A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19854 results in Negative / Null Result Report · page 345 of 662
Kam KW, Mehraban Far P, Yim TW et al. · 2026 · The Cochrane database of systematic reviews
Rationale Blepharitis is a common ocular condition characterized by inflammation of the eyelid margins, which can cause irritating symptoms and ocular surface damage. Conventional treatment of blepharitis consists of eyelid hygiene and…
Garg A, Nakhla O, Steeper M et al. · 2026 · The Cochrane database of systematic reviews
Rationale Assisted reproductive technologies (ART), including in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI), combine an egg and sperm outside the body to enhance the probability of fertilisation and pregnancy.…
Weber I, Whelan BM, Bruce JM et al. · 2026 · Sports health
Context There is significant interest in jugular venous compression (JVC) devices from multiple parties, including sports physicians, athletic trainers, athletes, and parents. Objective To examine the effects of JVC on repetitive head…
Mehta V, Galletti C, Mathur A et al. · 2026 · Systematic reviews
Background Oral candidiasis (OC) is among the most prevalent oral infections, frequently associated with immunosuppression, denture wearing, advanced age, and excessive antibiotic use. Given the growing concerns about antifungal…
Wu X, Zhang B, Yu M et al. · 2026 · Photodiagnosis and photodynamic therapy
Repeated low-level red-light therapy (RLRL) has emerged as a promising ocular photobiomodulation strategy for childhood myopia control. Published randomized trials have reported substantial reductions in axial elongation and refractive…
Curran T, Pymm J, Gabriel J et al. · 2026 · Preprint
Abstract Cardiac fitness and rehabilitation programs offer meaningful benefits for individuals with congenital heart disease (CHD), and newer delivery models include hybrid formats combining virtual and in-person training. We hypothesized…
Ordóñez-Riaño S, Jiménez-Leal W · 2026 · Acta psychologica
What motivates people to place trust in strangers-the sense that they ought to trust, or the feeling that they want to? Competing perspectives suggest that trust may be driven either by obligations or by desires. In two studies, we tested…
Seymore TN, Hoffmann S, Louro P et al. · 2026 · Preprint
Fetal health is heavily dictated by the maternal environment. Inhaling airborne pollutants, like particulate matter, is associated with pregnancy complications and fetal developmental pathologies, including fetal growth restriction (FGR).…
De Laet H, Nijhof AD, Wiersema JR · 2026 · Autism : the international journal of research and practice
While prevailing theories suggest social interaction difficulties are inherent to autism, the theory of the double empathy problem (DEP) proposes these difficulties arise from a mismatch between different neurotypes. The theory predicts…
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 258, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
Agarwal N, Rochat P · 2026 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
Kiang M, Lepock JR, Mizrahi R et al. · 2026 · The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
Objectives Patients at clinical high risk (CHR) for schizophrenia experience a wide range of clinical outcomes. Given this heterogeneity, long-term prognostic biomarkers are needed. The gamma-frequency EEG auditory steady-state response…
Csigai P, Sparrow L, Maquet L et al. · 2026 · Scientific reports
Resting heart rate variability (HRV) is considered a marker of individuals' capacity to adapt to environmental demands, although direct empirical evidence remains limited. This study examined whether resting HRV predicts subjective and…
Werle D, Sablottny L, Tuschen-Caffier B et al. · 2026 · Appetite
While the hierarchical model of approach-avoidance motivation suggests a heightened food-specific approach behavior for individuals with binge eating disorder (BED), empirical evidence does not confirm the postulated food approach bias.…
Flint RW Jr, Morehouse J, Chown AE et al. · 2026 · Psychological reports
Long-term reactivated memories undergo a time-dependent reconsolidation process during which they are susceptible to modulation. We report the results of an experiment examining the effect of multiple reminder treatments on reconsolidation…
Sharma A, Hanly M, Bhonagiri D · 2026 · Critical care medicine
Objectives This study aims to investigate the effect of culturally and linguistically diverse (CaLD) status on in-hospital mortality in patients admitted to ICUs with sepsis. We hypothesize that diverse cultural and ethnic backgrounds,…
van Doorslaer de Ten Ryen S, Warnier G, Antoine N et al. · 2026 · FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Satellite cells participate in myogenesis and contribute to skeletal muscle regeneration and hypertrophy. Amongst other stimuli, satellite cells can be activated by exercise and hypoxia. However, the cumulative effect of exercise on…
Hannibal W, Freitas-Oliveira R, Bernardes-Dias AC et al. · 2026 · Preprint
Abstract The study of species distribution has long intrigued naturalists, driven by ecological and evolutionary processes such as species interactions, climatic, and geological factors. Understanding these patterns is crucial for…
Tagami U, Imaizumi S · 2026 · Acta psychologica
Visual false pattern perception can increase in response to a lack of control. However, prior studies have manipulated control over relatively long timescales by altering participants' beliefs. We investigated whether short-timescale…
Wójcik M, Orłowski P, Adamczyk S et al. · 2026 · Preprint
Background Contemporary research indicates that psychedelics induce notable neurophysiological changes, some lasting weeks to months after a single dose. However, most evidence derives from acute administration studies and limited…
Inamura Y, Miyazaki S, Nitta J et al. · 2026 · Heart rhythm
Background A size-adjustable cryoballoon (SACB, POLARxFIT, Boston Scientific), switching between 28-mm and 31-mm diameters, was introduced for atrial fibrillation ablation; however, its efficacy and safety compared with conventional…
Chusyd DE, Austad SN, Brown JL et al. · 2026 · Preprint
Early-life trauma in humans, including maternal loss, is strongly associated with increased risk of chronic diseases, reduced life expectancy, and accelerated biological aging, as measured through epigenetic modifications, such as DNA…
Adami A, Vitacca M, Casaburi R et al. · 2026 · European journal of applied physiology
PURPOSE: Long-term oxygen therapy (LTOT) is an established treatment for patients with chronic obstructive pulmonary disease (COPD) diagnosed with hypoxemia at rest or during activity. Chronic hypoxemia is a potential mediator of loss of…
Pacheco CFO, Costa RF, Silva AEB et al. · 2026 · Forest Ecology and Management.
Mangroves face increasing threats from human degradation and extreme weather events, yet limited information exists on whether they can naturally recover after those disturbances. In this study, we attempted to fill this gap by assessing…
Antonarakis ES, Antonarakis ES, Cao Q et al. · 2026 · Clinical cancer research : an official journal of the American Association for Cancer Research
Purpose This multicenter, single-arm, phase II trial evaluated the safety and efficacy of cabazitaxel and carboplatin followed by abiraterone, plus androgen deprivation therapy (ADT), in patients with high-volume metastatic…
Wanner P, Ostermair F, Cristini J et al. · 2026 · Experimental brain research
A single bout of cardiovascular exercise (CVE) can promote neuroplasticity in an intensity-dependent manner. Consequently, performing CVE immediately after encoding may enhance motor memory consolidation, with stronger effects reported for…
Agarwal N, Rochat P · 2025 · Preprint
Across two experiments, children (N = 259, ages 4–10) evaluated protagonists who either protested unfair, arbitrary rules ("good trouble") or upheld the status quo. Study 1 demonstrates that from age 5, children prefer affiliating with…
Almeida OP, Page A, Etherton-Beer C · 2026 · International psychogeriatrics
Behavioural and psychological disturbances are common among individuals with dementia. It is unclear if the use of antidementia medicines reduces their presence. This study aimed to clarify if the introduction of antidementia medicines…
Getachew ED, Wronski ML, Van De Water AL et al. · 2026 · The International journal of eating disorders
Objective Avoidant/restrictive food intake disorder (ARFID) is an eating disorder characterized by persistent avoidant/restrictive eating unrelated to body image. Sex differences in clinical phenotypes and neurobiology of ARFID are…