laxative, both usually used for this purpose. AIMS: Assess the colon cleanliness comparing the use of mannitol and sodium picosulfate as well as evaluate the level of patient satisfaction, the presence of foam, pain, and abdominal dist

View details →DOI: 10.1590/s0004-28032007000300013
Negative / Null Result ReportOpen accessMedicine

Obesity and Dyslipidemia

Feingold KR · 2000

Abnormalities in lipid metabolism are very commonly observed in patients who are obese. Approximately 60-70% of patients with obesity are dyslipidemic. The lipid abnormalities in patients who are obese include elevated serum TG, VLDL,…

Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system

Changes in ankle joint motion after Supramalleolar osteotomy: a cadaveric model

Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu et al. · 2017 · BMC Musculoskeletal Disorders

Abstract Background Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. Methods Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers. They were harvested from five

View details →DOI: 10.1186/s12891-017-1749-0