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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21720 results · page 354 of 724

Failed Experiment ReportMedicine

Task measuring implicit attractiveness as a function of skin tone and facial features: a failed replication.

Stepanova EV, Strube MJ, Mazur KD · 2023 · The Journal of social psychology

In two studies, participants completed an implicit attractiveness task with faces as primes varying on (a) facial features from Afrocentric to Eurocentric and (b) skin tone from dark to light, and target pictures of environmental scenes…

View details →DOI: 10.1080/00224545.2021.2000355
Negative / Null Result ReportOpen accessMedicine

Evaluation of antioxidant co-therapy for polymyxin B-associated nephrotoxicity and mortality: a real-World retrospective cohort study.

Qi J, Yin Z, Peng Y et al. · 2025 · Journal of pharmaceutical policy and practice

Background Polymyxin B is increasingly used to treat infections caused by multidrug-resistant gram-negative bacteria; however, its widespread clinical use is hindered by the high incidence of nephrotoxicity. Antioxidants, such as vitamin…

View details →DOI: 10.1080/20523211.2025.2568673
Negative / Null Result ReportOpen accessMedicine

Temperature and nutrition do not interact to shape the evolution of metabolic rate.

Alton LA, Kutz T, Bywater CL et al. · 2024 · Philosophical transactions of the Royal Society of London. Series B, Biological sciences

Metabolic cold adaptation, or Krogh's rule, is the controversial hypothesis that predicts a monotonically negative relationship between metabolic rate and environmental temperature for ectotherms living along thermal clines measured at a…

View details →DOI: 10.1098/rstb.2022.0484
Negative / Null Result ReportOpen accessMedicine

Combined vaginal progesterone and cervical Pessary effect on preterm birth in Singleton pregnancies with short cervix: a retrospective cohort study.

Eshraghi N, Jayervand F, Hashemi N et al. · 2025 · BMC pregnancy and childbirth

Background To determine whether the combination of vaginal progesterone and cervical pessary initiated during the second trimester reduces the incidence of preterm birth and enhance neonatal outcomes among women diagnosed with singleton…

View details →DOI: 10.1186/s12884-025-08255-y
Negative / Null Result ReportOpen accessMedicine

The Acute Effect of Consuming Whey Versus a Plant-Based Protein Blend on Postprandial Metabolism and Appetite in a Sample of Healthy Adults.

Petkova YP, Johnston JD, Collins AL · 2026 · Food science & nutrition

There is controversy regarding the differential metabolic effects of proteins from plant and animal sources. Existing literature focuses on a limited range of plant proteins consumed just before, or as part of, a mixed meal, resulting in…

View details →DOI: 10.1002/fsn3.71485
Negative / Null Result ReportOpen accessMedicine

Lifelong cognitive and motor outcomes after being born small for gestational age or with fetal growth restriction.

Ventura GC, Ryan H, Yu HN et al. · 2026 · World journal of clinical pediatrics

Children born with fetal growth restriction (FGR) or small for gestational age (SGA) face an increased risk of motor and cognitive impairments, although prevalence and severity vary across studies due to differences in definitions,…

View details →DOI: 10.5409/wjcp.v15.i2.115027
Negative / Null Result ReportMedicine

Lack of Effect of Propranolol on the Reconsolidation of Conditioned Fear Memory due to a Failure to Engage Memory Destabilisation.

Rotondo F, Biddle K, Chen J et al. · 2022 · Neuroscience

The prospect of exploiting memory reconsolidation to treat mental health disorders has received great research interest, particularly following demonstrations that the β-adrenergic receptor antagonist propranolol, which is safe for use in…

View details →DOI: 10.1016/j.neuroscience.2021.11.008
Negative / Null Result ReportOpen accessMedicine

Assessing Large Language Models for Early Article Identification in Otolaryngology-Head and Neck Surgery Systematic Reviews.

Bakare AB, Lee Y, Hong J et al. · 2026 · Health care science

Background Assess ChatGPT and Bard's effectiveness in the initial identification of articles for Otolaryngology-Head and Neck Surgery systematic literature reviews. Methods Three PRISMA-based systematic reviews (Jabbour et al. 2017, Wong…

View details →DOI: 10.1002/hcs2.70048
Negative / Null Result ReportOpen accessMedicine

Individual and combined effects of ischemic conditioning strategies on infarct size after myocardial ischemia reperfusion.

Elmahdy A, Krasnikova M, Jha A et al. · 2025 · Scientific reports

Ischemic preconditioning (PreC), remote perconditioning (PerC), and postconditioning (PostC) are known to reduce myocardial infarct size, but their relative efficacy and potential additive effects remain unclear. This study compared the…

View details →DOI: 10.1038/s41598-025-17442-y
Negative / Null Result ReportMedicine

Dosimetric Parameters Related to Local Control and Rate of Distant Metastases in NSCLC SBRT Patients.

Lalonde RJ, Keller A, Huq S · 2021 · International journal of radiation oncology, biology, physics

Purpose/objective(s) Previous studies have suggested that the dose immediately outside the PTV may impact the incidence of distant metastases after stereotactic body radiation therapy (SBRT) for patients with early-stage non-small cell…

View details →DOI: 10.1016/j.ijrobp.2021.07.1251
Negative / Null Result ReportOpen accessMedicine

Re-evaluating transcranial static magnetic stimulation (tSMS): No inhibitory effects on motor cortex across hemispheres.

Lorenz S, Bartusch L, Heusler C et al. · 2026 · Clinical neurophysiology practice

Objective To investigate whether transcranial static magnetic stimulation (tSMS) exerts inhibitory effects on the human motor cortex and whether these effects differ between dominant and non-dominant hemispheres. Methods Participants…

View details →DOI: 10.1016/j.cnp.2026.02.008
Negative / Null Result ReportOpen accessMedicine

Feasibility of non-invasive neuromonitoring using BIS and NIRS during endovascular treatment of acute ischemic stroke.

Batra D, Chen M, Meis J et al. · 2025 · Neurological research and practice

Background Endovascular thrombectomy (EVT)-often combined with intravenous thrombolysis-is the standard of care for acute ischemic stroke (AIS) secondary to large vessel occlusions (LVO). While indications keep expanding, the feasibility…

View details →DOI: 10.1186/s42466-025-00420-0
Negative / Null Result ReportOpen accessMedicine

Impact of Father Involvement and Positive Parenting on Child Mental Health: Insights From a Survey of Ugandan Households.

Asiimwe R, Welch T, Dwanyen L et al. · 2026 · Family process

The influence of father positive parenting and involvement on children's mental health outcomes is underexplored in many sub-Saharan African countries, such as Uganda, despite research showing that fathers play a critical role in shaping…

View details →DOI: 10.1111/famp.70144
Negative / Null Result ReportOpen accessMedicine

The serotonin transporter and the serotonin 1B receptor in relation to social cognition in healthy adults.

Griffioen G, Tangen Ä, Veldman E et al. · 2026 · EJNMMI research

BACKGROUND: Social cognition is impaired across multiple psychiatric disorders and varies dimensionally in the general population. Studying healthy adults can therefore inform mechanisms relevant for social cognition. This study aimed to…

View details →DOI: 10.1186/s13550-026-01435-7
Negative / Null Result ReportOpen accessMedicine

Dyslexia Polygenic Index and Socio-Economic Status Interaction Effects on Reading Skills in Australia and the United Kingdom.

Bicona D, Mountford HS, Bridges EC et al. · 2025 · Behavior genetics

Literacy is a significant predictor of important life outcomes, such as attained education and income (Ritchie and Bates in Psychol Sci 24(7):1301-1308, 2013. 10.1177/0956797612466268) yet difficulties in reading and spelling are common.…

View details →DOI: 10.1007/s10519-025-10230-4
Negative / Null Result ReportOpen accessMedicine

The Impact of Baseline Anxiety on Drug Placebo Separation and Drug/Placebo Response in an Acute Schizophrenia Clinical Trial-A Post-hoc Analysis.

Kott A, Brannan S, Wang X et al. · 2023 · Schizophrenia bulletin open

Objectives We sought to evaluate the impact of baseline anxiety levels on drug placebo separation and drug and placebo response in acutely psychotic schizophrenic subjects. Methods In this post-hoc analysis, modified intent-to-treat…

View details →DOI: 10.1093/schizbullopen/sgad003
Negative / Null Result ReportOpen accessMedicine

Porcine Cytomegalovirus/Porcine Roseolovirus, Previously Transmitted During Xenotransplantation, Does Not Infect Human 293T and Mouse Cells with Impaired Antiviral Defense.

Jhelum H, Schäfer R, Kaufer BB et al. · 2025 · Viruses

Porcine cytomegalovirus, more accurately classified as porcine roseolovirus (PCMV/PRV), was shown to be pathogenic in the context of xenotransplantation. Transmission of PCMV/PRV to non-human primates receiving hearts or kidneys from…

View details →DOI: 10.3390/v18010021
Negative / Null Result ReportOpen accessMedicine

Anodal transcranial direct current stimulation does not alter GABA concentration or functional connectivity in the normal visual cortex.

Abuleil D, Gorbet D, McCulloch DL et al. · 2025 · Frontiers in neuroscience

Introduction Anodal direct current stimulation (a-tDCS) of the visual cortex is a potential rehabilitation tool for vision disorders such as amblyopia and macular degeneration. However, the underlying neural mechanisms are currently…

View details →DOI: 10.3389/fnins.2025.1639838
Negative / Null Result ReportOpen accessMedicine

Role of Zinc and Magnesium in Glycemic Status Among the Saudi Population.

Almajed N, Al-Musharaf S, Aldhwayan MM et al. · 2025 · International journal of general medicine

Purpose Certain trace minerals, such as zinc (Zn) and magnesium (Mg), may play a role in glucose regulation and insulin signaling pathways. However, population data from the Middle East are scarce and may differ in terms of dietary and…

View details →DOI: 10.2147/ijgm.s565497
Negative / Null Result ReportOpen accessMedicine

Large-sided games do not replicate the positional worst-case scenarios of official matches in professional football.

Herzig L, Stöckert J, Lochmann M et al. · 2026 · Frontiers in sports and active living

The aim of this study was to determine if positional Worst-Case-Scenarios (WCS) during official games (OG) are replicated in Large-Sided Games (LSG) with a similar Area per Player (ApP) as OG. Twenty-one football players from the second…

View details →DOI: 10.3389/fspor.2026.1797322
Replication FailureOpen accessMedicine

Awake targeted memory reactivation doesn't work.

Hoffman LJ, Foley JM, Tanrıverdi B et al. · 2025 · Memory & cognition

Memories are pliable and can be biased by post-encoding information. In targeted memory reactivation (TMR) studies, participants encode information then sleep, during which time sounds or scents that were previously associated with the…

View details →DOI: 10.3758/s13421-024-01576-x