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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20233 results in Negative / Null Result Report · page 318 of 675

Negative / Null Result ReportMedicine

The added value of artificial intelligence using Quantib Prostate for the detection of prostate cancer at multiparametric magnetic resonance imaging.

Russo T, Quarta L, Pellegrino F et al. · 2025 · La Radiologia medica

Purpose Artificial intelligence (AI) has been proposed to assist radiologists in reporting multiparametric magnetic resonance imaging (mpMRI) of the prostate. We evaluate the diagnostic performance of radiologists with different levels of…

View details →DOI: 10.1007/s11547-025-02017-8
Negative / Null Result ReportMedicine

Rheological properties, microstructure, and encapsulation efficiency of inulin-type dietary fiber-based gelled emulsions at different concentrations

Gomes A, Costa ALR, Fasolin LH et al. · 2025 · Carbohydrate Polymers.

Gelled emulsion systems offer promising matrices for encapsulating bioactive compounds, enhancing stability, bioavailability, and controlled release. Incorporating inulin-type dietary fibers into emulsion-filled gels can innovate food…

Negative / Null Result ReportMedicine

Caffeine's influence on vertical jump height: a real-life collegiate student-athlete approach.

Papadakis Z, Panoutsakopoulos V, Schwarz A et al. · 2025 · Journal of the International Society of Sports Nutrition

Background Caffeine's ergogenic potential in vertical jumping remains contested, particularly at dosages compliant with collegiate athletic regulations. The NCAA enforces a caffeine urinary threshold equivalent to ~5 mg/kg body mass, yet…

View details →DOI: 10.1080/15502783.2025.2501063
Negative / Null Result ReportOpen accessMedicine

Microencapsulated Quercetin and Bifidobacterium animalis Independently Preserve Jejunal Enteric Neurons During Colorectal Carcinogenesis.

Casagrande L, Bernardo CCO, Sestak SS et al. · 2026 · Neurogastroenterology and motility

Background Colorectal cancer (CRC) is a leading cause of cancer-related deaths, significantly disrupting enteric neurotransmission within the colon. While the effects of CRC on the enteric nervous system (ENS) of the colon are well…

View details →DOI: 10.1111/nmo.70190
Negative / Null Result ReportOpen accessMedicine

Listen for a change? A longitudinal field experiment on listening's potential to enhance persuasion.

Santoro E, Broockman DE, Kalla JL et al. · 2025 · Proceedings of the National Academy of Sciences of the United States of America

Scholars and practitioners widely posit that listening to other people enhances efforts to persuade them. Listening may enhance persuasion by promoting cognitive processing, reducing defensiveness, and improving perceptions of the…

View details →DOI: 10.1073/pnas.2421982122
Negative / Null Result ReportOpen accessMedicine

Automated AI fracture detection in initial presentation pediatric wrist X-rays: effects and benefits of adding follow-up examinations.

Scherkl M, Stranger N, Ciornei-Hoffman A et al. · 2026 · La Radiologia medica

Background Artificial Intelligence (AI) in radiology has shown promise in detecting fractures on initial X-rays. However, the role of follow-up examinations in enhancing AI performance remains unexplored. This study evaluates the impact of…

View details →DOI: 10.1007/s11547-025-02153-1
Negative / Null Result ReportOpen accessMedicine

In-house 3D printed porous implants: does strontium-coating enhance osseointegration? An <i>in-vivo</i> study in large animals.

Borgognoni AB, Freund SS, Baas J et al. · 2026 · Frontiers in surgery

Introduction Early osseointegration is essential for the long-term success of uncemented custom-made prostheses, particularly in oncologic bone reconstruction where bone stock is compromised. Strontium (Sr) has demonstrated osteogenic…

View details →DOI: 10.3389/fsurg.2026.1818358
Negative / Null Result ReportMedicine

The temporal copulatory patterns of female rat sexual behavior.

Oyem JC, Heijkoop R, Snoeren EMS · 2025 · Behavioural processes

Female sexual behavior is a naturally rewarding activity that plays an important role in reproduction and species survival. For female rats, regulating the timing of sexual interactions is essential for optimizing mating satisfaction and…

View details →DOI: 10.1016/j.beproc.2025.105148
Negative / Null Result ReportOpen accessMedicine

Limited Utility of the CALLY Index in Enhancing Mortality Prediction for Trauma Patients in Intensive Care Units: A Retrospective Analysis.

Kuo PJ, Huang CY, Liao KH et al. · 2026 · Risk management and healthcare policy

Background Accurate prognostication for trauma patients in intensive care units (ICUs) remains challenging. This study investigated whether incorporating the C-reactive protein-albumin-lymphocyte (CALLY) index into traditional ICU scoring…

View details →DOI: 10.2147/rmhp.s557174
Negative / Null Result ReportMedicine

Effect of one-week New Zealand blackcurrant extract on rowing performance and cognitive function in National team male rowers.

Naderi A, Gharaat MA, Berjisian E et al. · 2025 · Research in sports medicine (Print)

This research investigated the impact of New Zealand blackcurrant (NZBC) on 2000-meter rowing ergometer performance and cognitive abilities. Nine trained male rowers from Iran's national team participated in a double-blind,…

View details →DOI: 10.1080/15438627.2025.2455971
Negative / Null Result ReportMedicine

Increasing cervical penetrability in sheep by long-acting treatments with oxytocin (Carbetocin) and/or prostaglandin E2 (Dinoprostone).

Rodríguez-Piñón M, Casuriaga D, García-Barcelo G et al. · 2025 · Domestic animal endocrinology

The aim was to study the effect of long-acting treatments with oxytocin (Carbetocin, Cb) and/or prostaglandin E2 (Dinoprostone, Dp) on cervical penetrability and collagenolysis in synchronized ewes (12 days MAP-eCG). At 42 h post eCG, ewes…

View details →DOI: 10.1016/j.domaniend.2025.106920
Negative / Null Result ReportMedicine

PLASMA UTILIZATION EXACERBATES RENAL CORTEX INFLAMMATION IN A RODENT MODEL OF HEMORRHAGIC SHOCK AND RESUSCITATION.

Risinger WB, Matheson PJ, Franklin ME et al. · 2025 · Shock (Augusta, Ga.)

Abstract Background and Hypothesis: Resuscitation strategies incorporating fresh frozen plasma have become the standard of care in the management of traumatic hemorrhagic shock. While plasma resuscitation has been shown to augment the…

View details →DOI: 10.1097/shk.0000000000002563
Negative / Null Result ReportMedicine

Differential Impact of Concomitant Methotrexate and Glucocorticoids Dosages on Biologics and JAK Inhibitors: The ANSWER Cohort Study.

Ebina K, Etani Y, Okita Y et al. · 2025 · International journal of rheumatic diseases

Aim This multicenter retrospective study evaluated the differential impact of concomitant methotrexate (MTX) and glucocorticoids (GCs) administration by dosage on the effectiveness and safety of biological disease-modifying antirheumatic…

View details →DOI: 10.1111/1756-185x.70351
Negative / Null Result ReportMedicine

Oral Peanut Immunotherapy With Butyrate Adjuvant (OPIA) in Children: A Randomised, Controlled Trial.

Hsu PS, Barnes EH, Barnes M et al. · 2025 · Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Background Sustained unresponsiveness (SU) remains a major challenge for peanut OIT. The short chain fatty acid (SCFA) butyrate has the potential to upregulate regulatory T cells (Tregs) to improve long term tolerance. We conducted a…

View details →DOI: 10.1111/cea.70127
Negative / Null Result ReportOpen accessMedicine

The Effect of Transcranial Near-infrared Laser Therapy on Chronic Ischemic Stroke Patients: A Randomized, Single-blind, Sham-controlled Trial.

Hassan M, Al Balah O, Hegazy A et al. · 2026 · Journal of the Saudi Heart Association

Background Transcranial photobiomodulation (TPBM) using near-infrared (NIR) light is a novel, non-invasive neuromodulation strategy with potential to enhance neurorecovery. While preclinical studies are promising, clinical evidence in…

View details →DOI: 10.37616/2212-5043.1481
Negative / Null Result ReportOpen accessMedicine

Mind the Gap: Investigating Disaggregated Student Performance in an Upper-Division Biochemistry Course Following Team-Based Learning.

Woodbury J, Offerdahl E · 2024 · CBE life sciences education

Team-based learning (TBL) is a highly intense active learning pedagogy that uses a cycle of preclass preparation, formative assessment for readiness, mini-lectures, and complex team exercises. Consistent with the literature on active…

View details →DOI: 10.1187/cbe.24-02-0090
Negative / Null Result ReportOpen accessMedicine

Sneezing in response to naturalistic bright light exposure.

Bickerstaff L, Trinkl J, Munkwitz S et al. · 2025 · F1000Research

Background The photic sneeze reflex (PSR) is a common but underexplored phenomenon where bright light triggers sneezing, affecting ~30% of the population. This study aimed to characterise the light conditions inducing PSR. Methods One male…

View details →DOI: 10.12688/f1000research.167964.2
Negative / Null Result ReportOpen accessMedicine

Effect of <i>Echinacea purpurea</i> on cytokine gene expression (IL10, IL1β, TNFα, IFNγ), telomere length, lipid peroxidation, and nitric oxide in broilers reared at high altitude.

Bahadoran S, Vaeznia S, Hassanpour H · 2026 · Veterinary and animal science

This study evaluated the effects of dietary Echinacea purpurea supplementation on immune regulation, oxidative stress, and cellular aging in broiler chickens reared at high altitude (2100 m). One hundred and eight day-old male Ross 308…

View details →DOI: 10.1016/j.vas.2026.100675
Negative / Null Result ReportOpen accessMedicine

Assessing the roles of shape prototypicality and sexual dimorphism in ratings of the trustworthiness of faces.

Leger K, Dong J, DeBruine LM et al. · 2023 · Scientific reports

Perceptions of the trustworthiness of faces predict important social outcomes, including economic exchange and criminal sentencing decisions. However, the specific facial characteristics that drive trustworthiness perceptions remain poorly…

View details →DOI: 10.1038/s41598-023-42990-6
Negative / Null Result ReportOpen accessMedicine

Reporting of primary endpoint and associated spin in randomized myeloma trials.

Singstock M, Abdul Khader AHS, Wayant C et al. · 2026 · The oncologist

Background Oncology clinical trials, regardless of success in meeting their primary endpoint, often suffer from spin-the misrepresentation of research findings. Despite dramatic improvements in myeloma outcomes, numerous recent myeloma…

View details →DOI: 10.1093/oncolo/oyag221
Negative / Null Result ReportOpen accessMedicine

Achievement (not effort) makes people feel entitled to rewards.

Cusimano C, Kim J, Wong J · 2025 · Proceedings of the National Academy of Sciences of the United States of America

It is common to say that people feel entitled to rewards-they think they have earned or deserve them-based on their effort and achievement. However, effort and achievement draw on different principles to justify reward. They can also…

View details →DOI: 10.1073/pnas.2409131122
Negative / Null Result ReportOpen accessMedicine

Preoperative Systemic Inflammatory Marker Profile in Surgically Treated Intradural Spinal Tumors: A Retrospective Cohort Study.

Kırkgeçit M, Türkoğlu H, Yüzbaşı MF et al. · 2026 · Medicina (Kaunas, Lithuania)

Background and Objectives : We aimed to determine whether preoperative systemic inflammatory markers derived from complete blood count differ between patients with intradural spinal tumors and healthy controls, and whether any such…

View details →DOI: 10.3390/medicina62050950