A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 332 of 675
Fiedler M, Vasquez Limeta A, Reyes-Sanchez E et al. · 2026 · Preprint
ABSTRACT Pathologic cardiac hypertrophy requires increased protein synthesis, but the mechanosensors that link membrane stretch to translational control remain poorly understood. Polycystin-1 (PC1), encoded by PKD1 , has been proposed as a…
Nguy K, lapadula t, Devue C · 2026 · Preprint
Exposure to multiple unique images of the same face enhances recognition. Using ambient pictures and videos, face-learning studies have shown improved generalization, suggesting more refined memory representations for faces exhibiting…
McCarthy KM, Pierce KM, McKay ZC et al. · 2026 · Journal of dairy science
Concentrate feeds with a lower CP concentration are an effective means of reducing nitrogen (N) excretion from grazing dairy cows. Typically, imported feedstuffs such as soybean meal and maize are included in concentrate feeds to increase…
Ching ASM, Kim J, Davis C · 2026 · Preprint
This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…
Hackworth EE, Lastovich J, Carroll DM et al. · 2026 · Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
Introduction In January 2025, the US FDA announced a proposed rule for a reduced nicotine standard (RNS) in cigarettes. Evidence suggests that the use of very low nicotine content (VLNC) cigarettes decreases cigarette use and tobacco…
Laporte M, Casper AM · 2026 · CBE life sciences education
Course-based undergraduate research experiences (CURE) have been proposed as a mechanism to increase persistence in science. However, most evidence for their impact comes from self-reported surveys conducted under conditions of volunteer…
Alhabli I, Ishaque N, Kate M et al. · 2026 · Journal of neurointerventional surgery
Background Thrombus migration can occur in patients receiving IV thrombolysis for acute stroke. This study compared the effects of IV tenecteplase (0.25 mg/kg) versus alteplase (0.9 mg/kg) on thrombus movement in patients undergoing…
Costa A, Mulas O, Greco M et al. · 2026 · Annals of hematology
There is growing interest in the association between autoimmune diseases (AID) and myeloproliferative neoplasms (MPN), yet the specific clinical and prognostic implications of AID in myelofibrosis (MF) remain insufficiently characterized.…
Wienholz A, Nuhbalaoglu-Ayan D, Mani N et al. · 2026 · Journal of psycholinguistic research
The processing of referential expressions is influenced by their form, but also by the accessibility of their antecedents. In sign languages, discourse referents are typically assigned to referential loci (R-loci) in the signing space,…
Lidborg LH, Kohen Tuncer D, Burton AM et al. · 2026 · Biological psychology
Theoretical models of face processing incorporate within-pool inhibition - a mechanism by which representations compete with one another to support recognition. However, direct evidence for these inhibitory mechanisms is sparse in studies…
Alex L, Klutho PJ, Song L et al. · 2026 · Preprint
Genetic inhibition of cyclophilin D (CypD) delays the opening of the mitochondrial permeability transition pore (MPTP) and therefore reduces necrotic cell death. Elucidation of factors that impact CypD activity is therefore key to…
Trexler RV, Bruns MA, Borton MA et al. · 2026 · Preprint
Soil microbial inoculants have the potential to improve crop yield, enhance agricultural sustainability, and support soil restoration, but they often display unpredictable in-field performance across varied soil conditions.…
Wiechert S, de Groot E, Rutjens BT et al. · 2026 · Preprint
Over the past decade, psychology has embraced transparency and reproducibility reforms to address the replication crisis, raising the question of whether these signals help legal decision-makers identify which psychological evidence is…
Boxer B, Zhang Z, Folland JP et al. · 2026 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Impact and resistance exercise have potent osteogenic effects and may positively affect cartilage through tissue deformation. These effects may be mediated through inhibitors of Wnt signaling, such as sclerostin and Dickkopf WNT signaling…
Ashmore S, Russo D, Hornbach A et al. · 2026 · Urogynecology (Philadelphia, Pa.)
Importance Surgeons traditionally place the synthetic midurethral sling (MUS) after completing the apical suspension procedure during surgical procedures for pelvic organ prolapse (POP) and stress urinary incontinence (SUI). We hypothesize…
Çetin OG, Gülgöz S · 2026 · Memory (Hove, England)
The role of agency in collective memory is largely unexplored, and evidence that schema-congruent collective events are more readily integrated than incongruent ones remains largely correlational. Studying these factors experimentally is…
Moreno-Druet M, Pardaens S, Soudzilovskaia NA et al. · 2026 · Preprint
Climate change is reshaping soil microbial communities, yet the impact of warming in bacterial-fungal interactions (BFIs) remains underexplored. We investigated whether heatwave temperature influence BFIs and the mechanism supporting the…
Kawasaki Y, Suzuki Y, Miyazaki K et al. · 2026 · Fukushima journal of medical science
Aim To clarify the change in characteristics and body mass index standard deviation (BMI-SD) after guanfacine extended-release (GXR) administration for attention-deficit/hyperactivity disorder (ADHD) children, we undertook a clinical…
Lu C, Gil D, Lefeuvre M et al. · 2026 · The Journal of experimental biology
Climate variability and unpredictability present animals with challenging physiological and behavioural demands. However, empirical studies on endotherms involving manipulated environmental variability remain limited. This study…
Niemann AS, Ramon R, Mayor J et al. · 2026 · Life (Basel, Switzerland)
(1) Background: The reconstruction of periacetabular defects after tumor resection remains one of the most challenging procedures in orthopaedic oncology. The modular LUMiC ® system was designed to improve fixation stability and reduce…
Koomson E, Nkwain Y, Lutz N et al. · 2026 · Preprint
Abstract Background and aims: The West African Sahel faces severe soil degradation and declining productivity due to climate variability and unsustainable land use. Integrating the native shrub Piliostigma reticulatum into cereal-based…
Bellucci A, Alfares H, Gale C et al. · 2026 · Preprint
Obesity is considered a risk factor for metabolic diseases, including type 2 diabetes, and results from an imbalance between energy intake and energy expenditure. While pharmacological approaches such as tirzepatide, a dual GIP/GLP-1…
Ching ASM, Kim J, Davis C · 2025 · Preprint
This preregistered study investigated whether linguistic information can influence low-level visual perception. We argue that many previous studies supporting this view have significant shortcomings. Specifically, these studies conflate…
Koumpias AM, Kirch M, Steppe E et al. · 2026 · Journal of women's health (2002)
Background Obtaining a National Institutes of Health (NIH) career development (K) award is a pivotal milestone for early-career faculty, contributing not only to individual career progression but also to the diversity of the biomedical…
Comlekci M, Yıldız AE, Demirel A · 2026 · BMC sports science, medicine & rehabilitation
Background Ankle sprains are among the most common injuries in athletes, accounting for approximately 80% of all athletic injuries. Recurrent ankle sprains often progress to chronic ankle instability (CAI), which can impair athletic…
Swire M, Nayar SG, Jiang Y et al. · 2026 · Preprint
Summary Motor skill learning stimulates and requires generation of oligodendrocytes (OLs) from their precursors (OLPs) in the adult mouse brain, but the functional role(s) of the newly formed OLs is not known. We asked whether new compact…
Abdelnaby EA, Alhaider AK, Emam IA · 2026 · Veterinary sciences
This current study aimed to determine the impact of Mitoquinone (MitoQ) on the quality of frozen-thawed donkey semen. Ejaculates were collected from six male donkeys ( Equus asinus ), and ejaculates were polled and aliquoted into 12…
Trakarnvanich T, Nochaiwong S, Ruengorn C et al. · 2026 · Scientific reports
To date, little is known regarding the treatment effects of different timed-dosing antihypertensive medications among hypertensive patients with albuminuria. We aimed to investigate whether morning or evening dosing of antihypertensive…
Fan Y, Gao G, Jiang X et al. · 2026 · Preprint
The objective of this study was to evaluate the effects of partially replacing wheat bran with poplar wood composite fiber (PWCF) on growth performance, immune status, apparent total tract digestibility (ATTD), and gut microbial…
Lin M, Tapuc A, Matyjek M et al. · 2026 · Comprehensive psychiatry
Autistic traits are associated with atypical social behaviors, particularly in approach-avoidance tendencies. However, the differential impact of these traits on responses to social versus non-social stimuli, and the variation of these…