Negative / Null Result Report
Bixio M, Scamperle A, Quarantotto G et al. · 2026 · Preprint
Background: /Objectives: The use of IgM- and IgA-enriched intravenous immunoglobulins (eIg) in septic shock remains controversial due to the lack of high-quality evidence, despite indications from observational studies and meta-analyses…
View details →DOI: 10.20944/preprints202604.2104.v1 Negative / Null Result ReportMedicine
Clark C, Lira Calabrich S, Lallier M et al. · 2026 · Quarterly journal of experimental psychology (2006)
This study examined how orthographic characteristics relate to the learning and retention of novel written words in monolingual English and bilingual Welsh-English adults. Participants learned pseudowords designed to follow either…
View details →DOI: 10.1177/17470218261441260 Negative / Null Result ReportMedicine
Vijay A, Fruzzetti AE · 2026 · Journal of interpersonal violence
Sexual victimization and assault are significant public health problems. Survivors of sexual assault have significantly increased risk for psychological health problems, physical health problems, interpersonal difficulties, and other…
View details →DOI: 10.1177/08862605251412351 Negative / Null Result ReportMedicine
Wright PJ, Gruszczynski M · 2026 · Health communication
Pornography exposure and condomless sex studies to date have assumed a linear relationship and found only small effect sizes. The present study introduces the Disinhibition Threshold Hypothesis (DTH) in the context of emerging U.S. adults'…
View details →DOI: 10.1080/10410236.2026.2632149 Negative / Null Result ReportMedicine
Murayama Y, Soma D, Kameya M et al. · 2026 · Discover mental health
Loneliness is a key risk factor for youth mental health; however, existing scales often fail to capture its multidimensional and relational nature. This study developed the [blinded] University Loneliness Scale (KULoS) for students in…
View details →DOI: 10.1007/s44192-026-00462-z Negative / Null Result ReportMedicine
Shen Y, Nishikawa K, Hiruta SF et al. · 2025 · Zoological science
The water mite genus Hygrobates and the newt family Salamandridae are distributed widely in the northern hemisphere. However, only in Eastern and Southeastern Asia a host-parasite association developed, with several Hygrobates species,…
View details →DOI: 10.2108/zs240074 Negative / Null Result ReportMedicine
Podoly TY, Even-Ezra H, Doron G · 2025 · Journal of affective disorders
Misophonia is a condition characterized by strong, aversive reactions to specific sounds produced by others, often manifesting as intense negative emotions like anger or rage in response to nearby noises. The present study aimed to…
View details →DOI: 10.1016/j.jad.2025.03.060 Negative / Null Result ReportMedicine
Ala-Jaakkola R, Forssten SD, Cheng J et al. · 2025 · Molecular nutrition & food research
Functional constipation (FC) is characterized by difficult, infrequent, or incomplete bowel movements without clear physiological cause. Daily intake of Bifidobacterium lactis HN019 has been shown to reduce colonic transit time or…
View details →DOI: 10.1002/mnfr.70081 Negative / Null Result ReportMedicine
El-Nagdy NK, Mansour NO, Diab AAA et al. · 2025 · Pharmacotherapy
Background Midodrine has been primarily studied as an adjunctive oral therapy to reduce the need for vasopressors in intensive care units (ICU). Nonetheless, the available results evaluating midodrine as an adjuvant therapy in the…
View details →DOI: 10.1002/phar.70018 Negative / Null Result ReportMedicine
Barbakoff D, Glennie K, Yan M et al. · 2026 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
Supportive environmental features (SEFs) are attributes of homes that help people overcome activity limitations. Evidence suggests that SEFs may facilitate aging in place. However, real-life SEF implementation patterns are not fully…
View details →DOI: 10.1177/07334648261429572 Negative / Null Result ReportMedicine
Mest J, Flood A, Preston P et al. · 2026 · Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine
Objectives To investigate if sensorimotor function predicts pain-related cognition in people with lower limb tendinopathy. Design Single-cohort, cross-sectional study. Setting Sports and exercise research laboratory. Participants…
View details →DOI: 10.1016/j.ptsp.2026.101921 Negative / Null Result ReportMedicine
Rilveria JRC, Grepo LC, Lim PMQ et al. · 2026 · Npj mental health research
Mental health mobile applications are increasingly used to address psychological distress and promote well-being, yet evidence on how and when these tools exert their effects over time and what constitutes meaningful engagement remains…
View details →DOI: 10.1038/s44184-026-00219-0 Negative / Null Result Report
Cotet M, Poensgen D, Krajbich I · 2026 · Preprint
Learning is fundamental to adaptive behavior. In the typical learning task, each action is associated with only one outcome, which could be immediate or delayed. However, actions often have multiple consequences that unfold over time.…
View details →DOI: 10.31234/osf.io/eyjmg_v1 Negative / Null Result ReportMedicine
Zhang S, Song Y, Steptoe A et al. · 2026 · Psychology of sport and exercise
Previous research has demonstrated a link between physical activity and loneliness, though the direction of this relationship remains unclear. This study explored daily fluctuations in the temporal relationship between physical activity…
View details →DOI: 10.1016/j.psychsport.2026.103122 Negative / Null Result Report
Hill TG · 2026 · Preprint
Healthy personality profiles, characterized by higher extraversion, agreeableness, conscientiousness, and openness alongside lower neuroticism, are often assumed to support broad flourishing across the life course. Yet it remains unclear…
View details →DOI: 10.31234/osf.io/ky9u6_v1 Negative / Null Result ReportOpen accessMedicine
Büyükdemirtaş B, Benn M, Kwon HB et al. · 2026 · Psychopharmacology
Rationale Binge drinking during adolescence is associated with a higher risk of developing Alcohol Use Disorders and impaired stress reactivity in adulthood. The hypothalamic-pituitary-adrenal axis matures during adolescence and is under…
View details →DOI: 10.1007/s00213-025-06969-7 Negative / Null Result ReportMedicine
Isaacson BN, Serbin SP, Grabosky JC · 2025 · Forest Ecology and Management.
There is a vigorous debate around whether and how to manage forests for climate mitigation or for other goals such as biodiversity. To achieve any of these goals it is necessary to define the parameters within which they can exist;…
Negative / Null Result ReportOpen accessMedicine
Kanyorszky ET, Sterczer Á, Vizi Z et al. · 2026 · BMC veterinary research
BACKGROUND: Acute pancreatitis triggers the production of acute-phase proteins (APPs) in the body, among which C-reactive protein (CRP) is the most extensively studied and widely used for both diagnosis and prognosis. The diagnostic value…
View details →DOI: 10.1186/s12917-026-05409-8 Negative / Null Result Report
Ghamgosar Shahkhali M, Liu L, Ghamgosar Shahkhali MH et al. · 2025 · Preprint
Objective To explore potential genetic and/or causal associations between Post-Traumatic Stress Disorder and neurodegeneration-related isolated/idiopathic rapid-eye-movement sleep behavior disorder. Methods We conducted polygenic risk…
View details →DOI: 10.1101/2025.09.05.25335205 Negative / Null Result ReportMedicine
Yang T, Yuan X, Gao W et al. · 2024 · Internal and emergency medicine
Observational studies revealed paradoxically inverse associations between diabetes and aortic diseases (aortic aneurysm or aortic dissection), yet the causality remains to be determined. To investigate the causal associations between…
View details →DOI: 10.1007/s11739-024-03727-z Negative / Null Result ReportOpen accessMedicine
Zhang H, Zhao T, Zheng H et al. · 2026 · BMC neurology
Neuronal intranuclear inclusion disease (NIID) is a rare, progressive neurodegenerative disorder caused by abnormal GGC repeat expansions in the NOTCH2NLC gene, leading to multisystem involvement. Electrophysiological abnormalities in NIID…
View details →DOI: 10.1186/s12883-026-04898-2 Negative / Null Result ReportMedicine
Berger M, Bruggisser F, Schwarz A et al. · 2025 · Physiology & behavior
Objectives To investigate whether a single session of aerobic exercise improves inhibitory control in preadolescent children and whether this effect is mediated by changes in parasympathetic activity. Design In this experimental study, an…
View details →DOI: 10.1016/j.physbeh.2025.114820 Negative / Null Result Report
Su Z, Wyble B, Fu Y · 2024 · Preprint
This study explores the relationship between working memory and attention during visual search tasks, focusing on how time constraints affect the encoding of visual information into working memory. The research is based on the premise that…
View details →DOI: 10.31234/osf.io/d4hc5 Negative / Null Result ReportMedicine
de Bruin LJE, Hoegh M, Greve C et al. · 2024 · The Journal of orthopaedic and sports physical therapy
OBJECTIVE: To assess the causal role of the relationship between loading and the onset of nonspecific low back pain (NSLBP) and persistence of NSLBP (chronic low back pain [CLBP]). DESIGN : Scoping review. LITERATURE SEARCH : We searched…
View details →DOI: 10.2519/jospt.2024.11314 Negative / Null Result ReportMedicine
Xiang C, Zheng M, Li Y et al. · 2025 · Annals of vascular surgery
Background Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT), is the third most common cardiovascular disease. A low amount of mitochondrial DNA copy number (mtDNA-CN) reflects mitochondrial…
View details →DOI: 10.1016/j.avsg.2025.01.013 Negative / Null Result ReportOpen accessMedicine
Matsuzaki S · 2026 · Reproductive medicine and biology
Background Endometriosis is often diagnosed late due to a lack of noninvasive diagnostic tools and the varied presentation of its symptoms. Identifying risk factors for endometriosis is crucial for reducing diagnosis delays, mitigating the…
View details →DOI: 10.1002/rmb2.70041 Negative / Null Result Report
Florindo HS, Azevedo-Silva M, Pereira-Romeiro MP et al. · 2025 · Preprint
The factors that influence the organisms’ ability to reproduce are diverse. In ants, social structure may contribute to queens’ Reproductive Output (RO), alongside environmental conditions and genetic attributes. Polygynous species like…
View details →DOI: 10.1101/2025.05.05.652256 Negative / Null Result ReportOpen accessMedicine
Rolver MG, Emanuelsson F, Nordestgaard BG et al. · 2025 · Cardiovascular diabetology
Background and objectives Elevated C-reactive protein (CRP) is a well-established marker of low-grade systemic inflammation often accompanying cardiometabolic diseases like type 2 diabetes. We sought to determine if plasma CRP…
View details →DOI: 10.1186/s12933-025-03028-5 Negative / Null Result ReportOpen accessMedicine
Chen D, Zhu T, Liu C et al. · 2025 · Medicine
Several observational studies have reported the change in gut microbiota (GM) composition in individuals with osteoporosis (OP); however, the genetic correlation and causal association between GM and OP remain undetermined. Large-scale…
View details →DOI: 10.1097/md.0000000000045031 Negative / Null Result ReportMedicine
Wagner H, Lam D, Nguyen AL · 2025 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose Appropriate framing of health information influences the adoption of health behaviors. This study explored whether (1) gain- or loss-framed health promotion messages, emphasizing positive or negative consequences, respectively,…
View details →DOI: 10.1016/j.clae.2025.102387 