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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 319 of 662

Negative / Null Result ReportMedicine

Comprehensive approaches for mitigation of total cyanide in Maesil (<i>Prunus mume</i>) syrup: a stone fruit-derived product.

Ko HR, Cho SY, Kim HS et al. · 2026 · Food science and biotechnology

The East Asian fruit Maesil ( Prunus mume ) is primarily consumed as a sugar extract in South Korea. This stone fruit-derived product contains various forms of potentially toxic cyanide compounds. This study evaluated manufacturing…

View details →DOI: 10.1007/s10068-026-02100-4
Negative / Null Result ReportMedicine

Impact of Vancomycin-Resistant Enterococci (VRE)-Active Perioperative Prophylaxis in Liver Transplant Patients Colonized by VRE.

Burastero GJ, Wey EQ, Guidetti V et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Data regarding the effectiveness of vancomycin-resistant Enterococci (VRE)-active prophylaxis for preventing early post-liver transplantation (LT) VRE infections in VRE-colonized patients are scarce. Methods 131 pre-LT…

View details →DOI: 10.1093/cid/ciaf121
Negative / Null Result ReportMedicine

Alarms and alarm management with automated versus conventional ventilation in neurocritical care patients.

van Limpt GJC, van Vliet P, Molenaar MA et al. · 2026 · Intensive & critical care nursing

Introduction False or clinically irrelevant alarms are a major driver of ICU alarm fatigue and nursing workload. Ventilator alarms make up a large share, and although automated ventilation modes can reduce manual adjustments, their effect…

View details →DOI: 10.1016/j.iccn.2026.104471
Negative / Null Result ReportMedicine

Prostate cancer mortality among men with and without comorbidity: Long-term results from the European randomized study of screening for prostate cancer Rotterdam.

Westerhout SF, Remmers S, Bangma CH et al. · 2026 · European journal of cancer (Oxford, England : 1990)

Introduction Prostate-specific antigen (PSA)-based prostate cancer (PCa) screening can be improved by individualised, risk-stratified strategies. Comorbidity influences life expectancy, so may affect benefits of screening. We evaluated…

View details →DOI: 10.1016/j.ejca.2026.116741
Negative / Null Result ReportMedicine

Telehealth education for patients with cancer: a standalone solution for symptom relief?

Ruegg T, Zhao X, Mount MS et al. · 2026 · Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

Background Telehealth-delivered education offers a practical approach to chemotherapy teaching and symptom self-management support. Advanced practice providers (APPs) play an increasingly vital role in guiding oncology patients through…

View details →DOI: 10.1007/s00520-026-10519-y
Negative / Null Result ReportMedicine

The impact of closed-incision negative-pressure therapy on donor-site outcomes in drainless abdominal free flap breast reconstruction.

Kim J, Park C, Woo KJ et al. · 2026 · Journal of plastic, reconstructive & aesthetic surgery : JPRAS

Concerns regarding donor-site healing persist in abdominal-based free flap breast reconstruction. Although closed-incision negative-pressure therapy (CINPT) has demonstrated wound-related benefits, its efficacy without the use of drains…

View details →DOI: 10.1016/j.bjps.2026.01.027
Negative / Null Result ReportMedicine

Comparing the Antimicrobial Resistance Crisis to the Coronavirus Disease 2019 Pandemic: A Randomized Public Health Messaging Experiment.

Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…

View details →DOI: 10.1093/cid/ciag110
Negative / Null Result ReportOpen accessMedicine

Peanut ball during labor to reduce pain and anxiety: A single-blind randomized clinical trial.

Zelaya IO, Soto ORR, Ventura GPM et al. · 2026 · European journal of midwifery

Introduction Pain and anxiety are common during labor. Evidence on non-pharmacological tools like the peanut ball from public hospital settings in Honduras is limited. This study evaluated its efficacy in reducing pain and anxiety. Methods…

View details →DOI: 10.18332/ejm/220424
Negative / Null Result Report

Virtual embodiment of civic heroes preserves the conflict associated with anti-mafia intentions and enhances physiological discomfort in response to mafia-related crime

Placidi V, Lisi MP, Vabba A et al. · 2025 · Preprint

Although Mafia-type criminal organizations (MCOs) exert severe societal harm, evidence-based interventions fostering anti-mafia motives remain scarce. We investigated whether embodying virtual heroic characters enhances opposition to MCOs.…

View details →DOI: 10.31234/osf.io/va2k5_v2
Negative / Null Result ReportMedicine

Effect of two-session remote ischaemic preconditioning on myocardial injury after noncardiac surgery in patients undergoing abdominal surgery: a randomised clinical trial.

Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia

Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…

View details →DOI: 10.1016/j.bja.2026.03.029
Negative / Null Result ReportOpen accessMedicine

Efficacy of Liposomal Bupivacaine for Anterior Quadratus Lumborum Block in Laparoscopic Gynecological Surgery: A Randomized Controlled Trial.

Zhang YH, Xiao Y, Li YT et al. · 2026 · Drug design, development and therapy

Background Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine…

View details →DOI: 10.2147/dddt.s588939
Negative / Null Result ReportMedicine

Association Between Early Initiation of Electroconvulsive Therapy and Length of Stay in Acute Psychiatric Inpatients: A Retrospective Cohort Study in Taiwan.

Su PL, Ho MF, Liu PH et al. · 2026 · The journal of ECT

Objectives Electroconvulsive therapy (ECT) provides rapid relief for severe psychiatric disorders, but its impact on hospital length of stay (LOS) remains unclear in Asian settings. We hypothesized that early ECT (≤7 d after admission)…

View details →DOI: 10.1097/yct.0000000000001249
Negative / Null Result ReportMedicine

Plant functional diversity does not dilute virus infection, but community virus prevalence positively correlates with net C3 grass production

Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.

Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…

Negative / Null Result ReportMedicine

A Randomized Trial Evaluating Intraoperative Ischemic Preconditioning of Parathyroid Glands During Total Thyroidectomy: A Signal for Earlier Parathyroid Function Recovery.

Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research

Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…

View details →DOI: 10.1080/08941939.2026.2613617
Negative / Null Result ReportMedicine

Intravenous dexmedetomidine and blood loss during cesarean delivery under neuraxial anesthesia: a single-center retrospective study (2012-2016).

Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia

Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…

View details →DOI: 10.1016/j.ijoa.2026.104868
Negative / Null Result ReportMedicine

Changing portion size labels of main courses to encourage selection of smaller portions when dining out: A randomized controlled field experiment.

Hua SV, Roberto CA, Yam E et al. · 2026 · Appetite

Large portions contribute to excess consumption. We tested whether a portion size labeling intervention influenced consumers to select smaller lunch portions. Two cafés introduced a reduced-sized main course (half the original size and…

View details →DOI: 10.1016/j.appet.2026.108494
Negative / Null Result ReportMedicine

The impact of tracheal intubation attempts on chest compression fraction during pediatric CPR: a report from the Videography in Pediatric Resuscitation (VIPER) collaborative.

Jariyasakoolroj T, O'Connell K, MacDonald T et al. · 2026 · Resuscitation

Aim To examine the association between tracheal intubation (TI) attempts and chest compression (CC) pauses on chest compression fraction (CCF) during pediatric CPR across a network of emergency departments. Methods Prospective…

View details →DOI: 10.1016/j.resuscitation.2026.111018
Negative / Null Result ReportMedicine

Early high-dose vitamin C for out-of-hospital cardiac arrest: the VITaCCA randomized clinical trial.

Rozemeijer S, Dubois EA, de Grooth HJ et al. · 2026 · Intensive care medicine

Background Besides temperature management, there is currently no effective therapy to decrease the burden of post-cardiac arrest syndrome. The pleiotropic effects of vitamin C may improve clinical outcome. Purpose This trial investigated…

View details →DOI: 10.1007/s00134-026-08492-5
Negative / Null Result ReportMedicine

Deciphering serotonin's functional role in postharvest: Fruit-specific preservation of red fruit quality.

Arabia A, Muñoz P, Álvarez-Real S et al. · 2026 · Plant science : an international journal of experimental plant biology

Serotonin is a widely conserved signaling molecule essential for plant development and stress responses, but its role in fruit postharvest physiology remains largely unexplored. This study aimed to evaluate the effects of 100 μM exogenous…

View details →DOI: 10.1016/j.plantsci.2026.113003
Negative / Null Result ReportMedicine

Lactated Ringer's Solution at a Standard Infusion Rate in Post-endoscopic Retrograde Cholangiopancreatography Pancreatitis Prevention: A Retrospective Comparative Study.

Ko T, Sakai A, Nakano R et al. · 2026 · Digestive diseases and sciences

Background Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common complication, and its prevention remains challenging. Although aggressive infusion of lactated Ringer's solution (hereafter Lactated Ringer's)…

View details →DOI: 10.1007/s10620-026-09794-w
Negative / Null Result Report

Using Narrative to Explain Uncertainty in Climate Change

Freeman G, Rousseau A, Brunton M et al. · 2025 · Preprint

Abstract This study presents the findings on the use of narrative when communicating complex scientific uncertainties. A growing body of evidence in narrative cognition and communication has shown promise for the use of narrative in…

View details →DOI: 10.21203/rs.3.rs-7860451/v1
Negative / Null Result ReportMedicine

Longitudinal Reliability of Rheumatology Patient Safety Measures and Implications for CMS Case Minimums.

Roberts ET, Schmajuk G, Fitzpatrick J et al. · 2026 · Joint Commission journal on quality and patient safety

Background Metrics with acceptable reliability are necessary to ensure that quality measures reward performance. Low metric reliability may result from a lack of differences between reporting entities or low numbers of eligible patients.…

View details →DOI: 10.1016/j.jcjq.2026.01.008
Negative / Null Result ReportOpen accessMedicine

Long-term changes in overjet in individuals with and without orthodontic treatment : A 30-year cohort study.

Bokan J, Schmid JQ, Middelberg C et al. · 2026 · Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie

Purpose Large overjet increases the risk of traumatic dental injury (TDI). This study, part of the Münster Long-Term Study (MLS), aimed to investigate long-term changes in overjet with or without orthodontic treatment and to evaluate…

View details →DOI: 10.1007/s00056-025-00633-7
Negative / Null Result ReportMedicine

Hypopressive exercises for diastasis recti and pelvic floor symptoms in postpartum women: A randomized trial.

Moreira SE, Debs AL, de Oliveira EH et al. · 2026 · Brazilian journal of physical therapy

Background Diastasis recti abdominis (DRA) is a common postpartum condition that can persist for months, impair abdominal function, and negatively affect quality of life. Despite its prevalence, there is no gold standard treatment.…

View details →DOI: 10.1016/j.bjpt.2026.101584
Negative / Null Result ReportMedicine

Aspirin monotherapy or DAPT after CABG in ACS? Insights from the TACSI Trial.

Narayan P · 2025 · Indian journal of thoracic and cardiovascular surgery

Dual antiplatelet therapy (DAPT) is recommended after acute coronary syndrome (ACS), but evidence in coronary artery bypass graft (CABG) patients is limited. The TACSI (Dual Antiplatelet Therapy with Ticagrelor and Acetylsalicylic Acid…

View details →DOI: 10.1007/s12055-025-02121-4