A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 376 of 675
Kwaiser MM, King JF, Troyer LE et al. · 2026 · Preprint
Abstract Background Many physical activity interventions exist, but few are sustained, with additional barriers in rural populations. The primary objective was to evaluate the feasibility of a refined implementation strategy for a…
Diego-Navarro O, Copete S, Moreno-Martínez A et al. · 2026 · European journal of ophthalmology
PurposeTo evaluate functional and anatomical outcomes after intravitreal dexamethasone implant (DEXI) in macular edema secondary to retinal vein occlusion (ME-RVO), comparing treatment-naïve eyes with early-switch (ES) and late-switch (LS)…
Şafak A, Karakaya E, Yıldırım S et al. · 2026 · Transplantation proceedings
Introduction Although liver biopsy in patients with acute cellular rejection (ACR) is the gold standard for diagnosis, its invasive nature highlights the need for reliable noninvasive biomarkers. With evidence suggesting that peripheral…
Parapiboon W, Pattanapongpaibool A, Sanprasert S · 2026 · International urology and nephrology
Purpose The benefits of incremental peritoneal dialysis (IPD) with days off remain controversial. This study aimed to compare the survival rate between IPD with days off and standard-dose peritoneal dialysis (PD). Methods Participants who…
Musbahi O, Pouris K, Hadjixenophontos S et al. · 2025 · World journal of methodology
Background Relieving pain is central to the early management of knee osteoarthritis, with a plethora of pharmacological agents licensed for this purpose. Intra-articular corticosteroid injections are a widely used option, albeit with…
Bushaibah O · 2026 · Environmental monitoring and assessment
Understanding long-term microbial dynamics in semi-enclosed coastal systems is essential for evaluating wastewater-related impacts and informing management responses. This study applies an integrated nonparametric diagnostic framework to…
Alatrash M, Moustafa MS, Nashed GA et al. · 2026 · Preprint
Background: The gallbladder plays an essential role in lipid homeostasis through bile storage and regulated release. Gallstone disease is frequently associated with dyslipidemia, and cholecystectomy is one of the most common abdominal…
Torres K, Terzi S, Simón L · 2026 · Scientific reports
Healthier diets are associated with fewer mental health symptoms, whereas higher consumption of ultra-processed foods is associated with psychological distress. This pilot study aimed to evaluate the impact of a nutrition education…
Aytekin AM, Ulusoy HE, Efe MA et al. · 2026 · The journal of obstetrics and gynaecology research
Objective To evaluate the impact of bilateral salpingectomy added to hysterectomy performed via different surgical routes on ovarian reserve, ovarian stromal blood flow, and sexual function in premenopausal women. Methods This prospective…
Lee YJ, Clement ND, Asopa V et al. · 2026 · The Journal of arthroplasty
Background The objectives were to evaluate whether the EQ-5D-3L questionnaire demonstrated a ceiling effect after total hip arthroplasty (THA), identify which patients were more likely to reach the ceiling score, and determine whether this…
Bowman J, Cornelius JM, Schoen A et al. · 2026 · Journal of experimental zoology. Part A, Ecological and integrative physiology
The release of waterborne chemical cues is a well-documented anti-predator strategy in teleost fish, allowing individuals to detect, and respond to, predation threats. However, little is known about whether an ancient group of fishes,…
Balachandran A, Elliot JLN, Curtis S et al. · 2026 · Preprint
Abstract Background: Adolescents and young adults (AYAs) with congenital heart disease (CHD) are frequently lost to follow-up during transition to adult congenital heart disease (ACHD) care. Successful transition requires navigating…
Kikuchi M, Yoshimura Y, Tanaka S et al. · 2026 · Preprint
Abstract Facilitated drum circles may promote social bonding in children, yet endocrine responses vary widely. In a school-based pilot study (n = 11; aged 9–10 years), we examined whether the temporal structure of facilitator–child…
Booth SE, Rubins D, O'Donoghue AL et al. · 2026 · Applied clinical informatics
Intravenous (IV) and oral (PO) acetaminophen have equivalent bioavailability and effectiveness, but IV formulations are significantly more expensive. Clinical decision support (CDS) tools can encourage cost-effective prescribing. We…
Seijas R, Vázquez M, Barastegui D et al. · 2026 · International orthopaedics
Purpose To characterise recovery trajectories across nine patient-reported outcomes (PROs) during the first twelve months after hip arthroscopy for femoroacetabular impingement syndrome (FAIS), and to determine whether six-month assessment…
Aftabi S, Leslie WD · 2026 · Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
Dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing bone mineral density (BMD), but technical factors such as acquisition mode may affect measurement. On GE Healthcare DXA systems, Thin and Thick modes are often…
Singh PK, Kumar BS, Nandi S et al. · 2026 · Veterinary medicine international
Bisphenol A (BPA), an organic environment chemical, has extensive presence in consumer goods and food/feed items. The present study aimed to explore how BPA influenced the viability, proliferation, apoptosis, and steroidogenic activity of…
Lin YH, Teng MMH · 2026 · PloS one
Monitoring bone mineral density (BMD) changes can be challenging when both the spine and hips are included in follow-up assessments. This study aimed to evaluate BMD changes using different monitoring approaches, including comparisons…
Abd Elghany AA, Kamel Eyada MM, Maher SA et al. · 2026 · Cytokine
Background Alopecia areata (AA) is a common autoimmune disease which causes non-scarring patches of hair loss and has a 2% lifetime risk. Its chronic, recurrent nature makes treatment difficult. Potential roles of the JAK/STAT pathway,…
Boonperm P, Buaboon N, Vatanavilai C et al. · 2026 · Journal of human lactation : official journal of International Lactation Consultant Association
Background Breastfeeding is a key strategy for improving maternal and infant health; however, Thailand continues to fall short of national and international breastfeeding targets. Village Health Volunteers (VHVs) play an essential role in…
Seward M, Puiras E, Crocker CE et al. · 2026 · BMC psychiatry
Background 30% of individuals with schizophrenia do not respond to first line dopamine-blocking antipsychotic medications and meet criteria for treatment resistant schizophrenia (TRS). Elevated glutamate levels in the anterior cingulate…
Sinha R, Sabir M, Tripathi M et al. · 2026 · Indian journal of ophthalmology
Objective To evaluate the role of local oxygen supplementation in accelerated collagen cross-linking (CXL) in human subjects. Method Patients with progressive keratoconus were enrolled and randomized to undergo accelerated CXL in either…
Vasamsetti SR, Guddeti A, Kumar S et al. · 2026 · Nigerian journal of clinical practice
Background Hypothyroidism is a common condition, and thyroid hormones play a key role in metabolism and fat regulation. We examined how levothyroxine affects visceral adipose tissue (VAT) and body composition using dual-energy X-ray…
Kim S, Kim YJ, Yoon YH et al. · 2026 · International journal of retina and vitreous
Purpose This study aimed to investigate the spatial correlation between retinal structure and function in macular telangiectasia type 2 (MacTel) using Compass fundus-tracked microperimetry. Methods Medical records of 54 eyes from 28…
Ting J, Grills N, Sochet AA et al. · 2026 · Pediatric cardiology
Critical congenital heart disease (CCHD) screening using pulse oximetry was mandated by all states between 2011-2018. We sought to evaluate the effect on the age at initial admission to a children's hospital, the hospital length of stay…
Soliman S, Said D, Maqsood S et al. · 2026 · Advances in therapy
Introduction Infectious keratitis can lead to significant ocular morbidity and threaten vision if not treated promptly with antimicrobial therapy. Adjuvant treatment with corneal cross-linking (CXL) can improve visual outcomes in cases of…
Borhany M, Iqbal HT, Abid M et al. · 2026 · Clinical medicine insights. Pediatrics
Background Sickle cell disease (SCD) is characterized by a chronic hypercoagulable state. Hydroxyurea (HU) is known to reduce the frequency of vaso-occlusive events and transfusion requirements in affected individuals. Objective To assess…
Bonnet E, Ikpo D, Kodo M et al. · 2026 · Traffic injury prevention
Objective Road traffic injuries are a leading cause of death among children in Africa, especially in urban areas with inadequate infrastructure. Despite this, few scientifically taught educational initiatives to address this issue at the…
Gundrosen KF, Taraldsen K, Sverdrup K et al. · 2026 · European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity
Background This longitudinal study explored the one-year change in device-measured daily physical activity in patients attending a memory clinic. Methods Physical activity was recorded in 27 memory clinic patients over four days using…
Silverii H, Ahn J, Gopalan M et al. · 2026 · Journal of pediatric urology
Background While surgical coaching has been proven beneficial, the impact of a faculty focused coaching model on a surgeon's teaching ability and trainee education is unknown. In this study we aim to evaluate whether a surgeon's teaching…