Negative / Null Result ReportOpen accessMedicine
El-Hajj VG, El Choueiri J, Vasella F et al. · 2026 · Brain & spine
Introduction Central nervous system (CNS) melanocytomas are rare, pigmented tumors derived from leptomeningeal melanocytes. Although generally benign, they can exhibit locally aggressive behavior and recur. Despite increasing recognition,…
View details →DOI: 10.1016/j.bas.2025.105922 Negative / Null Result ReportOpen accessMedicine
Barber D, Wijeratne T, Singh L et al. · 2025 · Life (Basel, Switzerland)
Sporadic Parkinson's Disease (PD) affects 3% of people over 65 years of age. People are living longer, thanks in large part to improvements in global health technology and health access for non-neurological diseases. Consequently,…
View details →DOI: 10.3390/life15081169 Negative / Null Result ReportOpen accessMedicine
Lazarevic Lindblad M, Pålsson E, Lazarevic V et al. · 2026 · Infection prevention in practice
Background Central venous catheters (CVCs) are commonly used in patients with haematological diseases but are associated with infectious complications. The CVC Anti-infection Double Lumen Bundle was introduced in December 2020 to reduce…
View details →DOI: 10.1016/j.infpip.2026.100536 Negative / Null Result ReportOpen accessMedicine
Sunwoo JS, Cho YW, Shin WC et al. · 2025 · Journal of clinical neurology (Seoul, Korea)
Background and purpose To evaluate the clinical efficacy and safety of pregabalin in Korean adults with restless legs syndrome (RLS). Methods In this randomized, multicenter, double-blind, placebo-controlled trial, 78 patients with RLS…
View details →DOI: 10.3988/jcn.2025.0092 Negative / Null Result ReportMedicine
Gaeini Z, Mirmiran P, Azizi F · 2026 · Scientific reports
While emerging evidence from Western populations suggests that higher carbohydrate quality (assessed by indices incorporating fiber, glycemic index, whole grains, and solid carbohydrate sources) is inversely associated with cardiovascular…
View details →DOI: 10.1038/s41598-026-55845-7 Negative / Null Result ReportMedicine
Soral S, Bargale S, Dave B et al. · 2026 · Journal of the Indian Society of Pedodontics and Preventive Dentistry
Background Orthodontic treatment has long been associated with visible wires in the mouth. Clear aligners, once limited to mild crowding/spacing, are now supported for correcting more complex malocclusions. While Clear Aligner Therapy…
View details →DOI: 10.4103/jisppd.jisppd_15_26 Negative / Null Result ReportMedicine
Manca A, Palermiti A, Corcione S et al. · 2026 · Antibiotics (Basel, Switzerland)
Background/Objectives: Cefiderocol (FDC) is a siderophore-containing cephalosporin that retains activity against many β-lactamase-producing bacteria, such as New Delhi metallo-β-latamase-producing (NDM) K. pneumoniae . Its use in…
View details →DOI: 10.3390/antibiotics15060619 Negative / Null Result ReportOpen accessOils, fats, and waxes
刘芳1，吴苏喜1，2，蒋明芳1，谭传波3，李普选2LIU Fang1, WU Suxi1,2, JIANG Mingfang1, TAN Chuanbo3, LI Puxuan2 · 2022 · Zhongguo youzhi
为了了解不同制油工艺对油茶籽油生物活性成分含量和抗氧化活性的影响，以油茶果为原料，采取鲜榨法、浸提法、新水法、冷榨法和热榨法5种制油工艺分别制取油茶籽油，研究对比了5种制油工艺的提油率，所制取的油茶籽油的脂肪酸组成、生物活性成分(生育酚、角鲨烯及多酚)含量及其对DPPH自由基和ABTS自由基的清除能力。结果表明，5种制油工艺的提油率均在73%以上，其中浸提法（（96.45±3.02）%）最高，冷榨法（（73.72±2.76）%）最低，鲜榨法（（82.36±224）%）、新水法（（81.91±3.21）%）和热榨法（（80.34±2.09）%）没有显著差异；5种工艺所制取的油茶籽油具有相似的脂肪酸组成；在α-生育酚和总生育酚含量方面，新水法制取的油茶籽油含量最高（α-生育酚含量（263.77±1.58）mg/kg，总生育酚含量（280.55±1.64）mg/kg），鲜榨法、冷榨法和热榨法制取的油茶籽油中总生育酚含量接近，在233~244 mg/kg之间，浸提法制取的油茶籽油中总生育酚含量只有（17.10±0.76）mg/kg；在角鲨烯和多酚含量方面，鲜榨法制取的油茶籽油明显高于其他工艺的，分别为（350.56±7.60）mg/kg和（45.04±4.50）mg/kg，新水法制取的油茶籽油角鲨烯含量最低，为（249.99±3.73）mg/kg，浸提法制取的油茶籽油多酚含量最低，为（7
View details →DOI: 10.19902/j.cnki.zgyz.1003-7969.210470 Negative / Null Result ReportOpen accessBiology (General)
Muhammad Abba Isah Audu, Yusuf Idris, Muhammad Liman Muhammad et al. · 2022 · Botanica
The nutritional attributes of sesame, Sesamum indicum, vary substantially and are primarily influenced by the plant’s genetic makeup. This investigation accessed the biochemical composition of sesame mutants from two generations. Seeds of eleven M3 lines were planted in a Randomized Complete Block Design (RCBD) to raise M4 lines, which were advanced to M5 generation. The seeds were harvested at maturity, and their biochemical compositions were quantitatively determined following standard procedures. Results revealed significant differences (p 0.05) was observed in ash content of M4 and M5 muta
View details →DOI: https://doi.org/10.35513/botlit.2022.2.6 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Xiao-Xiao Han, Jia Qiao, Zhan-Ao Meng et al. · 2023 · Brain Sciences
Objectives: Investigate the biomechanical characteristics in tracheostomized patients with aspiration following acquired brain injury (ABI) and further explore the relationship between the biomechanical characteristics and aspiration. Methods: This is a single-center cross-sectional study. The tracheostomized patients with aspiration following ABI and age-matched healthy controls were recruited. The biomechanical characteristics, including velopharynx (VP) maximal pressure, tongue base (TB) maximal pressure, upper esophageal sphincter (UES) residual pressure, UES relaxation duration, and subgl
View details →DOI: 10.3390/brainsci13010091 Negative / Null Result ReportMedicine
Deng, Zhu, Cao et al. · 2026 · European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
The clinical evaluation of lumbar degenerative disease (LDD) severity relies on symptoms and imaging, lacking biologically specific diagnostic markers. This study investigated the role of serum complements in LDD to assess their potential…
View details →DOI: 10.1007/s00586-026-10086-0 Negative / Null Result ReportOpen accessMedicine
Xiuwen Sun, Xiaoling Li, Lingyu Ji et al. · 2018 · PeerJ
Based on the existing research on sound symbolism and crossmodal correspondence, this study proposed an extended research on cross-modal correspondence between various sound attributes and color properties in a group of non-synesthetes. In Experiment 1, we assessed the associations between each property of sounds and colors. Twenty sounds with five auditory properties (pitch, roughness, sharpness, tempo and discontinuity), each varied in four levels, were used as the sound stimuli. Forty-nine colors with different hues, saturation and brightness were used to match to those sounds. Result revea
View details →DOI: 10.7717/peerj.4443 Negative / Null Result ReportOpen accessAnimal culture
QIAN Ren-dong, WANG Lian-sheng, LUO Qiao-hua et al. · 2023 · Siliao yanjiu
The purpose of the study was to investigate the effects of wheat gluten replacing fish meal on growth performance, serum biochemistry, liver antioxidant and intestinal digestive enzyme activities of Cyprinus carpio . A total of 180 healthy Cyprinus carpio with an initial body weight of (9.16±0.03) g were selected and divided into three experimental groups, with three replicates in each group and 20 fish in each replicate. The control group (CW) was with 5% fish meal, and the experimental groups were with 50% (WA) and 100% (WB) fish meal replaced by wheat gluten. The experiment lasted for 56 d.
Negative / Null Result ReportOpen accessAnimal culture
Hang Wang, Xiaojie Qin, Xia Li et al. · 2020 · Poultry Science
This study was conducted to investigate the effects of air chilling (AC), water chilling (WC), combined chilling consisting of WC for 20 min and AC (CO20), and combined chilling consisting of WC for 30 min and AC (CO30) on the microbiological status, surface color, processing yield, and moisture content of yellow-feathered chicken carcasses. After chilling, the carcasses treated by AC exhibited the highest total viable counts (TVC) (4.7 cfu/cm2), followed by those treated by CO20 and CO30, whereas the carcasses treated by WC showed the lowest (P 0.05) was found among the carcasses treated by C
View details →DOI: 10.1016/j.psj.2019.11.020 Negative / Null Result ReportOpen accessPsychiatry
ّForough Farshidmanesh, Hosein Davoudi, Hasan Heidari et al. · 2019 · Taḥqīqāt-i ̒Ulūm-i Raftārī
Aim and Background: Many women begin their marital life with high intimate relationships, but with time, these intimate relationships are becoming less and more difficult, and it is just when then couple burnout has begun. The purpose of this study was to comparison of the effectiveness of mindfulness education and Emotional Focused Therapy (EFT) on couple intimacy, commitment and happiness women with couple burnout. Methods and Materials: The semi-experimental study was performed as pretest-posttest with a control group. The population included all women with couple burnout who was referred t
Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Elisabeth Möller, Carlotta Galeone, Therese M.-L. Andersson et al. · 2013 · Journal of Nutritional Science
Several individual components of the Mediterranean diet have been shown to offer protection against prostate cancer. The present study is the first to investigate the association between adherence to the Mediterranean diet and the relative risk of prostate cancer. We also explored the usefulness of the Mediterranean Diet Score (MDS) in a non-Mediterranean population. FFQ data were obtained from 1482 incident prostate cancer patients and 1108 population-based controls in the Cancer of the Prostate in Sweden (CAPS) study. We defined five MDS variants with different components or using either stu
View details →DOI: 10.1017/jns.2013.2 Negative / Null Result ReportOpen accessBiochemistry
Ljiljana Bošković-Rakočević, Tomo Milošević, Jelena Milivojević et al. · 2012 · Acta Scientiarum Polonorum: Hortorum Cultus
Mineral nutrition of apricot is very specific and depends on different factors such as soil fertility, soil pH, weather conditions, cultivars, rootstocks, fertilizers, age of trees etc. For these reasons, during 2008 and 2009 we evaluate nutrient status of five apricot cultivars (Vera, Aleksandar, Biljana, Harcot, Roxana) at 120 days after full bloom (DAFB) grown on acidic soil in the region of Čačak (Western Serbia). The results showed no statistically significant variations in the N, K and Ca content of apricot leaves among cultivars, as opposed to significant differences in the content of P
Negative / Null Result ReportOpen accessMedical physics. Medical radiology. Nuclear medicine
Sebastian M. Christ, Markus Schettle, Annina Seiler et al. · 2021 · Clinical and Translational Radiation Oncology
Background: Radiotherapy plays an important role for symptom control in advanced stage cancer patients. Yet patients need to be carefully selected, and its use and benefits must be weighed against time spent under treatment and patient priorities in the last phase of life. In this study, we assess prevalence, indications and outcomes of radiotherapy close to death. Methods: We screened all radiotherapy treatments performed at the Department of Radiation Oncology of the University Hospital Zurich between January 2010 and December 2019 to identify those which occurred near patients’ end-of-life.
View details →DOI: 10.1016/j.ctro.2021.06.010 Negative / Null Result ReportOpen accessSurgery
René Hage, Macé M. Schuurmans · 2022 · Transplantology
Introduction: We report on characteristics and lung function outcomes among lung transplant recipients (LTRs) after COVID-19 with infections occurring in the first year of the coronavirus pandemic prior to introduction of the vaccines. Methods: This was a retrospective study of 18 LTRs who tested positive for SARS-CoV-2 between 1 February 2020 and 1 March 2021. The mean age was 49.9 (22–68) years; 12 patients (67%) were male. Two patients died due to severe COVID-19. Results: During the study period, there were 18 lung transplant recipients with a community-acquired SARS-CoV-2 infection. In th
View details →DOI: 10.3390/transplantology3040028 Negative / Null Result ReportOpen accessInformation technology
Pang, Yan, Molton, James Steven, Ooi, Wei Tsang et al. · 2020 · JMIR mHealth and uHealth
BackgroundAs people living with HIV infection require lifelong treatment, nonadherence to medication will reduce their chance of maintaining viral suppression and increase the risk of developing drug resistance and HIV transmission. ObjectiveThis study aimed to evaluate the efficacy of a mobile app, Mobile Interactive Supervised Therapy (MIST), for improving adherence to oral HIV medications among HIV-infected adults in Singapore. MethodsWe conducted a two-group pilot randomized controlled trial (RCT) with a process evaluation, in which 40 HIV-infected participants with once-daily medication r
View details →DOI: 10.2196/15702 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Josef Pannee, Leslie M. Shaw, Magdalena Korecka et al. · 2021 · Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Abstract Introduction Blood‐based assays to measure brain amyloid beta (Aβ) deposition are an attractive alternative to the cerebrospinal fluid (CSF)–based assays currently used in clinical settings. In this study, we examined different blood‐based assays to measure Aβ and how they compare among centers and assays. Methods Aliquots from 81 plasma samples were distributed to 10 participating centers. Seven immunological assays and four mass‐spectrometric methods were used to measure plasma Aβ concentrations. Results Correlations were weak for Aβ42 while Aβ40 correlations were stronger. The rati
View details →DOI: 10.1002/dad2.12242 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Gulsen Ozen, Michael O'Rorke, Paul Romitti et al. · 2026 · ACR Open Rheumatology
Objective The aim of this study was to develop and validate International Classification of Diseases (ICD) code–based algorithms for identifying systemic sclerosis (SSc) cases within electronic health record (EHR) data and to evaluate algorithm performance. Methods We identified patients with at least one ICD, Ninth Revision (ICD‐9)/ICD‐10 code for SSc in a large multicenter EHR dataset (TriNetX Research Network). A random sample of patients underwent detailed medical record review to confirm SSc diagnosis (gold standard). All ICD‐9/10 codes assigned during inpatient or outpatient encounters a
View details →DOI: 10.1002/acr2.90091 Negative / Null Result ReportOpen accessAnimal culture
G. Martemucci, A. G. D'Alessandro · 2010 · Italian Journal of Animal Science
Two experiments were carried out in Martina Franca asses in order to study milk yield and udder healthy conditions in relation to daily milking number and frequency. Experiment I - A total of 15 asses were subdivided into three groups (N.5) corresponding to: one milking per day, after a 3 hour interval from foal separation by dams (Group A); three milkings per day with 3 hour frequency (Group B); three milkings per day with 2 hour frequency (Group 3M). Experiment II - Evaluation was made of the effect of a schedule of 6 milkings per day with frequency of 2 hours on milk yield (Group 6M; N. 5),
View details →DOI: 10.4081/ijas.2007.1s.643 Negative / Null Result ReportOpen accessImmunologic diseases. Allergy
Myrthe E. Sonneveld, Myrthe E. Sonneveld, Carolien A. M. Koeleman et al. · 2018 · Frontiers in Immunology
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3. Here, we analyzed 30 pregn
View details →DOI: 10.3389/fimmu.2018.00129 Negative / Null Result ReportOpen accessChemical technology
Caterina Pagnini, Giacomo Sampietro, Gaia Santini et al. · 2023 · Foods
Microalgae, because of their high nutritional value and bioactive molecule content, are interesting candidates for functional foods, including fermented foods, in which the beneficial effects of probiotic bacteria combine with those of biomolecules lying in microalgal biomass. The aim of this work was to evaluate the potential of Tisochrysis lutea F&M-M36 as a substrate for Lactiplantibacillus plantarum ATCC 8014 and to verify fermentation effects on functionality. Bacterium selection among three lactobacilli was based on growth and resistance to in vitro digestion. Microalgal raw biomass and
View details →DOI: 10.3390/foods12061128 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Maysa S. Campos, José B. Volpon, João Paulo B. Ximenez et al. · 2022 · Frontiers in Endocrinology
ObjectiveTo investigate the effects of vibration therapy on fracture healing in diabetic and non-diabetic rats.Methods148 rats underwent fracture surgery and were assigned to four groups: (1) SHAM: weight-matched non-diabetic rats, (2) SHAM+VT: non-diabetic rats treated with vibration therapy (VT), (3) DM: diabetic rats, and (4) DM+VT: diabetic rats treated with VT. Thirty days after diabetes induction with streptozotocin, animals underwent bone fracture, followed by surgical stabilization. Three days after bone fracture, rats began VT. Bone healing was assessed on days 14 and 28 post-fracture
View details →DOI: 10.3389/fendo.2022.909317 Negative / Null Result ReportMedicine
Xu, Wu, Liu et al. · 2026 · Annals of hematology
In adult patients with early-stage follicular lymphoma (FL), age-related differences in the risk of non-lymphoma-related death (LRD) during the follow-up period after treatment are unclear. We aimed to investigate the interactive effects…
View details →DOI: 10.1007/s00277-026-07144-4 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Ce Zhou, You Zhou, Niannian Shuai et al. · 2024 · Frontiers in Cardiovascular Medicine
Background and aimEstimated glomerular filtration rate (eGFR) is a key indicator of kidney function and is associated with numerous health conditions. This study examines the association between eGFR and cardiovascular disease (CVD) risk in a representative cohort of the US adult population.MethodsA cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018. The study included 31,020 participants aged 20 years and older. The eGFR estimates were calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD
View details →DOI: 10.3389/fcvm.2024.1417926 Negative / Null Result ReportOpen accessMedicine
Lijing Ma, Heng Su, Yan Wang et al. · 2020 · European Journal of Inflammation
Variants of the interleukin-1β (IL-1β) gene have been associated with type 2 diabetes (T2D) and coronary artery diseases (CAD). However, association of IL-1β polymorphisms with diabetic patients having CAD clinical manifestation has not been studied yet. In this study, we aim to decipher the role of IL-1β common promoter variants with susceptibility/resistance to development of CAD in T2D patients. T2D patients with (n = 134) or without CAD (n = 533) were enrolled. A total of 513 essentially healthy individuals from the same population were included in this study as control. Plasma levels of I
View details →DOI: 10.1177/2058739220918047 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Keyi Wu, Huamin Liu, Jiazhen Zheng et al. · 2022 · Frontiers in Aging Neuroscience
Background: Diabetes mellitus (DM) is a recognised risk factor for cognitive dysfunction. The purpose of this study was to explore the relationship between active treatment for DM and cognitive function in middle-aged (< 60 years) and older adults (≥60 years), respectively.Methods: A total of 13,691 participants (58.55 ± 9.64 years, 47.40% of men) from the Chinese Health and Retirement Longitudinal Study (CHARLS) were included. The participants were classified into three groups according to whether or not they have diabetes and to their diabetes treatment status: diabetes-free, treated-diabete
View details →DOI: 10.3389/fnagi.2021.753129 