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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 333 of 675

Negative / Null Result ReportOpen accessMedicine

Impact of repressing and thermomechanical fatigue on color stability and translucency of IPS Emax and Celtra press: an in vitro study.

Adawy SNE, Aboulftouh DM, AbuAmu ST et al. · 2026 · The Saudi dental journal

To evaluate the stain resistance of repressed IPS Emax and Celtra Press after thermo-mechanical fatigue. Two pressable glass ceramics, IPS e.max press (Ivoclar, Vivadent) and Celtra press (Dentsply, Sirona), were used in this study. Thirty…

View details →DOI: 10.1007/s44445-026-00177-5
Negative / Null Result ReportMedicine

Prevalent-New User Design for Biosimilar Safety Using Saudi Real-World Data.

Almadani O, Alfakhri A, Asiri I et al. · 2026 · Pharmacoepidemiology and drug safety

Objective Incidents of infections associated with biosimilar biological disease-modifying antirheumatic drugs (bDMARDs) have been communicated to the Saudi Food and Drug Authority (SFDA). This study aimed to evaluate the infection risk…

View details →DOI: 10.1002/pds.70388
Negative / Null Result ReportMedicine

Self-esteem in university students according to orthodontic treatment need (ICON) and angle classification: a cross-sectional study.

Özfevzi R, Taner RL · 2026 · BMC oral health

Background Orthodontic malocclusion may affect both functional and psychosocial aspects of health; however, its relationship with global self-esteem in young adults remains unclear. This study aimed to compare self-esteem levels according…

View details →DOI: 10.1186/s12903-026-08464-7
Negative / Null Result ReportOpen accessMedicine

Efficacy of Netarsudil in Open and Closed Angle Glaucomas Within the Vietnamese Population: A Single-Center, Retrospective Study.

Truong D, Nguyen KC, Chansangpetch S et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose To compare the intraocular pressure (IOP)-lowering efficacy and safety of netarsudil, a Rho-associated kinase (ROCK) inhibitor, among eyes with open-angle glaucoma (OAG), combined-mechanism glaucoma (CMG), and angle-closure…

View details →DOI: 10.2147/opth.s596749
Negative / Null Result ReportMedicine

Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury: a retrospective cohort study.

Wang R, Ren Y, Song Y et al. · 2026 · Journal of cardiothoracic surgery

Objective Comparison of the efficacy of the oXiris filter and the ST-100 filter in patients with postoperative cardiac surgery infections combined with acute kidney injury. Methods This is a retrospective cohort study of patients with…

View details →DOI: 10.1186/s13019-026-04329-w
Negative / Null Result ReportMedicine

Comparison of procedure-related complications and success rates between duodenoscopes with disposable end caps and conventional reusable duodenoscopes: a randomized trial.

Siddappa PK, Barakat MT, Zhou MJ et al. · 2026 · Surgical endoscopy

Background and aims Duodenoscopes with disposable distal end caps (DDEC) have been introduced to reduce the risk of transmitting multi-drug-resistant organisms compared to conventional reusable duodenoscopes (CRD). However, there have been…

View details →DOI: 10.1007/s00464-026-12886-3
Negative / Null Result ReportMedicine

Effect of Anti-Tubercular Therapy Duration (6 Months versus ≥9-Months) on Treatment Outcomes in Serpiginous-Like Choroiditis: A Multicenter Retrospective Observational Study.

Sharma I, Basu S, Nasir S et al. · 2026 · Ocular immunology and inflammation

Purpose Serpiginous-Like Choroiditis (SLC) is considered to be a subtype of tuberculosis associated uveitis and has been treated with either 6 or 9 months of Anti Tuberculosis therapy (ATT). However, ATT is associated with several adverse…

View details →DOI: 10.1080/09273948.2026.2681749
Negative / Null Result ReportMedicine

Endovascular treatment versus standard medical management in primary M3 or M4 occlusion stroke in clinical practice: the oriental-MeVO registry.

Zhu Y, Zhang C, Yang H et al. · 2026 · BMC neurology

Background Clinical evidence of the potential treatment benefit of endovascular treatment (EVT) for M3 occlusion of the middle cerebral artery (MCA) is sparse. This study aims to compare EVT versus standard medical management (SMM) for…

View details →DOI: 10.1186/s12883-026-05011-3
Negative / Null Result ReportMedicine

Utility of ophthalmologic evaluation for papilledema in pediatric emergency department encounters for shunt failure: a single-center retrospective study.

Tora MS, Fofana F, Roach K et al. · 2026 · Journal of neurosurgery. Pediatrics

Objective In shunted pediatric hydrocephalus patients, the potential for shunt failure is a frequent cause of emergency department (ED) presentation. The assessment of papilledema through ophthalmological fundoscopic examination (OFE) is…

View details →DOI: 10.3171/2026.1.peds25230
Negative / Null Result ReportOpen accessMedicine

Characterizing the in vitro and in vivo effect of bicarbonate on azithromycin activity against Acinetobacter baumannii.

Jaramillo H, Slarve M, Long D et al. · 2026 · PloS one

Carbapenem-resistant Acinetobacter baumannii (CRAB), a Gram-negative bacterial pathogen, has been identified by Centers for Disease Control (CDC) as the top priority pathogen for which new antibiotics are needed. We found that the addition…

View details →DOI: 10.1371/journal.pone.0350230
Negative / Null Result ReportOpen accessMedicine

Perforin and Granulysin-Mediated Cytotoxicity in Colorectal Cancer Patients.

Letica L, Lubina IŠ, Brekalo Z et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : The incidence of colorectal cancer (CRC) in developed Western countries is constantly growing. CRC represents the third most common cancer and the second leading cancer-related cause of death worldwide. Innate…

View details →DOI: 10.3390/medicina62040791
Negative / Null Result ReportOpen accessMedicine

Age-Based Comparison of Head and Neck Cancer Characteristics and Reconstructive Outcomes: Retrospective Review of 286 Patients.

Kang HI, Lee SJ, AlShomer F et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : Head and neck cancer (HNC) frequently necessitates reconstructive surgery due to defects following oncologic resection. The influence of age on reconstructive outcomes in head and neck cancer remains…

View details →DOI: 10.3390/medicina62050822
Negative / Null Result ReportOpen accessMedicine

Posterolateral plating increases peroneal tendon thickness without affecting clinical outcomes: a ultrasonographic comparative study of 76 SER ankle fractures.

Labronici PJ, de Campos JP, de Araújo Almeida JP et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

OBJECTIVES: To evaluate, using ultrasonography and the AOFAS (The American Orthopaedic Foot and Ankle Society) score, changes in the peroneal tendons of patients with ankle fractures resulting from a supination-external rotation (SER)…

View details →DOI: 10.1007/s00590-026-04736-8
Negative / Null Result ReportMedicine

EXPRESS: Effect of Intraoperative Positioning on Anesthetic Variables in Cats Undergoing a Perineal Urethrostomy.

Ruffin C, Schmiedt C, Dantino S et al. · 2026 · Journal of feline medicine and surgery

ObjectivesCats undergoing perineal urethrostomy (PU) often have acute kidney injury (AKI). Minimizing additional kidney injury during anesthesia is critical to prevent exacerbation of AKI. The impact of surgical positioning for PU on…

View details →DOI: 10.1177/1098612x261456257
Negative / Null Result ReportOpen accessMedicine

Difference in Background Parenchymal Enhancement on Contrast-Enhanced Mammography in Treatment-Naïve Versus Systemic Neoadjuvant Chemotherapy Patients.

Hoon OH, Leung SY, Ko TY et al. · 2026 · Cureus

Background and purpose Contrast-enhanced mammography (CEM) has emerged as a valuable imaging modality for breast cancer detection and management. Background parenchymal enhancement (BPE) reflects the level of normal glandular tissue…

View details →DOI: 10.7759/cureus.107590
Negative / Null Result Report

Limited Influence of Sleep on Drawings Made From Memory

Rosenthal S, Megla E, Bainbridge W · 2026 · Preprint

It is well known that memory fades over time, but it is unclear how actions taken between encoding and recall affect this fading, especially for visual recall. To assess the effect of sleep on visual recall, we conducted two experiments.…

View details →DOI: 10.31234/osf.io/9erf2_v1
Negative / Null Result ReportOpen accessMedicine

Sexual functioning after total versus subtotal laparoscopic hysterectomy-long term follow up results after 7 years.

Brodkorb T, Elnahrawy A, Spaich S et al. · 2026 · Archives of gynecology and obstetrics

Purpose The aim of this study was to evaluate sexual function in the long term after total laparoscopic hysterectomy (TLH) versus laparoscopic supracervical hysterectomy (LASH) in patients with benign indications. Methods As part of a…

View details →DOI: 10.1007/s00404-026-08479-z
Negative / Null Result ReportOpen accessMedicine

Clinical Assessment of the Effect of Hypericum perforatum Chewing Gum on Salivary Streptococcus mutans Count, pH, Plaque Index, and Gingival Bleeding: A Randomized Clinical Trial.

Jamali A, Hamishehkar H, Memar MY et al. · 2026 · Clinical and experimental dental research

Objectives Hypericum perforatum L. offers several beneficial effects, for example antioxidant, antitumor, wound healing. Our aim was to ascertain the effect of H. perforatum extract gum on salivary Streptococcus mutans count, pH, plaque…

View details →DOI: 10.1002/cre2.70285
Negative / Null Result ReportMedicine

Evaluation of predictive factors for conception after saline infusion sonosalpingography.

Ramadhan D, Al-Rasheedy M, Alsarraj L · 2026 · Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina

Objective For evaluation of predictive factors of sponataneous conception after saline infused sonosalpingography (SIS). Method A prospective study was conducted from August 2023 to December 2024 at reproductive medial unit  at…

View details →DOI: 10.17392/2021-23-01
Negative / Null Result ReportMedicine

A Novel Template for Intravesical Botulinum Toxin Injection in Patients With Idiopathic Overactive Bladder: A Cohort Study.

Salcedo GG, Galvis JSS, Medina SEM et al. · 2026 · Neurourology and urodynamics

Introduction The intravesical injection of onoabotulinum toxin A is a cornerstone in the management of overactive bladder. Traditionally, treatment involves 20 injection sites, avoiding the bladder trigone. Recent studies have shown that…

View details →DOI: 10.1002/nau.70340
Negative / Null Result ReportMedicine

Clinical real-world data evaluation: comparison of central macular thickness after anti-VEGF treatment in diabetic macular edema patients treated with or without topical anti-glaucoma agents.

Baybora H, Özal E, Özal SA · 2026 · BMC ophthalmology

Background There are research findings suggesting that antiglaucoma agents may reduce aqueous humor outflow and decrease the elimination of intravitreally administered anti-vascular endothelial growth factor agents, prolonging their…

View details →DOI: 10.1186/s12886-026-04925-3
Negative / Null Result Report

ASSOCIATIONS BETWEEN LEVEL OF STRESS AND DEPRESSION AMONG STUDENTS

Ahiati JM · 2026 · Preprint

This research study examined the level of stress and depression associated with students and how social support influences the stress and depression levels of students. There are several interactions between stress, depression, and social…

View details →DOI: 10.31234/osf.io/jhxp8_v1
Negative / Null Result ReportOpen accessMedicine

Mid-Term Oncological Outcomes of Vaginal Natural Orifice Transluminal Endoscopic Surgery Compared with Total Laparoscopic Hysterectomy for Early-Stage Endometrial Cancer: A Single-Center Retrospective Study.

Imai K, Abe J, Chikazawa K et al. · 2026 · Journal of clinical medicine

Background/Objectives : Vaginal natural orifice transluminal endoscopic surgery (vNOTES) is increasingly being used to avoid abdominal incisions; however, its mid-term oncological safety in endometrial cancer remains unclear. Methods :…

View details →DOI: 10.3390/jcm15093350
Negative / Null Result ReportMedicine

Comparing Refractive Outcomes of Secondary Lens Surgery between Ophthalmology Subspecialties in Patients with Good Final Vision.

Sharma K, Israilevich RN, Ross E et al. · 2026 · Retina (Philadelphia, Pa.)

Purpose The study compares refractive outcomes of secondary intraocular lens (SIOL) surgery performed by vitreoretinal, anterior segment, and both surgeons. Methods Eyes included in this study underwent SIOLfrom 2012-2024and had a final…

View details →DOI: 10.1097/iae.0000000000004879