Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression
Lea J. Mertens; Michael Koslowski; Felix Betzler; Manuela Brand; Ricarda Evens; Laura Kärtner; Andrea Jungaberle; Henrik Jungaberle · 2026 · JAMA Psychiatry
WASTE classifies this as Replication Failure · AI classification, approximate
A previously reported effect did not replicate here — verify it holds before you build on it.
Abstract (excerpt)
Importance: Psilocybin shows promise in treating depression, although limitations of previous research warrant further research. Objective: To investigate the efficacy and safety of oral psilocybin, 25 mg, with adjunct psychotherapy in…
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Metadata source: OpenAlex · DOI 10.1001/jamapsychiatry.2026.0132