A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21300 results · page 356 of 710
Cheng CW, Fang WF, Yang YM et al. · 2026 · Immunopharmacology and immunotoxicology
Background Hydroxychloroquine (HCQ) is a commonly used immunomodulatory drug in various autoimmune diseases; however, its role in autoimmune thyroid diseases (AITDs) remains unclear. Objective This study aimed to evaluate the potential…
Volpe G, Bonanata M, Peyla A et al. · 2026 · Ophthalmology and therapy
Introduction Intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard of care for neovascular age-related macular degeneration (nAMD) and other retinal vascular diseases. However, transient post-injection…
Genç E, Bilekyiğit Kurt C, Evrim Karadağ Saygi N et al. · 2026 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Musculoskeletal abnormalities are common to mucopolysaccharidoses (MPS) and can negatively affect the patient's quality of life. Data on course of musculoskeletal findings of MPS type IVA and VI are very insufficient. This study…
Fahmy A, Abdelfatah N, Keriakos N · 2026 · Preprint
Abstract Background Sepsis is a life-threatening condition characterized by an overwhelming systemic response to infection, often resulting in profound hemodynamic instability and multi-organ dysfunction. One of the critical aspects of…
Martikainen A, Eloranta AM, Schwab U et al. · 2026 · Trials
Background Lifestyle interventions can reduce the risk of becoming an overweight adult and reduce the risk of health problems. The aim was to investigate the effects of obesity treatment on BMI-for-age, metabolic markers, and quality of…
Holden A, Burns P, Devenny A et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Background Improved survival in cystic fibrosis (CF) has shifted clinical focus toward late complications, including altered body composition, bone health and cardiopulmonary fitness. The effects of Elexacaftor/Tezacaftor/Ivacaftor (ETI)…
Bhat YA, Mocavini I, O’Donnell E et al. · 2026 · Preprint
The Bre1 ubiquitin conjugating enzyme catalyzes the monoubiquitylation of histone H2B-K120/K123 at promoter proximal nucleosomes, contributing to transcriptional regulation. These same nucleosomes are targeted by the yeast SWR1C chromatin…
Cabrera GJ, Farías P, Sáez CG · 2026 · Journal of voice : official journal of the Voice Foundation
Introduction Parkinson's disease (PD) is frequently associated with voice and speech impairments that negatively affect communication and quality of life. Although several studies have identified vocal variables with potential clinical…
Celik M, Polat ME, Ceviz K et al. · 2026 · World journal of urology
Purpose Vasculogenic erectile dysfunction (ED) is associated with endothelial dysfunction and oxidative stress. This study evaluated the clinical efficacy of radial-type low-intensity extracorporeal shockwave therapy (Li-ESWT) and its…
Asbi T, Mayer Y, Sarikov R et al. · 2026 · The Saudi dental journal
Maxillectomy produces extensive oral and maxillofacial defects that disrupt normal physiology and often require obturator prostheses for functional and aesthetic rehabilitation. Although these devices are routinely used, their influence on…
Stoll PD, Thol F, Spuck N et al. · 2026 · The Journal of craniofacial surgery
Introduction Orthognathic surgery is traditionally considered painful, often prompting opioid use. In the context of rising opioid-related harm, this study assessed postoperative pain levels, factors influencing analgesic requirements, and…
Lafitte E, Sfumato P, Walz J et al. · 2026 · World journal of urology
Introduction Preoperative anemia (PA) and red blood cell transfusion (RBT) are associated with decreased survival in several cancers. In muscle-invasive bladder cancer (MIBC), anemia is frequent and may be worsened by neoadjuvant…
Kim D · 2026 · Preprint
The effect of political Governor or party on Renewable Portfolio Standard adoption is examined across 50 U.S. states from 2001 to 2024. Using fixed-effects panel regression with clustered standard errors, it is found that persistent…
Jones A, Johnco C, Beyersmann E et al. · 2026 · Child psychiatry and human development
Poor reading ability is associated with internalising symptoms in children; however, little research has been done with adolescents. The current study used self- and parent-report data from two cohorts of the Longitudinal Study of…
Majidi S, Rouhi A · 2026 · BMC primary care
Background Obsessive-Compulsive Disorder (OCD) is one of the psychiatric disorders which characterized by unwanted thoughts (obsessions) and repetitive behaviors (compulsions). Mental health problems can affect job performance of…
Yaemrattanakul W, Manachamni K, Ruangrattanapong J et al. · 2026 · BMC psychology
Background Healthcare undergraduate students often face high cognitive and emotional stress, negatively affecting their working memory and well-being. Mindfulness-based practices, such as sitting meditation and body scan, are proposed to…
Stankovičová V, Nováček VL, Rozsíval P · 2026 · Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti
Aim The aim of this study was to assess the effect of Rexon-Eye therapy, based on quantum molecular resonance (QMR) technology, optical parameters, tear film stability, and patients' subjective symptoms. Material and methods A total of 30…
Mancarella M, Novara L, Carignano S et al. · 2026 · The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
Objectives Uterine leiomyomas may cause disorders such as bleeding and bulky symptoms impacting on quality of life; a recent therapeutic option is relugolix, a GnRH antagonist effective in controlling bleeding and reducing the size of…
Thomas L, Hazell G, Baczynska K et al. · 2026 · Photochemistry and photobiology
Far-UVC (200-235 nm) has emerged as a safe and effective modality to inactivate pathogens in an indoor setting. trans-urocanic acid (UCA) is a chromophore that resides in the stratum corneum of the skin and is converted into the more…
McLintock C, Uprety S, McKelvie J et al. · 2026 · International ophthalmology
Background We aim to evaluate the effect of pharmacological pupil dilation on spherical and toric intraocular lens (IOL) power calculations using biometric measurements from the Anterion optical biometer. Methods This was a prospective…
Wieber N, Haney S, Lazarcik J et al. · 2026 · Preprint
Antibiotic resistance genes (ARGs) are an emerging class of environmental contaminants with significant implications for public health. Previous studies have linked fungicide exposure to elevated levels of ARGs in soil microbiomes, but…
Djasarie NRA, Idris I, Arsyad A et al. · 2026 · Preprint
Overweight has become a global health problem, reaching 1 billion cases in 2022. In Indonesia, its prevalence increased from 8.8% in 2013 to 21.8% in 2018, contributing to cardiovascular risk through elevated plasma and renal endothelin-1…
Singh K, Berneburg N, May A et al. · 2026 · Preprint
Background: /Objectives: Long-term clinical data on direct posterior composite restorations are scarce. This study evaluated their performance after almost three decades using selected FDI criteria. Temporal changes were tracked across…
Reinprayoon U, Yaisawang S, Israsena N et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)
Purpose Descemet Membrane Endothelial Keratoplasty (DMEK) is a surgical intervention for restoring endothelial function in Fuchs endothelial corneal dystrophy (FECD). However, changes in corneal biomechanical properties assessed using…
Howlett MR, Cary VE, Maitta RW · 2026 · Preprint
Abstract Immature platelets represent the youngest platelets in circulation. They are also present in all platelet units given to patients. However, there is limited knowledge of what occurs to these platelets during routine blood…
Akanuma S, Sugano Y, Shimmura S et al. · 2026 · Legal medicine (Tokyo, Japan)
DNA evidence can be used to link perpetrators to crime scenes or victims. We examined all Japanese criminal court cases included in a commercially available LEX/DB Internet (LEX database) from 1989, the year DNA analysis was first used as…
Ganidagli S, Akbas ES, Ozturk ZA · 2026 · Endocrine
Purpose Sodium-glucose cotransporter-2 inhibitors are widely used in older adults with type 2 diabetes mellitus; however, their effects on geriatric syndromes remain incompletely understood. This study evaluated the longitudinal effects of…
Subramaniam NK, Gagnon N, Guilbert C et al. · 2026 · Toxicological sciences : an official journal of the Society of Toxicology
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health burden and major contributor to chronic liver disease. Evidence suggests arsenic (As) and/or cadmium (Cd) exposure may influence MASLD development,…
Wen Z, Claeys K, García JG et al. · 2026 · Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology
The purpose of this study was to assess reliability of performance, knee functionality and movement quality parameters in agility T-test using markerless motion capture. Seventeen healthy participants performed two sessions of agility…
Polat E, Özal M · 2026 · Preprint
Abstract Background Wrestling is a weight-classified sport in which athletes commonly engage in rapid weight loss (RWL) to qualify for specific categories. However, research on the short-term physiological and performance effects of RWL…