Negative / Null Result ReportOpen accessMedicine (General)
Zhaleh Shadman, Nooshin Poorsoltan, Mahdieh Akhoundan et al. · 2014 · Journal of Fasting and Health
The aim of this study was to assess public knowledge about the effects of Ramadan fasting on various aspects of health and its association with fasting decision-making. This cross-sectional study was conducted on 600 subjects. The association between fasting and participants’ knowledge and attitudes toward Ramadan fasting, anthropometric measurements, physical activity, depression, anxiety, stress, dietary intake, and prior history of diseases was evaluated. The results indicated an adverse correlation between negative attitudes towards the effects of Ramadan fasting and adherence to fasting (
View details →DOI: 10.22038/jfh.2014.3682 Negative / Null Result ReportOpen accessMedicine
Kanglai Li, BD, Shangyan Liang, MD, Yuyan Shi, BD et al. · 2021 · Sexual Medicine
Introduction: Dehydroepiandrosterone sulfate (DHEAS) has been reported to be associated with sexual function and general psychological health respectively, however, no one has ever examined their mutual relationships in a single study. Aim: The aim of the present study was to find out whether DHEAS, general psychological health, and erectile function were all associated with each other. Methods: A cross-sectional study was conducted on 34 patients with erectile dysfunction (ED) and 32 healthy controls (HC). The levels of serum DHEAS were assessed by chemiluminescence method. Erectile function
View details →DOI: 10.1016/j.esxm.2021.100386 Negative / Null Result ReportOpen accessMedicine
Noriyuki Oka, Masaharu Sakoh, Misato Hirayama et al. · 2023 · Scientific Reports
Abstract The corticofugal tracts (CFT) are key agents of upper limb motor function. Although the tracts form high-intensity regions relative to surrounding tissue in T2-weighted magnetic resonance images (T2WI), the precise relations of signal intensities of the left and right CFT regions to hand function are unknown. Here, we tested the hypothesis that the different signal intensities between the left and right CFT signify clinically important differences of hand motor function. Eleven right-handed and eleven left-handed healthy volunteers participated in the study. Based on horizontal T2WI e
View details →DOI: 10.1038/s41598-023-29557-1 Negative / Null Result ReportOpen accessMedicine (General)
Xiaomin Liang, Qian Wang, Zemao Xing et al. · 2026 · Frontiers in Medicine
ObjectiveAcute ischemic stroke (AIS) is a leading cause of disability and mortality worldwide. Hematocrit (HCT), the proportion of blood volume occupied by red blood cells, has been associated with outcome in AIS patients, but the relationship remains controversial. This study aimed to investigate the association between HCT levels and 3-month adverse outcome in South Korean patients with AIS, with a focus on potential sex differences.MethodsThis secondary analysis utilized data from an existing South Korean prospective cohort study involving 1,896 AIS patients. HCT was assessed both as a cont
View details →DOI: 10.3389/fmed.2026.1721251 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
André Luiz Bortoliero, Ana Maria Bonametti, Helena Kaminami Morimoto et al. · 2006 · Revista do Instituto de Medicina Tropical de São Paulo
A cross-sectional study was carried out among 996 volunteer blood donors enrolled from May 1999 to December 1999 to determine the seroprevalence of hepatitis E virus (HEV) infection among volunteer blood donors of the Regional Blood Bank of Londrina, State of Paraná, Brazil, and to evaluate whether the rate of seroprevalence of IgG anti-HEV antibodies is associated with sociodemographic variables and with seropositivity for hepatitis A virus (HAV) infection. All participants answered the questionnaire regarding the sociodemographic characterisitcs. Serum samples were tested for IgG antibodies
View details →DOI: 10.1590/s0036-46652006000200006 Negative / Null Result ReportOpen accessMedicine (General)
Mohammad-Ali Seif-Rabiei, Mehrdad Hajilooi, Uldoz Roustaei et al. · 2011 · Acta Medica Iranica
There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, h
Negative / Null Result ReportOpen accessMedicine
Noura A. Almadhi, Ayman M. Sulimany, Hamad A. Alzoman et al. · 2021 · Saudi Dental Journal
Objective: To evaluate parents’ knowledge about halitosis, and to compare parents’ perception of halitosis in their children to the presence of halitosis clinically. Methods: Children between 3 and 8 years attended to Dental University Hospital, King Saud University, were screened. Children satisfying inclusion criteria and their parents agreed to participate were included. Questionnaires regarding parents’ knowledge and perception about halitosis in their children were filled by attending parents. Then, the assessment of halitosis in the participating children carried out by portable gas chro
View details →DOI: 10.1016/j.sdentj.2020.08.005 Negative / Null Result ReportOpen accessSpecialties of internal medicine
Dawn Yi Xin Lee, Chun En Yau, Maeve Pin Pin Pek et al. · 2024 · Resuscitation Plus
Background: Socioeconomic status (SES) is a well-established determinant of cardiovascular health. However, the relationship between SES and clinical outcomes in long-term out-of-hospital cardiac arrest (OHCA) is less well-understood. The Singapore Housing Index (SHI) is a validated building-level SES indicator. We investigated whether SES as measured by SHI is associated with long-term OHCA survival in Singapore. Methods: We conducted an open cohort study with linked data from the Singapore Pan-Asian Resuscitation Outcomes Study (PAROS), and the Singapore Registry of Births and Deaths (SRBD)
View details →DOI: 10.1016/j.resplu.2024.100610 Negative / Null Result ReportOpen accessMedicine
Patil PB, Chougule PG, Kamat SB et al. · 2026 · Journal of conservative dentistry and endodontics
Aim The aim of this in vitro study was to evaluate the effect of antacid syrup on surface roughness and microhardness of composites. Materials and methods Two different composite resin materials, Nanofilled and Suprananofilled were used.…
View details →DOI: 10.4103/jcde.jcde_121_26 Negative / Null Result ReportOpen accessMedicine (General)
Jiao LI, Qi LI, Shuang CHENG et al. · 2026 · 环境与职业医学
BackgroundGestational weight gain is closely related to maternal and infant health outcomes. Pregnant women are simultaneously exposed to four metals—lithium (Li), vanadium (V), uranium (U), and bismuth (Bi)—through inhalation of fine particulate matter and consumption of contaminated food and water. Existing studies suggest that exposure to these metals may be associated with gestational weight gain. However, no study has yet explored the complex relationships between exposure to mixtures of these four metals and weight gain at different stages of pregnancy.ObjectiveTo investigate the associa
View details →DOI: 10.11836/jeom25403 Negative / Null Result ReportOpen accessArctic medicine. Tropical medicine
Felipe da Silva Krawczak, Ilka Afonso Reis, Julia Angélica da Silveira et al. · 2015 · Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: The present study was designed to assess the occurrence of co-infection or cross-reaction in the serological techniques used for detecting the anti-Leishmania spp., -Babesia canis vogeli and -Ehrlichia canis antibodies in urban dogs from an area endemic to these parasites. METHODS: The serum samples from dogs were tested for the Babesia canis vogeli strain Belo Horizonte antigen and Ehrlichia canis strain São Paulo by immunofluorescence antibody test (IFAT) and by anti-Leishmania immunoglobulin G (IgG) antibody detection to assess Leishmania infection. We used the following four
View details →DOI: 10.1590/0037-8682-0291-2014 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Yangyang Guo, Bingyang Zhang, Lianmei Zhong et al. · 2026 · Frontiers in Neurology
BackgroundIntracranial and/or extracranial atherosclerotic stenosis is a common etiology of acute ischemic stroke (AIS). This study aimed to evaluate the impact of intracranial or extracranial atherosclerotic stenosis on early neurological deterioration (END), hemorrhagic transformation (HT) and 90-day clinical outcomes in patients receiving intravenous thrombolysis.MethodsWe retrospectively enrolled patients with AIS who received intravenous alteplase (0.9 mg/kg) at the First Affiliated Hospital of Kunming Medical University between February 2019 and August 2022. Data on demographics, stroke
View details →DOI: 10.3389/fneur.2025.1700753 Negative / Null Result ReportOpen accessMedicine
Piyusha Milani Atapattu, Chemindra Biyanwila, Manamalabaduge Upul Jerard Fernando · 2017 · American Journal of Experimental and Clinical Research
Chest radiographs are widely available, even in most hospitals in developing countries, and can detect a variety of lung pathologies. When adults are admitted to hospital with acute asthma, chest radiographs are often obtained. Studies on the usefulness of chest radiographs in acute asthma have shown varying results. This study aimed at evaluating the usefulness of chest radiographs in the management of acute asthma in adult asthmatics in a developing country. Plain chest radiographs performed within 24 hours of admission in 115 consecutive adult asthmatic patients (asthma defined by Asthma Ed
Negative / Null Result ReportOpen accessMedicine
Hawra Al-Ghafli, Bright Varghese, Mushira Enani et al. · 2019 · PLoS ONE
Despite low infectious potential of extrapulmonary tuberculosis (EPTB), it poses significant clinical challenges in terms of diagnosis and treatment monitoring. Understanding the main demographical risk factors for disease characteristics of EPTB plays a crucial role in speeding up diagnosis process and improving overall clinical experience. The aim of this study was to investigate the main demographical and clinical risk factors for EPTB among adults and adolescents for the first time in Saudi Arabia. A cross-sectional multicenter study was carried out on a collection of 902 extrapulmonary My
View details →DOI: 10.1371/journal.pone.0213846 Negative / Null Result ReportOpen accessMedicine
Martin Söderholm, Yan Borné, Bo Hedblad et al. · 2015 · PLoS ONE
Increased red cell distribution width (RDW) has been related to poor prognosis in patients with cardiovascular disease, and is a predictor of cardiovascular mortality in the general population. The purpose of the present study was to investigate if RDW is associated with increased incidence of stroke and its subtypes in individuals from the general population.Red cell distribution width was measured in 26,879 participants (16,561 women and 10,318 men aged 45-73 years) without history of coronary events or stroke, from the population-based Malmö Diet and Cancer Study. Incidences of total stroke
View details →DOI: 10.1371/journal.pone.0124957 Negative / Null Result ReportMedicine
Lauer, Leng, Chembe et al. · 2026 · The British journal of nutrition
Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to improve growth, development, and survival among young children in low-resource settings. One hypothesized pathway is through improvements in intestinal health,…
View details →DOI: 10.1017/s0007114526107818 Negative / Null Result ReportOpen accessDermatology
Anne Sofie Frølunde, Jan Brink Valentin, Lise Kristensen et al. · 2026 · Acta Dermato-Venereologica
Dermatophyte infections are common in general practice and occur more often in individuals with type 2 diabetes (T2D), but whether they signal undiagnosed T2D remains unclear. We conducted a register-based cohort study including positive PCR tests for dermatophyte infection from the feet or nails, matched 1:3 to individuals from the same geographic area in Denmark. Those with known diabetes, type 1 diabetes or aged under 20 were excluded. Incidence rates (IRs) and incidence rate ratios (IRRs) for new-onset T2D were estimated using Poisson regression. The final cohort comprised 78,140 individua
View details →DOI: 10.2340/actadv.v106.adv-2025-0125 Negative / Null Result ReportOpen accessMicrobiology
Bin Zhang, Hao Guo, Zhou Li et al. · 2025 · BMC Microbiology
Abstract Backgrounds Microbial dysbiosis in the gut and urine has been implicated in patients with benign prostatic hyperplasia (BPH) in previous studies. Additionally, emerging evidence suggests that salivary dysbiosis is associated with various diseases and oral health conditions. Building on these findings, this study aimed to investigate whether BPH patients exhibit a distinct salivary microbiome. Methods and materials We recruited a cohort of BPH patients (n = 50) and age- and BMI-matched healthy controls (HC; n = 50). Salivary samples were collected for 16S rRNA gene sequencing, and pros
View details →DOI: 10.1186/s12866-025-04444-z Negative / Null Result ReportOpen accessMedicine (General)
Hanan Al-Wakeel, Nadia Sewelam, Mohamed Khaled et al. · 2018 · Egyptian Journal of Medical Human Genetics
Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD). PAI-1 is the chief inhibitor of tissue plasminogen activator and urokinase plasminogen activator. PAI-1 has a crucial role in regulation of fibrinolysis. Aim of the study: Is to investigate the association between Plasminogen activator inhibitor-1 (PAI-1) 4G/5G, PAI-1C/G polymorphisms and CAD. In addition, studying the relation of these polymorphisms to the level of active PAI-1 in Egyptian patients presenting
View details →DOI: 10.1016/j.ejmhg.2018.05.003 Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Sailimai Man, Yuan Ma, Cheng Jin et al. · 2020 · Journal of Diabetes Research
Background. Studies suggest an association between H. pylori infection and extragastrointestinal disease. Limited studies provided conflicting results on the association between H. pylori infection and diabetes. The present study was aimed at examining the association between H. pylori infection and diabetes in a large health checkup population in China. Methods. A cross-sectional study was conducted; participants who attended health checkups at Beijing MJ Health Screening Center during 2017-2018 were included. H. pylori infection was diagnosed by 13C-urea breath test. Multivariate logistic re
View details →DOI: 10.1155/2020/7201379 Negative / Null Result ReportOpen accessMedicine
Marjolein M Iversen, Giesje Nefs, Grethe S Tell et al. · 2016 · PLoS ONE
Aim To examine whether elevated anxiety and/or depressive symptoms are related to all-cause mortality in people with Type 2 diabetes, not using insulin. Methods 948 participants in the community-wide Nord-Trøndelag Health Survey conducted during 1995-97 completed the Hospital Anxiety and Depression Scale with subscales of anxiety (HADS-A) and depression (HADS-D). Elevated symptoms were defined as HADS-A or HADS-D ≥8. Participants with type 2 diabetes, not using insulin, were followed until November 21, 2012 or death. Cox regression analyses were used to estimate associations between baseline e
View details →DOI: 10.1371/journal.pone.0160861 Negative / Null Result ReportOpen accessPathology
Yeganeh Shekari, Zahra Mahmoodi, Mohammadtaghi Ghorbani Hesari et al. · 2026 · Molecular Pain
Background: Chronic daily headache (CDH) is known to be a common and debilitating disease that is influenced by genetic, dietary, and lifestyle factors. Iron (Fe) plays a key role in energy metabolism and neurotransmitter synthesis, while the FTO gene polymorphism (rs9939609) may play a role in modulating nutritional responses and nutrient metabolism. This study aimed to determine the interaction between CDH odds, dietary iron intake, and FTO genotype. Methods: This case-control study was conducted on 150 CDH patients and 150 healthy individuals aged 40–80 years. Participants were assessed for
View details →DOI: 10.1177/17448069261439611 Negative / Null Result ReportMedicine
Stokbro, Liebregts, Baan et al. · 2026 · Scientific reports
The aim of this study was to evaluate the influences of surgical sequencing on the postoperative occlusion in bimaxillary osteotomies. Patients who underwent bimaxillary surgery without maxillary segmentation, based on a virtual surgical…
View details →DOI: 10.1038/s41598-026-52284-2 Negative / Null Result ReportOpen accessPublic aspects of medicine
Machiko Minatoya, Sachiko Itoh, Keiko Yamazaki et al. · 2018 · Environmental Health and Preventive Medicine
Abstract Background Studies reported adverse behavioral development including internalizing and externalizing problems in association with prenatal exposure to bisphenol A (BPA) and phthalates; however, findings were not sufficient due to using different assessment tools and child ages among studies. This study aimed to examine associations between maternal serum levels of BPA and phthalate metabolites and behavioral problems at preschool age. Methods The Strengths and Difficulties Questionnaire (SDQ) was used to assess behavioral problems at 5 years of age. BPA and phthalate metabolite levels
View details →DOI: 10.1186/s12199-018-0732-1 Negative / Null Result ReportOpen accessMedicine
Fauziyyah Ramadhani, Mohammad Ghozali, Leni Lismayanti · 2018 · Global Medical & Health Communication
Dengue hemorrhagic fever (DHF) is still the leading cause of hospitalization and death among children in Indonesia because of plasma leakage leading to shock syndromes. This study aimed to associate the hematocrit difference (first and second) from serial hematocrit (Hct) examination just after admission with DHF severity. A analytical cross-sectional study was involving medical records of pediatric patients with DHF admitted at the pediatric ward and the Pediatric Intensive Care Unit (PICU) of Dr. Hasan Sadikin General Hospital, Bandung in January–December 2015. The subjects excluded if other
View details →DOI: 10.29313/gmhc.v6i3.3079 Negative / Null Result ReportOpen accessMedicine (General)
Kelly Lim, Meng‐Ni Wu, Wei‐Chia Tsao et al. · 2026 · Kaohsiung Journal of Medical Sciences
ABSTRACT The long‐term cumulative impact of metabolic syndrome (MS) on cognitive decline remains uncertain. This study investigated how changes in MS status over 10 years relate to cognition and whether sex modifies this relationship. A total of 766 participants (mean baseline age: 54 years) from the Kaohsiung Atherosclerosis Longitudinal Study were enrolled. MS was defined using the modified National Cholesterol Education Program Adult Treatment Panel III criteria for Asian populations. Participants were categorized into four groups based on changes in MS status over the 10‐year follow‐up: ne
View details →DOI: 10.1002/kjm2.70138 Negative / Null Result ReportOpen accessNeurology. Diseases of the nervous system
Xing Zhang, Xiao-He Hou, Ya-Hui Ma et al. · 2020 · BMC Neurology
Abstract Background Inflammation plays an important role in atherosclerosis but the contribution of neutrophils to this process is unclear. We sought to assess whether neutrophil count is associated with intracranial atherosclerotic stenosis (ICAS). Methods A total of 2847 individuals were included in our study, including 1363 with acute ischemic stroke and 1484 normal controls without stroke. The presence of ICAS was confirmed by magnetic resonance angiography. The association between neutrophil count and ICAS was evaluated by multivariable logistic regression analysis. Results Among 2847 ind
View details →DOI: 10.1186/s12883-020-01641-3 Negative / Null Result ReportOpen accessScience (General)
Berliana Hamidah, Cennikon Pakpahan, Laksmi Wulandari et al. · 2024 · Heliyon
Excessive inflammatory response is a hallmark of severe COVID-19. This study investigated the associations between interferon-stimulated genes (ISGs) expression, genetic variation in the interferon α/β receptor 2 (IFNAR2) gene, and COVID-19 mortality.We investigated 67 patients with moderate-to-severe COVID-19. Of them, 22 patients (32.8 %) died because of COVID-19. We examined the expression of ISGs in total RNA of peripheral whole blood. We observed a significant increase in the expression of all ISGs examined in non-surviving patients, indicating a heightened interferon type I signaling act
View details →DOI: 10.1016/j.heliyon.2024.e39002 Negative / Null Result ReportOpen accessMedicine
Tamás Sebestyén, Zita Iloskics · 2020 · PLoS ONE
The spread of economic shocks in an increasingly interconnected global economy has been subject to several studies recently. These studies mostly focus on the synchronization of business cycles among economies and search for the relationship between trade linkages and shock contagion. In contrast to previous studies in the field, this paper focuses on the topological properties of the shock contagion network as measured by pairwise Granger causality between economic output of countries. This topological approach can bring new insights into the dynamics of contagion and the relationship between
View details →DOI: 10.1371/journal.pone.0238626 Negative / Null Result ReportOpen accessPediatrics
Radwa Iraqy, Mahmoud Hamdy, Laila Hussein et al. · 2026 · Egyptian Pediatric Association Gazette
Abstract Introduction Zinc plays a crucial role in both innate and adaptive immune responses by regulating intracellular signaling pathways in immune cells. Zinc deficiency has been implicated in up to 4.4% of infection-related deaths in developing countries. Acute lower respiratory infections (ALRIs), particularly pneumonia, are a leading cause of morbidity and mortality among young children which accounts for around 81% of deaths in the first two years of life. Method One hundred twenty children were enrolled in this study, divided in 2 groups: 60 critically ill children diagnosed with pneum
View details →DOI: 10.1186/s43054-026-00560-1 