Negative / Null Result ReportOpen accessGeriatrics
Lars Donath, Sebastian Ludyga, Daniel Hammes et al. · 2017 · BMC Geriatrics
Abstract Background Aging is accompanied by a decline of executive function. Aerobic exercise training induces moderate improvements of cognitive domains (i.e., attention, processing, executive function, memory) in seniors. Most conclusive data are obtained from studies with dementia or cognitive impairment. Confident detection of exercise training effects requires adequate between-day reliability and low day-to-day variability obtained from acute studies, respectively. These absolute and relative reliability measures have not yet been examined for a single aerobic training session in seniors.
View details →DOI: 10.1186/s12877-017-0634-x Negative / Null Result ReportOpen accessMedicine
Zehra Abdul Muhammad, Tashfeen Ahmad · 2025 · Journal of the Pakistan Medical Association
Objective: To assess the safety and pain reduction profile of routinely prescribed oral analgesics in patients of hip fracture surgery. Method: The single-centre, prospective, cohort study was conducted from June 2022 to July 2023 at the Aga Khan University Hospital, Karachi and comprised adult patients of either gender with hip fractures. The analgesics prescribed at the time of hospital discharge and 1-week follow-up were recorded along with pain and adverse effects till the 2-week post-discharge follow-up. Pain was recorded using the visual analogue scale, with the target score set at 3/10.
View details →DOI: 10.47391/jpma.20532 Negative / Null Result ReportOpen accessDentistry
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon et al. · 2012 · Journal of Applied Oral Science
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells. OBJECTIVES: This study evaluated the effect of a recombinant BMP-2 as well as the endogenous BMP-4 and BMP-7 in the osteogenic differentiation of adipose-derived stem cells (ASCs) in medium supplemented with ascorbate and -glycerophosphate. MATERIAL AND METHODS: Human ASCs were treated with osteogenic medium in the presence (ASCs+OM+BMP-2) or absence (ASCs+OM) of BMP-2. The alkaline phosphatase (ALP) activity was determined
Negative / Null Result ReportOpen accessMedicine
Niroshica Mohanathas, Lianna Montanari, Rachel Downey et al. · 2026 · PLoS ONE
Background Multitasking, such as listening while balancing, relies on integrated processing in the sensory, cognitive, and motor systems; systems that often decline with age. Hearing loss is linked to increased risks of both falls and cognitive decline. Improving cognitive processing through executive function (EF) training may support balance, especially in older adults with hearing loss. This randomized controlled study conducted across age groups and hearing abilities, examined the effects of a 12-week EF training program on postural outcomes (center of pressure (COP)) using an auditory-cog
View details →DOI: 10.1371/journal.pone.0331276 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Vadstrup Eva S, Frølich Anne, Perrild Hans et al. · 2011 · Health and Quality of Life Outcomes
Abstract Background Type 2 diabetes can seriously affect patients' health-related quality of life and their self-rated health. Most often, evaluation of diabetes interventions assess effects on glycemic control with little consideration of quality of life. The aim of the current study was to study the effectiveness of group-based rehabilitation versus individual counselling on health-related quality of life (HRQOL) and self-rated health in type 2 diabetes patients. Methods We randomised 143 type 2 diabetes patients to either a six-month multidisciplinary group-based rehabilitation programme in
View details →DOI: 10.1186/1477-7525-9-110 Negative / Null Result ReportMedicine
Schmidt TP, Jütten K, Bertram U et al. · 2026 · World neurosurgery
Degenerative cervical myelopathy (DCM) is the leading cause of chronic spinal cord dysfunction and can lead to severe neurological impairment if untreated. While decompressive surgery is the standard treatment, predicting postoperative…
View details →DOI: 10.1016/j.wneu.2026.125140 Negative / Null Result Report
Naydenov A, Uzunov T, Kostadinov G et al. · 2026 · Preprint
Abstract Objectives . This study aimed to compare the efficiency and productivity of a three-dimensional Generative Adversarial Network (3DGAN) with experienced digital operators and dental students in the design of screw-retained implant…
View details →DOI: 10.21203/rs.3.rs-9402895/v1 Negative / Null Result ReportMedicine
Klein J, Carl B, Schackert G · 2026 · Journal of neurological surgery. Part A, Central European neurosurgery
Objective Various studies have shown a beneficial effect of statins in patients with chronic subdural hematoma (cSDH) who do not require surgery. In surgical cohorts, however, the results of statin treatment in cSDH have been inconsistent,…
View details →DOI: 10.1055/a-2841-9614 Negative / Null Result ReportMedicine
Yabaş ŞM, Gümüşboğa ZŞ · 2026 · Dental traumatology : official publication of International Association for Dental Traumatology
Aim Tooth avulsion is among the traumatic dental injuries that require immediate intervention during childhood, and children are often with teachers or parents at the time of such incidents. This situation highlights the need to evaluate…
View details →DOI: 10.1111/edt.70089 Failed Experiment ReportMedicine
Hopkins S, Banks E, Bentley SA et al. · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To evaluate whether luminance-matching of non-target elements (Study 1) and incorporating artwork (Study 2) within the newly designed turtle optotype would impact visual acuity (VA) measures. Methods Study 1 evaluated the…
View details →DOI: 10.1002/ovs2.70009 Negative / Null Result ReportMedicine
Buis HT, Berger-Estilita J, Zirngast S et al. · 2026 · Journal of clinical monitoring and computing
Women with endometriosis are at increased risk of severe postoperative pain due to nociceptive sensitization. While multimodal analgesia reduces opioid use, the added value of objective nociception monitoring remains unclear. This study…
View details →DOI: 10.1007/s10877-026-01459-3 Negative / Null Result ReportMedicine
Ismail HS, Ali AI, Soliman HAN · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective To evaluate whether differences exist in marginal adaptation among beveled and non-beveled cavity designs, different bonding-banding sequences, and before and after thermomechanical loading. Methods Forty molars received…
View details →DOI: 10.1111/jerd.70199 Negative / Null Result ReportMedicine
Shirmohammadi P, Fazeli F, Zoghi A et al. · 2026 · Scientific reports
Spirulina platensis is a potential alternative food ingredient due to its bioactive compounds, nutritional composition, and a sustainable protein source. This study evaluated the effects of adding S. platensis powder (0, 0.5, 0.75, 1, 3,…
View details →DOI: 10.1038/s41598-026-42668-9 Negative / Null Result Report
Chen H, Mohamed ZA, Chen R et al. · 2026 · Preprint
Abstract Background Vitamin D deficiency has been associated with tic disorders (TDs), but its neurobiological mechanisms remain unclear. This study examined whether vitamin D status is associated with cortical hemodynamic responses in…
View details →DOI: 10.21203/rs.3.rs-9449969/v1 Negative / Null Result Report
Shojaei SA, Orouji M, Pakgohar A · 2026 · Preprint
This study examines the relationship between insurance market development and economic growth in 33 OECD countries over the period 2011–2021, with particular emphasis on life insurance markets and structural characteristics. To capture the…
View details →DOI: 10.20944/preprints202604.1857.v1 Negative / Null Result Report
Zhang X, Zou H · 2026 · Preprint
Abstract Background Sedentary behavior (SB) is a well-established risk factor for multiple chronic non-communicable diseases. However, evidence regarding its association with common ocular disorders remains limited and inconsistent. This…
View details →DOI: 10.21203/rs.3.rs-9780388/v1 Negative / Null Result Report
Trujillo-Vega F, Lopez-Delgado PA · 2026 · Preprint
Background Mean platelet volume (MPV) is a simple, low-cost biomarker that reflects platelet activation. Its prognostic value in septic shock remains controversial. We aimed to determine whether MPV at intensive care unit (ICU) admission…
View details →DOI: 10.64898/2026.05.29.26354453 Negative / Null Result Report
Wu H, Liang Y, Li J et al. · 2025 · Preprint
Abstract The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to…
View details →DOI: 10.21203/rs.3.rs-404499/v2 Failed Experiment ReportMedicine
Day M, Kearney S · 2026 · Optometry and vision science : official publication of the American Academy of Optometry
Purpose To explore methods of evaluating success of optical myopia control interventions, and to apply these methods retrospectively to a clinical population. Methods A retrospective cohort study was conducted on pediatric patients…
View details →DOI: 10.1002/ovs2.70075 Failed Experiment Report
Tibenderana JR, Kessy SA, Kimaro LJ et al. · 2026 · Preprint
Abstract Background Universal Health Coverage (UHC) aims to ensure that all individuals have access to essential healthcare services without financial hardship, including institutional childbirth which is key component for reducing…
View details →DOI: 10.21203/rs.3.rs-9518942/v1 Negative / Null Result ReportMedicine
Chaudhary D, Mukhopadhyay I · 2026 · Applied health economics and health policy
Background Universal health coverage has become central to health policy debates, particularly as a strategy to protect households from financial hardship and impoverishment related to out-of-pocket (OOP) spending. Many low- and…
View details →DOI: 10.1007/s40258-026-01051-5 Negative / Null Result ReportMedicine
Guevara-Freire D, Escudero RM, Calvo L et al. · 2026 · Meat Science.
This study evaluated the effect of dietary linoleic acid (C18:2) inclusion on fat deposition and fatty acid composition in barrows and gilts. A total of 960 Danbred pigs (half barrows, half gilts) were assigned to two dietary treatments…
Negative / Null Result ReportOpen accessMedicine
Amırlı H, Gurbanli E · 2026 · BMC psychology
The purpose of this study is to investigate the mediating roles of job satisfaction (JS) and life satisfaction (LS) in the relationship between psychological resilience (PR) and employee performance (EP). Data for this study, which…
View details →DOI: 10.1186/s40359-026-04520-7 Negative / Null Result Report
Li Z · 2026 · Preprint
Abstract Oily sludge, a characteristic hazardous solid waste generated during petroleum extraction, poses significant challenges for resource recovery due to its high water content and complex composition. Negative pressure drying…
View details →DOI: 10.21203/rs.3.rs-9183027/v1 Negative / Null Result ReportMedicine
Jager G, de Wild VWT, Camps G et al. · 2026 · Appetite
Eating rate (ER), the amount of food consumed per unit of time, is a key determinant of food intake, with faster ER associated with larger meal size. Research in adults has shown that both sensory properties like texture, and instructions…
View details →DOI: 10.1016/j.appet.2026.108697 Abandoned HypothesisMedicine
Katzer M · 2026 · Advances in health sciences education : theory and practice
The article critically examines Georg Lind's Moral Competence Test, which is often used to assess the moral abilities of healthcare professionals and students. Test results have purportedly shown that students' moral competence declines…
View details →DOI: 10.1007/s10459-026-10552-w Negative / Null Result ReportMedicine
Rye BJ, Tuer AG, Hertz S · 2026 · Journal of child sexual abuse
This study is a psychometric analysis of the Perceptions of Sex Offenders (PSO) scale, a reconceptualization of the Community Attitudes Toward Sex Offender scale. Using a student sample, a confirmatory factor analysis was conducted. The…
View details →DOI: 10.1080/10538712.2026.2683983 Negative / Null Result ReportMedicine
Levin N, Yosef E, Vainrib R et al. · 2026 · Neurourology and urodynamics
Purpose Detrusor underactivity (DU) is a significant cause of female lower urinary tract symptoms. We aimed to externally validate a non-invasive prediction model using age and voided volume (VV) in a tertiary center cohort. Methods This…
View details →DOI: 10.1002/nau.70352 Negative / Null Result ReportMedicine
Fernandes BP, Esteves A, Pimenta AC et al. · 2026 · BMJ case reports
Monoclonal gammopathy of renal significance is characterised by kidney injury caused by nephrotoxic monoclonal immunoglobulins produced by a pathogenic B cell or plasma cell clone. Cryoglobulinaemia in this context may lead to severe…
View details →DOI: 10.1136/bcr-2025-269981 Negative / Null Result Report
Peker¹ I, Özdemir¹ O, Kandemir¹ C et al. · 2026 · Preprint
Abstract Aim Prolonged intensive care unit (ICU) stay after coronary artery bypass graft (CABG) surgery is a significant clinical problem associated with increased morbidity, mortality, and healthcare costs. The aim of this study was to…
View details →DOI: 10.21203/rs.3.rs-9726889/v1 