e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19761 results in Negative / Null Result Report · page 41 of 659

Negative / Null Result ReportOpen accessMathematics

Determining organ weight toxicity with Bayesian causal models: Improving on the analysis of relative organ weights

Stanley E. Lazic, Elizaveta Semenova, Dominic P. Williams · 2020 · Scientific Reports

Regulatory authorities require animal toxicity tests for new chemical entities. Organ weight changes are accepted as a sensitive indicator of chemically induced organ damage, but can be difficult to interpret because changes in organ weight might reflect chemically-induced changes in overall body weight. A common solution is to calculate the relative organ weight (organ to body weight ratio), but this inadequately controls for the dependence on body weight - a point made by statisticians for decades, but which has not been widely adopted. The recommended solution is an analysis of covariance (

View details →DOI: 10.1038/s41598-020-63465-yCited by 131
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women

Stephen E. Alway, Jean L. McCrory, Kalen Kearcher et al. · 2017 · The Journals of Gerontology Series A

Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took either a placebo or resveratrol (RSV) (500 mg/d) to test the hypothesis that RSV treatment combined with exercise would increase mitochondrial…

View details →DOI: 10.1093/gerona/glx089Cited by 131
Negative / Null Result ReportMedicine

Etiologic Factors in Sialolithiasis

Kevin C. Huoh, David W. Eisele · 2011 · Otolaryngology

OBJECTIVES: The purpose of this study was to investigate etiologic factors for sialolithiasis in a population of patients from the United States. STUDY DESIGN: Retrospective, cohort study. SETTING: Tertiary university. MATERIALS AND…

View details →DOI: 10.1177/0194599811415489Cited by 131
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Comparative Genome-Wide Association Studies in Mice and Humans for Trimethylamine N -Oxide, a Proatherogenic Metabolite of Choline and l -Carnitine

Jaana Hartiala, Brian J. Bennett, W.H. Wilson Tang et al. · 2014 · Arteriosclerosis Thrombosis and Vascular Biology

OBJECTIVE: Elevated levels of plasma trimethylamine N-oxide (TMAO), the product of gut microbiome and hepatic-mediated metabolism of dietary choline and L-carnitine, have recently been identified as a novel risk factor for the development…

View details →DOI: 10.1161/atvbaha.114.303252Cited by 131
Negative / Null Result ReportOpen accessEngineering

Study of nonlinear radiative heat transfer with magnetic field for non-Newtonian Casson fluid flow in a porous medium

Payam Jalili, Ali Ahmadi Azar, Bahram Jalili et al. · 2023 · Results in Physics

This paper studies the effect of thermo-diffusion, electrical field, and nonlinear thermal radiation. Thermal radiant heat transfer has several industrial applications, and the analysis of radiation heat transfer in non-Newtonian fluids…

View details →DOI: 10.1016/j.rinp.2023.106371Cited by 130
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

Revisiting the determinants of local government performance

Frida Magda Sumual, David Paul Elia Saerang, Herman Karamoy et al. · 2021 · Accounting

This present study intends to analyze the factors affecting the performance of the local government of North Sulawesi. The population of this study includes the members of the Regional People’s Representative Assembly and the leaders of Regional Apparatus Organizations managing the Regional Revenue and Expenditure Budget (APBD). Those Regional Apparatus Organizations include Education and Culture Office, Health Office, Regional Revenue Service, Tourism Office, Public Works Office, and Auditor Inspectorate of North Sulawesi Province. The sampling technique used is the saturated sampling techniq

View details →DOI: 10.5267/j.ac.2021.4.022Cited by 130
Negative / Null Result ReportOpen accessDecision Sciences

The Effects of Effective Communication on Organizational Performance Based on the Systems Theory

Mukelabai M. Musheke, Jackson Phiri · 2021 · Open Journal of Business and Management

Communication is a very crucial and significant element in an organization, and it is necessary for creating collaboration within the work environment that has effects on organizational performance and decision making. This study on effects of effective communications on organizational performance using the systems theory is thus essential. The objectives of this study were to firstly identify the factors affecting effective communication based on the systems theory and secondly to devise a communication model that addresses these factors to improve organisational performance. A quantitative a

View details →DOI: 10.4236/ojbm.2021.92034Cited by 130
Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance

An Asset Pricing Approach to Liquidity Effects in Corporate Bond Markets

Dion Bongaerts, Frank de Jong, Joost Driessen · 2017 · Review of Financial Studies

We use an asset pricing approach to compare the effects of the liquidity level and liquidity risk on expected U.S. corporate bond returns. Using signed transaction data, we estimate effective transaction costs for bond portfolios by a…

View details →DOI: 10.1093/rfs/hhx005Cited by 130
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

The Histone Demethylase Jarid1b Ensures Faithful Mouse Development by Protecting Developmental Genes from Aberrant H3K4me3

Mareike Albert, Sandra U. Schmitz, Susanne M. Kooistra et al. · 2013 · PLoS Genetics

Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion of the H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) results in major neonatal lethality due to respiratory failure. Jarid1b knockout embryos have several neural defects including disorganized cranial nerves, defects in eye development, and increased incidences of exencephaly. Moreover, in line

View details →DOI: 10.1371/journal.pgen.1003461Cited by 130
Negative / Null Result ReportOpen accessMedicine

Clofarabine doubles the response rate in older patients with acute myeloid leukemia but does not improve survival

Alan K. Burnett, Nigel H. Russell, Ann E. Hunter et al. · 2013 · Blood

Better treatment is required for older patients with acute myeloid leukemia (AML) not considered fit for intensive chemotherapy. We report a randomized comparison of low-dose Ara-C (LDAC) vs the novel nucleoside, clofarabine, in untreated…

View details →DOI: 10.1182/blood-2013-04-496596Cited by 130
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Metarhizium anisopliae Pathogenesis of Mosquito Larvae: A Verdict of Accidental Death

Tariq M. Butt, Bethany P. J. Greenfield, Carolyn Greig et al. · 2013 · PLoS ONE

Metarhizium anisopliae, a fungal pathogen of terrestrial arthropods, kills the aquatic larvae of Aedes aegypti, the vector of dengue and yellow fever. The fungus kills without adhering to the host cuticle. Ingested conidia also fail to germinate and are expelled in fecal pellets. This study investigates the mechanism by which this fungus adapted to terrestrial hosts kills aquatic mosquito larvae. Genes associated with the M. anisopliae early pathogenic response (proteinases Pr1 and Pr2, and adhesins, Mad1 and Mad2) are upregulated in the presence of larvae, but the established infection proces

View details →DOI: 10.1371/journal.pone.0081686Cited by 130
Negative / Null Result ReportEconomics, Econometrics and Finance

Picking Winners? Investment Consultants’ Recommendations of Fund Managers

Tim Jenkinson, Howard Jones, José Vicente Martinez · 2015 · The Journal of Finance

ABSTRACT Investment consultants advise institutional investors on their choice of fund manager. Focusing on U.S. actively managed equity funds, we analyze the factors that drive consultants’ recommendations, what impact these…

View details →DOI: 10.1111/jofi.12289Cited by 130
Negative / Null Result ReportOpen accessMedicine

Perioperative risk of major non-cardiac surgery in patients with severe aortic stenosis: a reappraisal in contemporary practice

Teruko Tashiro, Sorin V. Pislaru, Jodi M Blustin et al. · 2014 · European Heart Journal

AIMS: Severe aortic stenosis (SAS) is a major risk factor for death after non-cardiac surgery, but most supporting data are from studies over a decade old. We evaluated the risk of non-cardiac surgery in patients with SAS in contemporary…

View details →DOI: 10.1093/eurheartj/ehu044Cited by 130
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Sperm Swimming Velocity Predicts Competitive Fertilization Success in the Green Swordtail Xiphophorus helleri

Clelia Gasparini, Leigh W. Simmons, Maxine Beveridge et al. · 2010 · PLoS ONE

Sperm competition is expected to favour the evolution of traits that influence the performance of sperm when they compete to fertilize a female's eggs. While there is considerable evidence that selection favours increases in sperm numbers, much less is known about how sperm quality contributes towards competitive fertilization success. Here, we determine whether variation in sperm quality influences competitive fertilization success in the green swordtail Xiphophorus helleri, a highly promiscuous livebearing fish. We use artificial insemination as a method of controlled sperm delivery and show

View details →DOI: 10.1371/journal.pone.0012146Cited by 130
Negative / Null Result ReportMedicine

Association Between a Medical School Admission Process Using the Multiple Mini-interview and National Licensing Examination Scores

Kevin W. Eva, Harold Reiter, Jack Rosenfeld et al. · 2012 · JAMA

CONTEXT: There has been difficulty designing medical school admissions processes that provide valid measurement of candidates' nonacademic qualities. OBJECTIVE: To determine whether students deemed acceptable through a revised admissions…

View details →DOI: 10.1001/jama.2012.36914Cited by 130
Negative / Null Result ReportEconomics, Econometrics and Finance

Does European aflatoxin regulation hurt groundnut exporters from Africa?

Bo Xiong, John C. Beghin · 2011 · European Review of Agricultural Economics

We provide an ex post econometric examination of the harmonisation and tightening of the EU maximum residue limit (MRL) on aflatoxins in 2002, and its impact on African exports of groundnut products. We find no evidence of the EU MRL…

View details →DOI: 10.1093/erae/jbr062Cited by 130
Negative / Null Result ReportChemistry

Reliable Identification of Significant Differences in Differential Hydrogen Exchange-Mass Spectrometry Measurements Using a Hybrid Significance Testing Approach

Tyler S. Hageman, David D. Weis · 2019 · Analytical Chemistry

Differential hydrogen exchange-mass spectrometry (HX-MS) measurements are valuable for identification of differences in the higher order structures of proteins. Typically, the data sets are large with many differential HX values…

View details →DOI: 10.1021/acs.analchem.9b01325Cited by 129
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Board gender diversity, corporate governance and bank efficiency in Ghana: a two stage data envelope analysis (DEA) approach

David Adeabah, Agyapomaa Gyeke‐Dako, Charles Andoh · 2018 · Corporate Governance

Purpose This study aims to analyze the efficiency of banks under board gender diversity and to examine the determinants of bank efficiency. Design/methodology/approach Data for analysis were sourced from annual reports of 21 banks for the…

View details →DOI: 10.1108/cg-08-2017-0171Cited by 129
Negative / Null Result ReportOpen accessMedicine

Impact of COVID‐19 pandemic on ST‐elevation myocardial infarction in a non‐COVID‐19 epicenter

Tarek A. Hammad, Melanie Parikh, Nour Tashtish et al. · 2020 · Catheterization and Cardiovascular Interventions

OBJECTIVES: We sought to study the impact of COVID-19 pandemic on the presentation delay, severity, patterns of care, and reasons for delay among patients with ST-elevation myocardial infarction (STEMI) in a non-hot-spot region.…

View details →DOI: 10.1002/ccd.28997Cited by 129
Negative / Null Result ReportOpen accessPhysics and Astronomy

SEARCH FOR GRAVITATIONAL WAVES ASSOCIATED WITH GAMMA-RAY BURSTS DURING LIGO SCIENCE RUN 6 AND VIRGO SCIENCE RUNS 2 AND 3

J. Abadie, B. P. Abbott, R. Abbott et al. · 2012 · The Astrophysical Journal

We present the results of a search for gravitational waves associated with 154 gamma-ray bursts (GRBs) that were detected by satellite-based gamma-ray experiments in 2009-2010, during the sixth LIGO science run and the second and third…

View details →DOI: 10.1088/0004-637x/760/1/12Cited by 129
Negative / Null Result ReportEconomics, Econometrics and Finance

Hedge Fund Crowds and Mispricing

Richard W. Sias, Harry J. Turtle, Blerina Bela Zykaj · 2015 · Management Science

Recent models and the popular press suggest that large groups of hedge funds follow similar strategies resulting in crowded equity positions that destabilize markets. Inconsistent with this assertion, we find that hedge fund equity…

View details →DOI: 10.1287/mnsc.2014.2131Cited by 129
Negative / Null Result ReportMedicine

Robotic Resection is a Good Prognostic Factor in Rectal Cancer Compared with Laparoscopic Resection: Long-term Survival Analysis Using Propensity Score Matching

Jin Kim, Se Jin Baek, Dong-Woo Kang et al. · 2017 · Diseases of the Colon & Rectum

BACKGROUND: Robotic total mesorectal excision for rectal cancer has rapidly increased and has shown short-term outcomes comparable to conventional laparoscopic total mesorectal excision. However, data for long-term oncologic outcomes are…

View details →DOI: 10.1097/dcr.0000000000000770Cited by 129
Negative / Null Result ReportOpen accessEnvironmental Science

Comparison of AOD between CALIPSO and MODIS: significant differences over major dust and biomass burning regions

Xiaoyan Ma, Kevin S. Bartlett, K. Harmon et al. · 2013 · Atmospheric measurement techniques

Abstract. Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) provide global vertical profiles of aerosol optical properties for the first time. In this study, we employed about 6 yr (2006–2011) of CALIPSO level 3 monthly mean gridded aerosol optical depth (AOD) products (daytime and nighttime) for cloud-free conditions, to compare with the Moderate Resolution Imaging Spectroradiometer (MODIS) Terra/Aqua level 3 monthly mean AOD dataset for the same time period. While the spatial distribution and seasonal variability of CALIPSO AOD is generally consistent with that of

View details →DOI: 10.5194/amt-6-2391-2013Cited by 129
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri

Thomas R. Connor, Clare R. Barker, Kate S. Baker et al. · 2015 · eLife

Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the

View details →DOI: 10.7554/elife.07335Cited by 128
Negative / Null Result ReportOpen accessMedicine

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

James Galea, Kayode Ogungbenro, Sharon Hulme et al. · 2017 · Journal of neurosurgery

OBJECTIVE Aneurysmal subarachnoid hemorrhage (aSAH) is a devastating cerebrovascular event with long-term morbidity and mortality. Patients who survive the initial bleeding are likely to suffer further early brain injury arising from a…

View details →DOI: 10.3171/2016.9.jns16615Cited by 128
Negative / Null Result ReportOpen accessSocial Sciences

Public attitudes toward COVID-19 vaccination: The role of vaccine attributes, incentives, and misinformation

Sarah Kreps, Nabarun Dasgupta, John S. Brownstein et al. · 2021 · npj Vaccines

While efficacious vaccines have been developed to inoculate against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; also known as COVID-19), public vaccine hesitancy could still undermine efforts to combat the pandemic. Employing a survey of 1096 adult Americans recruited via the Lucid platform, we examined the relationships between vaccine attributes, proposed policy interventions such as financial incentives, and misinformation on public vaccination preferences. Higher degrees of vaccine efficacy significantly increased individuals' willingness to receive a COVID-19 vaccine, whi

View details →DOI: 10.1038/s41541-021-00335-2Cited by 128
Negative / Null Result ReportOpen accessSocial Sciences

INTERNAL FACTOR EFFECTS IN FORMING THE SUCCESS OF SMALL BUSINESSES

Achmad Daengs GS · 2020 · Sinergi Jurnal Ilmiah Ilmu Manajemen

ABSTRACT. The objective of this study to analyses the effects of entrepreneurial competency, marketing capability, financial resources, technology usage, knowledge sharing to business success on Small-Micro Enterprises built by Industrial…

View details →DOI: 10.25139/sng.v10i1.1463Cited by 128
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

Social capital and its effect on business performance in the Nigeria informal sector

Olamide Akintimehin, Anthony Abiodun Eniola, Oluwatobi Joseph Alabi et al. · 2019 · Heliyon

This study was aimed at investigating the effect of internal and external social capital on the financial and non-financial performance of businesses in the Nigerian informal sector. The study further investigated the controlling role of firm age. A cross-sectional survey of 650 informal business owners in the Ikeja region of Lagos state, Nigeria was carried out. The analysis was carried out using the partial least square method of the structural equation model (SEM). Findings revealed that without the controlling variable of firm age, social capital had a significant effect on business perfor

View details →DOI: 10.1016/j.heliyon.2019.e02024Cited by 127
Negative / Null Result ReportEconomics, Econometrics and Finance

Derivative Pricing with Liquidity Risk: Theory and Evidence from the Credit Default Swap Market

Dion Bongaerts, Frank de Jong, Joost Driessen · 2011 · The Journal of Finance

ABSTRACT We derive an equilibrium asset pricing model incorporating liquidity risk, derivatives, and short‐selling due to hedging of nontraded risk. We show that illiquid assets can have lower expected returns if the short‐sellers have…

View details →DOI: 10.1111/j.1540-6261.2010.01630.xCited by 127
Negative / Null Result ReportOpen accessMaterials Science

Young’s equation revisited

Lasse Makkonen · 2016 · Journal of Physics Condensed Matter

Young's construction for a contact angle at a three-phase intersection forms the basis of all fields of science that involve wetting and capillary action. We find compelling evidence from recent experimental results on the deformation of a soft solid at the contact line, and displacement of an elastic wire immersed in a liquid, that Young's equation can only be interpreted by surface energies, and not as a balance of surface tensions. It follows that the a priori variable in finding equilibrium is not the position of the contact line, but the contact angle. This finding provides the explanatio

View details →DOI: 10.1088/0953-8984/28/13/135001Cited by 127