A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19850 results in Negative / Null Result Report · page 332 of 662
Koerte IK, Wiegand TLT, Bonke EM et al. · 2026 · JAMA network open
Importance Repetitive head impacts (RHIs) are associated with later-life neurodegeneration. Because soccer is the most widely played sport among youth worldwide, identifying early changes associated with RHI is important. Objective To…
Meza-Espinoza JP, Zavala-Rubio JD, Leal-Ugarte E et al. · 2025 · BMC research notes
Objective The CAPN10 gene encodes a protein that regulates insulin secretion and glucose uptake. Its variant Indel-19 has been associated with an increased risk of type 2 diabetes mellitus, diabetes-related traits, and some chronic…
Fleece H, Teglasi H · 2025 · Children (Basel, Switzerland)
Background/Objectives : Behavioral inhibition (BI) has been extensively studied as an early-appearing risk factor for adverse developmental outcomes. One pathway through which BI may confer risk is via reduced competence to interact…
Nehme R, Sponchiado IM, Limirio LS et al. · 2025 · Clinical nutrition ESPEN
Background & aims Muscle strength is a key predictor of both quality of life and mortality. Although numerous studies have investigated the relationship between omega-3 (ω-3) intake and muscle strength, the evidence remains inconclusive.…
Petre-Mandache B, Burada E, Cucu MG et al. · 2024 · Current oncology (Toronto, Ont.)
Colorectal cancer (CRC) is a major public health problem worldwide, currently ranking third in cancer incidence and second in mortality. Multiple genes and environmental factors have been involved in the complex and multifactorial process…
Duvenci Birben O, Yenibertiz D, Akkurt ES et al. · 2025 · BMC pulmonary medicine
Background/aim Pneumonia is a significant cause of morbidity and mortality within the first year after autologous hematopoietic stem cell transplantation in patients with multiple myeloma (MM), and nutritional status may influence…
Sæle RG, Aslaksen PM, Svartdal F et al. · 2026 · BMC psychology
BACKGROUND: Procrastination, the tendency to delay tasks despite negative consequences, is a widespread issue linked to poor mental health and reduced daily functioning. While often attributed to self-regulation failures, the specific…
Akbar M, Avdagic E, Carlos C et al. · 2024 · Journal of pediatric ophthalmology and strabismus
Purpose To evaluate for an association between systemic hypertension and intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP) treatment, due to a 2020 case report of a neonate with ROP developing systemic hypertension and…
Lanzarin JVM, Sabage LE, Louro MD et al. · 2024 · Journal of pediatric endocrinology & metabolism : JPEM
Objectives Seasonal environment at birth may influence diabetes incidence in later life. We sought evidence for this effect and analyzed the association between the month of birth and the risk of developing type 1 diabetes mellitus (T1DM).…
Yigit S, Nursal AF, Ozsoy F et al. · 2024 · Nucleosides, nucleotides & nucleic acids
Major depressive disorder (MDD), which is a prevalent psychiatric disorder, is characterized by sleep-wake disturbances. An underlying circadian rhythm disorder mainly may cause these disturbances. The study presented here was designed to…
Abdelgalil KAA, Fathi N, El Nouby FH et al. · 2025 · BMC rheumatology
BACKGROUND: Rheumatoid Arthritis (RA) is a prevalent autoimmune disease affecting approximately 84,338 individuals in Egypt. Genetic predispositions, such as the PTPN22 and PADI4 genes, are linked to RA risk. PTPN22, a protein tyrosine…
de Oliveira CAF, Amaral LMB, Micheleto JPC et al. · 2024 · Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
Introduction Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes. Methods This cross-sectional study included 32 dialysis patients, categorized…
Meins IA, van der Stouwe ECD, Aan Het Rot M et al. · 2026 · Schizophrenia research. Cognition
Background Empathy as a key component of social cognition may be impaired in individuals at ultra-high risk (UHR) for psychosis. The Empathic Accuracy Task (EAT) was designed to address the dynamic and interactive nature of real-world…
Joseph J, Chandranaath A, Louis J et al. · 2025 · Cureus
Background Wound healing relies on a balance between extracellular matrix remodelling by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Among all the MMPs, elevated MMP-9 levels are implicated in…
Alharazy S · 2024 · Pakistan journal of medical sciences
Background & objective Hypovitaminosis D has shown to be linked with T2DM development and control in numerous studies. The association of SNPs in genes related to VitD metabolism with T2DM has not been sufficiently studied. Consequently,…
Wang F, Wang C, Wang T et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America
Genotype-phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for…
Gu Y, Zhang W, Zhou J et al. · 2025 · International journal of nephrology
Background: Acute kidney injury (AKI) is a common postoperative event. Previous research suggests that intraoperative hypotension (IOH) is associated with postoperative AKI. This connection, however, has not been studied in patients…
Agbektas T, Genc HC, Zontul C et al. · 2025 · International journal of molecular sciences
(1) This cross-sectional study aims to elucidate the association between the XPO5 gene polymorphism (rs11544382) and colon cancer (CC). (2) Genotyping of XPO5 (rs11544382) was performed in 120 individuals (60 CC patients and 60 controls)…
Itoi M, Willcox MDP · 2024 · Contact lens & anterior eye : the journal of the British Contact Lens Association
Purpose This study aimed to assess the susceptibility of ocular isolates of Pseudomonas aeruginosa to two multi-purpose disinfectant solutions (MPDS) and to determine if there was a relationship with resistance to antibiotics. Methods…
Taft D, Quinones JM, Moreno ML et al. · 2024 · Preprint
Blood levels of uremic molecules generated through gut microbial metabolism are associated with disease risk, reduced quality of life, and mortality in patients with renal insufficiency. Modulation of the microbiome may offer therapeutic…
Nasirzadeh A, Mohammadzadeh F, Kazeminia S et al. · 2025 · Scientific reports
The presence of a known labor companion was shown to improve childbirth satisfaction. However, a companion's anxiety might affect the satisfaction of laboring women. Therefore, this study aimed to evaluate the relationship between the…
Alroba R, Alfakhri A, Badreldin HA et al. · 2024 · Preprint
Purpose: This study aims to investigate the potential causal relationship between the use of indapamide and rhabdomyolysis. Previous research and pharmacovigilance monitoring activities have suggested a potential association between…
Veenman F, Tibbertsma S, Wolvius EB et al. · 2025 · Caries research
Introduction Asthma and dental caries may be linked through frequent mouth breathing and the use of inhaled asthma medication. However, the current literature is inconclusive on whether asthma or asthma medications increase the risk of…
Watanabe RAS, Nishiyama F, Lyra L et al. · 2024 · Preprint
Background and Objectives Respiratory syncytial virus (RSV) is responsible for most cases of acute viral bronchiolitis (AVB) in childhood. The association of factors such as RSV subtype, viral load, and viral coinfection with severe…
Whelton SP, Yao J, Clish C et al. · 2026 · Journal of the American Heart Association
Background Aortic valve calcification (AVC) is the primary process leading to aortic stenosis. We examined whether polygenic risk scores (PRS) are associated with AVC beyond traditional atherosclerotic cardiovascular disease risk factors.…
Isaacs Q, Sofianos C, Muganza A et al. · 2026 · European burn journal
Background: Timely admission to a specialised burn unit is considered crucial for optimising outcomes in burn patients. However, the impact of delayed admission on hospital length of stay and clinical outcomes remains unclear, particularly…
Zhao J, Li W, Chen L et al. · 2024 · Frontiers in endocrinology
Objective Despite several observational studies attempting to investigate the potential association between type 1 diabetes mellitus (T1DM) and the risk of digestive cancers, the results remain controversial. The purpose of this study is…
Pietraszko P, Żórawski M, Bielecka-Richter E et al. · 2025 · International journal of molecular sciences
Mid-regional pro-adrenomedullin (MR-proADM) has emerged as a promising biomarker reflecting endothelial dysfunction and systemic inflammation. Its prognostic role in cardiovascular complications, particularly in the context of COVID-19…
Weber J, Heming M, Apolinário-Hagen J et al. · 2024 · Biological psychology
Valid approaches to conveniently measure stress reactivity are needed due to the growing evidence of its health-impairing effects. This study examined whether the Perceived Stress Reactivity Scale (PSRS) predicts cardiovascular and…
Kaabi YA, Abdelmola AA, Abdelwahab SI et al. · 2024 · Clinical laboratory
Background Type 2 diabetes mellitus (T2DM) is common in Saudi Arabia and represents a major health concern. Silent information regulator of transcription-1 (SIRT1) positively influences insulin sensitivity and might contribute to the…