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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20240 results in Negative / Null Result Report · page 319 of 675

Negative / Null Result ReportMedicine

Impact of dietary supplementation of black soldier fly larvae (Hermetia illucens L.) on nutrient digestibility, serum antioxidants, ruminal volatile fatty acids, and abundance of microbial dominant flora in goats

Lu S, Paengkoum S, Chen S et al. · 2025 · Animal Nutrition

This experiment aimed to investigate the potential impact of supplementing different levels of black soldier fly (BSF) on growth performance, serum antioxidants, and ruminal microbiota of goats. Twenty-four native Anglo-Thai male goats…

Negative / Null Result ReportMedicine

Embodied memory for emotional faces: Effects of cardiac cycle phases and post-learning stress on identity and expression memory.

Schommer S, Drost L, Finke J et al. · 2026 · Biological psychology

Human learning and memory are considered 'embodied', but it is unclear which body signals affect which memory facet. We investigated whether ascending cardiac signals affect memory encoding and consolidation. Due to its relevance for…

View details →DOI: 10.1016/j.biopsycho.2026.109283
Negative / Null Result ReportMedicine

Single- or two-visits endodontic treatment: Impact of irrigants on surface roughness, microhardness, topography, and fracture resistance of root dentin.

Padoin Y, de Pellegrin SF, Castillo DC et al. · 2026 · European journal of oral sciences

This study evaluated the effect of the number of simulated endodontic treatment visits and the type of irrigant on the surface roughness, microhardness, topography, and fracture resistance of root dentin. Bovine roots were distributed into…

View details →DOI: 10.1111/eos.70103
Negative / Null Result ReportOpen accessMedicine

Short course of antimicrobial treatment for uncomplicated enterococcal bacteremia.

Zimmermann V, Fourré N, Senn L et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Purpose Duration of treatment for uncomplicated enterococcal bacteremia is unknown. This study aims to evaluate the clinical outcomes of patients treated with short courses (4-10 days) compared to those receiving longer regimens (11-18…

View details →DOI: 10.1007/s10096-025-05348-6
Negative / Null Result ReportOpen accessMedicine

Randomized Phase 3 Comparison of a 2-Dose and 3-Dose Regimen of a Detoxified Toxin A/B <i>Clostridioides difficile</i> Vaccine in Adults 50 Years and Older.

Crook G, Lamberth E, Lockhart SP et al. · 2026 · Open forum infectious diseases

This phase 3 trial compared immunogenicity and safety of 2-dose versus 3-dose PF-06425090 Clostridioides difficile vaccine regimens in ≥50-year-olds (N = 1994) at increased C difficile infection risk. Because C difficile toxin-A but not C…

View details →DOI: 10.1093/ofid/ofag219
Negative / Null Result Report

Clinical Impact of Gastrointestinal Multiplex PCR Panels on Relapse Prediction in Ulcerative Colitis: A Prospective One-Year Follow-up Study

Buyukkoruk M, Tunccan OG, Yigit S et al. · 2026 · Preprint

Abstract Background: This study aimed to evaluate the effect of the gastrointestinal system multiplex PCR panel (GISP) on the relapse-free survival of ulcerative colitis (UC) both active and in remission patients. Methods: In this…

View details →DOI: 10.21203/rs.3.rs-9023219/v1
Negative / Null Result ReportMedicine

The impact of dietary inclusion of tomato pomace silage on feed utilization, health status, milk yield and milk nutritional composition in dairy cows.

Gunun N, Kaewpila C, Kesorn P et al. · 2026 · Animal bioscience

Objective The aim of this study was to evaluate the effect of the inclusion of tomato pomace silage (TPS) on feed intake, nutrient digestibility, blood parameters, immune response, milk yield, and milk nutritional composition in dairy…

View details →DOI: 10.5713/ab.250925
Negative / Null Result ReportMedicine

Effects of replacing dietary glucose with fructose on intestinal morphology, oxidative status, and epithelial responses in weaned pigs.

Wang M, Wang X, Zeng Y et al. · 2026 · Journal of animal science

This study evaluated the effects of replacing dietary glucose with fructose on intestinal development in weaned pigs and assessed epithelial growth using a small intestinal organoid model. A total of 26 weaned pigs ([Yorkshire × Landrace]…

View details →DOI: 10.1093/jas/skag153
Negative / Null Result ReportMedicine

[The effect of neuroprotectors on the level of BDNF, tumor necrosis factor alpha and apoptosis markers, and in acute cerebrovascular accidents].

Shchulkin AV, Chernykh IV, Abalenikhina YV et al. · 2026 · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

Objective To compare the effects of Mexidol, Cerebrolysin, and Cortexin on the levels of brain-derived neurotrophic factor (BDNF), tumor necrosis factor-alpha (TNF α ), and apoptosis markers in the rat brain following middle cerebral…

View details →DOI: 10.17116/jnevro2026126021123
Negative / Null Result ReportMedicine

Partial replacement of soybean meal with sprouted peas or sprouted soybeans in dairy diets in a dual-flow continuous culture system.

Vicente ACS, Salas-Solis GK, Johnson ML et al. · 2026 · Journal of dairy science

Peas (Pisum sativum L.) have 24% CP and could have the potential to partially replace soybean meal (SBM), which is the most used protein source in dairy diets in the USA. Sprouting can improve nutrient availability via enzymatic and…

View details →DOI: 10.3168/jds.2025-27713
Negative / Null Result ReportMedicine

Impaired growth after immunization with a bivalent oil-adjuvanted vaccine occurs without detectable changes to aerobic capacity in juvenile rainbow trout.

Wallbom N, Khansari AR, Sandblom E et al. · 2026 · Comparative biochemistry and physiology. Part A, Molecular & integrative physiology

The trade-off between growth and immunity in fish has been assumed to relate to energetic costs associated with immune functions. Here, we hypothesized that immunization with a bivalent mineral oil-adjuvanted vaccine elevates standard…

View details →DOI: 10.1016/j.cbpa.2026.112014
Negative / Null Result ReportMedicine

Impact of Storage Temperature and Duration on Dimensional Stability and Mechanical Properties of 3D-Printed Implant Surgical Guides.

Kim SJ, Park K, Daher R et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective This study aimed to evaluate the impact of storage temperature and duration on the dimensional stability and mechanical properties of 3D-printed surgical guides. Materials and methods Sixty surgical guides were designed using two…

View details →DOI: 10.1111/jerd.70198
Negative / Null Result ReportMedicine

Interplay between disinfection and the enigmatic diplomonad parasite Spironucleus salmonicida in Atlantic salmon.

Lazado CC, Brenne H, Olaisen D et al. · 2026 · Scientific reports

The diplomonad parasite Spironucleus salmonicida causes spironucleosis, a systemic infection characterised by internal haemorrhaging, splenomegaly, and granulomatous lesions in multiple organs. Prevention is the primary control strategy,…

View details →DOI: 10.1038/s41598-026-51626-4
Negative / Null Result ReportMedicine

Does stunting modify the impact of salivary factors and early childhood caries on oral health-related quality of life?

Setiawan AS, Caesarini M, Musnamirwan IA et al. · 2026 · BMC public health

Background Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further…

View details →DOI: 10.1186/s12889-026-27304-5
Negative / Null Result ReportMedicine

Financial incentives increase uptake and perceived effectiveness of autonomous medical AI, yet patients still seek human reconfirmation.

Yang H, Dai T, Wolf RM · 2026 · NPJ digital medicine

Artificial intelligence (AI) is increasingly used for diagnostic screening. In diabetic retinopathy screening, autonomous AI systems can identify disease without a specialist. However, patient trust in AI remains a challenge, and it…

View details →DOI: 10.1038/s41746-026-02635-0
Negative / Null Result ReportMedicine

The effect of the type of protein supplementation on splanchnic and mammary metabolism of dairy cows fed grass silage-based diets.

Roy C, Ouellet DR, Pellerin D et al. · 2026 · Journal of dairy science

The current experiment studied 2 situations proposed to lead to decreased milk protein yield (MPY). First, NRC (2001) predicts that substitution of soybean meal (SBM) by canola meal (CM) decreases MP supply, thereby negatively affecting…

View details →DOI: 10.3168/jds.2026-28332
Negative / Null Result ReportMedicine

BmK IT2 suppresses proliferation while differentially modulates migration and invasion of neural tumor cells: Association with down-regulation of functional VGSCs and transcriptional reprogramming.

Jing S, Wang J, Cheng S et al. · 2026 · Toxicon : official journal of the International Society on Toxinology

Voltage-gated sodium channels (VGSCs) are emerging therapeutic targets for cancers including neural tumors such as neuroblastomas and gliomas. BmK IT2, a neurotoxic polypeptide from the scorpion Buthus martensii Karsch, is a known…

View details →DOI: 10.1016/j.toxicon.2026.109166
Negative / Null Result ReportMedicine

Inositol biosynthesis is inversely regulated by glycolytic activity.

Onu CJ, Adu M, Jabbar D et al. · 2026 · Biochimica et biophysica acta. Molecular and cell biology of lipids

Inositol is an essential metabolite required for membrane biogenesis, cell signaling and trafficking, and gene expression. Its importance is underscored by the fact that inositol depletion leads to death in eukaryotic cells ranging from…

View details →DOI: 10.1016/j.bbalip.2026.159752
Negative / Null Result ReportMedicine

<i>In vitro</i> and <i>in vivo</i> inhibition of amyloid β aggregation by a Ru(II)-naphthalene diimide complex.

Tiburcio MA, Cali MP, Pereira LMB et al. · 2026 · Dalton transactions (Cambridge, England : 2003)

Amyloid deposits of amyloid-β (Aβ) and hyperphosphorylated tau are pathological hallmarks of Alzheimer's disease (AD), which accounts for most dementia cases worldwide. This study investigates the effect of the complex [Ru(phen) 2 (pNDIp)]…

View details →DOI: 10.1039/d5dt02853a
Negative / Null Result Report

Dietary omega-6 arachidonic acid and omega-3 docosahexaenoic acid supplementation differentially impact skeletal muscle inflammaging in mice

Lu X, Ferraz GA, Sivakumar S et al. · 2026 · Preprint

ABSTRACT Aging is associated with a gradual and progressive decline in skeletal muscle mass and strength known as sarcopenia, which has been attributed to chronic low-grade inflammation. Dietary long-chain polyunsaturated fatty acids…

View details →DOI: 10.64898/2026.06.05.729990
Negative / Null Result Report

Effects of Sensory Feedback on Simulated Online Slot Machine Gambling

Cherkasova M, Assi A, Craw M et al. · 2026 · Preprint

Objective: A prominent feature of land-based and online slot machines is audiovisual feedback that accompanies winning outcomes. Prior laboratory work suggests that this design feature may influence game experience, facilitate immersion,…

View details →DOI: 10.31234/osf.io/zps8c_v3
Negative / Null Result ReportOpen accessMedicine

Effects of Dietary Fermented Black Garlic Powder Supplementation on Performance, Carcass Traits, Serum Parameters, Immune Response and Antioxidant Status of Japanese Male Quails.

Sevim B · 2026 · Tropical animal health and production

This study investigated the effects of dietary supplementation with fermented black garlic powder on performance, carcass characteristics, serum parameters, immunological responses and antioxidant status in male Japanese quail. A total of…

View details →DOI: 10.1007/s11250-026-04871-8