Negative / Null Result Report
Kalkonde Y, Jadhao S, Bhusari V et al. · 2026 · Preprint
Background: Stroke is the second leading cause of death globally. We tested whether it was feasible to deliver a community-based intervention package for prevention of stroke and, whether such an intervention would reduce stroke mortality…
View details →DOI: 10.12688/wellcomeopenres.26002.1 Negative / Null Result ReportOpen accessMedicine
Jacquier M, Laroye C, Bensoussan D et al. · 2026 · Respiratory research
Background Although mesenchymal stromal cells (MSCs) have shown promising effects in preclinical pneumonia models, their ability to improve outcomes in ventilator-associated pneumonia (VAP) remains poorly explored, despite VAP being a…
View details →DOI: 10.1186/s12931-025-03457-6 Negative / Null Result ReportMedicine
Guo Y, Hu S, Wang Z et al. · 2026 · Journal of neurotrauma
The formation of brain edema is one of the key factors that determine patient outcomes following traumatic brain injury (TBI). Despite decades of research, no causal treatment is available to date. Among the many factors discussed,…
View details →DOI: 10.1177/08977151261451145 Negative / Null Result ReportMedicine
Björnsson O, Geirsson G, Leifsson ÁS et al. · 2026 · Scandinavian journal of urology
Introduction Transurethral resection of bladder tumor (TURBT) is the standard treatment for non-muscle-invasive bladder cancer (NMIBC), but early recurrences remain frequent. The objective of this study was to standardize TURBT management…
View details →DOI: 10.2340/sju.v61.45711 Negative / Null Result ReportMedicine
Mauter F, Anton M, van Engen R et al. · 2026 · Physics in medicine and biology
Objective. Digital mammography (DM) and dual-energy contrast-enhanced mammography (CEM) use the same anti-scatter grid, despite their differences in x-ray spectra. This study investigated grid performance under clinically relevant…
View details →DOI: 10.1088/1361-6560/ae2c39 Negative / Null Result ReportMedicine
Szarpak L, Al-Jeabory M, Pecold J et al. · 2026 · The aging male : the official journal of the International Society for the Study of the Aging Male
Introduction Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. Objectives To synthesise current…
View details →DOI: 10.1080/13685538.2026.2655544 Negative / Null Result ReportMedicine
Carnevali A, Chisari D, Mancini A et al. · 2026 · Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
Introduction Inferior retinal detachment (I-RD) complicated by proliferative vitreoretinopathy (PVR) is challenging to treat and prone to recurrence (retinal detachment recurrence [RDR]). Heavy silicone oil (HSO) tamponades such as…
View details →DOI: 10.1159/000551398 Negative / Null Result ReportMedicine
Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics
Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…
View details →DOI: 10.1007/s00431-026-06904-8 Negative / Null Result ReportMedicine
Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)
Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…
View details →DOI: 10.1097/gme.0000000000002808 Negative / Null Result ReportMedicine
Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine
Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…
View details →DOI: 10.1136/rapm-2024-106247 Negative / Null Result ReportMedicine
Uehara T, Itoh H, Abe H et al. · 2026 · Psychopharmacology
Rationale Apocynin-tandospirone derivatives (ATDs) have recently been shown to ameliorate methamphetamine (MAP)-induced behavioral abnormalities when administered chronically, presumably through antioxidant and interneuron-related…
View details →DOI: 10.1007/s00213-026-07040-9 Negative / Null Result ReportMedicine
Marzo-Escartín B, Villamarín-Melio M, Márquez-Algaba E et al. · 2026 · Surgical infections
Background Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial…
View details →DOI: 10.1177/10962964261438723 Negative / Null Result ReportMedicine
Rana CJ, Bakshi SG, Tarhane S et al. · 2026 · Indian journal of surgical oncology
Distract trial In the post-operative period, analgesics are complemented with non-pharmacological methods (NPM). However, the evidence is limited. Objectives Randomised control trial aimed to determine the effectiveness of NPMs of pain…
View details →DOI: 10.1007/s13193-026-02583-x Negative / Null Result ReportMedicine
Porter A, Nguyen J, Peng Y et al. · 2026 · The American journal of sports medicine
Background Intra-articular triamcinolone acetonide (TA) injections are commonly used to manage joint synovitis despite reports that they accelerate cartilage degeneration. Previous studies found that TA minimally affected bovine cartilage,…
View details →DOI: 10.1177/03635465261439028 Negative / Null Result ReportMedicine
Van de Perre E, Tielemans C, De Clerck D et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Background and hypothesis Hyperoxaluria is an important risk factor for kidney stone formation. Currently available treatment options for idiopathic hyperoxaluria have limited efficacy and are difficult to maintain in the long-term.…
View details →DOI: 10.1093/ndt/gfag103 Negative / Null Result ReportMedicine
Islam IS, McGetrick ME, Leon RL et al. · 2026 · The Annals of thoracic surgery
Background We implemented a preoperative screening brain magnetic resonance imaging (MRI) protocol for neonates undergoing cardiac surgery. The intent was to identify unrecognized central nervous system (CNS) injury that might alter the…
View details →DOI: 10.1016/j.athoracsur.2026.03.011 Negative / Null Result ReportMedicine
Tian Q, Tian B, Li K et al. · 2026 · Neurosurgical review
The effectiveness of surgical intervention for hydrocephalus in patients with prolonged disorders of consciousness (pDoC) remains controversial. To investigate the impact of ventriculoperitoneal shunt (VPS) on secondary hydrocephalus…
View details →DOI: 10.1007/s10143-026-04211-2 Negative / Null Result ReportMedicine
Rasmussen JJ, Bisgaard J, Hønge JL et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives Managing pain after median sternotomy is a clinical challenge of balancing adequate pain relief with avoidance of excessive opioid consumption. While regional anesthesia techniques are increasingly recommended and applied in…
View details →DOI: 10.1053/j.jvca.2026.03.042 Negative / Null Result Report
Tuzlali M, Baki N, Avcu GY et al. · 2026 · Preprint
Background: /Objectives: Full-arch zirconia prostheses for mandibular All-on-4 rehabilitations are provided as screw-retained monolithic zirconia or as a zirconia suprastructure luted to a CAD/CAM titanium bar. Because zirconia is a…
View details →DOI: 10.20944/preprints202602.0002.v1 Negative / Null Result ReportMedicine
Damázio AH, Carlos NR, Basting RT et al. · 2026 · Operative dentistry
Objective Because the application of violet light-emitting diode (LED) light may enhance the release of reactive oxygen species, and its combination with a high-concentration bleaching agents may accelerate collagen degradation, this study…
View details →DOI: 10.2341/24-176-l Negative / Null Result ReportMedicine
Ko HR, Cho SY, Kim HS et al. · 2026 · Food science and biotechnology
The East Asian fruit Maesil ( Prunus mume ) is primarily consumed as a sugar extract in South Korea. This stone fruit-derived product contains various forms of potentially toxic cyanide compounds. This study evaluated manufacturing…
View details →DOI: 10.1007/s10068-026-02100-4 Negative / Null Result ReportMedicine
Burastero GJ, Wey EQ, Guidetti V et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Data regarding the effectiveness of vancomycin-resistant Enterococci (VRE)-active prophylaxis for preventing early post-liver transplantation (LT) VRE infections in VRE-colonized patients are scarce. Methods 131 pre-LT…
View details →DOI: 10.1093/cid/ciaf121 Negative / Null Result ReportMedicine
van Limpt GJC, van Vliet P, Molenaar MA et al. · 2026 · Intensive & critical care nursing
Introduction False or clinically irrelevant alarms are a major driver of ICU alarm fatigue and nursing workload. Ventilator alarms make up a large share, and although automated ventilation modes can reduce manual adjustments, their effect…
View details →DOI: 10.1016/j.iccn.2026.104471 Negative / Null Result ReportMedicine
Westerhout SF, Remmers S, Bangma CH et al. · 2026 · European journal of cancer (Oxford, England : 1990)
Introduction Prostate-specific antigen (PSA)-based prostate cancer (PCa) screening can be improved by individualised, risk-stratified strategies. Comorbidity influences life expectancy, so may affect benefits of screening. We evaluated…
View details →DOI: 10.1016/j.ejca.2026.116741 Negative / Null Result ReportMedicine
Ruegg T, Zhao X, Mount MS et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Background Telehealth-delivered education offers a practical approach to chemotherapy teaching and symptom self-management support. Advanced practice providers (APPs) play an increasingly vital role in guiding oncology patients through…
View details →DOI: 10.1007/s00520-026-10519-y Negative / Null Result ReportMedicine
Kim J, Park C, Woo KJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Concerns regarding donor-site healing persist in abdominal-based free flap breast reconstruction. Although closed-incision negative-pressure therapy (CINPT) has demonstrated wound-related benefits, its efficacy without the use of drains…
View details →DOI: 10.1016/j.bjps.2026.01.027 Negative / Null Result Report
Freitas NM, Silva ACA, Tebaldi ND · 2025 · Preprint
Abstract Lettuce bacterial leaf spot, caused by Xanthomonas hortorum pv. vitians is one important pathogen of lettuce. The use of nanoparticles offers a new approach to controlling the disease. The objective of this work was to investigate…
View details →DOI: 10.21203/rs.3.rs-6066801/v1 Negative / Null Result ReportMedicine
Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…
View details →DOI: 10.1093/cid/ciag110 Negative / Null Result ReportOpen accessMedicine
Zelaya IO, Soto ORR, Ventura GPM et al. · 2026 · European journal of midwifery
Introduction Pain and anxiety are common during labor. Evidence on non-pharmacological tools like the peanut ball from public hospital settings in Honduras is limited. This study evaluated its efficacy in reducing pain and anxiety. Methods…
View details →DOI: 10.18332/ejm/220424 Negative / Null Result Report
Placidi V, Lisi MP, Vabba A et al. · 2025 · Preprint
Although Mafia-type criminal organizations (MCOs) exert severe societal harm, evidence-based interventions fostering anti-mafia motives remain scarce. We investigated whether embodying virtual heroic characters enhances opposition to MCOs.…
View details →DOI: 10.31234/osf.io/va2k5_v2 