e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19847 results in Negative / Null Result Report · page 318 of 662

Negative / Null Result ReportMedicine

Levan-derived oligosaccharides (LOS) confer selective resistance against Phytophthora capsici but not Botrytis cinerea in melon and watermelon.

Yang M, Chen Y, Yang L et al. · 2026 · International journal of biological macromolecules

Plants face significant threats from pathogens while chemical pesticides remain the primary method for disease control. However, excessive use of chemical pesticides has led to increased pathogen resistance and environmental hazards,…

View details →DOI: 10.1016/j.ijbiomac.2026.152953
Negative / Null Result Report

Influence of Adjuvants and Air Velocity on Spray Drift Deposition in Wind Tunnel Applications of a Bacillus thuringiensis -Based Bioinsecticide

Lima VHA, Reis EFd, Devilla IA et al. · 2026 · Preprint

Most studies in the field of application technology have focused on the interaction between adjuvants and agrochemicals, highlighting the need for further research to evaluate the behavior of adjuvants in association with other classes of…

View details →DOI: 10.20944/preprints202604.0247.v1
Negative / Null Result ReportMedicine

The defense-inducing compound N-hydroxy pipecolic acid is a major substrate for the methyltransferase PbBSMT of Plasmodiophora brassicae.

Benade F, Jülke S, Schwelm A et al. · 2026 · Journal of experimental botany

The clubroot pathogen Plasmodiophora brassicae has an effector protein that can methylate the plant defense compound salicylic acid (SA), and the protein sequence is highly conserved in different isolates worldwide. Sequencing the…

View details →DOI: 10.1093/jxb/eraf548
Negative / Null Result ReportMedicine

Outcomes Following Supplementary Oral Methylprednisolone Pack After Outpatient Total Knee Arthroplasty: A Matched Cohort Study.

Lam AD, Foreman SR, Davidson SJ et al. · 2026 · The Journal of arthroplasty

Background The growing expansion of outpatient total knee arthroplasty (TKA) and emphasis on multimodal pain control to reduce opioid consumption are essential in optimizing perioperative care. This study aimed to assess postoperative…

View details →DOI: 10.1016/j.arth.2026.03.033
Negative / Null Result ReportMedicine

Early risk assessment and aspirin prophylaxis did not reduce preterm preeclampsia in Sweden: a population-based study.

Mans-Gallart N, Carlhäll S, Hildebrand E et al. · 2026 · American journal of obstetrics and gynecology

Background Preeclampsia is a substantial cause of maternal and perinatal morbimortality, with complications becoming more severe the earlier it manifests during pregnancy. The Fetal Medicine Foundation has developed a method that combines…

View details →DOI: 10.1016/j.ajog.2025.10.028
Negative / Null Result ReportMedicine

Fighting fire with fire: Prebunking with the use of a plausible meta-conspiracy framing.

Biddlestone M, Green R, Toribio-Flórez D et al. · 2025 · British journal of psychology (London, England : 1953)

Prebunking can be used to pre-emptively refute conspiracy narratives. We developed a new approach to prebunking - fighting fire with fire - which introduces a plausible 'meta-conspiracy' suggesting that conspiracy theories are deliberately…

View details →DOI: 10.1111/bjop.70023
Negative / Null Result Report

Five days of heat acclimation improves cardiovascular and thermoregulatory responses without altering renal stress biomarkers in endurance athletes

Snape D, Wainwright B, Parsons IT et al. · 2026 · Preprint

Short-term heat acclimation (HA) induces cardiovascular and fluid-regulatory adaptations, but it’s impact on markers of renal tubular injury and acute kidney injury risk (AKI) during exercise-heat stress remains unclear. Fourteen healthy…

View details →DOI: 10.64898/2026.03.06.710014
Negative / Null Result ReportMedicine

Randomized field trial on the effects of on-arrival intranasal vaccination against bovine coronavirus on pneumonia and average daily gain in beef-on-dairy calves.

Jourquin S, Lowie T, Clinquart J et al. · 2026 · Journal of dairy science

This randomized clinical trial evaluated the effect of upon-arrival intranasal vaccination against bovine coronavirus (BCoV) on pneumonia risk in a beef-on-dairy veal production system. Secondary objectives were to assess the effect…

View details →DOI: 10.3168/jds.2026-28339
Negative / Null Result ReportMedicine

Targeted Antimicrobial Agent Prophylaxis Fails to Reduce Peristomal Infections by Multi-Drug-Resistant Bacteria Following Percutaneous Endoscopic Gastrostomy: A Prospective Cohort Study.

Marzo-Escartín B, Villamarín-Melio M, Márquez-Algaba E et al. · 2026 · Surgical infections

Background Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial…

View details →DOI: 10.1177/10962964261438723
Negative / Null Result ReportMedicine

A Single-Centre, Single-Blinded Randomized Control Trial Evaluating the Role of Distraction Therapy in Pain Management Following Major Abdominal Surgeries in Adult Cancer Patients.

Rana CJ, Bakshi SG, Tarhane S et al. · 2026 · Indian journal of surgical oncology

Distract trial In the post-operative period, analgesics are complemented with non-pharmacological methods (NPM). However, the evidence is limited. Objectives Randomised control trial aimed to determine the effectiveness of NPMs of pain…

View details →DOI: 10.1007/s13193-026-02583-x
Negative / Null Result ReportMedicine

Lanthanum carbonate does not reduce urinary oxalate excretion in hyperoxaluric kidney stone formers.

Van de Perre E, Tielemans C, De Clerck D et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis Hyperoxaluria is an important risk factor for kidney stone formation. Currently available treatment options for idiopathic hyperoxaluria have limited efficacy and are difficult to maintain in the long-term.…

View details →DOI: 10.1093/ndt/gfag103
Negative / Null Result ReportMedicine

Results of a Preoperative Screening Brain Magnetic Resonance Imaging Protocol in Neonates Undergoing Cardiopulmonary Bypass.

Islam IS, McGetrick ME, Leon RL et al. · 2026 · The Annals of thoracic surgery

Background We implemented a preoperative screening brain magnetic resonance imaging (MRI) protocol for neonates undergoing cardiac surgery. The intent was to identify unrecognized central nervous system (CNS) injury that might alter the…

View details →DOI: 10.1016/j.athoracsur.2026.03.011
Negative / Null Result ReportMedicine

Outcomes following shunt for secondary hydrocephalus in patients with prolonged disorders of consciousness: a matched cohort study.

Tian Q, Tian B, Li K et al. · 2026 · Neurosurgical review

The effectiveness of surgical intervention for hydrocephalus in patients with prolonged disorders of consciousness (pDoC) remains controversial. To investigate the impact of ventriculoperitoneal shunt (VPS) on secondary hydrocephalus…

View details →DOI: 10.1007/s10143-026-04211-2
Negative / Null Result ReportMedicine

Efficacy of Surgeon-Administered Regional Anesthesia in Cardiac Surgery: A Double-Blinded, 2-Center, Randomized, Placebo-Controlled Trial.

Rasmussen JJ, Bisgaard J, Hønge JL et al. · 2026 · Journal of cardiothoracic and vascular anesthesia

Objectives Managing pain after median sternotomy is a clinical challenge of balancing adequate pain relief with avoidance of excessive opioid consumption. While regional anesthesia techniques are increasingly recommended and applied in…

View details →DOI: 10.1053/j.jvca.2026.03.042
Negative / Null Result Report

Weibull-Based Reliability of Full-Arch Zirconia Prostheses in a Mandibular All-on-4 Model: Monolithic Versus Titanium-Bar–Supported Designs

Tuzlali M, Baki N, Avcu GY et al. · 2026 · Preprint

Background: /Objectives: Full-arch zirconia prostheses for mandibular All-on-4 rehabilitations are provided as screw-retained monolithic zirconia or as a zirconia suprastructure luted to a CAD/CAM titanium bar. Because zirconia is a…

View details →DOI: 10.20944/preprints202602.0002.v1
Negative / Null Result ReportMedicine

Closed incisional negative-pressure wound therapy vs standard surgical dressing for groin incisions following arterial vascular surgery: A prospective multicenter randomized clinical trial.

Lenselink E, Ruig M, Grootendorst DC et al. · 2026 · Journal of vascular surgery

Objective Groin wound complications-including surgical site infections, hematomas, seroma leakage, necrosis, and wound dehiscence-are frequently reported after arterial vascular surgery and significantly impact patient morbidity and…

View details →DOI: 10.1016/j.jvs.2026.04.017
Negative / Null Result ReportMedicine

Effects of tumour necrosis factor and interleukin-6 inhibitor therapy on exercise-related visceral adipose tissue reduction in rheumatoid arthritis.

Jønck S, Adamsen ML, Rasmussen IE et al. · 2026 · Experimental physiology

Excess visceral adipose tissue (VAT) mass increases cardiovascular disease risk. Exercise supports overall health and VAT mass reduction in rheumatoid arthritis (RA). Unlike tumour necrosis factor (TNF), interleukin-6 (IL-6) is upregulated…

View details →DOI: 10.1113/ep093787
Negative / Null Result ReportMedicine

Postprocedural Anticoagulation After Primary Percutaneous Coronary Intervention: 1-Year Results From the RIGHT Trial and Meta-analyses.

Yan Y, Wang X, Fan Z et al. · 2026 · JACC. Asia

Background The RIGHT trial was designed to assess the efficacy and safety of postprocedural anticoagulation (PPA) in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI).…

View details →DOI: 10.1016/j.jacasi.2026.04.003
Negative / Null Result ReportMedicine

Primary Prophylaxis for Clostridioides difficile Infection in Lung Transplant Recipients: A Retrospective Study.

Irwin M, Leedy N, Nandavaram S et al. · 2026 · Transplant infectious disease : an official journal of the Transplantation Society

Background Clostridioides difficile infection (CDI) is a common complication in patients receiving broad-spectrum antibiotics and causes significant morbidity, especially in solid organ transplant recipients. Oral vancomycin has shown…

View details →DOI: 10.1111/tid.70182
Negative / Null Result ReportMedicine

Comparison of international league of associations for rheumatology and pediatric rheumatology international trials organization classification criteria for juvenile idiopathic arthritis: insights from an African multicenter cohort.

Hamdi W, Ben Nessib D, Hashad S et al. · 2025 · European journal of pediatrics

The International League of Associations for Rheumatology (ILAR) classification criteria for juvenile idiopathic arthritis (JIA) are currently widely used in clinical practice. However, new criteria have recently been proposed by the…

View details →DOI: 10.1007/s00431-025-06617-4
Negative / Null Result ReportMedicine

Biodegradable patch based on chitosan-collagen with glycerol plasticizer as scaffold for tympanic membrane perforation.

Widiyanti P, Putra AF, Rudyardjo DI · 2026 · The International journal of artificial organs

Perforation on tympanic membrane could decrease the hearing ability. In some cases, myringoplasty should be performed. Myringoplasty requires material as patch to cover tympanic membrane's hole. This study is aimed to create innovation…

View details →DOI: 10.1177/03913988251412204
Negative / Null Result ReportMedicine

Effect of neuromuscular blockade on opioid consumption in high-risk children undergoing adenotonsillectomy: A randomized-controlled trial.

Efune PN, Nakonezny PA, Pinales P et al. · 2026 · Journal of clinical anesthesia

Background Protective reflexes like coughing occur frequently during pediatric adenotonsillectomy (AT) and are difficult to blunt with anesthetics, potentially leading to higher than necessary opioid administration. Our objective was to…

View details →DOI: 10.1016/j.jclinane.2026.112232
Negative / Null Result ReportMedicine

Impact of Violet LED Light and High-Concentration Hydrogen Peroxide on Dentin Mechanical Properties, Collagen, and Enzymatic Activity.

Damázio AH, Carlos NR, Basting RT et al. · 2026 · Operative dentistry

Objective Because the application of violet light-emitting diode (LED) light may enhance the release of reactive oxygen species, and its combination with a high-concentration bleaching agents may accelerate collagen degradation, this study…

View details →DOI: 10.2341/24-176-l