A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20240 results in Negative / Null Result Report · page 327 of 675
Peake SL, Macdonald SPJ, Howe BD et al. · 2026 · The New England journal of medicine
Background The optimal approach to early resuscitation in septic shock is unknown. Equipoise exists between the use of larger volumes of intravenous fluids to restore perfusion and the use of early vasopressor therapy along with smaller…
Wang YX, Holz FG, Coenen M et al. · 2026 · Preprint
Abstract Background Epidermal growth factor (EGF) has been suggested to play a role in myopic axial elongation, and EGF receptor blockade may be of potential therapeutic benefit. Here we examined the ocular and systemic toxicity of…
Alaka MO, Ogunjobi JK, Omoruyi OE et al. · 2026 · Scientific reports
This study addresses the environmental challenges posed by the waste generated during the extraction of cashew nut shell (CNS) liquid by proposing a sustainable repurposing method. Extracted CNS (waste) was pyrolyzed at varying…
Coticchio LA, Cassill DL · 2026 · Journal of medical entomology
Recluse spiders are arachnids of potential medical significant due to their necrotic venom. However, in areas populated by the brown recluse, Loxosceles reclusa, bites and necrosis are rare. In Florida, USA, public media reports and…
Rupietta AE, Meyer T, Margraf J et al. · 2026 · Journal of behavior therapy and experimental psychiatry
Background Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…
Grue C, Getsinger KD, Heilman MA et al. · 2026 · Environmental toxicology and chemistry
Florpyrauxifen-benzyl (aquatic tradename ProcellaCOR) is an aquatic herbicide commonly used to control Eurasian watermilfoil (Myriophyllum spicatum) and other invasive aquatic plants. Previous studies have demonstrated effective Eurasian…
Thuluva S, Gunneri S, Ningaiah S et al. · 2026 · Vaccines
Background: Pneumococcal conjugate vaccines (PCVs) have substantially reduced pneumococcal disease in children; however, serotype distribution varies geographically, and residual disease due to non-PCV13 serotypes persists. Biological E's…
Oltrogger FT, Howe G, McNevin D et al. · 2026 · Science & justice : journal of the Forensic Science Society
Over the last few years, additive manufacturing, by means of fused deposition modelling 3D printing, has become increasingly popular and accessible due to the relative low costs, flexibility, and continually lowering barriers for entry.…
Achatz V, Sebastian S, Mitterer JA et al. · 2026 · The Journal of arthroplasty
Background Gram-negative (GN) periprosthetic joint infections (PJIs) are still less frequent than gram-positive (GP) PJIs. There is only little data available on a direct comparison of GP- and GN-associated PJIs. Therefore, we investigated…
Li L, Gao S, Zhu H et al. · 2026 · European journal of obstetrics, gynecology, and reproductive biology
Introduction Frozen embryo transfer offers improved cumulative pregnancy rates and reduces complications compared to fresh cycles. Successful outcomes depend on both embryonic potential and endometrial receptivity, necessitating…
Holtkamp M, Jost G, Salhöfer L et al. · 2026 · RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin
Purpose The effect of iodine preparation concentration on vascular attenuation during computed tomography angiography (CTA) is a topic of controversy. Iodine-based contrast media (CM) formulations are used in different iodine preparation…
Bauerle WB, Allsbrook A, Green A et al. · 2026 · Surgical infections
Introduction Surgical site infections (SSIs) are a substantial contributor to morbidity and mortality rates. 405 nm visible light disinfection (VLD) has been shown to reduce bacterial burden in operating rooms (ORs); however, its effect on…
Sîrbu I, Custura A, Radu A et al. · 2026 · Dentistry journal
Background : Additively manufactured surgical guides require post-processing and subsequent decontamination prior to intraoral use. Steam sterilization and chemical disinfection protocols may influence the dimensional stability of…
Rupietta AE, Meyer T, Margraf J et al. · 2025 · Preprint
Background: Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…
Åberg S, Nordin E, Iversen KN et al. · 2026 · Clinical nutrition (Edinburgh, Scotland)
Background and aims Wholegrain rye foods have shown promising effects on metabolic regulation and weight-loss, which may be mediated via gut microbiota and derived metabolites. This study aimed to investigate effects of hypocaloric diets…
Houshmand Chatroudi A, Yotsumoto Y · 2025 · Preprint
When a temporal interval is marked by flickering stimuli, its subjective duration is overestimated. The cortical origin of this temporal illusion, termed flicker-induced time dilation (FITD), is not yet well understood. In this…
Best AN, Vlutters M, Wu AR · 2025 · IEEE transactions on bio-medical engineering
Objective Healthy individuals have the ability to overcome perturbations when walking without falling. They have multiple stability strategies at their disposal, but it remains unclear how these different strategies compensate for one…
Neufeld MR, Hanson KR, Mochel JP et al. · 2026 · Journal of the American Veterinary Medical Association
Objective To evaluate the efficacy and safety of transmucosal administration of detomidine gel to induce emesis in cats. Methods Cats presenting on an emergency basis due to dietary indiscretion were eligible for enrollment at 2 emergency…
Kim B, Boustany C, Fethney J et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Purpose This study aimed to report the incidence, common reasons, and associated risk factors for unplanned hospital presentations during chemotherapy treatment. Methods A secondary analysis using data from a randomized controlled trial…
Xie L, Lian H, Yin H et al. · 2026 · Bioresource technology
Inert colloidal substances (ICS) are ubiquitous in industrial wastewater; however, their effects on the stability of anaerobic granular sludge beds remain insufficiently understood. Using polyacrylamide as a model ICS, this study…
Song I, Park SYJ, Chung YA et al. · 2025 · Preprint
Abstract Pharmaceutical therapy can provide effective symptomatic relief for Parkinson’s disease (PD) initially, but symptoms become more complex and refractory as the disease progresses, necessitating alternative therapeutic approaches.…
Roongpisuthipong W, Klangjareonchai T, Kurathong S et al. · 2026 · The Journal of dermatological treatment
Background The management of psoriasis presents challenges, prompting many patients to seek alternative treatments. Cannabidiol (CBD) has demonstrated potential antioxidant and anti-inflammatory properties which may offer therapeutic…
Dasmeh U, Mohammadi AA, Shahrokhi R et al. · 2025 · Journal of wound care
Objective This study aimed to investigate whether application of autologous platelet-rich plasma (PRP) at split-thickness skin grafting (STSG) donor sites in patients with burns can promote wound healing. Method A randomised crossover…
Lin YS, Hung CC · 2025 · Microsurgery
Introduction Peroneal artery-based free flaps, including fibula and peroneal flaps, are commonly used in reconstructive surgeries. Despite their clinical utility, donor site morbidity remains a concern. Elastography is a non-invasive…
Hando BR, Rhon DI, Barker D et al. · 2026 · The Journal of orthopaedic and sports physical therapy
OBJECTIVE: To determine the effect on Shoulder Pain and Disability Index (SPADI) scores of adding dry needling to a program of exercise and manual therapy in individuals with subacromial pain syndrome (SAPS). DESIGN: Three-arm randomized…
Liang C, He J · 2025 · Journal of Visualized Experiments
Autografts are always used in anterior cruciate ligament (ACL) reconstruction. Traditional sources, such as hamstring tendons, bone-patellar tendon-bone, and quadriceps tendon, are popular choices but may result in muscle imbalances and…
Marean-Reardon CL, Reardon PN, Mortimer NT · 2025 · Preprint
Many insect species use self-medication, the consumption of an environmental compound with antipathogen activity, as a defense against pathogen infection. One well-studied example is the interaction between Drosophila melanogaster and…
Bailhache M, El-Khoury F, Chazelas E et al. · 2026 · Academic pediatrics
Objective To determine the association between parental psychological intimate partner violence (IPV) before and around the time of the child's birth, and their use of an emergency department (ED) and hospitalization from 2 months to 10…
Conceicao D, Helayel P, Garcia J et al. · 2025 · Preprint
Abstract Background: Midshaft clavicular fractures account for approximately 5% of bone fractures. Surgical correction is often necessary to ensure adequate functional recovery. There is no consensus in the literature on which Regional…
Türkiş NA, Taşdemir N · 2026 · Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses
Purpose Postoperative nausea and vomiting (PONV) is one of the most common complications in surgical patients during the first 24 hours after general anesthesia. This research aimed to evaluate the effect of cold application on early PONV…