Negative / Null Result ReportOpen accessAnimal culture
X.L. Chen, L.Z. Gong, J.X. Xu · 2013 · Animal
In this study, antioxidant capability and protective effect of probiotics on reproductive damage induced by diet oxidative stress were investigated. Thirty male Sprague-Dawley rats were randomly divided into three groups with 10 rats in each group. The control group consumed a normal standard diet (5% fat, w/w). The other two treatment groups were fed with a high-fat diet (20% fat, w/w), and a high-fat diet supplemented with 2% probiotics (w/w), respectively. At the end of the experimental period, that is, after 6 weeks, rats were killed. Activities of superoxide dismutase (SOD), glutathione p
View details →DOI: 10.1017/s1751731112001528 Negative / Null Result ReportOpen accessInfectious and parasitic diseases
Seyed Ebrahim ESKANDARI, Alireza FIROOZ, Mansour NASSIRI-KASHANI et al. · 2019 · Iranian Journal of Parasitology
Background: We aimed to evaluate the safety of SinaAmpholeish in a double-blind, randomized, phase 1 clinical trial in healthy human volunteers. Methods: The study was carried out in DermaLab of Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran in 2012. A topical Nano-liposomal formulation of 0.4% Amphotericin B was developed against Leishmania under trade name of SinaAmpholeish. In this randomized, double-blind, right-left, comparative, phase I clinical trial, in 2 steps; 7 and 20 healthy volunteers were recruited and applied Si
View details →DOI: 10.18502/ijpa.v14i2.1130 Negative / Null Result ReportOpen accessSports medicine
Raziyeh Shiri, Mahsa Abdi, Sadegh Amani Shalamzari · 2022 · فیزیولوژی ورزش و فعالیت بدنی
Purpose: One of the changes that occurs in the vascular structure of skeletal muscle during exercise to resolving stress is the process of angiogenesis that has been considered by researchers. Thus, the aim of this study was to investigate the effect of 6-week resistance training with different Time under Tension (TUT) on some serum vascular growth factors in inactive girls.Methods: 20 female volunteer students (mean age 22.3 yrs) were randomly and equally divided into two groups with different TUT of (1s – 1s) and (2s – 4s). Resistance training was performed for 6-week, three times per week,
View details →DOI: 10.52547/joeppa.15.1.97 Negative / Null Result ReportOpen accessMedicine
Caitlin N Jacques, Anna K Hulbert, Shelby Westenskow et al. · 2020 · PLoS ONE
BACKGROUND:Recently, it was found that 1% Phytagel plates used to conduct Arabidopsis thaliana seedling phenotypic analysis no longer reproduced previously published results. This Phytagel, which is produced in China (Phytagel C), has replace American-made Phytagel (Phytagel), which is no longer commercially available. In this study, we present the impact of Phytagel produced in the United States vs. China on seedling phenotypic analysis. As a part of this study, an alternative gelling agent has been identified that is capable of reproducing previously published seedling morphometrics. RESULTS
View details →DOI: 10.1371/journal.pone.0228515 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Julie Van, Sam E. Nielsen, C. Brock Kirwan · 2022 · NeuroImage: Reports
Common research practices in neuroimaging studies using functional magnetic resonance imaging may produce outcomes that are difficult to replicate. Results that cannot be replicated have contributed to a replication crisis in psychology, neuroscience, and other disciplines over the years. Here we replicate two previous papers in which the authors present two analysis paths for a dataset in which participants underwent fMRI while performing a recognition memory test for old and new words. Both studies found activation in the medial temporal lobe including the hippocampus, with the first demonst
View details →DOI: 10.1016/j.ynirp.2022.100135 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Shunchuan Zhang, Lauren E Springer, Han-Zhi Rao et al. · 2021 · PLoS Pathogens
Cytomegalovirus (CMV) causes clinically important diseases in immune compromised and immune immature individuals. Based largely on work in the mouse model of murine (M)CMV, there is a consensus that myeloid cells are important for disseminating CMV from the site of infection. In theory, such dissemination should expose CMV to cell-mediated immunity and thus necessitate evasion of T cells and NK cells. However, this hypothesis remains untested. We constructed a recombinant MCMV encoding target sites for the hematopoietic specific miRNA miR-142-3p in the essential viral gene IE3. This virus diss
View details →DOI: 10.1371/journal.ppat.1009255 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Lars Hausfeld, Lars Hausfeld, Niels R. Disbergen et al. · 2021 · Frontiers in Neuroscience
Numerous neuroimaging studies demonstrated that the auditory cortex tracks ongoing speech and that, in multi-speaker environments, tracking of the attended speaker is enhanced compared to the other irrelevant speakers. In contrast to speech, multi-instrument music can be appreciated by attending not only on its individual entities (i.e., segregation) but also on multiple instruments simultaneously (i.e., integration). We investigated the neural correlates of these two modes of music listening using electroencephalography (EEG) and sound envelope tracking. To this end, we presented uniquely com
View details →DOI: 10.3389/fnins.2021.635937 Negative / Null Result ReportOpen accessMedicine
Karen E Mulak, Hannah S Sarvasy, Alba Tuninetti et al. · 2021 · PLoS ONE
Adapting laboratory psycholinguistic methods to fieldwork contexts can be fraught with difficulties. However, successful implementation of such methods in the field enhances our ability to learn the true extent and limitations of human behavior. This paper reports two attempts to run word learning experiments with the small community of Nungon speakers in Towet village in the Saruwaged Mountains, Papua New Guinea. A first attempt involved running a cross-situational task in which word-object pairings were presented ambiguously in each trial, and an explicit word learning task in which pairings
View details →DOI: 10.1371/journal.pone.0257393 Negative / Null Result ReportOpen accessAstrophysics
Mohit Bhardwaj, Victoria M. Kaspi, K. W. Masui et al. · 2025 · The Astrophysical Journal
Despite hundreds of detected fast radio bursts (FRBs), the faint-end slope ( γ ) of their energy distribution remains poorly constrained, hindering understanding of whether bright, cosmological FRBs and faint, Galactic magnetar SGR 1935+2154-like bursts share a common origin. In this study, we constrain this faint-end slope, modeled with a Schechter-like distribution, by searching for potential associations between bursts from the CHIME/FRB Catalog-1 and galaxies in the Local Volume. We crossmatched CHIME/FRB Catalog-1 FRBs with 495 Local Volume galaxies within 21 Mpc, identified from the HECA
View details →DOI: 10.3847/1538-4357/aded17 Negative / Null Result ReportOpen access
Miftahul Jannah, Zulpikar Zulpikar, Muliani Muliani · 2021 · Acta Aquatica
Tilapia (Oreochromis niloticus) is a type of freshwater fish that is widely cultivated by Indonesians. The problem that often arises in cultivation is lack of water quality. One of the ways to improve water quality is by using aquaponics…
View details →DOI: 10.29103/aa.v8i3.3711 Negative / Null Result ReportOpen accessMedicine
Teerachate Nantakeeratipat · 2026 · Frontiers in Digital Health
BackgroundLarge Language Models (LLMs) in healthcare holds immense promise yet carries the risk of perpetuating social biases. While artificial intelligence (AI) fairness is a growing concern, a gap exists in understanding how these models perform under conditions of clinical ambiguity, a common feature in real-world practice.MethodsWe conducted a study using an ambiguity-probe methodology with a set of 42 sociodemographic personas and 15 clinical vignettes based on the 2018 classification of periodontal diseases. Ten were clear-cut scenarios with established ground truths, while five were int
View details →DOI: 10.3389/fdgth.2025.1687820 Negative / Null Result ReportOpen accessGynecology and obstetrics
Jingting Liu, Yijun Dong, Yawei Zhou et al. · 2024 · BMC Pregnancy and Childbirth
Abstract Background Observational epidemiological studies suggested that immunological dysregulation and inflammation play a significant role in the placental and renal dysfunction that leads to maternal hypertension. The immunophenotypes' possible causalities with hypertensive disease of pregnancy remain ambiguous. We performed two-sample Mendelian randomization (MR) analyses to comprehensively investigate the causal effect of immunophenotypes on hypertensive disorder of pregnancy (HDP). Methods The large-scale genome-wide association studies (GWASs) data on immunological traits was taken fro
View details →DOI: 10.1186/s12884-024-06950-w Negative / Null Result ReportOpen accessMedicine (General)
Emily Sheppard, MScPT, Michael Smyth, MSc, Todd Dow, BSc et al. · 2020 · Archives of Rehabilitation Research and Clinical Translation
Objective: To assess the effect the Pre-clerkship Residency Exploration Program (PREP) had on student career interest and improving understanding of physical medicine and rehabilitation (PMR). Design: During a 2-week program, students were exposed to a PMR elective, workshop, career presentation, and panel discussion with PMR residents. Interest and understanding were assessed using pre- and postprogram questionnaires. Setting: PREP was held at a Canadian medical school during the summer between the second and third years of undergraduate medical training. Participants: Second-year medical stu
View details →DOI: 10.1016/j.arrct.2019.100035 Negative / Null Result ReportOpen accessEducation (General)
Wonseok Chang, Yura Kim, Hye Jin Park · 2024 · Korean Journal of Medical Education
Purpose Although interest in various forms of learning media is increasing due to the coronavirus disease 2019 (COVID-19) pandemic there is relatively little research on influencing student motivation by intervening in cognitive processing. The purpose of this study was to present the optimal form of learning materials provided to medical students. Methods This study provided learning materials in class at a level according to social cues (script, video [artificial intelligence (AI) voice], video [professor voice]) based on the principle of voices among the principles of personalization, voice
View details →DOI: 10.3946/kjme.2024.288 Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Dan Liang, Chang Liu, Xingyu Zhang · 2026 · Food, Nutrition and Health
Abstract Background This study aimed to investigate the relationship between dietary iron intake and risk of abdominal aortic calcification (AAC) in middle-aged and older US adults. Methods We analyzed data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). Multivariate linear and logistic regression models were employed to evaluate the association between dietary iron intake and AAC score, as well as the likelihood of both AAC and severe AAC. To investigate potential non-linear dose-response relationships, we performed restricted cubic spline (RCS) modeling. In addi
View details →DOI: 10.1007/s44403-026-00060-5 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Yinuo Li, Xi Liu, Qian Hong et al. · 2024 · Frontiers in Cardiovascular Medicine
BackgroundRecent epidemiological studies have indicated a correlation between platelet indices and pulmonary arterial hypertension (PAH), yet the causality between them remains unclear. To explore the causal relationship between four platelet indices and PAH, with the aim of providing a theoretical basis for clinical prevention and treatment.MethodsSingle-nucleotide polymorphisms (SNPs) associated with platelet-related traits were selected as exposure factors from published genome-wide association studies (GWAS), including: platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV),
View details →DOI: 10.3389/fcvm.2024.1395245 Negative / Null Result ReportOpen accessMedicine
Bohan Jia, Junyi Sun, Di Zhu et al. · 2025 · Scientific Reports
Abstract Cancer significantly contributes to the unfavorable prognosis of coronavirus disease 2019 (COVID-19) patients. The efficacy and safety of azvudine and nirmatrelvir/ritonavir (Paxlovid) in cancer patients with COVID-19 remain uncertain. Therefore, we designed a comprehensive retrospective study encompassing clinical data of 32,864 hospitalized COVID-19 patients, 691 of whom were cancer patients treated with azvudine and 200 were cancer patients treated with Paxlovid. After 2:1 propensity score matching, 397 patients in the azvudine group and 199 patients in the Paxlovid group were enro
View details →DOI: 10.1038/s41598-025-85677-w Negative / Null Result ReportOpen accessDentistry
Disha Kumar, Anant Gopal Nigam, Nikhil Marwah et al. · 2018 · Journal of Indian Society of Pedodontics and Preventive Dentistry
Background and Objectives: The aim of this study was to examine the arch dimensions of beta thalassemia major patients in comparison with normal individuals. Materials and Methods: Dental arch dimensions were compared between thalassemic patients and normal individuals in the age group of 12–16 years in the maxillary and mandibular arch corresponding to each other regarding age, sex and Angle's molar relationship. A total number of sixty cases in each group were taken. Maxillary and mandibular impressions were made with alginate for all the sixty participants in each group and poured with die
View details →DOI: 10.4103/jisppd.jisppd_283_16 Negative / Null Result ReportOpen accessMedicine (General)
M.A. Arbex, L.C. Martins, L.A.A. Pereira et al. · 2007 · Brazilian Journal of Medical and Biological Research
Studies of cooking-generated NO2 effects are rare in occupational epidemiology. In the present study, we evaluated the lung function of professional cooks exposed to NO2 in hospital kitchens. We performed spirometry in 37 cooks working in four hospital kitchens and estimated the predicted FVC, FEV1 and FEF25-75, based on age, sex, race, weight, and height, according to Knudson standards. NO2 measurements were obtained for 4 consecutive days during 4 different periods at 20-day intervals in each kitchen. Measurements were performed inside and outside the kitchens, simultaneously using Palm diff
Negative / Null Result ReportOpen accessOphthalmology
Ahmed S Abdel-Wanes, Abelrahman G Salman, Azza M.A Said et al. · 2020 · Journal of the Egyptian Ophthalmological Society
Aim To determine the risk factors responsible for opaque bubble layer (OBL) formation in femtosecond-laser-assisted in situ keratomileusis (FSL-LASIK). Patients and methods A retrospective, comparative study was carried out from January 2015 to January 2017 in El-Watany Eye Hospital. Two hundred eyes who were eligible for FSL-laser-assisted in situ keratomileusis (FSL was done using FS200, wavelight, Germany SR/1025-1-380) were classified into two groups. Group I: the study group with OBL formation during surgery (100 eye) and group (II): the control group without OBL formation during surgery
View details →DOI: 10.4103/ejos.ejos_24_20 Negative / Null Result ReportOpen accessMedicine
Zagorac Slaviša, Bumbaširević Marko, Lešić Aleksandar et al. · 2008 · Srpski Arhiv za Celokupno Lekarstvo
Introduction Multiple trauma is one of the leading causes of mortality and morbidity in the population of people under 45 years of age. The consequences of multiple trauma have huge epidemiological, social and economic significance. Objective The aim of the paper was to analyze the conclusive treatment outcome of multiply traumatized patients with respect to their sex, age, injury mechanism and type. METHOD This retrospective study included 100 patients with multiple injuries (ISS>16) treated in the Emergency Room of the Clinical Centre of Serbia in the course of 2004. Clinical, X-ray, laborat
View details →DOI: 10.2298/sarh0804136z Negative / Null Result ReportOpen accessMedicine
Levent Cigerim, Erkan Feslihan · 2019 · Journal of Oral Health and Oral Epidemiology
BACKGROUND AND AIM: Alterations in blood pressure (BP) and variability of heart rate (HR) throughout dental procedures were not clearly understood. The aim of this study is to evaluate the effects of body mass index (BMI) on BP and HR in patients undergoing tooth extraction. METHODS: Based on BMI, 831 patients who underwent single tooth extraction were divided into two groups; group 1: underweight and normal-weight patients, group 2: overweight and obese patients. BP and HR were monitored before local anesthesia and after tooth extraction. For statistical analysis of the data, Number Cruncher
View details →DOI: 10.22122/johoe.v8i4.1026 Negative / Null Result ReportOpen accessSports medicine
Tim Wang MD, Van Krueger, Roslyn Kackman et al. · 2025 · Orthopaedic Journal of Sports Medicine
Objectives: Osteochondral allograft (OCA) transplantation is an effective treatment method for articular cartilage damage in the knee. The mid- and long-term outcomes of patellofemoral OCA transplantation has been less frequently reported compared to those of the medial and lateral compartments of the knee, and these grafts often show lower survival rates and worse patient-reported outcomes. The unique morphology and biomechanics of the patellofemoral compartment leads to different pathologies than other areas of the knee. The purpose of this study was to assess graft survivorship and patient-
View details →DOI: 10.1177/2325967125s00085 Negative / Null Result ReportOpen accessAnesthesiology
Marzieh khalaji, Mohadese Babaie, Fatemeh Bayat et al. · 2025 · BMC Anesthesiology
Abstract Aim This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation. Design This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city of Karaj. Methods A total of 100 patients, aged 18 to 40 years and classified as ASA I or II, who were candidates for elective surgery, were randomly assigned to two equal groups. Prior to intubation, patients received lidocaine spray (5 puffs of Lidocaine 10%) in one group, and magnesium sulfate sp
View details →DOI: 10.1186/s12871-025-02962-x Negative / Null Result ReportOpen accessDentistry
Polavarapu Venkata Ravi Chandra, Vemisetty Hari Kumar, Surakanti Jayaprada Reddy et al. · 2015 · Dental Research Journal
Background: The aim of this study was to evaluate and compare the in vitro biofilm forming capacity of Enterococcus faecalis on Gutta-percha points disinfected with four disinfectants. Materials and Methods: A total of 50 Gutta-percha points used in this study were divided into four test groups based on disinfectant (5.25% sodium hypochlorite, 2% chlorhexidine gluconate, 20% neem, 13% benzalkonium chloride [BAK]), and one control group. The Gutta-percha points were initially treated with corresponding disinfectants followed by anaerobic incubation in Brain Heart Infusion broth suspended with h
View details →DOI: 10.4103/1735-3327.161446 Negative / Null Result ReportOpen accessMedicine (General)
Fatemeh Zanganeh, Amir Jalali, Hamid Galehdari et al. · 2014 · Iranian South Medical Journal
Background: Cytochrome P450 2E1 (CYP2E1) is a main enzyme which plays a major role in activating and detoxifying many xenobiotics, carcinogens and drugs. Available studies suggest that CYP2E1 single nucleotide polymorphisms (SNPs) are involved in the risk of developing certain cancers after exposure to carcinogens. The purpose of the present study was to assess genotype and allele frequencies of polymorphic CYP2E1*5B in the Iranian population. Material and Methods: This study was performed on 200 healthy individuals (female: 100, male: 100) in medical laboratories of Ahvaz during 2011. The CYP
Negative / Null Result ReportOpen accessVeterinary medicine
Sladojević Ž., Kasagić D., Kukolj B. et al. · 2013 · Veterinarski Glasnik
The objective of this work was to investigate the influence of housing conditions, number of farrowing and number of pigs in litter on weight loss in sows during lactation. The experiment included 60 sows, half breed developed by cross breeding of Big Yorkshire and Swedish Landrace in lactation. Body weight of the sows (kg) was determined 2nd, 7th, 14th, 21st and 28th day after farrowing. On the basis of the obtained values, there was calculated the difference in body weight between two consecutive investigation periods. The sows were divided into two groups and held in different housing condi
View details →DOI: 10.2298/vetgl1306337s Negative / Null Result ReportOpen accessHistory of scholarship and learning. The humanities
Asmaa Al-suhimi · 2023 · مجلة جامعة الأنبار للعلوم الإنسانية
The current study aimed to design a counseling program based on gratitude for the development of psychological well-being, verify the effectiveness of this program and identify the continuity of its impact through the results of follow-up measurement after a month of its application. An intentional sample of (24) female students from the College of Education at King Khalid University, were randomly divided into two groups, a control, and an experimental group, each group consisted of 12 students, and the research tools used to measure the psychological well-being of university students Prepare
View details →DOI: 10.37653/juah.2023.138251.1158 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
Emanuelle Santos de Carvalho Cardoso, Bruna Laís Santos de Jesus, Luciano Gama da Silva Gomes et al. · 2015 · Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Although urine is considered the gold-standard material for the detection of congenital cytomegalovirus (CMV) infection, it can be difficult to obtain in newborns. The aim of this study was to compare the efficiency of detection of congenital CMV infection in saliva and urine samples. METHODS: One thousand newborns were included in the study. Congenital cytomegalovirus deoxyribonucleic acid (DNA) was detected by polymerase chain reaction (PCR). RESULTS: Saliva samples were obtained from all the newborns, whereas urine collection was successful in only 333 cases. There was no stat
View details →DOI: 10.1590/0037-8682-0200-2014 Negative / Null Result ReportOpen accessSurgery
Cláudio de Saboya David, Alberto Goldenberg · 2018 · Acta Cirúrgica Brasileira
Abstract Purpose: To evaluate the behavior of arterial circulation and testicular volume in patients submitted to conventional inguinal hernia repair without the use of a synthetic prosthesis to reinforce the posterior wall. Methods: A prospective observational clinical trial was performed on 26 male patients with unilateral inguinal hernia types I and II by the Nyhus classification, who underwent surgical correction using the modified Bassini technique. Bilateral Doppler ultrasonography was performed preoperatively, at the third and at the sixth postoperative month. The studied variables were
View details →DOI: 10.1590/s0102-865020180030000009 