A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
444 results in Replication Failure · page 4 of 15
Triin Kikas, Kristiina Rull, Robin N. Beaumont et al. · 2019 · Frontiers in Genetics
= 6830) did not replicate these findings. In summary, the study emphasizes the role of genetic variation in driving the transcriptome profile of the human placenta and the importance to explore further its functional implications.
Brian Chin, Andrea Copeland, Lucas Gallo et al. · 2019 · Plastic & Reconstructive Surgery
Background: The fragility index has been proposed as a metric to evaluate the robustness of statistically significant findings in randomized controlled trials. It measures the number of events that a trial result relies on to maintain…
Anthony T.�C. Chan, Edwin P. Hui, Roger K.C. Ngan et al. · 2017 · Journal of Clinical Oncology
6002 Background: The benefit of adjuvant CT in NPC is unclear. Post-RT EBV DNA predicts poor survival and may be a biomarker of subclinical residual disease. We conducted a biomarker driven RCT using post-RT EBV DNA to select high risk NPC…
Bjørn Sætrevik, Hallgeir Sjåstad · 2022 · Meta-Psychology
Mortality salience (MS) effects, where death reminders lead to ingroup-bias and defensive protection of one’s world-view, have been claimed to be a fundamental human motivator. MS phenomena have ostensibly been identified in several hundred studies within the “terror management theory” framework, but transparent and high-powered replications are lacking. Experiment 1 (N = 101 Norwegian lab participants) aimed to replicate the traditional MSeffect on national patriotism, with additional novel measures of democratic values and pro-sociality. Experiment2 (N = 784 US online participants) aimed to
Omar Brito‐Estrada, Yasuhide Kuwabara, Aaron M. Gibson et al. · 2025 · Circulation Research
BACKGROUND: Calcium (Ca 2+ ) dysregulation is a hallmark of heart failure, impairing excitation-contraction coupling and contributing to pathological remodeling. The sarco/endoplasmic reticulum Ca 2+ ATPase isoform 2a (SERCA2a) mediates Ca…
Luca Testa, J M De La Torre Hernandez, Giovanni Luigi De Maria et al. · 2026 · New England Journal of Medicine
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used for revascularization of unprotected left main coronary artery disease. Whether intravascular ultrasonographic (IVUS) guidance during PCI results in better clinical…
M Lebwohl, Andrew Blauvelt, Cynthia E. Kartman et al. · 2026 · JAMA Dermatology
Importance: Overweight and obesity affect 60% to 78% of patients with psoriasis, affecting disease severity, treatment response, and clinical outcomes. However, no large, randomized, active-controlled clinical trial has evaluated a treatment strategy that addresses both diseases simultaneously. Objective: To evaluate the efficacy and safety of ixekizumab with or without tirzepatide in participants with psoriasis and overweight or obesity. Design, Setting, and Participants: This phase 3b, randomized, open-label, 52-week clinical trial was conducted at 72 sites in the US in adults with moderate
Xiaoyu Kang, Mingxing Xia, Jun Wang et al. · 2025 · Gut
BACKGROUND: Recent meta-analyses suggested diclofenac may be superior to indomethacin in preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The aim of our study was to compare the efficacy of 100 mg…
Nichola Cooper, James B. Bussel, Maciej Kaźmierczak et al. · 2024 · British Journal of Haematology
Summary Primary immune thrombocytopenia (ITP) is an antiplatelet‐antibody‐mediated disorder with accelerated platelet clearance and decreased platelet production. Rozanolixizumab, a monoclonal IgG4 anti‐FcRn antibody, blocks IgG recycling and decreases IgG levels. We report efficacy and safety of rozanolixizumab in adults with persistent/chronic ITP in 24‐week phase 3 studies (TP0003; TP0006), and their 52‐week open‐label extension (OLE). Primary end‐point was durable clinically meaningful platelet response (DCMPR) of ≥50 × 10 9 /L for 8/12 weeks during Weeks 13–25 in the double‐blind studies.
Yitao Zheng, Yan‐Jun Xiang, Hongqi Shi et al. · 2024 · Journal of Hepatocellular Carcinoma
Purpose: Combining transarterial chemoembolization (TACE) with systemic therapy has shown significant efficacy for intermediate-stage hepatocellular carcinoma (HCC) patients. This study aimed to validate the therapeutic efficacy of TACE…
Xueying Chen, Xi Liu, Ruogu Li et al. · 2026 · JAMA Cardiology
Importance: Left bundle-branch pacing (LBBP) has been proposed as an alternative to biventricular pacing (BiVP) for patients with heart failure with left bundle-branch block (LBBB). However, robust clinical evidence from randomized clinical trials is lacking. Objective: To evaluate the long-term clinical outcomes of LBBP and BiVP. Design, Setting, and Participants: This multicenter, prospective, randomized clinical trial enrolled 200 patients at 6 centers in China with a left ventricular ejection fraction (LVEF) of 35% or less and LBBB from October 2020 to March 2022. This study was took place
S Bangalore, Santosh Kumar Sinha, Rakendra Singh et al. · 2026 · JAMA Cardiology
Importance: The optimal dual antiplatelet therapy after percutaneous coronary intervention (PCI) in patients with diabetes is not clearly defined. Although both ticagrelor and prasugrel are potent inhibitors of P2Y purinergic receptor 12…
Johann Bauersachs, Scott D. Solomon, Stefan D. Anker et al. · 2026 · Nature Medicine
Abstract MicroRNA-132 (miR-132) is a central regulator of adverse cardiac remodeling. Here we evaluated CDR132L, a synthetic antisense oligonucleotide miR-132 inhibitor, in a multinational, randomized, double-blind, placebo-controlled phase 2 trial (HF-REVERT) in patients with recent myocardial infarction (MI) and left ventricular (LV) systolic dysfunction. Within 3–14 days after MI, 294 patients were randomized to receive CDR132L 5 mg kg −1 , CDR132L 10 mg kg −1 or placebo as three intravenous doses at 4-week intervals plus guideline-directed therapy. In total, 280 patients (245 men and 35 wo
Farhan Sheth, Ishika Chatter, Manvendra Jasra et al. · 2025 · Plant Methods
Herbs have historically been central to medicinal practices, representing one of the earliest forms of therapeutic intervention. While synthetic drugs are often highly effective in treating acute conditions, their use is frequently…
Gail D’Onofrio, Andrew A. Herring, Kathryn F. Hawk et al. · 2026 · JAMA
Importance: Extended-release injectable buprenorphine may expand the reach of initiating medications for opioid use disorder in high-risk and hard-to-reach individuals who visit the emergency department (ED) and can be administered in low…
Ralf Reilmann, Andrew Feigin, Anne Rosser et al. · 2025 · Nature Medicine
Huntington's disease (HD) is a rare, neurodegenerative disorder for which only symptomatic treatments are available. The PROOF-HD study was a randomized, double-blind, placebo-controlled phase 3 trial evaluating the efficacy and safety of pridopidine, a selective Sigma-1 receptor agonist, in HD. The primary and key secondary endpoints, change in total functional capacity (TFC) and composite Unified Huntington's Disease Rating Scale (cUHDRS) score at week 65, were not met in the overall population. The TFC least-squares mean difference between pridopidine and placebo was -0.18 (95% confidence i
Dian Zhu, Jianan Zhao, Tong Wu et al. · 2025 · JMIR mhealth and uhealth
Background: Exercise is a primary recommended treatment for knee osteoarthritis (KOA), as it helps alleviate symptoms and improves joint functionality. Personalized exercise programs, tailored to individual patient needs, have demonstrated promising results in maintaining physical fitness and enhancing overall well-being. In recent years, digital health applications have emerged as innovative tools for supervising and facilitating rehabilitation programs. Leveraging computer vision (CV) technology, these applications offer the potential to provide precise feedback and support personalized exer
Lisa H. Glynn, E Moloney, Stephen Lane et al. · 2025 · JMIR mhealth and uhealth
BACKGROUND: Chronic obstructive pulmonary disease (COPD) negatively impacts clinical health outcomes, resulting in frequent exacerbations, increased hospitalizations, reduced physical activity, deteriorated quality of life, and diminished self-efficacy. Previous studies demonstrated that a self-management program tailored for adults with COPD improves self-management decisions, resulting in a positive effect on clinical health outcomes. Limitations of these studies include issues regarding heterogeneity among interventions used, patient population characteristics, outcome measures, and longitu
Casey B. Roos, S. Luke Schulert, Lara E. Zetzsche et al. · 2025 · Nature
The synthesis of enantiopure materials is vital for pharmaceutical and agrochemical industries owing to the inherently chiral nature of biological systems and the fact that two enantiomers can have markedly different biochemical…
Anna Persson, Åsa Axén, Andrea Johansson Capusan et al. · 2025 · JAMA Network Open
Importance: Trauma-focused treatments are effective for posttraumatic stress disorder (PTSD) but are rarely offered to patients with comorbid substance use disorder. Research suggests gender-based differences in prevalence and treatment needs for these patients, but treatment trials have mainly included men. Objective: To evaluate whether integrated trauma-focused psychological treatment (ie, integrated treatment) leads to greater reduction in PTSD symptom severity and weekly alcohol use than usual treatment (ie, relapse prevention) for alcohol use disorder (AUD) in women. Design, Setting, and
Lea J. Mertens, Michael Koslowski, Felix Betzler et al. · 2026 · JAMA Psychiatry
Importance: Psilocybin shows promise in treating depression, although limitations of previous research warrant further research. Objective: To investigate the efficacy and safety of oral psilocybin, 25 mg, with adjunct psychotherapy in…
Caroline Thng, Sharareh Eskandari, Fengyi Jin et al. · 2026 · npj Vaccines
Neisseria gonorrhoeae (NG) causes significant morbidity globally, and no licensed vaccine currently exists. Observational studies suggest the four-component meningococcal B (4CMenB) vaccine may provide cross-protection against NG. We conducted MenGO, an open-label, randomized controlled trial to evaluate the efficacy, safety, and immunogenicity of 4CMenB against NG in gay and bisexual men (GBM). Participants were randomized 1:1 to receive two doses of 4CMenB, or no vaccine, and were followed for 2 years with 3-monthly visits. 4CMenB vaccination did not significantly reduce gonorrhoea incidence
Jean‐Christophe Rozé, Gilles Cambonie, Cyril Flamant et al. · 2026 · Archives of Pediatrics and Adolescent Medicine
Importance: Controversies persist about management of the ductus arteriosus by nonsteroidal anti-inflammatory drugs in extremely preterm infants. Acetaminophen (paracetamol) appears to be a promising alternative with possibly fewer adverse…
Pallav L. Shah, Dirk‐Jan Slebos, Richard Sue et al. · 2025 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale AIRFLOW-3 was a 1:1 randomized, double-blind, sham-controlled trial of the D’Nerva targeted lung denervation (TLD) system in patients with chronic obstructive pulmonary disease (COPD). Objective To evaluate the impact of…
Daniel Chin, Tamara Hernández-Beeftink, Lauren J. Donoghue et al. · 2026 · European Respiratory Journal
ABSTRACT Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease that might represent potential new drug targets, and it has been shown that drug targets with support from genetic studies are more likely to be successful in clinical development. Previous genome-wide association studies (GWAS) of IPF susceptibility have identified more than 20 signals implicating genes involved in multiple mechanisms, including telome
Min Gao, Megan Kirk, Heather Knight et al. · 2026 · JAMA Psychiatry
Importance: Preclinical evidence and case reports suggest potential therapeutic benefits of ketogenic diets (KDs) in the treatment of depression, but evidence from well-controlled randomized clinical trials (RCTs) is lacking. Objective: To assess the efficacy of a KD compared with a control diet in adults with treatment-resistant depression (TRD). Design, Setting, and Participants: This RCT was conducted between February 22 and June 15, 2024. Participants aged 18 to 65 years with TRD and a score of 15 or greater on the 9-item Patient Health Questionnaire (PHQ-9) from across the UK were include
David Erritzøe, Tommaso Barba, Tiffanie Benway et al. · 2026 · Nature Medicine
Major depressive disorder (MDD) is a leading cause of disability worldwide, yet many patients have inadequate responses to current treatments. Dimethyltryptamine (DMT), a serotonergic psychedelic with rapid onset and short duration, shows promise as a potential antidepressant (AD), although clinical evidence in MDD remains limited. We conducted a phase IIa, double-blind, placebo-controlled, randomized clinical trial to evaluate the efficacy and safety of intravenous DMT (SPL026; DMT fumarate) in adults with moderate-to-severe MDD. Participants received a single 21.5-mg dose of DMT or placebo i
Julien Vionnet, Jorge P. Torres-Yaguana, Rosa Miquel et al. · 2024 · American Journal of Transplantation
The maintenance of stable allograft status in the absence of immunosuppression (IS), known as operational tolerance, can be achieved in a small proportion of liver transplant recipients, but we lack reliable tools to predict its spontaneous development. We conducted a prospective, multicenter, biomarker-strategy design, IS withdrawal clinical trial to determine the utility of a predictive biomarker of operational tolerance. The biomarker test, originally identified in a patient cohort with high operational tolerance prevalence, consisted of a 5-gene transcriptional signature measured in liver
Kang Wang, Jinkai Feng, Hongming Yu et al. · 2025 · Signal Transduction and Targeted Therapy
Transarterial chemoembolization (TACE) is the standard treatment for intermediate-stage hepatocellular carcinoma (HCC), yet its efficacy as a standalone therapy remains suboptimal. This phase 2 trial (ChiCTR2100049829) evaluated the feasibility and safety of TACE combined with atezolizumab and bevacizumab in patients with intermediate-stage HCC. Participants received TACE followed by atezolizumab and bevacizumab until disease progression, unacceptable toxicity, or death. The primary endpoint was objective response rate (ORR) assessed per Response Evaluation Criteria in Solid Tumors (RECIST) v1
Hubert H. Fernandez, S. H. Isaacson, Robert A. Hauser et al. · 2026 · JAMA Neurology
Importance: Development of motor fluctuations is common in people with Parkinson disease (PD) treated with oral levodopa, and currently available dopamine (D) agonists adjunctive to levodopa offer additional motor control but may increase…