Negative / Null Result ReportOpen accessMedicine
Mahdiyeh Harati-Sadegh, Leila Kohan, Batool Teimoori et al. · 2019 · Journal of Biomedical Science
Abstract Background Preeclampsia (PE), as a multisystem disorder, is associated with maternal hypertension and proteinuria. Apoptosis seems to be involved in the pathophysiology of PE, although its precise pathogenic mechanisms are not well established. In this study, we aimed to identify the association between maternal TP53-rs1042522, P21-rs1801270, and P21-rs1059234 polymorphisms and PE. In addition, we examined the effects of promoter methylation and TP53 and P21 polymorphisms on placental mRNA expression in PE women. Methods The blood of 226 PE women and 228 normotensive pregnant women wa
View details →DOI: 10.1186/s12929-019-0586-x Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Bharath Pandu, KHANNA D, Mohandass P et al. · 2022 · Iranian Journal of Medical Physics
Introduction: The study aims to compare target coverage and critical structure dose difference between various dose computing algorithms with small segment dose calculation in Intensity Modulated Radiation Therapy (IMRT) and large segment dose calculation in 3-Dimensional Conformal Radiation Therapy (3DCRT) treatment plan for Head and Neck (H&N) tumor.Material and Methods: For the present study, thirty-eight H&N cancer patients were selected retrospectively. Twenty-seven patients were planned with IMRT plan using Monte Carlo (MC) algorithm and eleven patients with 3DCRT plan using Collapsed Co
View details →DOI: 10.22038/ijmp.2022.63548.2082 Negative / Null Result ReportOpen accessDermatology
Fadime Mutlu İçduygu, Isil Deniz Oguz, Egemen Akgun et al. · 2026 · Dermatology Practical & Conceptual
Introduction: Psoriasis, a widespread inflammatory cutaneous disease, is driven by an interplay of genetic and environmental risk factors. miR-155 and miR-146a have been implicated in the regulation of inflammatory pathways. Objectives: In the current study, we examined the association between miR-155 rs767649 and miR-146a rs2910164 variants and the predisposition to psoriasis and psoriatic arthritis. Methods: A total of 544 individuals, including 284 psoriasis cases (68 with psoriatic arthritis) and 260 controls, were enrolled in the present study. Real-time polymerase chain reaction (qPCR) m
View details →DOI: 10.5826/dpc.1601a5977 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Feng-Hang Chang, Alan M. Jette, Mary D. Slavin et al. · 2018 · BMC Musculoskeletal Disorders
Abstract Background The intent of this study was to examine and compare the ability to detect change of two patient reported outcome (PRO) instruments that use a computerized adaptive test (CAT) approach to measurement. The Patient Reported Outcomes Measurement Information System (PROMIS®) Physical Function scale is a generic PRO, while the Osteoarthritis Computerized Adaptive Test (OA-CAT) is an osteoarthritis-specific PRO. Methods This descriptive, longitudinal study was conducted in a community setting, involving individuals from the greater Boston area. Inclusion criteria: age > 50, self-r
View details →DOI: 10.1186/s12891-018-1942-9 Negative / Null Result ReportOpen accessMining engineering. Metallurgy
Yutaka ITO, Masato TAKEUCHI, Shuto MIKAMI et al. · 2020 · Journal of MMIJ
Productivity, safety and its improvement is also an integral part of a good mining operation. In recent times, due to constraints on time and cost, it has become increasingly harder to conduct training and safety inductions at mine sites. For the purpose of overcoming these limitations, the use of virtual reality (VR) is proposed for mining education and training. VR has already been introduced in the education and training of miners overseas, and quantitative studies on the effects of using VR for miner's education and training have been made. However, Japan has only one such application
View details →DOI: 10.2473/journalofmmij.136.33 Negative / Null Result ReportOpen accessMedicine
Oliver Hendricks, Mikkel Østergaard, Susanne Juhl Pedersen et al. · 2026 · RMD Open
Introduction Evidence of treat-to-target strategies including secukinumab dose escalation in patients with axial spondyloarthritis (axSpA) remains limited. We investigated the effect of a treat-to-target approach aiming for Axial Spondyloarthritis Disease Activity Score (ASDAS) remission, assessed by clinical and MRI outcomes over 24 weeks.Methods TRACE was a multicentre study including biologic-naïve patients with active axSpA. Sixteen weeks after secukinumab 150 mg initiation, patients in ASDAS remission (<1.3)(week 16 remitters) continued the same dose, while non-remitters (week 16 non-remi
View details →DOI: 10.1136/rmdopen-2026-006774 Negative / Null Result Report
Zhang X, Liu X, Wang L et al. · 2026 · Preprint
Abstract Objective Breast cancer is a prevalent malignant disease among women. Currently, the primary clinical treatment strategies involve classifying breast cancer based on the expression of Ki67, estrogen receptor (ER), progesterone…
View details →DOI: 10.21203/rs.3.rs-9088621/v1 Negative / Null Result ReportOpen accessMedicine
Serkan Oner, Yusuf Secgin, Zulal Oner et al. · 2022 · Medicine Science
The aim of this study was to evaluate the correlation between triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) hormones and thyroid gland volume with volumetric analysis performed by using computed tomography (CT) images. In this retrospective study, IV contrasted thoracic CT images taken for different indications between 2019 January and 2020 January were scanned from the archive system of the hospital. 67 (31F, 36M) individuals chosen randomly among patients whose CT results were reported as normal and who had taken thyroid hormone tests within the past week were
View details →DOI: 10.5455/medscience.2022.02.037 Negative / Null Result ReportOpen accessSports
Anna Cronström, Eva Ageberg, Erika Zeraidi et al. · 2023 · JSAMS Plus
Objective: To investigate associations between postural orientation errors (POEs) in patients undergoing rehabilitation for anterior cruciate ligament reconstruction (ACLR) and patient-reported outcomes (PROMs) at 2-year follow-up. Design: Prospective cohort study. Methods: Fifty-three participants (mean (SD) 27 (6.5) years, 24 women), (mean (range) 7 (4–10) months post ACLR) were included. At baseline, all participants were visually assessed for POEs using a validated test battery. The POE subscales Activities of Daily Living and Sport were used in the analysis. At 2-years, the following PROM
View details →DOI: 10.1016/j.jsampl.2023.100039 Negative / Null Result ReportOpen accessSurgery
Nasibe Golestani, Najmeh Shamspour, Jalal Azmandian et al. · 2024 · Egyptian Liver Journal
Abstract Introduction HBV infection is a significant concern in dialysis patients, influenced by various factors. This study aims to investigate the impact of serum uric acid levels on the immunogenicity of hepatitis Bvaccination in dialysis patients. Method A cross-sectional study was conducted, involving 125 hemodialysis patients. Prior to dialysis, assessments were made for uric acid, vitamin D, HBsAg, andHBsAb. Patients were divided into two groups based on uric acid levels: high level (≥ 6.5 mg/dl) and low level ( 10). In patients with low uric acid, 1 (7.7%) had low HBsAb and 12 (92.3%)
View details →DOI: 10.1186/s43066-024-00328-5 Negative / Null Result ReportOpen accessMedicine
Roman Panovský, Martina Doubková, Mary Luz Mojica-Pisciotti et al. · 2021 · Orphanet Journal of Rare Diseases
Abstract Background Sarcoidosis is a systemic granulomatous disease affecting different organs including the heart. Myocardial strain analysis could potentially detect the early stages of cardiac dysfunction in sarcoidosis patients. The present study aims to assess the use of cardiac magnetic resonance (CMR) strain analysis using feature tracking (FT) in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and thirteen CMR studies of patients with sarcoidosis of the respiratory tract and/or extrapulmonary sarcoidosis without pre-existing kno
View details →DOI: 10.1186/s13023-021-02038-2 Negative / Null Result ReportOpen accessPublic aspects of medicine
Tao Zeng, Xinliang Liao, Jie Wu · 2025 · Environmental Health and Preventive Medicine
Background: Exposure to air pollution and adherence to a healthy lifestyle have been identified to be related to sarcopenia. However, the interactive effects between these two factors remain insufficiently elucidated. The present study was designed to investigate the potential interaction exposure to air pollution with healthy lifestyle on the risk of developing sarcopenia. Methods: In the retrospective cohort study, all data was extracted from China Health and Retirement Longitudinal Study. Household air pollution was assessed based on the utilization of solid fuels for cooking and heating. A
View details →DOI: 10.1265/ehpm.24-00280 Negative / Null Result ReportOpen accessMedicine (General)
Guo Zheng, Huiling Gao, Zhao Jin et al. · 2026 · Frontiers in Medicine
BackgroundPreservation of ovarian perfusion is a critical consideration during uterine artery embolization (UAE), as inadvertent disruption can reduce ovarian reserve. Given the complex and variable anatomy of ovarian blood supply, this study aimed to characterize its anatomical origins and variations using digital subtraction angiography (DSA) in patients undergoing UAE for cesarean scar pregnancy (CSP).MethodsThis retrospective study included patients with type II or III CSP who underwent first-time UAE at Heibei Maternity Hospital, China, between August 2020 and October 2024. Pre-embolizati
View details →DOI: 10.3389/fmed.2026.1730033 Negative / Null Result ReportOpen accessHuman anatomy
Ricardo Jonker, Glen J. Paton, Shahed Nalla · 2025 · Translational Research in Anatomy
Background: This study investigated the angulation of the odontoid process in a South African skeletal population to establish normative vertical angulation in the sagittal plane and assess variations across population affinity groups, biological sexes, and age categories. The study also investigated standardizing techniques for measuring the angle of the odontoid process. Methods: A cross-sectional study was conducted on 200 cervical axis vertebrae from the Raymond A. Dart Collection. Angulation measurements were taken using digital photographs, ImageJ software and statistical analyses (one-w
View details →DOI: 10.1016/j.tria.2025.100388 Negative / Null Result ReportOpen accessMedicine
Huang C, Wu M, Li Y et al. · 2026 · Clinical, cosmetic and investigational dermatology
Background Androgenetic alopecia (AGA) is the most common type of hair loss, and platelet-rich plasma (PRP) has emerged as a promising therapy. However, preparation methods may influence clinical outcomes. Objective To compare buffy coat…
View details →DOI: 10.2147/ccid.s606548 Negative / Null Result Report
mbarek NB · 2026 · Preprint
Abstract This study examines the long-run and short-run relationships between water stress, agricultural efficiency, energy use, and CO₂ emissions in six GCC countries over the period 1992–2023. Using second-generation panel econometric…
View details →DOI: 10.21203/rs.3.rs-8844668/v1 Negative / Null Result ReportOpen accessMedicine
Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · F1000Research
Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…
View details →DOI: 10.12688/f1000research.176261.3 Negative / Null Result ReportMedicine
Mehrabi A, Mohamadi-Nejad A, Ghorbani M et al. · 2026 · Brazilian journal of biology = Revista brasleira de biologia
Contract farming has gained popularity in recent years. Understanding farmers' preferences for contracts can help make contracts more sustainable and profitable. Therefore, the present study aimed to investigate farmers' preferences for…
View details →DOI: 10.1590/1519-6984.299694 Negative / Null Result ReportMedicine
Kim J, Cho Y · 2026 · Archives of environmental & occupational health
This study explored the impact of exposure to nonstandard work on workers' depression and suicidal ideation. Using data from the 12th to 18th waves of the Korea Welfare Panel Study, longitudinal analyses were conducted employing cox…
View details →DOI: 10.1080/19338244.2026.2685604 Negative / Null Result Report
Vargas-Santillan A, Rutiaga-Quiñones JG, Martínez-Cinco MA et al. · 2026 · Preprint
Abstract In the present study, the factors and interactions affecting the degree of delignification, brightness level, and various physico-mechanical properties of Kraft pulp were analyzed by subjecting it to ultraviolet (UV) light…
View details →DOI: 10.21203/rs.3.rs-8744525/v1 Negative / Null Result ReportMedicine
Bayrami M, Dadashi Mazraeh S · 2026 · Acta psychologica
This study compared the effects of cognitive rehabilitation and binaural beats on creativity, psychological well-being, and academic performance in 45 undergraduate students using a quasi-experimental pretest-posttest design with a control…
View details →DOI: 10.1016/j.actpsy.2026.107319 Negative / Null Result ReportMedicine
Agbajelola VI, Roachell WD, Lane GS et al. · 2026 · Acta tropica
Chagas disease remains an important public health concern across the Americas, affecting both human and animal populations. The triatomine bug Rhodnius prolixus, an obligate hematophagous vector of Trypanosoma cruzi, is commonly associated…
View details →DOI: 10.1016/j.actatropica.2026.108097 Negative / Null Result Report
Dao T, Khuc VQ · 2026 · Preprint
Abstract Foreign direct investment (FDI) is widely regarded as a catalyst for economic growth in developing countries, yet its growth effects remain heterogeneous across country contexts. This study examines how macroeconomic and…
View details →DOI: 10.21203/rs.3.rs-9616690/v1 Negative / Null Result Report
Heitzig C, Mackenna B, Rehkopf D · 2026 · Preprint
Incidence of type 2 diabetes is increasing at ages when education, work, family, and financial transitions are taking place, yet we lack robust evidence of whether earlier treatment changes life-course outcomes and over which time span…
View details →DOI: 10.64898/2026.06.06.26355069 Negative / Null Result Report
Ostad-Ali-Askari K, Vanani HR · 2026 · Preprint
Abstract In this article, the effect of water quality on the hydraulic parameters of furrow irrigation was tested with 60 experiments with the quality of fresh water (FW), magnetic (MW) and non-magnetic effluent (WW). It was found that…
View details →DOI: 10.21203/rs.3.rs-5950807/v1 Negative / Null Result ReportOpen accessMedicine
Csontos J, Brown N, Edwards A et al. · 2026 · BMC public health
BACKGROUND: Adults (age 18–64 years) are recommended 150–300 min of moderate-to-vigorous or 75–150 min of vigorous-intensity physical activity per week. Irrespective, the number of women not meeting recommended physical activity is 5%…
View details →DOI: 10.1186/s12889-026-27122-9 Negative / Null Result ReportOpen accessMedicine
Corcoran E, Samuel Z, Force A et al. · 2026 · Orthopaedic journal of sports medicine
Background Osteochondral defects (OCDe) of the knee in pediatric patients can significantly impact long-term joint function. This study aimed to evaluate the impact of lesion size on patient characteristics, treatment decisions, and…
View details →DOI: 10.1177/2325967126s00110 Negative / Null Result ReportOpen accessMedicine
Castro M, Carrasco-Zambrano N, Pezo F et al. · 2026 · Frontiers in veterinary science
The routine prophylactic use of antibiotics in sperm preservation for reproductive biotechnologies poses increasing concerns due to its potential role in promoting antimicrobial resistance. Therefore, developing storage systems that…
View details →DOI: 10.3389/fvets.2026.1774926 Negative / Null Result Report
Abebe GM, Demissie WM, Zewdie MC · 2026 · Preprint
Abstract Mechanization has immense potential to improve agricultural productivity and overall production, while crop–livestock diversification plays a crucial role in enhancing nutrition security; however, the combined effects of…
View details →DOI: 10.21203/rs.3.rs-10046750/v1 Negative / Null Result ReportOpen accessMedicine
Belnap MA, Witkiewitz K, Schacht JP et al. · 2026 · Alcohol, clinical & experimental research
Background The U.S. Food and Drug Administration (FDA) recommends a minimum duration of 6 months for randomized controlled trials (RCTs) evaluating pharmacotherapies for alcohol use disorder (AUD). The relationship between trial length and…
View details →DOI: 10.1111/acer.70306 