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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21300 results · page 358 of 710

Negative / Null Result ReportOpen accessMedicine

Does the number of pages received per hour affect resident productivity?

Mangino A, Stenson BA, Leventhal EL et al. · 2023 · Journal of the American College of Emergency Physicians open

Background Workflow interruptions are common for emergency physicians and are shown to have downstream consequences such as patient dissatisfaction, delay in clinical response, and increase in medical error. However, the impact of passive…

View details →DOI: 10.1002/emp2.13071
Negative / Null Result ReportMedicine

Actigraphy-based sleep and muscle sympathetic nerve activity in humans.

Bigalke JA, Greenlund IM, Bigalke JR et al. · 2024 · American journal of physiology. Regulatory, integrative and comparative physiology

Short and insufficient sleep are prevalent and associated with cardiovascular disease, with the sympathetic nervous system as a suspected mediator. The purpose of the present study was to investigate the association between objective,…

View details →DOI: 10.1152/ajpregu.00113.2024
Negative / Null Result ReportOpen accessMedicine

Clinical Features Associated With Fatigue in People With Fibrotic Interstitial Lung Disease: Cross-Sectional Study.

Kawachi S, Hoffman M, Holland AE · 2025 · Respirology (Carlton, Vic.)

Background and objective Fatigue significantly impacts quality of life in fibrosing interstitial lung diseases (fILDs). Oxyhaemoglobin desaturation contributes to fatigue in chronic obstructive pulmonary disease; however, this has not been…

View details →DOI: 10.1111/resp.70091
Negative / Null Result ReportOpen accessMedicine

Impact of cognitive behavioral therapy on attention in patients with fibromyalgia: a randomized controlled trial.

Kazemipour S, Yamin JB, Moore D et al. · 2026 · Pain reports

Introduction More than three-fourths of people with fibromyalgia complain of cognitive difficulties, including memory and attention problems, which result in impaired job performance and disability. Cognitive behavioral therapy (CBT) is…

View details →DOI: 10.1097/pr9.0000000000001378
Negative / Null Result ReportMedicine

Food processing according to the NOVA classification is not associated with glycemic index and glycemic load: results from an analysis of 1995 food items.

Basile AJ, Ruiz-Tejada A, Mohr AE et al. · 2024 · The American journal of clinical nutrition

Background Ultraprocessed foods (UPFs) comprise most calories in the United States diet. Glycemic index (GI) and glycemic load (GL) are measures of the quality and quantity of carbohydrates in food based on their effect on postprandial…

View details →DOI: 10.1016/j.ajcnut.2024.08.024
Negative / Null Result ReportMedicine

Daily exposure to combat-related cues and posttraumatic stress symptoms among veterans: Moderating effects of peri- and postdeployment experiences.

Mojallal M, Simons RM, Simons JS et al. · 2024 · Journal of traumatic stress

One of the central symptoms of posttraumatic stress disorder (PTSD) is a heightened reactivity to trauma cues. The current study used experience sampling to investigate the associations between exposure to combat-related cues and PTSD…

View details →DOI: 10.1002/jts.22991
Negative / Null Result ReportOpen accessMedicine

Altering visual feedback during reaching: no mitigating effect on pain for individuals with complex regional pain syndrome, but visuomotor adaptation is preserved.

Dagenais M, Sutter C, Brun C et al. · 2025 · Frontiers in human neuroscience

Introduction Complex regional pain syndrome (CRPS) is often associated with pain-related fear of movement, and virtual reality has been proposed as a potential rehabilitation intervention to overcome this issue. Therefore, this…

View details →DOI: 10.3389/fnhum.2025.1701633
Negative / Null Result ReportMedicine

Primary Care Physicians' and Hospitalists' Experience with Advance Care Planning with South Asian Canadian Older Adults before and during COVID-19.

Vashisht A, Gutman G, Mackey D et al. · 2024 · Canadian journal on aging = La revue canadienne du vieillissement

Few older adults discuss their end-of-life care wishes with their physician, and even fewer minorities do this. We explored physicians' experience with advance care planning (ACP) including the barriers/facilitating factors encountered…

View details →DOI: 10.1017/s0714980823000739
Negative / Null Result ReportOpen accessMedicine

Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose.

Schlosser G, Murgaš M, Godbersen GM et al. · 2025 · Frontiers in neuroscience

Ketamine is a rapid-acting antidepressant approved in the indication of treatment-resistant depression. As its clinical use expands, identifying underlying molecular mechanisms is essential. The serotonin transporter (SERT) is well known…

View details →DOI: 10.3389/fnins.2025.1651016
Negative / Null Result ReportOpen accessMedicine

Exploring physiological factors underlying individual differences in exercise-induced blood pressure responses.

Ogoh S, Takeda R, Kunimatsu N et al. · 2026 · Experimental physiology

Even among healthy individuals, arterial blood pressure (ABP) responses to exercise vary widely. However, the mechanisms underlying this individual variability remain unclear. To investigate these mechanisms, 29 participants performed…

View details →DOI: 10.1113/ep093208
Negative / Null Result ReportOpen accessMedicine

Association of LR treatment response category with outcome of patients with hepatocellular carcinoma on explant pathology.

Khurana A, Chai N, Gibson A et al. · 2025 · Abdominal radiology (New York)

Objectives Liver transplant (LT) is an effective treatment for hepatocellular carcinoma (HCC) in appropriately selected patients. Locoregional therapy (LRT) is often performed to extend a patient's eligibility for LT. Imaging has a modest…

View details →DOI: 10.1007/s00261-025-04811-4
Negative / Null Result ReportMedicine

Do hyperparasitoids disrupt the biological control of Pseudococcus longispinus in persimmon?

Plata Á, Gómez-Martínez MA, Beitia FJ et al. · 2023 · Biological Control.

The long-tailed mealybug, Pseudococcus longispinus, represents a threat for several crops worldwide and has become the main pest of Mediterranean persimmon. Parasitoids are the primary natural enemies of P. longispinus, but their efficacy…

View details →DOI: 10.1016/j.biocontrol.2023.105310
Negative / Null Result ReportMedicine

Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity.

do Carmo JM, Hall JE, Dai X et al. · 2026 · American journal of physiology. Regulatory, integrative and comparative physiology

Maternal obesity increases the risk of preterm delivery and rapid transition of offspring from a hypoxemic environment to a normal or elevated oxygen environment, especially if the baby receives oxygen therapy. Maternal obesity may also…

View details →DOI: 10.1152/ajpregu.00221.2025
Negative / Null Result ReportOpen accessMedicine

Duration and mode of delivery: Does maternal sleep matter?

Parttimaa H, Paavonen EJ, Perasto L et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective Poor sleep quality in late pregnancy has been identified as a risk factor for operative deliveries. In this study, we investigated the associations between maternal sleep throughout pregnancy and its impact on both the duration…

View details →DOI: 10.1002/ijgo.70673
Negative / Null Result ReportMedicine

HeartWare Left Ventricular Assist Device Exercise Hemodynamics With Speed Adjustment Based on Left Ventricular Filling Pressures.

Ali O, Arnold AC, Cysyk J et al. · 2024 · ASAIO journal (American Society for Artificial Internal Organs : 1992)

Functional capacity remains limited in heart failure patients with left ventricular assist devices (LVADs) due to fixed pump speed and inability to offload the left ventricle adequately. We hypothesized that manually adjusting LVAD speed…

View details →DOI: 10.1097/mat.0000000000002096
Negative / Null Result ReportOpen accessMedicine

A family history of suicide in bipolar disorders: powerful, powerless

Sagué Vilavella M, Fico G, Anmella G et al. · 2023 · European psychiatry : the journal of the Association of European Psychiatrists

Introduction When completing the medical record of a patient with bipolar disoder (BD), hardly anything is more impacting than a family history of completed suicide (FHS). In fact, FHS is a main risk factor for personal suicide attempts…

Negative / Null Result ReportMedicine

Distress tolerance, coping motives, and alcohol craving and consumption: Two experiments testing momentary responses to a mood induction.

Augur IF, Wolkowicz NR, Ham LS · 2023 · Drug and alcohol dependence

Background The current studies examined the relationship between state and trait distress tolerance (DT), drinking-related variables (alcohol craving and consumption), and the moderating role of drinking to cope with negative affect (i.e.,…

View details →DOI: 10.1016/j.drugalcdep.2023.111034
Negative / Null Result ReportOpen accessMedicine

The Role of Screentime and Family Resiliency in Overweight/Obesity in Children and Children with Developmental Disabilities Before and During COVID-19.

Mudnal PS, Chuang E, Lindly OJ et al. · 2025 · Children (Basel, Switzerland)

Background/objectives This study examines factors associated with child overweight/obesity (OW/OB), pre-COVID-19 and during the COVID-19 pandemic, among all U.S. children aged 10-17 years, with or without developmental disabilities (DD)…

View details →DOI: 10.3390/children13010066
Replication FailureMedicine

Locomotor play behavior evolves by random genetic drift but not as a correlated response to selective breeding for high voluntary wheel-running behavior.

Whitehead NN, Kelly SA, Demes JS et al. · 2023 · Behavioural processes

Locomotor play is vigorous and seemingly purposeless behavior, commonly observed in young mammals. It can be costly in terms of energy expenditure, increased injury risk, and predator exposure. The main hypothesized benefit of locomotor…

View details →DOI: 10.1016/j.beproc.2023.104973
Negative / Null Result ReportOpen accessMedicine

The independent and combined effect of price increase and price labelling on sugar-sweetened beverage vending machine sales in an Australian university: a factorial randomised controlled trial.

Blake MR, Dancey J, Cameron AJ et al. · 2026 · The international journal of behavioral nutrition and physical activity

BACKGROUND: No studies have examined how price increases on unhealthy drinks in university vending machines impact customer purchasing or vendor financial implications. Vending machines often display prices only upon product selection,…

View details →DOI: 10.1186/s12966-026-01890-4
Negative / Null Result ReportOpen accessMedicine

Variations of sex-hormones in reproductive aged females do not impact the repeated bout effect following maximal unaccustomed eccentric exercise of the elbow flexors.

Rilling A, Power GA · 2025 · Biology of sport

Neuromuscular function is impaired following unaccustomed eccentric exercise, the repeated bout effect (RBE) however, protects from damage following a subsequent bout. Muscle damage may be mitigated in females due to protective effects of…

View details →DOI: 10.5114/biolsport.2025.150041
Negative / Null Result ReportMedicine

The effect of Section 1557 of the Affordable Care Act on surgical outcomes in non-English primary language speakers.

Bakillah E, Finn CB, Sharpe J et al. · 2024 · American journal of surgery

Background In 2016, Section 1557 mandated use of qualified language interpreter services. We examined the effect of Section 1557 on surgical outcomes. Methods Utilizing the Healthcare Cost and Utilization Project State Inpatient Database…

View details →DOI: 10.1016/j.amjsurg.2023.10.018
Negative / Null Result ReportMedicine

Interaction between cold ischemia time and Kidney Donor Profile Index on postrenal transplant outcomes.

Cashion WT, Zhang X, Puttarajappa C et al. · 2024 · American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

We analyzed whether there is an interaction between the Kidney Donor Profile Index (KDPI) and cold ischemia time (CIT) in recipients of deceased donor kidney transplant (KTs). Adults who underwent KTs in the United States between 2014 and…

View details →DOI: 10.1016/j.ajt.2024.01.026
Negative / Null Result ReportMedicine

Patients with chronic bipolar disorder show impairments in interpreting literary fiction - A preliminary explorative study with the short story task.

Herold M, Kovács GX, Herold R et al. · 2024 · Journal of psychiatric research

Introduction Theory of mind (ToM) is a crucial skill in navigating and functioning in the social world. Significant ToM impairment was consistently found in bipolar disorder; it can be both a state and trait marker of the disorder.…

View details →DOI: 10.1016/j.jpsychires.2024.01.022