A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20253 results in Negative / Null Result Report · page 428 of 676
Serrano, Gueugneau, Ravier · 2026 · Scientific reports
This study examined modulations of the cardiac autonomic nervous system, neuromuscular performance and psychological states during the menstrual cycle (MC) in naturally menstruating women. Fifteen healthy young females were tested during…
Kitahara, Ohshima, Nakajima et al. · 2026 · Scientific reports
Full-endoscopic spine surgery performed under local anesthesia offers clinical advantages, particularly for elderly patients. However, its reliance on fluoroscopy raises concerns about occupational radiation exposure. Although several…
da Silva, Alves, Jalkh et al. · 2026 · Dental materials : official publication of the Academy of Dental Materials
To evaluate microbial inhibition at the implant-abutment interface of 5Y-PSZ zirconia abutments coated with boron-doped soda-lime glass, with or without silver, and to evaluate the fatigue lifetime of boron-doped soda-lime glass-coated…
Shang, Ma, Chen et al. · 2026 · Waste management (New York, N.Y.)
Ammonia (NH 3 ) is a key odorous gas emitted from livestock and poultry farming, and biofiltration has been widely used for NH 3 removal. Temperature plays a critical role in regulating microbial activity and greenhouse gas emissions in…
Zhou, He, Cheng et al. · 2026 · CNS neuroscience & therapeutics
To compare the real-world effectiveness, surgical and economic outcomes of preoperative rapid antibody clearance therapy (RACT: lymphoplasmapheresis (LPE), efgartigimod (EFG)) versus oral immunosuppressants (Oral IS) in generalized…
Fukuda, Blackwood, Kim et al. · 2026 · Journal of neurointerventional surgery
Combined delivery catheter systems (CDCS) with ledge-reducing obturators are designed to streamline aspiration-first mechanical thrombectomy, yet comparative multicenter data across platforms remain limited. To determine whether an…
Giorgini, Xavier, da Silva et al. · 2026 · Topics in companion animal medicine
LINE-1 (long interspersed nuclear element-1) is a family of related class I transposable elements in the DNA that is dispersed throughout the entire genome and the study of its methylation pattern is used in the understanding of several…
Tran, Padda, Sharma et al. · 2026 · Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
A major challenge in teaching slit-lamp biomicroscopy is providing adequate depth perception and anatomical detail; the Deep Reality Viewer (DRV) addresses this by enabling stereopsis. This study evaluated the utility of DRV for slit-lamp…
Björkman, Malusek, Persson et al. · 2026 · European radiology experimental
The aim was to compare the image quality of photon-counting detector CT (PCD-CT) and energy-integrating detector CT (EID-CT) in patients with tibial plateau fractures treated with metallic osteosynthesis material, and to identify optimal…
Hironori Sadamatsu, Yuki Kurihara, Koichiro Takahashi et al. · 2019 · Case Reports in Oncology
Paraneoplastic limbic encephalitis (PLE) is a rare neurologic disorder that can complicate various malignancies, including lung cancer. PLE is most frequently found the initial presentation of lung cancer. In this study, we reported the case of a 74-year-old Japanese woman who developed PLE after partial remission of small cell lung cancer (SCLC) by first-line systemic chemotherapy. Brain magnetic resonance imaging showed no metastatic tumor or cerebrovascular disease. Anti-glutamic acid decarboxylase (GAD) and anti-amphiphysin antibodies were detected in her serum. She was diagnosed as having
Luana D. Felizari, Luke K. Fuerniss, Jonathan L. Beckett et al. · 2025 · Veterinary Sciences
This study evaluates the effects of a proprietary tannin blend (BX), supplemented with or without sodium monensin (MON), on beef cattle performance, carcass traits, and health. Steers ( n = 2986; initial shrunk body weight (SBW) 254 ± 9.2 kg) were allocated into 48 pens (61–62 steers/pen; 12 pens/treatment) fed for 230 d. Treatments included: (1) no feed additives (CTL); (2) BX (7.95 g/animal daily); (3) MON + Tylosin phosphate (TYL; 437.52 mg MON/animal daily + 80 mg TYL/animal daily); or (4) MON + BX (437.52 mg MON/animal daily + 7.95 g BX/animal daily). Data were analyzed in R 4.2.1 using a
Kyle Hayes, Elizabeth Warner, Chris Bollinger et al. · 2020 · BMC Nephrology
Abstract Background Focal segmental glomerulosclerosis (FSGS) causes renal fibrosis and may lead to kidney failure. FSGS and its common complication, proteinuria, are challenging to treat. Corticosteroids are ineffective in many patients with FSGS, and alternative treatments often yield suboptimal responses. Repository corticotropin injection (RCI; Acthar® Gel), a naturally sourced complex mixture of purified adrenocorticotropic hormone analogs and other pituitary peptides, may have beneficial effects on idiopathic FSGS via melanocortin receptor activation. Methods Two studies in a preclinical
Michael R Gionfriddo, Yirui Hu, Bhumika Maddineni et al. · 2022 · JMIR Formative Research
BackgroundDespite routine review of medication lists during patient encounters, patients’ medication lists are often incomplete and not reflective of actual medication use. Contributing to this situation is the challenge of reconciling medication information from existing health records, along with external locations (eg, pharmacies, other provider/hospital records, and care facilities) and patient-reported use. Advances in the interoperability and digital collection of information provides a foundation for integration of these once disparate information sources. ObjectiveWe aim to evaluate th
Pei-Chih Lee, Yuqing Yang, Kaywalee Chatdarong et al. · 2026 · Frontiers in Veterinary Science
IntroductionDry-preservation of gametes offers a promising alternative to cryobanking by potentially storing cells at ambient temperatures; however, successful preservation of whole oocytes remains limited by dehydration-induced cellular damages. This study evaluated whether intracellular delivery of trehalose via a membrane-permeable derivative, trehalose hexaacetate (6-O-Ac-Tre), could enhance dehydration tolerance of domestic cat cumulus–oocyte complexes (COCs), a relevant model for mammalian fertility preservation.MethodsCat COCs were incubated with 0, 3, 10, or 30 mM of 6-O-Ac-Tre to asse
Nurfitri Iriani Utami, Abd. Karman, Moh Syarifudin · 2022 · OIKONOMIKA : Jurnal Kajian Ekonomi dan Keuangan Syariah
The massive digital transformation was escalating due to the emergence of the Covid-19 Pandemic occurred in almost all industrial sectors including the banking sector. To respond to this challenge, banking presents an innovation that is…
Yuka Nadai, Yuka Nadai, Kathrin Held et al. · 2019 · Frontiers in Immunology
Background: A better understanding of the parameters influencing vaccine-induced IgG recognition of individual antigenic regions and their variants within the HIV Envelope protein (Env) can help to improve design of preventive HIV vaccines.Methods: Env-specific IgG responses were mapped in samples of the UKHVC003 Standard Group (UK003SG, n = 11 from UK) and TaMoVac01 (TMV01, n = 17 from Tanzania) HIV vaccine trials. Both trials consisted of three immunizations with DNA, followed by two boosts with recombinant Modified Vaccinia Virus Ankara (MVA), either mediating secretion of gp120 (UK003SG) o
R. mawar, S. Lodha · 2002 · Phytopathologia Mediterranea
The combined effect of Brassica amendments (mustard oil–cake or mustard residue at 2.5 tons ha-1) and summer irrigation was tested for survival of Macrophomina phaseolina and Fusarium oxysporum f. sp. cumini and on the severity of dry root rot on clusterbean in the rainy season and on wilt of cumin in the subsequent winter season in the same field. Seed coating with a Bacillus sp., an antagonist bacterium against M. phaseolina, was also integrated with pod residues to improve control of dry root rot. The soil temperature of amended soil after one summer irrigation in June ranged from 38–44°C a
Bela Scapec, Jozo Grgic, Dorian Varovic et al. · 2024 · Journal of the International Society of Sports Nutrition
Background Caffeine is one of the most popular ergogenic aids consumed by athletes. Caffeine’s ergogenic effect has been generally explained by its ability to bind to adenosine receptors, thus modulating pain and reducing perceived exertion. Another pharmacological agent that may improve performance due to its analgesic proprieties is paracetamol. This study aimed to explore the effects of caffeine, paracetamol, and caffeine + paracetamol consumption on muscular endurance, strength, power, anaerobic endurance, and jumping performance.Methods In this randomized, crossover, double-blind study, 2
Ananda Krisma Delya, Tri Naimah, U. Wibowo et al. · 2023 · AL-TANZIM : JURNAL MANAJEMEN PENDIDIKAN ISLAM
This study aims to determine the organizational climate's effect on work happiness with Islamic religiosity as a moderator variable for Islamic-based school teachers in the Banyumas Regency. A correlational quantitative approach was used…
Christopher J. Kirwan, Barbara J. Philips, Iain A. M. MacPhee · 2013 · Critical Care Research and Practice
Introduction. RIFLE and AKIN provide a standardised classification of acute kidney injury (AKI), but their categorical rather than continuous nature restricts their use to a research tool. A more accurate real-time description of renal function in AKI is needed, and some published data suggest that equations based on serum creatinine that estimate glomerular filtration rate (eGFR) can provide this. In addition, incorporating serum cystatin C concentration into estimates of GFR may improve their accuracy, but no eGFR equations are validated in critically ill patients with AKI. Aim. This study t
Phietica R. R. Silva, Phietica R. R. Silva, Regina H. Silva et al. · 2020 · Frontiers in Psychology
Empathy is the ability to (a) be affected by and share the emotional state of another; (b) assess the reasons for the other’s state; and (c) identify with the other, adopting their perspective. This phenomenon has been shown to exist in several species and is proposed as a motivator for prosocial behavior. The experimental study of this feature in laboratory rodents is a more viable alternative in comparison to wild animals. A recent report showed that rats opened a door to free their cage mate from a restraint box. Although this behavior has been suggested to be motivated by empathy, this fac
Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
M. Sadaka, M. Loutfy, M. Sobhy · 2013 · The Egyptian Heart Journal
Aim: The purpose of this study was to compare the impact of incomplete revascularization (IR) plus optimal medical therapy (OMT) to OMT alone on 1 year clinical outcomes in patients with multivessel coronary artery disease (MVD) who were not eligible for coronary bypass graft surgery (CABG). Methods: This is a prospective randomized study conducted on 50 selected patients with chronic stable angina with documented MVD and CABG was refused by the surgeon due to poor distal vessel quality. Patients were randomized 1:1 into two groups, group (I): 25 patients were subjected to OMT alone and group
Tobias Wollersheim, Julius J. Grunow, Niklas M. Carbon et al. · 2019 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Early mobilization improves physical independency of critically ill patients at hospital discharge in a general intensive care unit (ICU)‐cohort. We aimed to investigate clinical and molecular benefits or detriments of early mobilization and muscle activating measures in a high‐risk ICU‐acquired weakness cohort. Methods Fifty patients with a SOFA score ≥9 within 72 h after ICU admission were randomized to muscle activating measures such as neuromuscular electrical stimulation or whole‐body vibration in addition to early protocol‐based physiotherapy (intervention) or early p
Solberg Peter, Were Willy, Downing Robert S et al. · 2007 · AIDS Research and Therapy
Abstract Background CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. Methods We conducted a cross-sectional study of HIV-infected adults in Uganda, who presented for assessment for ART-eligibility with WHO clinical stages I, II or
Colleen M. Badke, Matthew L. Friedman, Z. Leah Harris et al. · 2020 · Resuscitation Plus
Aim: To determine if an untrained cardiopulmonary resuscitation (CPR) Coach, with no access to real-time CPR feedback technology, improves CPR quality. Methods: This was a prospective randomized pilot study at a tertiary care children's hospital that aimed to integrate an untrained CPR Coach into resuscitation teams during simulated pediatric cardiac arrest. Simulation events were randomized to two arms: control (no CPR Coach) or intervention (CPR Coach). Simulations were run by pediatric intensive care unit (PICU) providers and video recorded. Scenarios focused on full cardiopulmonary arrest;
Cassandra A. A. Locatelli, My-Anh Nguyen, Nadya M. Morrow et al. · 2026 · Cardiovascular Diabetology
Abstract Background The ketogenic diet (KD) is widely recognized for its potential benefits in individuals with type 2 diabetes, but findings from both human and animal studies remain inconsistent. Type 2 diabetes is often comorbid with liver steatosis and atherosclerosis which are characterized by inflammation and dysregulated lipid metabolism. Moreover, whereas KD has shown mixed, sometimes detrimental, effects on circulating cholesterol levels in humans, it is currently unclear the whole-body balance of risk and benefit across hepatic, atherosclerotic, and pancreatic effects. Methods We use
Abolghasem Pourreza, Ali Mohammad Mosadeghrad, Parsa Zoleikani · 2017 · پژوهشهای سلامتمحور
Background & Objectives: Accreditation, as a formal external evaluation system, has a critical role in improving quality, safety and effectiveness of hospital services. The aim of this study was to evaluate the effects of accreditation standards on the performance of Accident and Emergency (A&E) departments of hospitals in Sari, Iran. Methods: This cross-sectional descriptive - analytic study was carried out in eight hospitals in Sari, Iran. Information related to the accreditation scores and five performance indicators of A&E departments (i.e., average triage time, percentage of cardiopulmona
Fatemeh Asgharian Asl, Sajjad Abbaszade, Sajjad Abbaszade et al. · 2024 · Frontiers in Psychiatry
BackgroundExciting left DLPFC activity with high frequency and inhibiting right DLPFC with low frequency repetitive transcranial magnetic stimulation (rTMS) has shown antidepressant effects in major depressive disorder (MDD) and executive functions. However, few studies have directly compared unilateral and bilateral protocols.MethodsForty-seven individuals with treatment-resistant MDD underwent 10 sessions of rTMS over left DLPFC (20 Hz), bilateral DLPFC (left 20 Hz, right 1 Hz), or sham stimulation. Outcomes were depression (Beck Depression Inventory-II), visual-spatial memory (Corsi Block T
Elias Stathatos, Panagiotis Lianos · 2002 · International Journal of Photoenergy
Dye-sensitized photoelectrochemical cells based on TiO2 mesoporous films, a ruthenium bipyridyl derivative as photosensitizer and a SiO2/poly(ethylene glycol)-200 nanocomposite thin film as electrolyte support, have been constructed. TiO2 films have been deposited on conductive transparent Indium-Tin Oxide glass slides by means of a sol-gel procedure carried out in reverse-micellar solutions. The photosensitizer has been adsorbed on titania films from ethanolic solutions while the electrolyte layer has been synthesized by a sol-gel procedure. The presence of silica in the nanocomposite electro