A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21294 results · page 337 of 710
Goto K, Ishizuka S, Nakamura-Takahashi A et al. · 2026 · Journal of oral biosciences
Objectives Hypophosphatasia (HPP) is a congenital disease caused by mutations in the tissue non-specific alkaline phosphatase gene. HPP is characterized by impaired hard tissue mineralization and premature tooth loss. Mild-type HPP…
Van Daele A, Labarque V, Dereymaeker A et al. · 2026 · Neuropediatrics
Background Neonatal stroke is a rare but potentially severe condition that may lead to long-term neurological impairment. Several factors may influence both its occurrence and outcomes. Methods In this retrospective, single-center cohort…
Zeni NG, Perricone V, Tognoli C et al. · 2026 · Poultry science
The poultry sector faces increasing sustainability challenges related to feed-food competition, volatility in the cereal markets and the environmental impact of poultry production. In this context, the use of products from the bakery and…
Flämig L, Felix Zhu W, Hoffmann K et al. · 2026 · Organic & biomolecular chemistry
Agonists of the κ-opioid receptor are useful drugs for the treatment of severe pain, itching skin diseases and inflammatory and immunological diseases. Herein, novel κ agonists with the κ-pharmacophoric ethylenediamine system embedded in a…
Chiang YW, Chang JY, Yeh KL et al. · 2026 · Investigative ophthalmology & visual science
Purpose To investigate whether exposure to artificial lighting with different correlated color temperatures (CCTs) affects ocular structure and myopia-related molecular signaling pathways before axial elongation in a murine model. Methods…
Yamakawa R, Sakaue Y, Okada S et al. · 2026 · Gait & posture
Background Hip osteoarthritis (HOA) often leads to compensatory movements such as trunk lateral bending during gait due to pain and restricted range of motion. Because multiple joints coordinate to control the center of mass (CoM) during…
van der Velde M, de Boer J, Arslan B et al. · 2026 · Preprint
Background. Multiplication is a key skill in primary education, but traditional teaching methods vary in effectiveness and may not suit individual needs. Adaptive learning systems personalise practice and promote the use of effective study…
Swainson A, Cerminara NL, Apps R et al. · 2026 · Psychology and aging
Studies over the past 3 decades have shown decreased motor adaptation with age. The most widely supported theory for this change proposes that older adults fail to successfully implement cognitive strategies to facilitate performance.…
Yu H, Wang T, Chen X et al. · 2026 · Preprint
Abstract Motherwort (MW) is known for its renoprotective effects, but it has also been reported to potentially cause kidney damage. This study aimed to explore the distinct mechanisms underlying the protective and detrimental effects of MW…
Ma Y, Lai A, Deng X et al. · 2026 · Food chemistry
β-glucan could regulate starch retrogradation and digestion; however, its combined role with starch fine molecular structures remains unknown. Therefore, nine starches were selected, and their retrogradation and digestion properties were…
Sharma P, Sivaramakrishnan P, Dahal S et al. · 2026 · Respiratory medicine
In malignant pleural effusion (MPE), malignant cells may settle in a gravity-dependent gradient due to the weight of cells. We aimed to compare diagnostic yield of cytology between aspirates from lower, upper and 5th intercostal spaces in…
Nijssen KMR, Adam TC, Mensink RP et al. · 2026 · Metabolism: clinical and experimental
Introduction Nutritional ketosis may prevent age-related cognitive decline, but underlying mechanisms remain unclear. This study investigated acute ketone monoester (KME) supplementation on brain insulin responsiveness and cognitive…
Bonifácio DB, da Silva A, Estrada YMF et al. · 2026 · Nutrition, metabolism, and cardiovascular diseases : NMCD
Background and aims The effect of consuming a mix of Brazilian nuts on energy metabolism has not been explored. Thus, the present study aimed to evaluate the effects of acute and chronic consumption of mixed nuts on markers of energy…
Fan Y, Gao G, Jiang X et al. · 2026 · Veterinary sciences
The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…
Lelis ALJ, da Silva LAF, Casali DM et al. · 2026 · Scientific reports
This study evaluated the effects of rumen-protected metabolizable methionine (RPM) supplementation on performance, carcass traits, ruminal morphometry, cecal histology, and meat quality of crossbred heifers finished on Urochloa brizantha…
Flora C, Engdahl S, Pettit RS · 2026 · Pediatric pulmonology
Background Many people with cystic fibrosis (PwCF) are colonized with Pseudomonas aeruginosa. Some studies have found that PwCF who use both tobramycin (TOB) and azithromycin during PEx treatment, have worse clinical outcomes, including a…
Akkan Aydogmus FS, Gursoy T, Ozdemir O et al. · 2026 · BMC ophthalmology
Background To evaluate the outcome of treat and extend (T&E) for neovascular age related macular degeneration (nAMD) at 12, 18 and 24 months and the impact of clinical characteristics on treatment success defined as extension of treatment…
Roubalová R, Luthar J, Procházková P et al. · 2026 · NPJ biofilms and microbiomes
Anorexia nervosa (AN) is a severe eating disorder that profoundly affects quality of life. Despite increasing understanding of the neurobiological basis of the disease, many patients develop a chronic course of illness accompanied by a…
Schade AC, Vilella KD, Neves ETB et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry
Objective To assess the impact of parental psychosocial profile on the effectiveness of educational interventions aiming to improve oral hygiene among preschool children living in a rural area. Methods A controlled randomised trial…
Persons AL, Napier TC · 2026 · Drug and alcohol dependence reports
Background The addiction profile of opioids reflects imbalances in downstream transmitters, including dopamine and serotonin (5-HT). The atypical antidepressant mirtazapine has multiple sites of action, including antagonism at 5-HT 2A…
Gallagher CA, Chandler DJ, Manvich DF · 2025 · Preprint
ABSTRACT Background The persistent threat of the opioid epidemic warrants investigation into risk factors that predispose individuals to opioid use disorder (OUD). Adolescent stress has been linked to enhanced risk for OUD in humans,…
Lu S, Paengkoum S, Chen S et al. · 2025 · Animal Nutrition
This experiment aimed to investigate the potential impact of supplementing different levels of black soldier fly (BSF) on growth performance, serum antioxidants, and ruminal microbiota of goats. Twenty-four native Anglo-Thai male goats…
Schommer S, Drost L, Finke J et al. · 2026 · Biological psychology
Human learning and memory are considered 'embodied', but it is unclear which body signals affect which memory facet. We investigated whether ascending cardiac signals affect memory encoding and consolidation. Due to its relevance for…
Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences
This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…
Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…
Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases
This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…
Wirta D, Lipsky W, Toyos M et al. · 2024 · BMC ophthalmology
Background Dry eye disease (DED) includes neurosensory abnormalities as part of its multifactorial etiology. Nerve growth factor is important for maintaining corneal nerve integrity and wound healing. Cenegermin (recombinant human nerve…
Kim SJ, Park K, Daher R et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]
Objective This study aimed to evaluate the impact of storage temperature and duration on the dimensional stability and mechanical properties of 3D-printed surgical guides. Materials and methods Sixty surgical guides were designed using two…
Zhong Y, Le F, Cheng J et al. · 2026 · Oncology reports
Following the publication of the above article, the authors contacted the Editorial Office to explain that they had made inadvertent errors in compiling a couple of the figures in the above paper; first, regarding the immunohistochemical…
Toczylowski K, Lewandowski D, Martonik D et al. · 2026 · Preprint
Abstract Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease (KD) are pediatric hyperinflammatory conditions with overlapping features, but their molecular basis remains poorly defined. Matrix metalloproteinases…