Negative / Null Result ReportOpen accessMedicine
Alberta Simona Tinu, Doina Lucia Ghergic, Mirel Stoian et al. · 2018 · Romanian Journal of Stomatology
Objectives. We performed a retrospective observational analytical study to determine the incidence of complications in the oral cavity in a group of patients diagnosed with diabetes mellitus. Material and method. We have studied 68 diabetic patients, who have been referred to dental practices seeking specialized treatment. Patient data sheets were centralized, categorized, and statistically processed with IBM SPSS Statistics 22 and Microsoft Excel 2010 depending on: sex of patients, age, type of diabetes, time elapsed from diagnosis of diabetes, the environment of origin of the patients, the l
View details →DOI: 10.37897/rjs.2018.1.1 Negative / Null Result ReportOpen accessMedicine
Yunsur Çevik, Fatma Nur Karaarslan, Şeref Kerem Çorbacıoğlu et al. · 2022 · Eurasian Journal of Emergency Medicine
Aim:The aim of this study was to examine the relationship between immature granulocyte (IG) counts and the severity of the disease and to evaluate the effectiveness of IG in predicting the poor outcomes in polymerase chain reaction-confirmed Coronavirus disease-2019 (COVID-19) cases.Materials and Methods:The study was conducted prospectively and observationally at the emergency department. Patients were divided into three groups according to the clinical severity indicators such as mild, moderate and severe. The IG level was measured from the whole blood samples taken at the admission to the e
View details →DOI: 10.4274/eajem.galenos.2021.79836 Negative / Null Result ReportOpen accessMedicine
Rasa Liutkevičienė, Ramunė Sungailienė, Alvita Vilkevičiūtė et al. · 2017 · Acta Medica Lituanica
Background. Age-related macular degeneration (AMD) is the most common cause of irreversible visual loss in industrialized countries. Early symptoms of AMD include drusen and changes in retinal pigment epithelium. However, the etiology of AMD and drusen formation is not fully understood. Recent studies suggest that CYP2C8-related metabolic processes might play an important role in the development of AMD. The aim of our study is to investigate CYP2C8 rs10509681 and CYP2C8 rs11572080 genotype frequencies in patients with early AMD and to compare them with healthy controls. Materials and Methods.
View details →DOI: 10.6001/actamedica.v24i2.3487 Negative / Null Result ReportOpen accessDiseases of the digestive system. Gastroenterology
Hao Lu, Shikuan Li, Chengzhi Wang et al. · 2025 · BMC Gastroenterology
Abstract Objective To investigate the impact of peritoneal lavage on the incidence of intra-abdominal abscess (IAA) after laparoscopic appendectomy (LA) in adults with perforated appendicitis. Methods Clinical data from adult patients intraoperatively diagnosed with perforated appendicitis and undergoing LA at the Affiliated Hospital of Qingdao University between January 2020 and January 2025 were retrospectively analyzed. Patients were divided into a no-peritoneal lavage group and a peritoneal lavage group based on whether peritoneal lavage was performed. A total of 128 patients were included
View details →DOI: 10.1186/s12876-025-04397-7 Negative / Null Result ReportOpen accessMedicine (General)
Maria Aparecida A.O. Serra, PhD, Arlene T. Medeiros, RN, Mateus D. Torres, RN et al. · 2021 · Journal of Taibah University Medical Sciences
الملخص: أهداف البحث: الأعراض الهضمية هي الشكاوى الأكثر شيوعا من قبل المرضى الذين يسعون للحصول على خدمات الرعاية الصحية الأولية. تهدف هذه الدراسة إلى تحديد أعراض الجهاز الهضمي وتحديد ارتباطها بنتائج التنظير المعوي العلوي لدى المرضى الذين عولجوا في مركز التنظير العام في شمال شرق البرازيل. طرق البحث: أجرينا دراسة مقطعية باستخدام بيانات ٧٥١ مريضا يعانون من أعراض الجهاز الهضمي ولديهم حاجة للتنظير المعوي العلوي. حددنا الارتباط بين هذه المتغيرات من خلال اختبار فيشر الدقيق وحسبنا نسبة الاحتمالات. النتائج: أظهرت النتائج أن ٨٣٪ من المرضى يعانون من آلام شرسوفية، ٧٢.٦٪ من الامتلاء بعد الأكل، و٧٢.٣٪ من حرق
View details →DOI: 10.1016/j.jtumed.2020.12.020 Negative / Null Result ReportOpen accessDermatology
Imran Majid, Gousia Sheikh, Farhath Kanth et al. · 2016 · Indian Journal of Dermatology
Background: The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. Aim: This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. Materials and Methods: A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cruris were included in the study. The enrolled patients were administered oral terbinafine 250 mg once daily for 2 weeks. All clinically cured patients were then followed up for 12 weeks to look for any rel
View details →DOI: 10.4103/0019-5154.190120 Negative / Null Result ReportOpen accessMedicine
Damkoeng Purnindu · 2023 · Siriraj Medical Journal
Dissection of one-half of adult pelvis in 197 Thai and 44 Chinese cadavers disclosed that the obturator artery arose from the internal iliac and umbilical arteries in 34.9%, from the inferior gluteal artery in 10.4%, from the internal pudendal artery in 8.7%, from the superior gluteal - inferior gluteal trunk in 4.2%, from the inferior gluteal - internal pudendal trunk in 9.1%, from the inferior epigastric artery in 12.0%, from the external iliac artery in 1.2%, and from the superior gluteal and the inferior epigastric arteries in 0.4%. There were no statistically significant differences of fi
Negative / Null Result ReportOpen accessAnesthesiology
Orhan Kılıç, Murat Yaşar Özkalkanlı, Fulya Yılmaz et al. · 2022 · Ain Shams Journal of Anesthesiology
Abstract Background Malnutrition is an important and widespread problem in hospitalised elderly orthopaedic patients. It is an important predictor of morbidity and mortality and has been associated with an increased risk of complications. Although it is a common problem in the elderly, there is neither a universally accepted criterion for the diagnosis of malnutrition nor a screening tool accepted as the gold standard to detect patients at risk of malnutrition. There is still no consensus on which is the most recommended for screening hospitalised patients for nutritional risk. The aim of this
View details →DOI: 10.1186/s42077-022-00280-9 Negative / Null Result ReportOpen accessDentistry
Deece Patuti, Harmas Yazid Yusuf, Bethy Suryawathy Hernowo · 2010 · Padjadjaran Journal of Dentistry
Introduction: CD10 can also facilitate the ability of tumour metastasis by its ability to invade blood vessel walls.Correlation of CD10 immunoexpression and eosinophil count in stromal tissue as predictors of prognosis of squamous cell carcinoma of the oral cavity. Methods: This study was preceded by collecting data on squamous cell carcinoma of the oral cavity in the medical record and paraffin blocks in the Anatomy Pathology section of 15 samples with enlarged regional lymph nodes and 15 samples without enlargement of regional lymph nodes. Then two preparations were made, the first preparati
View details →DOI: 10.24198/pjd.vol22no2.26873 Negative / Null Result ReportOpen accessMedicine
Tasić Danijela, Kovačević Zorana, Mitrović Miroslav et al. · 2021 · Scripta Medica
Background/Aim: Orthostatic hypotension (OH) is considered to be a drop in the systolic and diastolic blood pressure (> 20 mmHg; > 10 mmHg) 3 minutes from postural changes. The objective of this study was to analyse the correlation of body mass index (BMI) and OH during the treatment with trandolapril, as a single-drug treatment of hypertension. Methods: The study involved 255 patients (average age 54.3 ± 11.7; 54.1 % men) with poorly regulated hypertension, who were given trandolapril as a single-drug treatment. The patients were divided into two groups regarding stage of hypertension: first-
View details →DOI: 10.5937/scriptamed52-32561 Negative / Null Result ReportOpen accessMedicine
Hall, Natalie J, Berry, Sameer K, Aguilar, Jack et al. · 2021 · JMIR Formative Research
BackgroundA potential benefit of electronic health records (EHRs) is that they could potentially save clinician time and improve documentation by auto-generating the history of present illness (HPI) in partnership with patients prior to the clinic visit. We developed an online patient portal called AEGIS (Automated Evaluation of Gastrointestinal [GI] Symptoms) that systematically collects patient GI symptom information and then transforms the data into a narrative HPI that is available for physicians to review in the EHR prior to seeing the patient. ObjectiveThis study aimed to compare whether
View details →DOI: 10.2196/23599 Negative / Null Result ReportOpen accessDiseases of the genitourinary system. Urology
Dursun Baba, Necati Ekici, Arda Taşkın Taşkıran et al. · 2025 · BMC Urology
Abstract Background Urinary stone disease is a common urological disorder, particularly among middle-aged individuals. Extracorporeal Shock Wave Lithotripsy (ESWL) is often the first-line treatment for kidney and ureteral stones. Traditionally, fluoroscopy is used for stone targeting in ESWL, but it exposes patients and clinicians to radiation and cannot visualize non-opaque stones. Ultrasonographic targeting eliminates these issues. This study compares the advantages and disadvantages of fluoroscopy and ultrasound-targeted ESWL. Methods At Düzce University Hospital, 100 patients with radio-op
View details →DOI: 10.1186/s12894-025-01716-8 Negative / Null Result ReportOpen accessMicrobiology
Bakori, H. S., Kumurya, A. S., Idris, A. M. · 2024 · UMYU Journal of Microbiology Research
Mycoplasma genitalium is an emerging sexually transmitted pathogen with potential implications for reproductive health. This study aimed to investigate and compare the seroprevalence of M. genitalium among fertile and infertile women to provide insights into its potential association with fertility outcomes. A cross-sectional study was conducted involving a total of 90 women, including 31 fertile and 59 infertile women. Serum samples were collected and tested for the presence of M. genitalium-IgG antibodies using ELISA detection techniques. Data on demographic characteristics, including age an
View details →DOI: 10.47430/ujmr.2492.014 Negative / Null Result ReportOpen accessSurgery
Taner İyigun, Mugisha Kyaruzi, Barış Timur et al. · 2019 · Turkish Journal of Vascular Surgery
Objectives: This study aims to compare midterm results of patch angioplasty with primary closure techniques in patients undergoing carotid endarterectomy (CEA) in terms of restenosis. Patients and methods: This prospective, single-center, randomized study included a total of 137 patients (42 females, 95 males; mean age 64.4±8.8 years; range 36 to 86 years) who underwent CEA between January 2010 and October 2015. The patients were divided into two groups: the patch angioplasty group (n=70) and the primary closure group (n=67). The mean follow-up was 2-7 years. Carotid computed tomography angiog
Negative / Null Result ReportOpen accessMedical technology
Simon Marchant, Shona Michael, Laura Milner et al. · 2019 · Journal of Rehabilitation and Assistive Technologies Engineering
Introduction Functional electrical stimulation uses clinician-set parameters to modify stimulation. This study aimed to investigate whether timing parameters in the ODFS Pace functional electrical stimulation device have an effect on the gait of the general population of functional electrical stimulation users who have a foot drop. Methods Twelve functional electrical stimulation users with foot drop resulting from upper motor neurone disorders were recruited from the functional electrical stimulation Service in Leeds, UK. A crossover trial design was used, comparing adjusted values of rising
View details →DOI: 10.1177/2055668319859142 Negative / Null Result ReportOpen accessEducation
ولاء أحمد عباس مرسى · 2018 · تکنولوجیا التعلیم: سلسلة دراسات و بحوث
هدف البحث إلى تحديد انسب نمط لبيئة التعلم المقلوب (تدريس الأقران مقابل الاستقصائي) في إطار تفاعله مع استراتيجية التنظيم الذاتي للتعلم (البحث عن المساعدة مقابل البحث عن المعلومات)، ودراسة مدى تأثيرها في تنمية التحصيل الفوري والمرجأ، ودافعية الإنجاز، والرضا عن بيئة التعلم لدى طلاب تکنولوجيا التعليم. وقد استخدم في هذا البحث التصميم التجريبي ذي المجموعات التجريبية الأربعة، وهو امتداد للتصميم التجريبي ذي المجموعة الواحدة، واشتمل البحث على متغير مستقل وله مستويان: بيئة التعلم المقلوب (تدريس الأقران مقابل الاستقصائي)، مع استراتيجية التنظيم الذاتي للتعلم (البحث عن المساعدة مقابل البحث عن المعلومات)، و
View details →DOI: 10.21608/tesr.2018.124659 Negative / Null Result ReportOpen accessSurgery
Amber M. Parker, MD, Nicholas Genovese, MD, Alexy Ilchuk, BS et al. · 2026 · Journal of Hand Surgery Global Online
Purpose: To assess and compare the associative value of comorbidity fracture-specific index (CFI) versus the Charlson comorbidity index (CCI) in identifying patients at risk for early complications after open reduction and internal fixation (ORIF) of distal radius fractures (DRFs). Methods: We performed a single-center retrospective cohort study including patients ≥40 years who underwent ORIF for closed DRF using a volar locking plate with a minimum of 1 year follow-up. CCI and CFI scores were calculated based on comorbidities over the prior 15 years. The primary outcome was 90-day postoperati
View details →DOI: 10.1016/j.jhsg.2026.100959 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Grisel J. Lopez, Jens Lichtenberg, Nahid Tayebi et al. · 2022 · Frontiers in Neurology
ObjectiveBiallelic mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase, cause the lysosomal storage disorder Gaucher disease (GD). In addition, mutations in GBA1 are the most common genetic risk factor for future development of Parkinson's disease (PD). However, most mutation carriers will never develop parkinsonism. Olfactory dysfunction is often a prodromal symptom in patients with PD, appearing many years prior to motor dysfunction. The purpose of this study was to assess olfactory function longitudinally in individuals with and without parkinsonism who carry at least o
View details →DOI: 10.3389/fneur.2022.1039214 Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens
Xingwang Li, Xingwang Li, Shaoqing Guo et al. · 2025 · Frontiers in Oncology
ObjectivesThe field of view through transanal endoscopic provides new treatment approaches for solving complex clinical problems. TAMIS belongs to single-port endoscopic surgery, and the operation is complex. Analyzing the learning curve of TAMIS aims to facilitate its better clinical promotion.MethodsA retrospective cohort study analyzed the clinical data of 58 patients who underwent TAMIS by the same surgeon from January 2018 to October 2024. The learning curve of TAMIS was obtained using the cumulative sum (CUSUM) analysis, and the optimal number of surgeries was determined based on the pea
View details →DOI: 10.3389/fonc.2025.1545589 Negative / Null Result ReportOpen accessOrthopedic surgery
A.N. Toro-Ibarguen, E. Sánchez Benito, J.M. Cortés Villar · 2026 · Revista Española de Cirugía Ortopédica y Traumatología
Background and objective: The primary objective is to evaluate the clinical and functional outcomes of tape reinforcement in anterior cruciate ligament (ACL) reconstructions, recording complications, as well as the rate of reinterventions and graft failure. Materials and methods: Retrospective analysis of ACL reconstructions with hamstring (HS) autograft that were reinforced with high-strength tape. We included patients in whom we obtained a graft of HS <8 mm or ≥8 mm of poor quality. Age, sex, body mass index (BMI), and previous activity were recorded. Clinical and functional evaluation were
View details →DOI: 10.1016/j.recot.2025.11.004 Negative / Null Result ReportOpen accessMedicine (General)
Sacide Karakas, Ayfer Metin Tellioglu, Mehmet Bilgin et al. · 2019 · Eurasian Journal of Medicine
Abstract Objective: Thalassemias major are the most common autosomal recessive disorders; they are characterized by anomalies in the synthesis of the beta chains of hemoglobin and are often associated with varying degrees of craniofacial anomalies. The purpose of this study was to evaluate the craniofacial dimensions of β-thalassemia patients and to identify differences by comparing them to those of a control group. Materials and Methods: The study comprised 43 thalassemia major patients and 26 age- and sex- matched healthy control subjects. Anthropometric measurements were performed in six di
View details →DOI: 10.5152/eurasianjmed.2016.150013 Negative / Null Result ReportOpen accessScience
Michelle E. Cameron, Susan Pfeiffer · 2014 · South African Journal of Science
Diaphyseal cross-sectional geometry can be used to infer activity patterns in archaeological populations. We examined the cross-sectional geometric (CSG) properties of adult Later Stone Age (LSA) herder–forager long bones from the inland lower Orange River Valley of South Africa (n=5 m, 13 f). We then compared their CSG properties to LSA forager adults from the coastal fynbos (n=23 m, 14 f) and forest (n=17 m, 19 f) regions, building on a previous report (Stock and Pfeiffer, 2004). The periosteal mould method was used to quantify total subperiosteal area, torsional strength, bilateral asymmetr
View details →DOI: 10.1590/sajs.2014/20130369 Negative / Null Result ReportOpen accessMedicine
Priscila Lima de Luna FREIRE, Priscila Hernández CAMPOS, Fabíola Galbiatti CARVALHO et al. · Revista de Odontologia da UNESP
Abstract Introduction Methods of decontamination or sanitization of toothbrushes have been questioned. Objective This study assessed the effectiveness of pomegranate peels infusion as a disinfectant of toothbrushes against Streptococcus mutans. Material and method A sample of 16 schoolchildren aged between 7 and 9 years performed brushing 5 days/week, with a careful brushing once a day. After each day of brushing, the toothbrushes were washed and sprayed with one disinfectant solution. This procedure was repeated for 4 weeks using one of the different solutions per week: distilled water (G1; n
View details →DOI: 10.1590/1807-2577.01416 Methods Dead-EndOpen accessFinance
Manuel Rosinus, Jan Lansky · 2025 · International Journal of Financial Studies
As investors increasingly use Environmental, Social, and Governance (ESG) criteria, a key challenge remains: ESG data is typically reported annually, while financial markets move much faster. This study investigates whether incorporating annual ESG scores can improve monthly stock return forecasts for German DAX-listed firms. We employ a multivariate long short-term memory (LSTM) network, a machine learning model ideal for time series data, to test this hypothesis over two periods: an 8-year analysis with a full set of ESG scores and a 16-year analysis with a single disclosure score. The evalu
View details →DOI: 10.3390/ijfs13030167 Failed Experiment ReportOpen accessDentistry
Alper Yuzbasioglu, Cennet Neslihan Eroglu · 2024 · BMC Oral Health
Abstract Background Alveolar osteitis is a type of small-scale osteomyelitis of the alveolar bone that occurs after tooth extraction, the etiology of which remains unknown, and alternative methods are being investigated for its treatment. The aim of this study was to compare the effectiveness of advanced platelet-rich fibrin (A-PRF), photobiomodulation (PBM), and Alveogyl (butamben, idoform, eugenol), which have shown success in the treatment of alveolar osteitis, with that of pentoxifylline (PTX) to determine whether PTX could be an alternative treatment for alveolar osteitis. Methods This st
View details →DOI: 10.1186/s12903-024-05372-6 Failed Experiment ReportOpen accessMedicine
Lorenzo Porta, Sih-Shiang Huang, Chen Wei et al. · 2022 · PLoS ONE
Objectives While corticosteroids have been hypothesized to exert protective benefits in patients infected with SARS-CoV-2, data remain mixed. This study sought to investigate the outcomes of methylprednisone administration in an Italian cohort of hospitalized patients with confirmed SARS-CoV-2 infection. Methods Patients with confirmatory testing for SARS-CoV-2 were retrospectively enrolled from a tertiary university hospital in Milan, Italy from March 1st to April 30th, 2020 and divided into two groups by administration of corticosteroids. Methylprednisolone was administered to patients not r
View details →DOI: 10.1371/journal.pone.0266901 Negative / Null Result ReportOpen accessGeriatrics
Michael S. Kain, David Saper, Kyle Lybrand et al. · 2020 · Geriatrics
In current clinical practice, orthopedic surgeons often delay the surgery intervention on geriatric hip fracture patients to optimize the international normalized ratio (INR), in order to decrease the risk of postoperative hematological complications. However, some evidence suggests that full reversal protocols may not be necessary, especially for patients with prior thromboembolic history. Our study aims to compare the surgical outcomes of patients with normal versus elevated INR values. We conducted a retrospective chart review on 217 patients who underwent surgeries on hip fractures at two
View details →DOI: 10.3390/geriatrics5030043 Negative / Null Result ReportOpen accessAnimal culture
Í.R.R. Castro, G.B.C. Leite, I.F. Carrari et al. · 2025 · Animal
Available literature on the effect of various physical forms of starter feed (PFSF) on calf performance is conflicting. Thus, this study aimed to investigate the effect of the PFSF on feed intake, growth performance, blood metabolites, and the health of dairy calves. Twenty-four female Holstein calves (5-d-old; 40.4 ± 3.86 kg BW; mean ± SD) were used in a completely randomized block design. Calves were individually housed and randomly assigned to the treatments (n = 12 calves/treatment): (1) textured starter feed (TSF, a mix of pelleted ingredients and whole-kernel corn) and (2) pelleted start
View details →DOI: 10.1016/j.animal.2024.101400 Negative / Null Result ReportOpen accessMedicine
Sarah M. Alghamdi, Paul N. Schofield, Robert Hoehndorf · 2022 · Disease Models & Mechanisms
Computing phenotypic similarity helps identify new disease genes and diagnose rare diseases. Genotype–phenotype data from orthologous genes in model organisms can compensate for lack of human data and increase genome coverage. In the past decade, cross-species phenotype comparisons have proven valuble, and several ontologies have been developed for this purpose. The relative contribution of different model organisms to computational identification of disease-associated genes is not fully explored. We used phenotype ontologies to semantically relate phenotypes resulting from loss-of-function mu
View details →DOI: 10.1242/dmm.049441 Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Maria Antonietta Gambacorta, Antonino De Paoli, Marco Lupattelli et al. · 2018 · Clinical and Translational Radiation Oncology
Purpose: The aim of this study is to evaluate the long term survival of the addition of gefitinib to chemoradiotherapy (CRT) in locally advanced rectal cancer (LARC). Methods and materials: This previously published multicentre, open-label, phase I-II study, enrolled patients (pts) with LARC to receive CRT with concurrent 5-fluorouracil continuous intravenous infusion and a dose escalation of orally administered gefitinib, followed 6–8 weeks later by surgery. An intra-operative radiotherapy boost of 10 Gy was planned. Adjuvant chemotherapy was administrated in ypN1-2 pts. After a median f/u of
View details →DOI: 10.1016/j.ctro.2018.02.003 