Negative / Null Result ReportMedicine
Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences
This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…
View details →DOI: 10.1111/eos.70103 Negative / Null Result ReportOpen accessMedicine
Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…
View details →DOI: 10.1007/s10096-025-05348-6 Negative / Null Result ReportOpen accessMedicine
Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases
This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…
View details →DOI: 10.1093/ofid/ofag219 Failed Experiment ReportOpen accessMedicine
Wirta D, Lipsky W, Toyos M et al. · 2024 · BMC ophthalmology
Background Dry eye disease (DED) includes neurosensory abnormalities as part of its multifactorial etiology. Nerve growth factor is important for maintaining corneal nerve integrity and wound healing. Cenegermin (recombinant human nerve…
View details →DOI: 10.1186/s12886-024-03564-w Negative / Null Result Report
Buyukkoruk M, Tunccan OG, Yigit S et al. · 2026 · Preprint
Abstract Background: This study aimed to evaluate the effect of the gastrointestinal system multiplex PCR panel (GISP) on the relapse-free survival of ulcerative colitis (UC) both active and in remission patients. Methods: In this…
View details →DOI: 10.21203/rs.3.rs-9023219/v1 Negative / Null Result ReportMedicine
Palmi S, Arponen O, Murto M et al. · 2026 · JAMA network open
Importance Statin use has been associated with improved survival in patients with breast cancer, but there are no data on the association between statin use and survival in different intrinsic breast cancer subtypes. Objective To assess…
View details →DOI: 10.1001/jamanetworkopen.2026.16375 Negative / Null Result ReportMedicine
Gunun N, Kaewpila C, Kesorn P et al. · 2026 · Animal bioscience
Objective The aim of this study was to evaluate the effect of the inclusion of tomato pomace silage (TPS) on feed intake, nutrient digestibility, blood parameters, immune response, milk yield, and milk nutritional composition in dairy…
View details →DOI: 10.5713/ab.250925 Negative / Null Result ReportMedicine
Sunada S, Kuroishi T · 2026 · Journal of oral biosciences
Immunoglobulin A (IgA)-producing cells in the three major murine salivary glands (SGs) were analyzed using flow cytometry. Sublingual glands (SLGs) had significantly higher frequencies of IgA + cells than other SGs. IgA + cells expressed…
View details →DOI: 10.1016/j.job.2026.100773 Negative / Null Result ReportMedicine
Wang M, Wang X, Zeng Y et al. · 2026 · Journal of animal science
This study evaluated the effects of replacing dietary glucose with fructose on intestinal development in weaned pigs and assessed epithelial growth using a small intestinal organoid model. A total of 26 weaned pigs ([Yorkshire × Landrace]…
View details →DOI: 10.1093/jas/skag153 Negative / Null Result ReportMedicine
Shchulkin AV, Chernykh IV, Abalenikhina YV et al. · 2026 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
Objective To compare the effects of Mexidol, Cerebrolysin, and Cortexin on the levels of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF α ), and apoptosis markers in the rat brain following middle cerebral…
View details →DOI: 10.17116/jnevro2026126021123 Negative / Null Result ReportMedicine
Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science
Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…
View details →DOI: 10.3168/jds.2025-27713 Negative / Null Result ReportMedicine
Wallbom N, Khansari AR, Sandblom E et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard…
View details →DOI: 10.1016/j.cbpa.2026.112014 Negative / Null Result ReportMedicine
Rout M, Blackett P, Sanghera DK · 2026 · Nutrients
Background: Vitamin D (25(OH)D) deficiency affects over one billion people globally and is associated with type 2 diabetes (T2D) and cardiometabolic diseases. However, causal relationships remain unclear, as vitamin D supplementation has…
View details →DOI: 10.3390/nu18121944 Negative / Null Result ReportMedicine
İren AY, Yiğit E · 2026 · BMC oral health
BACKGROUND: The aim of this in-vitro study was to evaluate the effect of preheating on the flexural strength, flexural modulus and microhardness of several commercially available single-shade universal resin composites (SSURCs). METHODS:…
View details →DOI: 10.1186/s12903-026-08188-8 Negative / Null Result ReportMedicine
Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids
Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…
View details →DOI: 10.1016/j.bbalip.2026.159752 Negative / Null Result ReportMedicine
Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)
Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…
View details →DOI: 10.1039/d5dt02853a Negative / Null Result Report
Gaudeul A, Krawczyk M · 2026 · Preprint
Abstract We conducted an online experiment with 3420 participants in Bulgaria, Germany and Spain to evaluate the consequences of digital access to food information via QR codes. Participants made incentivized choices between food products…
View details →DOI: 10.21203/rs.3.rs-8549197/v1 Negative / Null Result Report
Lu X, Ferraz GA, Sivakumar S et al. · 2026 · Preprint
ABSTRACT Aging is associated with a gradual and progressive decline in skeletal muscle mass and strength known as sarcopenia, which has been attributed to chronic low-grade inflammation. Dietary long-chain polyunsaturated fatty acids…
View details →DOI: 10.64898/2026.06.05.729990 Negative / Null Result Report
Cherkasova M, Assi A, Craw M et al. · 2026 · Preprint
Objective: A prominent feature of land-based and online slot machines is audiovisual feedback that accompanies winning outcomes. Prior laboratory work suggests that this design feature may influence game experience, facilitate immersion,…
View details →DOI: 10.31234/osf.io/zps8c_v3 Negative / Null Result ReportOpen accessMedicine
Sevim B · 2026 · Tropical animal health and production
This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…
View details →DOI: 10.1007/s11250-026-04871-8 Negative / Null Result ReportMedicine
Silva ACD, Varela Junior AS, França RT et al. · 2026 · Cell biochemistry and function
Lectins are carbohydrate-binding proteins that recognize specific glycan patterns on cell surfaces and have been increasingly explored as analytical tools in reproductive biology. This study characterized the interaction of a lectin…
View details →DOI: 10.1002/cbf.70247 Negative / Null Result ReportMedicine
Wang NN, Luo CJ, Liu LG et al. · 2026 · Ying yong sheng tai xue bao = The journal of applied ecology
Litter decomposition is a core process regulating the formation and stability of soil organic carbon. Under the background of climate warming, the intrinsic mechanisms by which the expansion of alpine shrubs affects carbon balance of…
View details →DOI: 10.13287/j.1001-9332.202606.011 Negative / Null Result Report
Sanei A, Asgarian FS, Ebrahiminezhad M · 2026 · Preprint
Abstract Background The lack of studies and sometimes conflicting results in this field, has required that this study be conducted with the aim of improving treatment results in dental health care system. Methods The present study was…
View details →DOI: 10.21203/rs.3.rs-8080200/v1 Negative / Null Result Report
Suarez-Baquero DE, Boido D, Assali A et al. · 2026 · Preprint
Abstract In brain gray matter, neurovascular coupling (NVC) maintains brain metabolism homeostasis by modulating blood flow according to neuronal activity. In white matter, the energy cost of information transmission along myelinated axons…
View details →DOI: 10.21203/rs.3.rs-9086876/v1 Negative / Null Result Report
Tan X, Ding Z · 2026 · Preprint
Astrocytes are the most abundant glial cells in the brain and an integrative component of the neural network. Studies have shown that ethanol altered expression of an astrocyte marker, i.e., glial fibrillary acidic protein (GFAP), in two…
View details →DOI: 10.64898/2026.03.10.710881 Negative / Null Result ReportMedicine
Gokdemir MT, Gokdemir GS · 2026 · BMC infectious diseases
Background Studies have reported that the Coronavirus Disease 2019 (COVID-19) vaccine causes other serious health problems, including myocarditis, pericarditis, neurological problems, and problems resulting from the reactivation of chronic…
View details →DOI: 10.1186/s12879-026-13542-w Negative / Null Result ReportMedicine
Shehata MA, Khirallah MG, Al Nafesa A et al. · 2026 · Pediatric surgery international
Purpose To evaluate whether routine omentectomy improves outcomes during laparoscopic placement of peritoneal dialysis (PD) catheters in children. Methods This multicenter retrospective study included children ≤ 5 years who underwent…
View details →DOI: 10.1007/s00383-026-06464-w Negative / Null Result ReportOpen accessMedicine
Matsuoka C, Takatama N, Muraoka T et al. · 2026 · Genes and environment : the official journal of the Japanese Environmental Mutagen Society
Background Previous research using the Ames assay showed that licoricidin (LCD) and isoliquiritigenin (ILTG) can block mutations caused by N-methyl-N-nitrosourea (MNU) in Salmonella typhimurium (S. typhimurium) TA1535. With the aim to…
View details →DOI: 10.1186/s41021-026-00361-3 Negative / Null Result ReportOpen accessMedicine
Loayza J, Taylor CJL, Renstrom JG et al. · 2026 · eNeuro
Tourette syndrome (TS) has been linked to reduced GABAergic inhibition, the so-called neural disinhibition, in the dorsal striatum. Dorsal striatal neural disinhibition in animal models, caused by local microinfusion of GABA-A receptor…
View details →DOI: 10.1523/eneuro.0068-26.2026 Negative / Null Result ReportMedicine
Caenepeel C, Deleu S, Vazquez Castellanos JF et al. · 2025 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Rigorous donor preselection on microbiota level, strict anaerobic processing, and repeated fecal microbiota transplantation (FMT) administration were hypothesized to improve FMT induction of remission in ulcerative…
View details →DOI: 10.1016/j.cgh.2024.05.017 